C Diff Drug Stewardship

Similar to studies demonstrating efficacy in immunocompetent patients, shorter antibiotic courses should be considered for immunocompromised hosts with presumed bacterial infections. Organ recipients and patients with neutropenic fever syndromes should be prioritized for study in randomized controll …

Implementation of antimicrobial stewardship-initiated restriction criteria can reduce inappropriate utilization of meropenem, overall number of orders, and total duration of therapy.

Long-term treatment of functional dyspepsia with proton-pump inhibitors can alter the gut microbiome. A new pilot randomized, double-blind, placebo-controlled trial suggests the potential of spore-forming probiotics in patients with functional dyspepsia.

Health systems and payers can protect patients by encouraging responsible prescribing

The use of antibiotic prophylaxis was associated with low rate of bacteremia in the pre-engraftment period and a 10% risk of C. diff infections. More studies are needed to better evaluate the efficacy of antibiotic prophylaxis in HSCT patients.

Ampicillin was associated with comparable clinical outcomes in comparison to ceftriaxone for patients who were hospitalized due to CAP. Ampicillin was associated with significantly lower rate of CDI. Results need to be confirmed by more robust study designs.

It has been over a year since the launch of Special Interest Groups (SIGs) in the Middle East and Africa by Oracle Cerner with over 10 sessions on various topics related to data analytics and clinical informatics.

Fantastic work from @USouthFlorida @USFHealth!Ever wondered why cephalosporin (CF) treatment promotes #Cdiff infection? In this multi-PI report (mainly Xingmin Sun and Yu Chen labs) we show the mechanistic details of CF resistance and Zn-binding PBPs.https://t.co/i9pWgdvZ8b— Prahathees Eswara ☀️🌴 (@Eswara_Lab) August 2, 2022

Proton pump inhibitor use was cited as the only avoidable risk factor for mortality in patients with Clostridioides difficile infection.

In 2020, resistant hospital-related infections and deaths increased at least 15%, CDC reports.

Objective To determine whether the long-term care facility (LTCF) Centers for Medicare & Medicaid Services (CMS) Antimicrobial Stewardship (AMS) mandate was associated with a change in the combined rate of LTCF-acquired multidrug-resistant organism infection or colonization (MDRO-I/C) and …

We observed no difference in treatment failure rates for patients receiving an oral BL compared to an oral FQ or SXT for step-down therapy of BSIs due to E. coli, K. pneumoniae, and P. mirabilis.

This retrospective single-center study included children aged 2 months to 18 years who were prescribed an oral antibiotic for microbiologically confirmed urinary tract infection (UTI). The primary outcomes were re-encounter to the hospital, emergency department, or urgent care within 30 days and mod …

Clostridioides difficile infection (CDI) is associated with high mortality rates among patients with chronic illnesses. We aimed to identify avoidable risk factors to reduce the mortality rate in CDI patients. A total of 306 patients with diarrhea and clinical suspicion of CDI were enrolled, and fec …

According to a survey, more than 70% of doctors said they would administer antibiotics to treat asymptomatic bacteria found in urine tests, disobeying recommended guidelines A study of primary care doctors found that, on the basis of a single positive urine sample, an estimated 70% of them would

C. diff survivor and Peggy Lillis Foundation Advocates Council member Christina talks about her experience with the disease, both her own battle and that of her daughter.

This article demonstrates that daily PPI use was the only avoidable risk factor for death. With more extended PPI use, the mortality rate was higher in patients with CDI. Decreases in Prevotella copri and Ruminococcus gnavus and increases in ...

The key to mitigate adverse effects is the rational use of PPIs at the lowest effective dose and in the shortest possible duration. Although these adverse effects have a potential clinical impact, their causal association is still subject to validation.

These findings suggest that doxycycline may have a low propensity to promote C. difficile colonization because it causes relatively limited alteration of the indigenous microbiota that provide colonization resistance and because it provides inhibitory activity against some C. difficile …

Antimicrobial resistance (AMR) is a serious problem that poses an imminent threat to patient safety. But drug-resistant bacteria can be prevented from spreading in hospital facilities by impleme...

The majority of cases were mild to moderate in severity.

C. diff is one of the most serious side effects of antibiotics. It can cause severe diarrhea that leads to colon damage or even death. It’s important to be aware! #cdiff #cdifficile #antibiotics #antibioticawareness #antibioticresistance pic.twitter.com/U80MA390RU— Peggy Lillis Fund (@PeggyFund) July 7, 2022

Critically ill patients are at an increased risk for developing stress ulcers of the mucosa of the upper gastrointestinal (GI) tract. Bleeding from stress ulcers was previously associated with a longer stay in the intensive care unit and an increased risk of death. Thus, most patients admitted to th …

“Diarrhea is very common among the critically ill, including patients with burns,” Parisa Shoaei, PhD, and Bahareh Vakili, PhD, note. “Following a burn injury, intestinal permeability, displacement of bacteria, and/or endotoxins lead to serious complications, including gut-derived infection, inflammatory bowel disease, colon cancer, obesity, and inflammation in the lungs, liver, and intestines. The gut flora

At the end of September 2021, Freda Pyles, a resident of rural Pennsylvania, began an antibiotic for a dental infection. That set off a 6-month battle with Clostridioides difficile, which was misdiagnosed a few times before she was treated at Yale-New Haven Hospital. Here, she describes how she contracted the infection and what happened afterwards.

The lawyer for B.C.'s naturopathic regulator has pushed back on a suggestion that the profession is not "bound by science" during a court hearing related to one naturopath's business producing fecal transplants for autistic children.

Antibiotics have become a mainstay of healthcare in the past century due to their activity against pathogens. This manuscript reviews the impact of antibiotic use on the intestinal microbiota in the context of mass drug administration (MDA). The importance of the gut microbiota to human metabolism and physiology is now well established, and antibiotic exposure may impact host health via collateral effects on the microbiota and its functions. To gain further insight into how gut microbiota respond to antibiotic perturbation and the implications for public health, factors that influence the impact of antibiotic exposure on the microbiota, potential health outcomes of antibiotic-induced microbiota alterations, and strategies that have the potential to ameliorate these wider antibiotic-associated microbiota perturbations are also reviewed. Graphical Abstract