C Diff Drug Stewardship

In February 2021 I received care from a neighborhood physician's assistant for a hangnail that had become infected. After having the infection drained, I

Background: Broad-spectrum antibiotic agents are sometimes utilized for prophylaxis of Gustilo grade III open fractures. However, this practice is not recommended by current guidelines, and it is unknown how patient outcomes are impacted. This study aimed to determine if prophylaxis wi …

Background: Clostridioides difficile infection (CDI) can result in life-threatening illness requiring surgery. Surgical options for managing severe or fulminant, non-perforated C. difficile colitis include total abdominal colectomy with end ileostomy or creation of a dive …

Surgical site infections similar versus shorter-duration prophylactic IV regimen

Non-aspirin nonsteroidal anti-inflammatory drugs do not increase the risk for Clostridioides difficile infection, according to a retrospective review of nearly 1,500 people.

Rabeprazole oral tablet (Aciphex) is used to reduce the amount of acid produced by the stomach. Learn about side effects, warnings, dosage, and more.

ABPC/SBT after esophagectomy was better at preventing early-onset pneumonia compared with CEZ and was feasible regarding the development of antimicrobial resistance.

Probiotic supplement may help protect against some of the harmful side effects on the gut microbiome that are common with antibiotic use.

Background and Objectives: Spontaneous bacterial peritonitis (SBP) is a life-threatening complication of liver cirrhosis. Antibiotic prophylaxis is effective but can lead to an increased incidence of Clostridioides difficile infection (CDI). The aim of this study was to evaluate the in …

Both proton pump inhibitors and histamine 2 receptor antagonists are commonly prescribed for stress ulcer prophylaxis in critically ill patients.

These model data suggest that the minimal impact of first-generation cephalosporins, namely cefalexin and cefradine, on the intestinal microbiota results in a low propensity to induce CDI.

Available data suggest Empiric Therapy may offer no clinical benefit to this population, regardless of whether vancomycin-resistant enterococcus is identified in blood culture or no pathogen is found. Such an approach may only expose the majority of patients to unnecessary vancomycin-resistant enter …

Our systematic review and meta-analysis demonstrate that immunosuppressive therapy is a risk factor for complicated outcomes of CDI.

Popularity of the stomach- and intestine-protecting drugs has skyrocketed, but related adverse events, like osteoporotic fractures, C difficile infection, and pneumonia, are problematic.

The reports of experiences in implementing ASPs in ED show heterogeneous antimicrobial use indicators, which makes it difficult to compare results. Therefore, antimicrobial use indicators for ASPs must be standardised between hospital units.

Prior research identified an increased risk for Clostridioides difficile infection (CDI) following exposure to certain non-steroidal anti-inflammatory drugs (NSAIDs). We conducted a retrospective case-control study to evaluate the risk for CDI associated with NSAID use. NSAID use was not associated …

Five years of inappropriate antibiotic treatment finally ended after proper diagnosis

Patients prescribed proton pump inhibitors had roughly double the risk of community-associated Clostridioides difficile infection compared with those not taking the drugs.

Adherence to antimicrobial prophylaxis guidelines in cardiac implantable electronic device procedures in two Australian teaching hospitals https://t.co/beIwxoEANy #cdi #cdiff— Dave Roberts (@CDifficile1) September 3, 2021

PPIs were associated with CIGB; however, the overall rate of CIGB was low. Compared to H2RAs, PPIs were associated with hospital mortality. Further identification of appropriate selection criteria for ulcer prophylaxis and comparisons of pharmacologic prevention strategies are warranted.

Objective This study investigated antibiotic prophylaxis (AP) guideline adherence and the cardiac implantable electronic device (CIED) infection rate in two major Australian public teaching hospitals.MethodsIn a retrospective observational study, the medical records of patients who underwent CIED pro …

Abstract Background COVID-19 frequently presents with acute gastrointestinal (GI) symptoms, but it is unclear how common these symptoms are after recovery. The purpose of this study was to estimate...

Patients who received probiotics had statistically significantly fewer C. difficile diagnostic stool tests performed (4% vs. 16%, p = 0.005) and fewer additional infectious diagnostic testing performed (4% vs. 10%, p = 0.096), respectively. Further research is warranted to optimize and standardize probiotic prescribing in high-risk patients.

To determine if there were significant differences produced by 5 of the most prevalent causes of equine enterocolitis, we studied retrospectively the gross and microscopic pathology of 90 cases of enterocolitis submitted to the San Bernardino laboratory of the California Animal Health and Food Safet …

Fluoroquinolones use within 14 days of transplantation was 1 of the strongest risk factors for C difficile infections.

BACKGROUND Wells syndrome is an uncommon inflammatory dermatosis that presents as tender or mildly pruritic cellulitis-like eruptions. The clinical presentation can include papular and nodular eruptions, annular plaques, vesicles, bullae, and urticaria. This syndrome can be promoted by inappropriate …

Fluoroquinolones are associated with an increased risk of Clostridioides difficile infection (CDI). Probiotic supplementation has been shown to reduce the risk of antibiotic-associated diarrhea with variable effects on CDI. The objective of this study was to evaluate receipt of probiotics on …