C Diff Drug Stewardship

The aim of this study was to estimate healthcare costs and mortality associated with serious fluoroquinolone-related adverse reactions in Finland from 2008 to 2019. Serious adverse reaction types were identified from the Finnish Pharmaceutical Insurance Pool's pharmaceutical injury claims and the Fi …

Discontinuation of extended antimicrobial prophylaxis was associated with a significant decrease in the incidence of C. difficile infection without a concomitant change in postprocedural infections or EVD-associated infection. This study provides evidence in support of specialtfy-wide discontinuatio …

Our antimicrobial pharmacist-led intervention included: (a) a structured review of antibiotic prescriptions; (b) educating prescribers on antimicrobial therapy; (c) monthly reporting of department-level rates of blood sampling for culture. Daily review began in May 2018 and was discontinued after 10 …

Antibiotic use is often the target of interventions in health care organizations that aim to decrease healthcare-associated infections (HAI) such as Clostridioides difficile (CDI); this is particularly important for fluoroquinolones (FQ), which are frequently used in critical care settings. I …

Antibiotic prescribing can lead to adverse drug events and antibiotic resistance, which pose ongoing urgent public health threats (1). Adults aged ≥65 years (older adults) are recipients of the highest rates of outpatient antibiotic prescribing and are at increased risk for antibiotic-related advers …

Patients in hospitals and nursing homes often receive antibiotics that can make them resistant to their benefits, researchers report.

Implementation of an antibiotic de-escalation guideline resulted in decreased use of intravenous antipseudomonal β-lactams and fewer episodes of C difficile colitis, without adversely impacting patient outcomes. Additional studies are needed, preferably in the form of randomized controlled trials, t …

Lower use of antimicrobials for clostridium difficile infection associated with a shorter length of stay in hospitals.

Scientific Reports - Impact of long-term dietary habits on the human gut resistome in the Dutch population

A virus causes COVID-19, but many doctors still prescribe antibiotics to those who don't need them.

The findings of this study suggest that high-risk, hospital-based antibiotics are a potentially high-value target to reduce MDROs in postacute care NHs. This study underscores the potential utility of integrated hospital and NH stewardship programming on regional MDRO epidemiology.

Hospitals with lower-than-expected CDI antimicrobial use had on average fewer beds, shorter length of stay, and higher proportion of undergraduate or nonteaching medical school affiliation.

The paradigm of antivirulence therapy dictates that bacterial pathogens are specifically disarmed but not killed by neutralizing their virulence factors. Clearance of the invading pathogen by the immune system is promoted. As compared to antibiotics, the pathogen-selective antivirulence drugs hold p …

ClinicalTrials.gov NCT05020418.

It started with a rash on my back that I suspect started from the barber I was seeing.  Scratching it made it worse. I went to the doctor’s office and was tended to by a PA. It was decided that this infection should be treated with a broad-spectrum antibiotic. After …

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The prevalence rate of LabID CDI had a significant dose-response association with first-line antibiotics for treating CDI. We identified hospitals with extreme discordance between CDI prevalence and CDI AU, highlighting potential opportunities for data validation and improvements in diagnostic and t …

The present study strengthens the argument for including RIF in the list of antibiotics that can induce CDI, particularly in elderly men suffering from underlying conditions. Although careful attention must be paid to the possibility of CDI recurrence, a strategy of re-administration of RIF is feasi …

Infectious Disease News | In 2014, the CDC established The Core Elements of Hospital Antibiotic Stewardship to help hospitals improve their prescribing practices. Over the next 2 years, it also published guidance for nursing homes and the outpatient setting.As of 2019, 84% of hospitals reported having a program that meets the CDC’s seven “core elements.” We asked experts to tell us about the essential

Periprocedural antimicrobial prophylaxis are administered and in some cases continued for extended periods of time while the patient has a surgical drain in place.

Background/ Rationale Clostridioides difficile infection (CDI) is transmitted via the fecal-oral route and is implicated in antibiotic-associated colitis. Similar to CDI, patients with coronavirus disease 2019 (COVID-19) require early identification and isolation, appropriate personal protect …

Of 10 HAIs, 8 had highest incidences during periods of lowest IP staffing and experience. Some HAI rates varied inversely with levels of IP staffing and experience and others appeared to be more influenced by nursing levels or other confounders.

Non-aspirin nonsteroidal anti-inflammatory drugs do not increase the risk for emClostridioides difficile/em infection, according to a retrospective review of nearly 1,500 people.