C Diff Drug Stewardship

C Diff Drug Stewardship

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Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre
Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre
Serious concerns have been raised about a possible increase in cases of Clostridioides difficile infection (CDI) during the COVID-19 pandemic. We conducted a retrospective observational single centre study which revealed that total combined community and hospital-based quarterly rates of CDI decreas …
·pubmed.ncbi.nlm.nih.gov·
Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre
Assessment of Antibiotic De-escalation by Spectrum Score in Patients With Nosocomial Pneumonia: A Single-Center, Retrospective Cohort Study
Assessment of Antibiotic De-escalation by Spectrum Score in Patients With Nosocomial Pneumonia: A Single-Center, Retrospective Cohort Study
De-escalation and NDE resulted in similar rates of 30-day treatment failure; however, DE was associated with fewer antibiotic days, episodes of C difficile infection, and days of hospitalization.
·pubmed.ncbi.nlm.nih.gov·
Assessment of Antibiotic De-escalation by Spectrum Score in Patients With Nosocomial Pneumonia: A Single-Center, Retrospective Cohort Study
Misuse of antibiotics in pandemic building resistant bacteria, health agency warns
Misuse of antibiotics in pandemic building resistant bacteria, health agency warns
Overuse of antibiotics and other antimicrobial drugs during the coronavirus pandemic is helping bacteria develop resistance that will render these important medicines ineffective over time, the Pan American Health Organization (PAHO) warned on Wednesday.
·reuters.com·
Misuse of antibiotics in pandemic building resistant bacteria, health agency warns
A Retrospective Multicenter Evaluation of Eravacycline Utilization in Community and Academic Hospitals
A Retrospective Multicenter Evaluation of Eravacycline Utilization in Community and Academic Hospitals
These results illustrate the potential versatility of eravacycline with a broad spectrum of activity, good safety and tolerability profile, flexibility for use in patients with renal injury or antibiotic allergies, and positive clinical outcomes in this large real-world cohort.
·pubmed.ncbi.nlm.nih.gov·
A Retrospective Multicenter Evaluation of Eravacycline Utilization in Community and Academic Hospitals
A Comparison Between Cefepime and Piperacillin-Tazobactam in the Management of Septic Shock
A Comparison Between Cefepime and Piperacillin-Tazobactam in the Management of Septic Shock
Introduction Septic shock is defined as a dysregulated host response to infection characterized by hemodynamic instability. Concern for the increased risk of acute kidney injury (AKI) with piperacillin-tazobactam in combination with vancomycin may prompt more use of alternative broad-spectrum antips …
·pubmed.ncbi.nlm.nih.gov·
A Comparison Between Cefepime and Piperacillin-Tazobactam in the Management of Septic Shock
Evaluation of Prolonged Versus Continuous Infusions of Piperacillin/Tazobactam During Shortages of Small Volume Parenteral Solutions
Evaluation of Prolonged Versus Continuous Infusions of Piperacillin/Tazobactam During Shortages of Small Volume Parenteral Solutions
Background: In 2017, a national drug shortage of small volume solutions significantly affected the preparation of intravenous antibiotics. In response, a continuous infusion administration protocol for piperacillin/tazobactam (PIP/TAZ) was implemented. Objective: To compare the outcome …
·pubmed.ncbi.nlm.nih.gov·
Evaluation of Prolonged Versus Continuous Infusions of Piperacillin/Tazobactam During Shortages of Small Volume Parenteral Solutions
Clostridioides difficile Infection in Children: The Role of Infection Prevention and Antimicrobial Stewardship
Clostridioides difficile Infection in Children: The Role of Infection Prevention and Antimicrobial Stewardship
There are 2 primary approaches to prevent Clostridioides difficile infection (CDI) in children: prevent transmission and acquisition of the organism and prevent the progression from colonization to disease. The most important interventions to reduce the risk of transmission include contact precautio …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection in Children: The Role of Infection Prevention and Antimicrobial Stewardship
Risk Factors for Clostridioides Difficile Diarrhea In Solid Organ Transplantation Recipients
Risk Factors for Clostridioides Difficile Diarrhea In Solid Organ Transplantation Recipients
Sixty-seven patients from 1089 SOT recipients (6.2%) suffered at least one episode of CDI. The mean age was 55 ± 12 years and 20 cases (69%) were men. The accumulated incidence was 8% in liver transplantation, 6.2% in lung transplantation, 5.4% in heart transplantation, and 4.7% in kidney transplant …
·pubmed.ncbi.nlm.nih.gov·
Risk Factors for Clostridioides Difficile Diarrhea In Solid Organ Transplantation Recipients
The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden
The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden
Public Health Agency of Sweden.
·pubmed.ncbi.nlm.nih.gov·
The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden
The Role of Antimicrobial Stewardship in Deterring C Difficile - Contagionlive.com
The Role of Antimicrobial Stewardship in Deterring C Difficile - Contagionlive.com
The development of these programs are being looked at for private practices in the community settings to try to create better prescribing practices and avoid the potential progression to health care associated infections.
·contagionlive.com·
The Role of Antimicrobial Stewardship in Deterring C Difficile - Contagionlive.com
Nivolumab dose escalation triggered immune checkpoint inhibitor-induced colitis after 147 weeks of prolonged stable use in a patient with lung cancer: a case report
Nivolumab dose escalation triggered immune checkpoint inhibitor-induced colitis after 147 weeks of prolonged stable use in a patient with lung cancer: a case report
A 56-year-old man with advanced lung adenocarcinoma presented to the emergency department with a 6-day history of diarrhea. He was treated for lung cancer with nivolumab 3 mg/kg (144 mg/body) every 2 weeks (Q2W), followed by an increase to 240 mg Q2W for 147 weeks, for a total of 69 administrations. …
·pubmed.ncbi.nlm.nih.gov·
Nivolumab dose escalation triggered immune checkpoint inhibitor-induced colitis after 147 weeks of prolonged stable use in a patient with lung cancer: a case report
The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden - The Lancet
The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden - The Lancet
Temocillin was found to be less selective than cefotaxime of Enterobacterales with reduced susceptibility to third-generation cephalosporins, and it could therefore be a favourable alternative in the empirical treatment of febrile UTI. Use of this antibiotic could reduce hospital transmission and health-care-associated infections by these pathogens.
·thelancet.com·
The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden - The Lancet
Antibiotics Can Kill Healthy Gut Bacteria - Healthline
Antibiotics Can Kill Healthy Gut Bacteria - Healthline
Experts say some antibiotics can kill healthy gut bacteria. They recommend people eat yogurt and other fermented foods while taking the medications.
·healthline.com·
Antibiotics Can Kill Healthy Gut Bacteria - Healthline
An evaluation of toxigenic Clostridioides difficile positivity as a patient outcome metric of antimicrobial stewardship in Saudi Arabia
An evaluation of toxigenic Clostridioides difficile positivity as a patient outcome metric of antimicrobial stewardship in Saudi Arabia
The rate of toxigenic C. difficile positivity may be a useful patient outcome metric for evaluating the long-term impact of antimicrobial stewardship on CDI, especially in settings with limited surveillance resources. The accuracy of this metric is, however, dependent on the avoidance of arbi …
·pubmed.ncbi.nlm.nih.gov·
An evaluation of toxigenic Clostridioides difficile positivity as a patient outcome metric of antimicrobial stewardship in Saudi Arabia
Change in Antimicrobial Use during COVID-19 Pandemic in South Carolina Hospitals: A Multicenter Observational Cohort Study
Change in Antimicrobial Use during COVID-19 Pandemic in South Carolina Hospitals: A Multicenter Observational Cohort Study
This retrospective cohort study examined the impact of the pandemic on antimicrobial use (AU) in South Carolina hospitals. AU in days of therapy (DOT) per 1000 days-present was evaluated in 17 hospitals in South Carolina. Matched-pairs mean difference was used to compare AU during the pandemic (Marc …
·pubmed.ncbi.nlm.nih.gov·
Change in Antimicrobial Use during COVID-19 Pandemic in South Carolina Hospitals: A Multicenter Observational Cohort Study
Corticosteroids Do Not Increase the Likelihood of Primary Clostridioides difficile Infection in the Setting of Broad-Spectrum Antibiotic Use
Corticosteroids Do Not Increase the Likelihood of Primary Clostridioides difficile Infection in the Setting of Broad-Spectrum Antibiotic Use
We demonstrated a 46% relative reduction in the odds of developing CDI in patients who received corticosteroids in the past 90 days. We believe that our results provide the best clinical evidence to further support mechanistic studies underlying this phenomenon.
·pubmed.ncbi.nlm.nih.gov·
Corticosteroids Do Not Increase the Likelihood of Primary Clostridioides difficile Infection in the Setting of Broad-Spectrum Antibiotic Use
Changes in antibiotic consumption, AMR and Clostridioides difficile infections in a large tertiary-care center following the implementation of institution-specific guidelines for antimicrobial therapy: A nine-year interrupted time series study
Changes in antibiotic consumption, AMR and Clostridioides difficile infections in a large tertiary-care center following the implementation of institution-specific guidelines for antimicrobial therapy: A nine-year interrupted time series study
·pubmed.ncbi.nlm.nih.gov·
Changes in antibiotic consumption, AMR and Clostridioides difficile infections in a large tertiary-care center following the implementation of institution-specific guidelines for antimicrobial therapy: A nine-year interrupted time series study