Proton-pump inhibitor use and the risk of community-associated Clostridium difficile infection - MD Linx
C Diff Drug Stewardship
Harms of UTI prophylaxis outweigh benefits in older adults - Healio
Older adult patients who received antibiotic prophylaxis for UTIs experienced an increased risk for hospitalization, sepsis and bloodstream infection, according to a study in Clinical Infectious Diseases.“Older patients have a higher risk of infection than younger patients due in large part to immunosenescence, but at the same time they are more prone to the harms of antibiotics such as
Elevated Risk for C diff with Proton-Pump Inhibitor Use - MD Magazine
Exposure to PPIs was associated with a moderate increase in the risk of community-acquired C diff infection, even after treatment discontinuation.
C diff Risk Increases with PPI Usage - Contagionlive.com - Contagionlive.com
According to one new study, proton-pump inhibitors (PPI) exposure demonstrated a moderate increase in the risk of community-acquired C diff infection.
Proton Pump Inhibitor Use Linked to Increased C. Diff Risk - MD Magazine
Researchers found 8 meta-analysis and systematic reviews showing the positive link between PPI use and the risk of clostridium difficile infections.
Q&A: Quality improvement program 'removed barriers' to antibiotic stewardship in hospitals - Healio
A quality improvement program reduced antibiotic use and strengthened antimicrobial stewardship in hospitals, according to an analysis published in JAMA Network Open. Pranita D. Tamma, MD, MHS, associate professor of pediatrics and director of the pediatric antimicrobial stewardship program at Johns Hopkins Medicine, and colleagues evaluated the effectiveness of the Agency for Healthcare
Health Experts Establish Targets to Improve Hospital Antibiotic Prescribing - The Pew Charitable Trusts
According to the Centers for Disease Control and Prevention, at least 2.8 million antibiotic-resistant infections occur each year, killing at least 35,000 people. All antibiotic use contributes to resistance. To slow the rise of this growing public health threat, antibiotics should be used only when needed and when prescribed appropriately: the proper drug at the correct dose for the right duration.
Sepsis Colorectal Surgery Linked With Increased C. diff Recurrences - Gastroenterology & Endoscopy News
Study identifies high-impact postoperative complications in older patients undergoing hip fracture repair - GlobeNewswire
Article in April 2021 issue of The Joint Commission Journal on Quality and Patient Safety...
Impact on the Gut Microbiota of Intensive and Prolonged Antimicrobial Therapy in Patients With Bone and Joint Infection
There is a growing interest in the potentially deleterious impact of antibiotics on gut microbiota. Patients with bone and joint infection (BJI) require prolonged treatment that may impact significantly the gut microbiota. We collected samples from patients with BJI at baseline, end of antibiotics ( …
Antibiotic Stewardship Programs Need Infection Preventionists - Infection Control Today
Arjun Srinivasan, MD: “There’s a lot of potential for synergy between the infection prevention program and the antibiotic stewardship program.”
A cluster randomized stepped-wedge trial to de-implement unnecessary post-operative antibiotics in children: the optimizing perioperative antibiotic in children (OPerAtiC) trial
NCT04366440. Registered April 28, 2020, https://clinicaltrials.gov/ct2/show/NCT04366440 .
Role of high-risk antibiotic use in incidence of health-care-associated Clostridioides difficile infection in Quebec Canada: a population-level ecological study - The Lancet
Multicentre stepped-wedge cluster randomised controlled trial of an antimicrobial stewardship programme in residential aged care: protocol for the START trial
NCT03941509.
Impact of pharmacist-led selective audit and feedback on outpatient antibiotic prescribing for UTIs and SSTIs
A pharmacist-led audit-and-feedback outpatient stewardship strategy was demonstrated to achieve significant improvement in outpatient antibiotic prescribing for UTI and SSTI.
How Long Is Long Enough? The Ongoing Saga of Antibiotic Therapy - Infectious Disease Special Edition
Antibiotic Stewardship | American Academy of Pediatrics - AAP News
1. Rebecca G. Same, MD* 2. Pranita D. Tamma, MD, MHS* 1. *Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD The discovery of antibiotics was one of the most important medical advances of the 20th century. Their use continues to be critically important in the care of both children and adults with serious infections. However, increasing antibiotic use has also led to the development of antibiotic resistance and a rise in harms related to antibiotics, including antibiotic-associated adverse events and Clostridioides ...
Antibiotics and healthcare facility-associated Clostridioides difficile infection: systematic review and meta-analysis 2020 update
This review provides the most up-to-date synthesis of evidence in relation to the risk of HCFA-CDI associated with exposure to specific antibiotic classes. Studies were predominantly conducted in North America or Europe and more studies outside of these settings are needed.
Risks & Benefits of UTI Prophylaxis in Older Adults - Physician's Weekly
Assessment of antimicrobial stewardship programs within governmental hospitals in Qatar: a SWOC analysis
Although ASPs were implemented in all governmental hospitals in Qatar, national efforts and more resources are needed to further develop and improve these programs.
Identifying the Association of C Difficile Infections from Vonoprazan Use - MD Magazine
Colonization with Gastrointestinal Pathogens Prior to Hematopoietic Cell Transplantation and Associated Clinical Implications
Infectious diarrhea following hematopoietic cell transplantation (HCT) significantly contributes to morbidity and mortality. Most HCT recipients experience diarrhea in the post-transplantation period, and infectious pathogens are frequently detected during diarrheal episodes. However, little is know …
An algorithm for safe de-labelling of antibiotic allergy in adult hospital in-patients
Tackling inappropriate penicillin allergy labelling is important because a "penicillin allergy" label potentially leads to the use of sub-optimal alternative antibiotics (e.g. vancomycin instead of flucloxacillin) and is associated with poorer outcomes including increased risk of Clostridioides (C) …
Impact of cascade reporting of antimicrobial susceptibility on fluoroquinolone and meropenem consumption at a Veterans' Affairs medical center
Ciprofloxacin consumption significantly decreased after the implementation of cascade reporting. Mean meropenem consumption decreased after cascade reporting was implemented, but we observed no significant change in the slope of consumption. cascade reporting may be a useful strategy to optimize ant …
Stewardship Program Helps Hospitals Reduce Antibiotic Use Prevent Bacterial Infections - Pharmacy Times
The overuse of antibiotics in hospitals can lead to the emergence of drug-resistant strains of bacteria or outbreaks of infections by bacteria, such as Clostridiodes difficile (C. difficile).
Doctors' Group Says Antibiotics Can Be Taken for Shorter Periods - U.S. News & World Report
Potent Acid Suppression With Vonoprazan vs Proton Pump Inhibitors Does Not Have Higher Association With Clostridioides difficile Infection
We found a significant positive association between vonoprazan use and CDI; however, the magnitude of the association was not beyond that in PPI users. This is the first report on any potential adverse effects of vonoprazan.
The microbial diversity following antibiotic treatment of Clostridioides difficile infection
In total, 84 patients with CDI were enrolled in the study; all had received antibiotics prior to disease onset. Due to comorbidities, 46 patients (55%) had received more than one class of antibiotics. The most common class of antibiotics used was cephalosporins (n = 44 cases). The intestinal microbi …
The duration of antibiotic treatment is associated with carriage of toxigenic and non-toxigenic strains of Clostridioides difficile in dogs
Antibiotic exposure and the risk of hospital-acquired diarrhoea and Clostridioides difficile infection: a cohort study
Preventing HAD and CDI should focus on reducing the overall use of antibiotics and shortening antibiotic exposure, rather than focusing on specific agents.