#EmergencyMedicine Docs, Please STOP prescribing antibiotics for patients presenting with #COVID. We are seeing lots of #Cdiff in those who end up getting admitted few days later. Sincerely, Your #Hospitalist colleagues.
C Diff Drug Stewardship
Rigorous antibiotic stewardship in the hospitalized elderly population: saving lives and decreasing cost of inpatient care
Rigorous de-escalation and curtailing of antibiotic therapies were beneficial and without risk for the hospitalized patients 65 years and over.
In COVID-19 Era, Modeling Shows Promise in Preventing Health Care–Associated Infections - AJMC.com Managed Markets Network
Use of diagnostic and antimicrobial stewardship practices to improve Clostridioides difficile testing among SHEA Research Network hospitals
Antibiotic resistance: Alternating between drugs not the answer - Medical News Today
Correlation between antibiotic consumption and the incidence of healthcare facility-onset Clostridioides difficile infection: a retrospective chart review and analysis
Doctors see uptick in a serious bowel infection during Covid | Pune News - Times of India Repeated disregard for warnings against antibiotic overuse has led to rise in cases of serious bowel infection triggered by Clostridium difficile, oft timesofindia.indiatimes.com
Acurx Pharmaceuticals Joins the Antimicrobials Working Group - Yahoo Finance
The Antimicrobials Working Group (AWG) announced today the addition of Acurx Pharmaceuticals, Inc. (NASDAQ: ACXP) (Acurx) to its coalition of companies with the mission to combat drug resistant infections and spur life-saving innovations. This new addition brings AWG's membership to 13 antimicrobial drug companies.
New Recommendations for Antibiotic Prophylaxis Prior to Dental Procedures - Contagionlive.com
Antimicrobial stewardship and infection prevention interventions targeting healthcare-associated Clostridioides difficile and carbapenem-resistant Klebsiella pneumoniae infections: a scoping review
Prospective Multicenter Study of Chemotherapy-Induced Clostridium (Clostridioides) difficile Infection in Patients With Lung Cancer: North Japan Lung Cancer Study Group Trial 1204
Preoperative screening urinalysis is widely used—but usually unnecessary, study finds - Massachusetts General Hospital
Impact of a computerized physician order entry (CPOE)-based antibiotic stewardship intervention on the treatment duration for pneumonia and COPD exacerbations
Our study demonstrates the short-term effectiveness of a CPOE-based ABS intervention to reduce antibiotic treatment duration for uncomplicated pneumonia. This approach may be particularly suitable for hospitals with limited ABS resources.
Calcineurin Inhibitors May Increase Risk for Community-Acquired Clostridioides difficile Infection - Infectious Disease Advisor
Letter to the Editor: Response to Maziade et al; Enhanced Clostridioides difficile infection prevention with a pharmacy-controlled policy that adds a three-strain Lactobacillus probiotic concomitantly to antibiotic therapy
Molecular epidemiology and clinical risk factors for rifaximin-nonsusceptible Clostridioides difficile infection in South Korea: a prospective multicenter observational study
The rifaximin-nonsusceptibility rates for the C. difficile isolates identified in this study were reasonably high with most of these resistant strains belonging to either the 018 or 017 RT. The widespread dissemination of these clones may be the result of the antimicrobial selection pressure introdu …
Among first-line UTI agents, TMP/SMX associated with higher risk for adverse drug events - Healio
Between two first-line agents for uncomplicated UTIs, trimethoprim-sulfamethoxazole was associated with a higher risk for several adverse drug events compared with nitrofurantoin, researchers reported in Clinical Infectious Diseases. Non-first-line agents also were associated with a higher risk for adverse drug events compared with nitrofurantoin, in addition to potential microbiome-related
COVID-19 & C. difficile Infections - Peggy Lillis Foundation
The COVID-19 pandemic has given us a new appreciation for the role of public health. While our public health departments and hospitals continue to manage vaccination and cases resulting from new variants, we also know that those of you battling C. diff infections still need our help. Please know that …
Poor clinical outcomes associated with suboptimal antibiotic treatment among older long-term care facility residents with urinary tract infection: a retrospective cohort study
In this national cohort study, suboptimal antibiotic treatment was associated with a 6% increased risk of the composite measure of poor clinical outcomes, in particular, a 94% increased risk of CDI. Beyond the decision to use antibiotics, clinicians should also consider the potential harms of subopt …
Seres Therapeutics microbiome drug flunks Phase 2 test in ulcerative colitis - MedCity News
Are Antibiotics Really the Answer for UTIs in Women? - HealthDay News
Impact of a 4-year antimicrobial stewardship program implemented in a Greek tertiary hospital
RT @FfitzP: How to manage #cdiff when concomitant antibiotics? Stop the antibiotic if possible / if you can’t limit it’s duration & change…
How to manage #cdiff when concomitant antibiotics? Stop the antibiotic if possible / if you can’t limit it’s duration & change to low risk class / stop PPI if possible / avoid metronidazole / treat with fidaxomicin / consider bezkotoxumab @ESCMID #ECCMID2021 @iscm_micro— Fidelma Fitzpatrick (@FfitzP) July 10, 2021
Clinical impact of a Clostridioides (Clostridium) difficile bedside infectious disease stewardship intervention
Decreasing ICU-associated Clostridioides difficile infection through fluoroquinolone restriction, the FIRST trial: a study protocol
NCT03848689.
Evaluating an Antibiotic Stewardship Collaborative in New York State Hospitals - Contagionlive.com
Average annual discharges were significantly higher in participating hospitals.
Antibiotic choice impacts C. difficile shedding and hospital contamination, study finds - Healio
Fidaxomicin and vancomycin reduced shedding of Clostridioides difficile spores faster and were associated with lower rates of hospital contamination compared with metronidazole, according to study findings.“One unique facet of infectious diseases is the infectious part. How we treat our patients matters not just to their own health but to those around them as well,” Nicholas Turner,
Class-specific relationship between use of immunosuppressants and risk for community-acquired Clostridioides difficile infection
Calcineurin inhibitors were associated with a modest but significantly increased risk of CA-CDI. The greatest risk was observed among patients using multiple classes of immunosuppressants. Future studies should recognize that CDI risk differs based on immunosuppressant class.
Incidence of Clostridioides difficile infection (CDI) related to antibiotic prescribing by GP surgeries in Wales
An increased risk of CDI is demonstrated at a primary care practice population level, reflecting their antibiotic prescribing rates, particularly clindamycin, and population demographics.
Empiric Antibiotic De-escalation Needed After Negative Cultures for Pneumonia - Infectious Disease Advisor
Fewer than 1 in 7 eligible patients with pneumonia had their empiric antibiotic coverage de-escalated following negative cultures.