C Diff Drug Stewardship

Lower use of antimicrobials for clostridium difficile infection associated with a shorter length of stay in hospitals.

Scientific Reports - Impact of long-term dietary habits on the human gut resistome in the Dutch population

A virus causes COVID-19, but many doctors still prescribe antibiotics to those who don't need them.

The findings of this study suggest that high-risk, hospital-based antibiotics are a potentially high-value target to reduce MDROs in postacute care NHs. This study underscores the potential utility of integrated hospital and NH stewardship programming on regional MDRO epidemiology.

Hospitals with lower-than-expected CDI antimicrobial use had on average fewer beds, shorter length of stay, and higher proportion of undergraduate or nonteaching medical school affiliation.

The paradigm of antivirulence therapy dictates that bacterial pathogens are specifically disarmed but not killed by neutralizing their virulence factors. Clearance of the invading pathogen by the immune system is promoted. As compared to antibiotics, the pathogen-selective antivirulence drugs hold p …

ClinicalTrials.gov NCT05020418.

It started with a rash on my back that I suspect started from the barber I was seeing.  Scratching it made it worse. I went to the doctor’s office and was tended to by a PA. It was decided that this infection should be treated with a broad-spectrum antibiotic. After …

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The prevalence rate of LabID CDI had a significant dose-response association with first-line antibiotics for treating CDI. We identified hospitals with extreme discordance between CDI prevalence and CDI AU, highlighting potential opportunities for data validation and improvements in diagnostic and t …

The present study strengthens the argument for including RIF in the list of antibiotics that can induce CDI, particularly in elderly men suffering from underlying conditions. Although careful attention must be paid to the possibility of CDI recurrence, a strategy of re-administration of RIF is feasi …

Infectious Disease News | In 2014, the CDC established The Core Elements of Hospital Antibiotic Stewardship to help hospitals improve their prescribing practices. Over the next 2 years, it also published guidance for nursing homes and the outpatient setting.As of 2019, 84% of hospitals reported having a program that meets the CDC’s seven “core elements.” We asked experts to tell us about the essential

Periprocedural antimicrobial prophylaxis are administered and in some cases continued for extended periods of time while the patient has a surgical drain in place.

Background/ Rationale Clostridioides difficile infection (CDI) is transmitted via the fecal-oral route and is implicated in antibiotic-associated colitis. Similar to CDI, patients with coronavirus disease 2019 (COVID-19) require early identification and isolation, appropriate personal protect …

Of 10 HAIs, 8 had highest incidences during periods of lowest IP staffing and experience. Some HAI rates varied inversely with levels of IP staffing and experience and others appeared to be more influenced by nursing levels or other confounders.

Non-aspirin nonsteroidal anti-inflammatory drugs do not increase the risk for emClostridioides difficile/em infection, according to a retrospective review of nearly 1,500 people.

A multiphase quality improvement project aimed to improve management of beta-lactam allergies and access to graded challenges led to an increase in beta-lactam utilization without an increase in anaphylaxis, even with limited access to PST.

Following implementation of a levofloxacin prophylaxis guideline, we observed a significant decrease in BSIs due to Gram-negative rods and NHSN CLABSIs. Vigilant monitoring of outcomes post guideline implementation is critical to track emergence of resistant organisms.

The NHS trust in charge of Queen’s and King George hospitals has urged staff to be more disciplined in antibiotic use.

Antibiotics are known to induce gut dysbiosis and increase the risk of antibiotic resistance. While antibiotic exposure is a known risk factor leading to compromised colonization resistance against enteric pathogens such as Clostridioides difficile, the extent and consequences of antibiotic perturba …

In FQ-treated hospitalized patients, DAV132 was well tolerated, and FQ plasma concentrations unaffected. DAV132 preserved intestinal microbiota diversity and C. difficile colonization resistance.

Our study did not identify an increased risk of CDI associated with vedolizumab vs anti-TNFa agents after controlling for UC severity. We hope that these findings will reassure UC providers considering vedolizumab as a first-line biologic agent in the context of gastrointestinal infectious risks.

Ferring’s Microbiome Health Index is a diagnostic tool that may help distinguish a healthy gut microbiome from post-antibiotic dysbiosis, and could potentially identify debilitating illnesses such as C difficile infection

Implementation of a β-lactam side chain-based cross-reactivity chart and enhanced allergy assessment was associated with increased use of β-lactams in patients with pneumonia without increasing allergic reactions.