C Diff Drug Stewardship

Calcineurin inhibitors were associated with a modest but significantly increased risk of CA-CDI. The greatest risk was observed among patients using multiple classes of immunosuppressants. Future studies should recognize that CDI risk differs based on immunosuppressant class.

An increased risk of CDI is demonstrated at a primary care practice population level, reflecting their antibiotic prescribing rates, particularly clindamycin, and population demographics.

Fewer than 1 in 7 eligible patients with pneumonia had their empiric antibiotic coverage de-escalated following negative cultures.

We found large variations in C. difficile infection risk for antibiotic courses used for the same common indications. Risk could be substantially reduced if pre

We observed improvement in antimicrobial stewardship indicators following SpectrumTM implementation. We cannot determine the cause of these improvements.

This review identified several published associations between PPIs and adverse outcomes, however, further investigation is needed to understand their clinical significance and the likelihood of causal relationship. If higher quality evidence is generated substantiating the potential risks, it may be …

Clostridioides difficile (CD) is widely reported as one of the most prevalent multi-drug resistant (MDR) organisms. Assessment of temporally disparate…

Acute bronchitis caused by bacteria is far less common than viral bronchitis, but it may require treatment with antibiotics. Here’s what to expect.

Clostridioides difficile is the most common pathogen responsible for hospital-acquired diarrhea. This complication of antibiotic treatment mainly endangers the health of elder patients. Preventing the development of C. difficile infections (CDI) is still a challenge that needs to be ad …

In a busy inpatient setting, we developed a feasible way to assess PPI therapy, de-implement non-guideline-concordant PPI use, and provide follow-up to assess any unintended consequences. We documented barriers, facilitators, and provider recommendations that should be considered before implementing …

Clindamycin oral capsule is a prescription medication that is used to treat bacterial infections. These infections include acne and bacterial vaginosis. Clindamycin oral capsule is available as a generic drug and as the brand-name drug Cleocin. Learn about its side effects, warnings, dosage, and more.

Proton pump inhibitors (PPIs) are the first-line treatment for many gastrointestinal conditions since their introduction in the 1980s.[i] They are amongst the top ten most widely used agents in...

[This corrects the article DOI: 10.36469/001c.11149.].

Implementation of a pharmacy-driven BLA reconciliation significantly increased β-lactam preoperative use without negative safety outcomes.

Cancer patients are more than twice as likely to acquire hospital-associated Staphylococcus aureus bacteraemia (HA-SAB) and Clostridioides difficile infection (HA-CDI) than others, a new study from Australia found.

No difference was observed in any of the outcomes and there was no impact on the duration of therapy.

Clostridioides difficile infection (CDI) has been an epidemic for many years. Our biggest challenge in treating CDI is preventing recurrence, which is seen in approximately 25% of patients with initial infection and in 40-60% of those with subsequent episodes. Given the major disease burden o …

Across 15 hospitals, there were differing opinions on the feasibility of implementing antibiotic restrictions for third/fourth-generation cephalosporins and fluoroquinolones. While the perceived barrier to implementing restrictions was frequently high, many hospitals were effectively using restricti …

New study paves the way for revaccination campaign in the autumn

Using piperacillin/tazobactam increases the risk for acute kidney injury, and this risk can be exacerbated by concurrent vancomycin.

The U.S. CDC and the European Centre for Disease Prevention and Control have identified antimicrobial resistance as an alarming global public health threat. The use of a host-response marker...

People who have faced debilitating side effects say we need better warnings on drugs. The FDA hasn’t been enthusiastic.

In addition to less antibiotic use, participating hospitals saw a 20% drop in hospital-onset C difficile.

In March, nearly 40 individuals from across the country will meet with their legislators to urge Congress to take bipartisan action to prioritize the battle against antibiotic resistance: a looming global health threat that threatens the future of modern medicine. As part of The Pew Charitable Trusts’ Stand Up to Superbugs initiative, this year’s ambassadors include health care professionals, public health officials, scientists, farmers and ranchers, veterinarians, superbug survivors, and people who have lost loved ones to an antibiotic-resistant infection. They will meet virtually with fed...

Dr David Johnson comments on new data indicating that it may be time to move away from metronidazole plus a fluoroquinolone in certain patients.

The findings should assuage concerns about small intestinal bacterial overgrowth when prescribing treatment with proton pump inhibitors.