C Diff Drug Stewardship

You have received antibiotic treatment for a respiratory infection, and a week later, you have watery stools and abdominal tenderness. You are breathing better but now you are nauseated.

Our quality improvement intervention successfully decreased piperacillin-tazobactam administration without increasing the rate of surgical site infections in patients with acute appendicitis.

We observed no differences in clinical or safety outcomes among three guideline-recommended empiric CAP regimens. Empiric doxycycline + β-lactam may be a safe empiric regimen for hospitalized CAP patients with non-severe CAP, although additional research is needed to corroborate these observations w …

Clostridioides difficile is a Gram-positive bacteria that causes nosocomial infections, significantly impacting public health. In the present study, we aimed to describe the clinical characteristics, outcomes, and relationship between antibiotic exposure and Clostridioides difficile in …

We identified four associated risk factors in the risk-prediction model. The tool showed good discrimination that might help predict, identify, and evaluate hospitalized patients at risk of developing CDI.

Extended anaerobic coverage is likely unnecessary in aspiration pneumonia because it is associated with no additional mortality benefit, only an increased risk of C. difficile colitis.

C'est difficile: an encounter with infection while taking antibiotics

Innate lymphoid cells (ILCs) play a critical role in maintaining intestinal health in homeostatic and diseased conditions. During Clostridium difficile infection (CDI), IL-33 activates ILC2 to protect from colonic damage and mortality. The function of IL-33 and ILC is tightly regulated by the …

Extended anaerobic coverage is likely unnecessary in aspiration pneumonia because it is associated with no additional mortality benefit, only an increased risk of C. difficile colitis.

PHILADELPHIA (February 19, 2024) — Stem cell transplant recipients can reduce their risk of Clostridioides difficile (C. diff) infection by taking the oral antibiotic vancomycin preventively, according to research from Fox Chase Cancer Center presented at a scientific meeting. However, the study also shows that taking this antibiotic can increase these patients’ risk of gram-negative bacteremia.

Evidence of more side effects, lack of survival benefit with extended anaerobic coverage

Saturday, October 7. Wake up with intense abdominal pain. Run to the bathroom. Relief.

Khalid Eljaaly, PharmD, MS, CAPPS, BCPS, explains why carbapenem antibiotics cause higher rates of C. diff and superinfections.

Prophylaxis and Recurrent Clostridioides difficileA 68-year-old woman is admitted with pyelonephritis. Two months earlier, she had been treated for pneumonia and subsequently developed Clostridioides difficile colitis, which resolved with 10 days of oral vancomycin. When you start trea …

The comparable antibiotic use metrics before and after the general medical service assumed care of the CLC residents may be explained by constancy in resident population and other facility-related factors. Differences in the types of agents used suggests that antibiotic stewardship efforts can be ta …

Study shows both recent and earlier use of these medications significantly heightens the risk.

Antibiotics and proton pump inhibitors may not be the best mix, according to a study published Jan. 24 in the Journal of Antimicrobial Chemotherapy.

Ciprofloxacin, ceftriaxone, and piperacillin/tazobactam showed the greatest associations with adverse drug reaction case reports related to CDI.

Implementing AOS into the EMR was associated with a statistically significant reduction in SAAR, antibiotic DOT per 1,000 PD, selected antibiotic orders, and CDI cases.

In a population-based study, patients recently exposed to antibiotics and proton pump inhibitors had an 18-fold increase in the risk of C diff infection.

Recent and less recent use of PPIs and systemic antibiotics was associated with an increased risk of CDI, particularly in combination.

I got C. diff from antibiotics for a sinus infection, and I had diarrhea for 13 days. Ironically, the treatment was another antibiotic, vancomycin.

In 2022, WHO released the WHO AWaRe (Access, Watch, Reserve) antibiotic book to promote the rational use of antibiotics. Here, we review the AWaRe antibiotic book from the perspective of implementation in low-resource settings, using the Lao PDR (Laos) as a case study. Not all recommendations in the …

Advancement in solid organ transplantation and hematopoietic stem cell transplant continues to improve the health outcomes of patients and widens the number of eligible patients who can benefit from the medical progress. Preserving the effectiveness of antimicrobials remains crucial, as otherwise tr …

Purpose: The implementation of an automated, pharmacist-driven, scoring system within the EMR has been shown to improve patient care in patients with Staphylococcus aureus bacteremia by increasing the adherence to disease specific quality-of-care measures. However, there are a lack of …

Increased risk of clostridium difficile infection may be associated with exposure to linezolid and clindamycin.

Patients who are immunocompromised generally had worse risk and severity of CDI.

A Polish research team concluded that there are two mortality models for patients with pneumonia being treated for Clostridium difficile infection. and recommended the exclusion of one antibiotic from pneumonia treatment in hospitals.

Background: Surgical antibiotic prophylaxis practice became common in the 1970s and has since become almost universal. The earliest articles used three doses over 12 hours with the first being administered before the start of the operation. Conclusions: The duration of pr …

Impact of strict isolation measures, surgical activity and antimicrobial use on Clostridioides difficile infection during COVID-19