C Diff Drug Stewardship

Serious concerns have been raised about a possible increase in cases of Clostridioides difficile infection (CDI) during the COVID-19 pandemic. We conducted a retrospective observational single centre study which revealed that total combined community and hospital-based quarterly rates of CDI decreas …

De-escalation and NDE resulted in similar rates of 30-day treatment failure; however, DE was associated with fewer antibiotic days, episodes of C difficile infection, and days of hospitalization.

The core interventions to prevent Clostridioides difficile infection (CDI) include contact precautions, hand hygiene, environmental disinfection, and antimicrob

Overuse of antibiotics and other antimicrobial drugs during the coronavirus pandemic is helping bacteria develop resistance that will render these important medicines ineffective over time, the Pan American Health Organization (PAHO) warned on Wednesday.

These results illustrate the potential versatility of eravacycline with a broad spectrum of activity, good safety and tolerability profile, flexibility for use in patients with renal injury or antibiotic allergies, and positive clinical outcomes in this large real-world cohort.

Introduction Septic shock is defined as a dysregulated host response to infection characterized by hemodynamic instability. Concern for the increased risk of acute kidney injury (AKI) with piperacillin-tazobactam in combination with vancomycin may prompt more use of alternative broad-spectrum antips …

Background: In 2017, a national drug shortage of small volume solutions significantly affected the preparation of intravenous antibiotics. In response, a continuous infusion administration protocol for piperacillin/tazobactam (PIP/TAZ) was implemented. Objective: To compare the outcome …

There are 2 primary approaches to prevent Clostridioides difficile infection (CDI) in children: prevent transmission and acquisition of the organism and prevent the progression from colonization to disease. The most important interventions to reduce the risk of transmission include contact precautio …

The National Academies report reviews several challenges, and ways to overcome them for optimal antimicrobial stewardship.

But your chances also go up as you get older or if your immune system is weakened.

Amoxicillin is a penicillin antibiotic that treats bacterial infections by binding to penicillin-binding proteins to stop replicating bacteria.

PINEHURST – Antibiotics save lives, but their overuse and misuse can put patients at unnecessary risk for preventable side effects and drug-resistant infections.

Background and Aim Data are limited on whether Clostridioides difficile infection (CDI) in the first year after liver transplantation (LT) is associated with increased mortality. In an Australian se...

Sixty-seven patients from 1089 SOT recipients (6.2%) suffered at least one episode of CDI. The mean age was 55 ± 12 years and 20 cases (69%) were men. The accumulated incidence was 8% in liver transplantation, 6.2% in lung transplantation, 5.4% in heart transplantation, and 4.7% in kidney transplant …

MVB was well tolerated and effective for the majority of patients in this case series.

Public Health Agency of Sweden.

The development of these programs are being looked at for private practices in the community settings to try to create better prescribing practices and avoid the potential progression to health care associated infections.

A 56-year-old man with advanced lung adenocarcinoma presented to the emergency department with a 6-day history of diarrhea. He was treated for lung cancer with nivolumab 3 mg/kg (144 mg/body) every 2 weeks (Q2W), followed by an increase to 240 mg Q2W for 147 weeks, for a total of 69 administrations. …

Dr. Feuerstadt presented data about RBX2660 during the recent ACG 2021 meeting.

Temocillin was found to be less selective than cefotaxime of Enterobacterales with reduced susceptibility to third-generation cephalosporins, and it could therefore be a favourable alternative in the empirical treatment of febrile UTI. Use of this antibiotic could reduce hospital transmission and health-care-associated infections by these pathogens.

Experts say some antibiotics can kill healthy gut bacteria. They recommend people eat yogurt and other fermented foods while taking the medications.

Higher use of 7 major antibiotics in hospitals is corelated with higher rates of Clostridioides difficile infection.

The rate of toxigenic C. difficile positivity may be a useful patient outcome metric for evaluating the long-term impact of antimicrobial stewardship on CDI, especially in settings with limited surveillance resources. The accuracy of this metric is, however, dependent on the avoidance of arbi …

This retrospective cohort study examined the impact of the pandemic on antimicrobial use (AU) in South Carolina hospitals. AU in days of therapy (DOT) per 1000 days-present was evaluated in 17 hospitals in South Carolina. Matched-pairs mean difference was used to compare AU during the pandemic (Marc …

We demonstrated a 46% relative reduction in the odds of developing CDI in patients who received corticosteroids in the past 90 days. We believe that our results provide the best clinical evidence to further support mechanistic studies underlying this phenomenon.