C Diff Drug Stewardship

Antibiotics have become a mainstay of healthcare in the past century due to their activity against pathogens. This manuscript reviews the impact of antibiotic use on the intestinal microbiota in the context of mass drug administration (MDA). The importance of the gut microbiota to human metabolism and physiology is now well established, and antibiotic exposure may impact host health via collateral effects on the microbiota and its functions. To gain further insight into how gut microbiota respond to antibiotic perturbation and the implications for public health, factors that influence the impact of antibiotic exposure on the microbiota, potential health outcomes of antibiotic-induced microbiota alterations, and strategies that have the potential to ameliorate these wider antibiotic-associated microbiota perturbations are also reviewed. Graphical Abstract

“RT @IDstewardship: Cefepime kills Pseudomonas And a whole lot of bacterial flora too Try to use it wisely Or there could be lots of liqu…”

Based on the reviewed evidence, remote antimicrobial stewardship programs may aid in the more judicious use of antimicrobials by decreasing utilization rates. More studies are needed to clarify patient-oriented outcomes. Telestewardship has positive effects in terms of cost savings, although savings …

This randomized clinical trial assesses the effect of a multispecies probiotic on the risk of antibiotic-associated diarrhea in children.

OBLs appear to be non-inferior to FQ/SXT in the rate of all-cause hospital readmission within 30 days. However, OBLs may be associated with increased readmissions with recurrent UTI.

Antibiotic-associated diarrhea (AAD) describes any unexplained diarrhea associated with the use of antibiotics. AAD develops through diverse mechanisms, ranging from pharmacologic effects on gut...

The coronavirus disease 2019 (COVID-19)-pandemic-related overload of health systems has compromised the application of antimicrobial stewardship (AS) models and infection prevention and control (IPC) programs. We aimed to evaluate the impact of COVID-19 on antimicrobial consumption (AC) and antimicr …

The progressive increase in antibiotic resistance in recent decades calls for urgent development of new antibiotics and antibiotic stewardship programs to help select appropriate treatments with the goal of minimising further emergence of resistance and to optimise clinical outcomes. Three new tetra …

We need to be judicious in the use of our antibiotics, says Adam Faye, MD

/PRNewswire/ -- Bausch Health Companies Inc. (NYSE/TSX: BHC) ("Bausch Health") and its gastroenterology business, Salix Pharmaceuticals, ("Salix"), one of the...

Ertapenem is one of the carbapenems recommended for treating extended-spectrum β-lactamase (ESBL)-producing Enterobacterales. However, efficacy data are limited. We compared 30-day mortality rates for patients receiving ertapenem and other carbapenems for treatment of ESBL-producing Entero …

Antibiotic treatment alters the composition and magnitude of got microbiota species.

Clostridioides difficile infection is an uncommon postoperative complication of appendectomy and is associated with worse outcomes and higher mortality. Older patients, female sex, those with sepsis, and those undergoing open surgery are at higher risk for developing Clostridioides difficile infecti …

The results suggest that a persuasive educational approach to antimicrobial stewardship, with the introduction of an empiric antimicrobial manual and continuous education, resulted in reductions in both antimicrobial use and healthcare-associated BSI caused by multidrug-resistant organisms. More stu …

Non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) do not increase the risk for Clostridioides difficile infection.

TUESDAY, May 31, 2022 (HealthDay News) -- Inappropriately prescribed antibiotics to children pushed up U.S. health care costs by at least $74 million in just one year, new research shows.Antibiotics can make a difference in bacterial infections, but not viral illnesses.Prescribing them needlessly or...

An estimated 70 percent of primary care physicians reported in a survey that they would still prescribe antibiotics to treat asymptomatic infections based solel

Withdrawal: This content is part of a Special Issue and will be available in the full issue publication Summer 2022.

We need to be judicious in the use of our antibiotics, says Adam Faye, MD

71 percent of the doctors would give a patient antibiotics for an infection — even if the treatment went against recommended guidelines.

Antibiotics are modifiable risk factors for Clostridioides difficile infection (CDI), driving pathogenesis via gut microbiome disruption. The management of patients with CDI prescribed concomitant non-CDI antibiotics is problematic and influences CDI outcome and recurrence risk. Though an assessment …

"Seeing the numbers really does crystallize the urgency of this issue."

A new study from Washington University in St. Louis and The Pew Charitable Trusts analyzing private health insurance claims data found that inappropriate antibiotic prescribing among children diagnosed with seven common outpatient infections resulted in $74 million in excess health care costs in the U.S. in 2017.

In this cohort study of children with common infections treated in an outpatient setting, inappropriate antibiotic prescriptions were common and associated with increased risks of adverse drug events and higher attributable health care expenditures. These findings highlight the individual- and natio …

Children who were prescribed antibiotics inappropriately were more likely to develop complications such as diarrhea and skin rashes than children who were treated according to medical guidelines, according to a new study from Washington University School of Medicine in St. Louis and The Pew Charitable Trusts. This misuse of antibiotics resulted in at least $74 million in excess health-care costs in the U.S. in 2017.

Researchers found that inappropriate antibiotic prescriptions were associated with avoidable adverse drug events in children, including Clostridioides difficile, and substantial health care expenditures.