C Diff Drug Stewardship

Older adult patients who received antibiotic prophylaxis for UTIs experienced an increased risk for hospitalization, sepsis and bloodstream infection, according to a study in Clinical Infectious Diseases.“Older patients have a higher risk of infection than younger patients due in large part to immunosenescence, but at the same time they are more prone to the harms of antibiotics such as

Exposure to PPIs was associated with a moderate increase in the risk of community-acquired C diff infection, even after treatment discontinuation.

According to one new study, proton-pump inhibitors (PPI) exposure demonstrated a moderate increase in the risk of community-acquired C diff infection.

Researchers found 8 meta-analysis and systematic reviews showing the positive link between PPI use and the risk of clostridium difficile infections.

A quality improvement program reduced antibiotic use and strengthened antimicrobial stewardship in hospitals, according to an analysis published in JAMA Network Open. Pranita D. Tamma, MD, MHS, associate professor of pediatrics and director of the pediatric antimicrobial stewardship program at Johns Hopkins Medicine, and colleagues evaluated the effectiveness of the Agency for Healthcare

According to the Centers for Disease Control and Prevention, at least 2.8 million antibiotic-resistant infections occur each year, killing at least 35,000 people. All antibiotic use contributes to resistance. To slow the rise of this growing public health threat, antibiotics should be used only when needed and when prescribed appropriately: the proper drug at the correct dose for the right duration.

Article in April 2021 issue of The Joint Commission Journal on Quality and Patient Safety...

There is a growing interest in the potentially deleterious impact of antibiotics on gut microbiota. Patients with bone and joint infection (BJI) require prolonged treatment that may impact significantly the gut microbiota. We collected samples from patients with BJI at baseline, end of antibiotics ( …

Arjun Srinivasan, MD: “There’s a lot of potential for synergy between the infection prevention program and the antibiotic stewardship program.”

NCT04366440. Registered April 28, 2020, https://clinicaltrials.gov/ct2/show/NCT04366440 .

NCT03941509.

A pharmacist-led audit-and-feedback outpatient stewardship strategy was demonstrated to achieve significant improvement in outpatient antibiotic prescribing for UTI and SSTI.

1. Rebecca G. Same, MD* 2. Pranita D. Tamma, MD, MHS* 1. *Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD The discovery of antibiotics was one of the most important medical advances of the 20th century. Their use continues to be critically important in the care of both children and adults with serious infections. However, increasing antibiotic use has also led to the development of antibiotic resistance and a rise in harms related to antibiotics, including antibiotic-associated adverse events and Clostridioides ...

This review provides the most up-to-date synthesis of evidence in relation to the risk of HCFA-CDI associated with exposure to specific antibiotic classes. Studies were predominantly conducted in North America or Europe and more studies outside of these settings are needed.

Although ASPs were implemented in all governmental hospitals in Qatar, national efforts and more resources are needed to further develop and improve these programs.

Infectious diarrhea following hematopoietic cell transplantation (HCT) significantly contributes to morbidity and mortality. Most HCT recipients experience diarrhea in the post-transplantation period, and infectious pathogens are frequently detected during diarrheal episodes. However, little is know …

Tackling inappropriate penicillin allergy labelling is important because a "penicillin allergy" label potentially leads to the use of sub-optimal alternative antibiotics (e.g. vancomycin instead of flucloxacillin) and is associated with poorer outcomes including increased risk of Clostridioides (C) …

Ciprofloxacin consumption significantly decreased after the implementation of cascade reporting. Mean meropenem consumption decreased after cascade reporting was implemented, but we observed no significant change in the slope of consumption. cascade reporting may be a useful strategy to optimize ant …

The overuse of antibiotics in hospitals can lead to the emergence of drug-resistant strains of bacteria or outbreaks of infections by bacteria, such as Clostridiodes difficile (C. difficile).

We found a significant positive association between vonoprazan use and CDI; however, the magnitude of the association was not beyond that in PPI users. This is the first report on any potential adverse effects of vonoprazan.

In total, 84 patients with CDI were enrolled in the study; all had received antibiotics prior to disease onset. Due to comorbidities, 46 patients (55%) had received more than one class of antibiotics. The most common class of antibiotics used was cephalosporins (n = 44 cases). The intestinal microbi …

Preventing HAD and CDI should focus on reducing the overall use of antibiotics and shortening antibiotic exposure, rather than focusing on specific agents.

Trial enrichment using gut microbiota derived biomarkers by high-risk individuals can improve the feasibility of randomized controlled trials for prevention of Clostridioides difficile infection (CDI). Here, we report in a prospective observational cohort study the incidence of CDI and assess potent …