C Diff Drug Stewardship

New research published in the Frontiers in Pediatrics on pediatric patients with clostridium difficile infections (CDI) could ultimately result in future studies identifying risk factors within...

In this cohort study, concurrent PRF and CDSS were associated with limiting the use of piperacillin-tazobactam and carbapenems while reducing use of other antibiotics.

A Johns Hopkins Children’s Center-led national quality improvement collaborative highlights a “less is more” method that may prevent antibiotic overprescr

Heard emotional #CDiff patient survivor stories @PeggyFund So powerful Most received “just-in-case” unnecessary #antibiotics from #physicians #Dentists Working hard to educate appropriate use 💊 👍@MartyMakary @juliomayol @AmerDentalAssn @IDSAFoundation @SIDPharm @ACCP— Debbie Goff (@idpharmd) May 3, 2022

Temocillin is an old antibiotic, but given its particular characteristics, it may be a suitable alternative to carbapenems for treating infections due to ESBL-producing Enterobacterales and uncomplicated UTI due to KPC-producers. In this narrative review, the main research question was to sum …

Background Proton pump inhibitors (PPIs) are one of the most commonly prescribed pharmacological groups. Their high prevalence and duration of use are of important health concern due to the risk they can cause to patients. Despite these risks, their use remains particularly high, especially in the elderly population. We determined the trend in the prevalence of PPI consumption in the population of the Lleida Health Region between 2002 and 2015 to explore patterns of use and associated characteristics. Methods An analysis of secular trends between 2002 and 2015 was performed. The database included all individuals who used PPIs in the Lleida Health Region, which had 358.070 inhabitants in 2015. PPI use was evaluated using prescription dispensing data from the public health system. All types of PPIs approved by the pharmaceutical agency were included. Trends were investigated by age and sex. Results For the whole study period, a total of 215,417 individuals accounted for 292,122 dispensations. Overall, 48% were women, and the mean age was 62 years. The dispensing prevalence of PPI use in 2015 was 18.0% overall—20.4% for women and 15.7% for men—and was 54.6% for those over 65 years. In terms of the subtypes of PPIs, 16.8% of prescriptions were for omeprazole, 0.66% were for pantoprazole, and 0.48% were for lansoprazole. The evolution of the annual PPIs dispensation prevalence showed a progressive increase from 11.3% in 2002 to 18.0% in 2015, which was attributable to an increase in the use of omeprazole (9.0% vs. 16.8%) and, to a lesser extent, esomeprazole (0.02% vs. 0.4%). Conclusion An increase in the prevalence of PPI dispensation was observed over 14 years of follow-up. The prevalence of dispensation was especially high for the population older than 65 years, despite the risk of cognitive decline and falls. Comprehensive actions are required to to increase rational prescribing of PPIs, especially in high-risk populations.

Pediatric patients with CDI had a higher number of previous-day hospital admissions, hospitalizations, and total hospital admissions.

A study found that hospital providers who prescribe unnecessarily high rates of antibiotics are likely to continue doing so over time.

Among patients with CAP at US hospitals, CDI was uncommon, occurring in ∼0.33% of patients. We did not detect a significant association between the choice of empiric guideline recommended antibiotic therapy and the development of CDI.

Researchers found that 64% of antibiotic prescriptions to Black patients and 74% of antibiotic prescriptions to patients 65 and older were deemed inappropriate.

The risk of a community-acquired C difficile infection was 7-fold higher for outpatients with antibiotic exposure.

Study results show at a molecular level how fidaxomicin selectively targets these bacteria, while sparing others in the gut microbiome.

Scientists suggest bacteria that safely break down antibiotics could prevent opportunistic infections and reduce the spread of antibiotic resistance.

Nature Biomedical Engineering - A strain of Lactococcus lactis engineered to altruistically degrade β-lactam antibiotics through the secretion and extracellular assembly of a heterodimeric...

Follow best practices when prescribing antibiotics in the pediatric population

The risk of a community-acquired C difficile infection was 7-fold higher for outpatients with antibiotic exposure.

2 weeks left for the early registration discount for #MADID2022! Don't miss more cutting edge content in our "C. difficile Infections: Past, Present and Future" session featuring Drs. Colleen Kelly and Kevin Garey @TheGareyLab @cdiffFoundation #cdiffhttps://t.co/s14V2z1RD5 pic.twitter.com/Fr6FjxoOm9— MAD-ID The Antimicrobial Stewardship Meeting®️ (@MAD_ID_ASP) April 4, 2022

MIT researchers engineered a strain of bacteria that can help protect the natural flora of the human digestive tract from antibiotics and curb the emergence of antimicrobial resistance.

A research team at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Massachusetts Institute of Technology (MIT), using a synthetic biology approach, has developed an engineered live biotherapeutic product (eLBP) that, when given together with commonly used antibiotics known as beta-lactams (which includes the well-known antibiotic penicillin), protects the gut microbiome from dysbiosis. The study is published in Nature Biomedical Engineering.

“Be antibiotic aware and avoid taking unnecessary antibiotics by following these simple guidelines #cdiff #cdifficile #amr #antibiotics #antibioticaware #antibioticresistance #infectiousdisease #IDtwitter”

Clostridioides difficile is a micro-organism well known to cause pseudomembranous colitis with rare extraintestinal manifestations. We present the case of an elderly male with multiple comorbidities who presented with acute onset of fever/chills and hypotension, found to have polymicrobial ba …

NCT04976829.

Background: Solid organ transplant recipients have several risk factors for peri-operative multi-drug-resistant infection: their immune system is dampened as a result of critical illness and surgical stress that may be further impaired by induction immunotherapy and broad-spectrum anti …

This review aims to summarize current progress in the management of critically ill, using biomarkers as guidance for antimicrobial treatment with a focus on antimicrobial stewardship. Accumulated evidence from randomized clinical trials (RCTs) and observational studies in adults for the biomarker-gu …