C Diff Drug Stewardship

A 56-year-old man with advanced lung adenocarcinoma presented to the emergency department with a 6-day history of diarrhea. He was treated for lung cancer with nivolumab 3 mg/kg (144 mg/body) every 2 weeks (Q2W), followed by an increase to 240 mg Q2W for 147 weeks, for a total of 69 administrations. …

Dr. Feuerstadt presented data about RBX2660 during the recent ACG 2021 meeting.

Temocillin was found to be less selective than cefotaxime of Enterobacterales with reduced susceptibility to third-generation cephalosporins, and it could therefore be a favourable alternative in the empirical treatment of febrile UTI. Use of this antibiotic could reduce hospital transmission and health-care-associated infections by these pathogens.

Experts say some antibiotics can kill healthy gut bacteria. They recommend people eat yogurt and other fermented foods while taking the medications.

Higher use of 7 major antibiotics in hospitals is corelated with higher rates of Clostridioides difficile infection.

The rate of toxigenic C. difficile positivity may be a useful patient outcome metric for evaluating the long-term impact of antimicrobial stewardship on CDI, especially in settings with limited surveillance resources. The accuracy of this metric is, however, dependent on the avoidance of arbi …

This retrospective cohort study examined the impact of the pandemic on antimicrobial use (AU) in South Carolina hospitals. AU in days of therapy (DOT) per 1000 days-present was evaluated in 17 hospitals in South Carolina. Matched-pairs mean difference was used to compare AU during the pandemic (Marc …

We demonstrated a 46% relative reduction in the odds of developing CDI in patients who received corticosteroids in the past 90 days. We believe that our results provide the best clinical evidence to further support mechanistic studies underlying this phenomenon.

Fear of antibiotic overuse and frustration with practitioners who prescribe them too freely are key sentiments from women with recurrent urinary tract infections.

Vedanta revealed positive new data for its C. difficile microbiome therapeutic. But is it too late an entrant into the field?

In February 2021 I received care from a neighborhood physician's assistant for a hangnail that had become infected. After having the infection drained, I

Background: Broad-spectrum antibiotic agents are sometimes utilized for prophylaxis of Gustilo grade III open fractures. However, this practice is not recommended by current guidelines, and it is unknown how patient outcomes are impacted. This study aimed to determine if prophylaxis wi …

Background: Clostridioides difficile infection (CDI) can result in life-threatening illness requiring surgery. Surgical options for managing severe or fulminant, non-perforated C. difficile colitis include total abdominal colectomy with end ileostomy or creation of a dive …

Surgical site infections similar versus shorter-duration prophylactic IV regimen

Non-aspirin nonsteroidal anti-inflammatory drugs do not increase the risk for Clostridioides difficile infection, according to a retrospective review of nearly 1,500 people.

Rabeprazole oral tablet (Aciphex) is used to reduce the amount of acid produced by the stomach. Learn about side effects, warnings, dosage, and more.

ABPC/SBT after esophagectomy was better at preventing early-onset pneumonia compared with CEZ and was feasible regarding the development of antimicrobial resistance.

Probiotic supplement may help protect against some of the harmful side effects on the gut microbiome that are common with antibiotic use.

Background and Objectives: Spontaneous bacterial peritonitis (SBP) is a life-threatening complication of liver cirrhosis. Antibiotic prophylaxis is effective but can lead to an increased incidence of Clostridioides difficile infection (CDI). The aim of this study was to evaluate the in …

Both proton pump inhibitors and histamine 2 receptor antagonists are commonly prescribed for stress ulcer prophylaxis in critically ill patients.

These model data suggest that the minimal impact of first-generation cephalosporins, namely cefalexin and cefradine, on the intestinal microbiota results in a low propensity to induce CDI.

Available data suggest Empiric Therapy may offer no clinical benefit to this population, regardless of whether vancomycin-resistant enterococcus is identified in blood culture or no pathogen is found. Such an approach may only expose the majority of patients to unnecessary vancomycin-resistant enter …

Our systematic review and meta-analysis demonstrate that immunosuppressive therapy is a risk factor for complicated outcomes of CDI.

Popularity of the stomach- and intestine-protecting drugs has skyrocketed, but related adverse events, like osteoporotic fractures, C difficile infection, and pneumonia, are problematic.

The reports of experiences in implementing ASPs in ED show heterogeneous antimicrobial use indicators, which makes it difficult to compare results. Therefore, antimicrobial use indicators for ASPs must be standardised between hospital units.