C Diff Drug Stewardship

BACKGROUND Wells syndrome is an uncommon inflammatory dermatosis that presents as tender or mildly pruritic cellulitis-like eruptions. The clinical presentation can include papular and nodular eruptions, annular plaques, vesicles, bullae, and urticaria. This syndrome can be promoted by inappropriate …

Fluoroquinolones are associated with an increased risk of Clostridioides difficile infection (CDI). Probiotic supplementation has been shown to reduce the risk of antibiotic-associated diarrhea with variable effects on CDI. The objective of this study was to evaluate receipt of probiotics on …

Rigorous de-escalation and curtailing of antibiotic therapies were beneficial and without risk for the hospitalized patients 65 years and over.

The Antimicrobials Working Group (AWG) announced today the addition of Acurx Pharmaceuticals, Inc. (NASDAQ: ACXP) (Acurx) to its coalition of companies with the mission to combat drug resistant infections and spur life-saving innovations. This new addition brings AWG's membership to 13 antimicrobial drug companies.

Our study demonstrates the short-term effectiveness of a CPOE-based ABS intervention to reduce antibiotic treatment duration for uncomplicated pneumonia. This approach may be particularly suitable for hospitals with limited ABS resources.

The rifaximin-nonsusceptibility rates for the C. difficile isolates identified in this study were reasonably high with most of these resistant strains belonging to either the 018 or 017 RT. The widespread dissemination of these clones may be the result of the antimicrobial selection pressure introdu …

Between two first-line agents for uncomplicated UTIs, trimethoprim-sulfamethoxazole was associated with a higher risk for several adverse drug events compared with nitrofurantoin, researchers reported in Clinical Infectious Diseases. Non-first-line agents also were associated with a higher risk for adverse drug events compared with nitrofurantoin, in addition to potential microbiome-related

The COVID-19 pandemic has given us a new appreciation for the role of public health. While our public health departments and hospitals continue to manage vaccination and cases resulting from new variants, we also know that those of you battling C. diff infections still need our help. Please know that …

In this national cohort study, suboptimal antibiotic treatment was associated with a 6% increased risk of the composite measure of poor clinical outcomes, in particular, a 94% increased risk of CDI. Beyond the decision to use antibiotics, clinicians should also consider the potential harms of subopt …

How to manage #cdiff when concomitant antibiotics? Stop the antibiotic if possible / if you can’t limit it’s duration & change to low risk class / stop PPI if possible / avoid metronidazole / treat with fidaxomicin / consider bezkotoxumab @ESCMID #ECCMID2021 @iscm_micro— Fidelma Fitzpatrick (@FfitzP) July 10, 2021

NCT03848689.

Average annual discharges were significantly higher in participating hospitals.

Fidaxomicin and vancomycin reduced shedding of Clostridioides difficile spores faster and were associated with lower rates of hospital contamination compared with metronidazole, according to study findings.“One unique facet of infectious diseases is the infectious part. How we treat our patients matters not just to their own health but to those around them as well,” Nicholas Turner,

Calcineurin inhibitors were associated with a modest but significantly increased risk of CA-CDI. The greatest risk was observed among patients using multiple classes of immunosuppressants. Future studies should recognize that CDI risk differs based on immunosuppressant class.