C Diff Drug Stewardship

Arjun Srinivasan, MD: “There’s a lot of potential for synergy between the infection prevention program and the antibiotic stewardship program.”

NCT04366440. Registered April 28, 2020, https://clinicaltrials.gov/ct2/show/NCT04366440 .

NCT03941509.

A pharmacist-led audit-and-feedback outpatient stewardship strategy was demonstrated to achieve significant improvement in outpatient antibiotic prescribing for UTI and SSTI.

1. Rebecca G. Same, MD* 2. Pranita D. Tamma, MD, MHS* 1. *Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD The discovery of antibiotics was one of the most important medical advances of the 20th century. Their use continues to be critically important in the care of both children and adults with serious infections. However, increasing antibiotic use has also led to the development of antibiotic resistance and a rise in harms related to antibiotics, including antibiotic-associated adverse events and Clostridioides ...

This review provides the most up-to-date synthesis of evidence in relation to the risk of HCFA-CDI associated with exposure to specific antibiotic classes. Studies were predominantly conducted in North America or Europe and more studies outside of these settings are needed.

Although ASPs were implemented in all governmental hospitals in Qatar, national efforts and more resources are needed to further develop and improve these programs.

Infectious diarrhea following hematopoietic cell transplantation (HCT) significantly contributes to morbidity and mortality. Most HCT recipients experience diarrhea in the post-transplantation period, and infectious pathogens are frequently detected during diarrheal episodes. However, little is know …

Tackling inappropriate penicillin allergy labelling is important because a "penicillin allergy" label potentially leads to the use of sub-optimal alternative antibiotics (e.g. vancomycin instead of flucloxacillin) and is associated with poorer outcomes including increased risk of Clostridioides (C) …

Ciprofloxacin consumption significantly decreased after the implementation of cascade reporting. Mean meropenem consumption decreased after cascade reporting was implemented, but we observed no significant change in the slope of consumption. cascade reporting may be a useful strategy to optimize ant …

The overuse of antibiotics in hospitals can lead to the emergence of drug-resistant strains of bacteria or outbreaks of infections by bacteria, such as Clostridiodes difficile (C. difficile).

We found a significant positive association between vonoprazan use and CDI; however, the magnitude of the association was not beyond that in PPI users. This is the first report on any potential adverse effects of vonoprazan.

In total, 84 patients with CDI were enrolled in the study; all had received antibiotics prior to disease onset. Due to comorbidities, 46 patients (55%) had received more than one class of antibiotics. The most common class of antibiotics used was cephalosporins (n = 44 cases). The intestinal microbi …

Preventing HAD and CDI should focus on reducing the overall use of antibiotics and shortening antibiotic exposure, rather than focusing on specific agents.

Trial enrichment using gut microbiota derived biomarkers by high-risk individuals can improve the feasibility of randomized controlled trials for prevention of Clostridioides difficile infection (CDI). Here, we report in a prospective observational cohort study the incidence of CDI and assess potent …

We performed secondary analyses of a postdischarge decolonization trial of MRSA carriers that reduced MRSA infection and hospitalization by 30%. Hospitalized MRSA infection was associated with 7.9 days of non-MRSA antibiotics and CDI in 3.9%. Preventing MRSA infection and associated hospitalization …

When 70% of antibiotic users took a three-strain Lactobacillus probiotic preparation the hospital-wide rate of Healthcare-Associated Clostridioides difficile infection (CDI) improved significantly. The incidence of CDI for those taking the probiotic along with multiple antibiotics or a single high-r …

Previously reported associations between hospital-level antibiotic use and hospital-onset Clostridioides difficile infection (HO-CDI) were reexamined using 2012-2018 data from a new cohort of US acute-care hospitals. This analysis revealed significant positive associations between total, third-gener …

This variation in antimicrobial agents and regimens may well contribute to the varying incidence of surgical site infection seen across the UK and ROI.

The study comes at a time when—despite all the attention and health care resources being thrown at COVID-19—medical experts have begun to turn a wary eye toward bacteriological pathogens.

Oral vancomycin prophylaxis was found by a small study to prevent C diff infection in thoracic transplant patients.

Updated review and meta-analysis identifies the classes of antibiotics most strongly linked to healthcare facility-associated Clostridioides difficile infection.

Patients with C. diff infections had nearly a 5 day longer length of hospital stay than a group without CDI.