C Diff Drug Stewardship

Use of a barrier-targeted multifaceted approach, including electronic clinical decision support, education, focus groups to guide the adaptation of the implementation plan, and local site champions, resulted in a high probiotic adherence rate in the Prevent CDI-55 + study.

Ciprofloxacin, ceftriaxone, and piperacillin/tazobactam showed the greatest associations with adverse drug reaction case reports related to C difficile.

Additionally, changes in gut microbiome in bipolar disorder might be used for biomarker identification with a potential to help in diagnosis and monitoring of the condition. It is an important area for further research and may provide improved therapeutic outcomes.

gov NCT03374800. November 21, 2017.

In hospitalized patients, the utilization of pantoprazole intermittent bolus is not only comparably efficacious but potentially represents a safer and economically advantageous alternative compared to the current guideline recommendation of a 72-hour pantoprazole continuous infusion. Further studies …

Although research on the role of the gut microbiota (GM) in human health has sharply increased in recent years, what a "healthy" gut microbiota is and how it responds to major stressors is still difficult to establish. In particular, anticancer chemotherapy is known to have a drastic impact on the m …

THURSDAY, Nov. 30, 2023 (HealthDay News) -- For patients with community-acquired pneumonia (CAP), doxycycline is associated with a reduced risk for Clostridioid

Ciprofloxacin, ceftriaxone, and piperacillin/tazobactam showed the greatest associations with adverse drug reaction case reports related to CDI.

Group A streptococcal bacteremia is a severe infection with a high readmission and mortality rate. Use of PO step-down therapy was common with similar readmission and mortality rates compared with definitive IV therapy.

To assess the prevalence and abundance of antibiotic resistance genes in human and livestock gut microbiomes, 87 humans (healthy individuals and patients with Clostridioides difficile infection (CDI)) and 108 livestock (swine, cattle, and chickens) were enrolled. Gut microbiomes and fluoroquinolone- …

Use of mirtazapine, nortriptyline, and trazodone among hospitalized patients was associated with a greater risk of CDI.

The Gram-positive anaerobic bacterium Clostridioides difficile (CD) can produce intense exotoxins, contributing to nosocomial infections, and it is the most common cause of health-care-associated infectious diarrhea. Based on spontaneous Individual Case Safety Reports from EudraVigilance (EV) …

Assessment of functional status, especially combined with comorbidities, was significantly associated with developing CDI and may also be useful in predicting in-hospital mortality.

The campaign aims to help patients feel more confident that over-the-counter medications, and not antibiotics, are the best treatment for cold and flu symptoms.

BACKGROUND Clostridium difficile (C. difficile) is a gram-positive, anaerobic, spore-forming bacillus. It can lead to pseudomembranous colitis characterized by electrolyte disturbances, toxic megacolon, and septic shock. The risk of C. difficile infection is higher with use of certain classes of ant …

Photo: Dr. Ian Ball with screen showing the digital clinical pathways and guidelines developed by the Antimicrobial Stewardship ProgramNovember 20, 2023

Results could provide insights into how NSAID-mediated mitochondrial uncoupling affects diseases such as small intestinal injury, IBD, and colorectal cancer.

Antibiotics can help you feel better after some common illnesses by fighting the bacteria that cause these infections. UR Medicine experts share some lesser-known things that can help you recover as quickly as possible.

Cephalosporins are the most common triggers of healthcare-associated Clostridioides difficile infections (CDI). Here, we confirm gene-level drivers of cephalosporin resistance and their roles in promoting disease. Genomic-epidemiologic analyses of 306 C. difficile isolates from a hospi …

In this video roundtable discussion, Jaspal Singh, MD, MHA, MHS, interviews Dr Lisa Davidson, MD, and Ryan Maves, MD, about the importance of antimicrobial stewardship, fighting antimicrobial resistance, diagnostic stewardship, minimizing toxicity, and maximizing infection control.

### What you need to know A 42 year old man visits his general practitioner with a three month history of intermittent nausea and central chest discomfort, particularly after fatty and sweet meals. He occasionally has a bad taste in his mouth when he wakes up from sleep. His body mass index is 32, he has no significant medical history, and he takes no regular medications. After asking him about alarm symptoms, you make a diagnosis of gastro-oesophageal reflux disease. You are considering prescribing a proton pump inhibitor as a first line therapy. Prevalence of proton pump inhibitor (PPI) use is about 15% of the UK population, according to two primary care database studies.12 In 2022-23, 73 million NHS prescriptions for PPIs were dispensed in England at a cost of about £190 million, equating to 1.8% of total primary care prescription costs and 6% of all prescriptions dispensed.3 The two most commonly prescribed PPIs in England are omeprazole and lansoprazole, which were among the five most commonly dispensed drugs in 2020. There is strong evidence to support the use of PPIs across a range of indications.4 PPIs are used in the treatment of upper gastrointestinal disorders characterised by excessive acid production and damage to upper gastrointestinal tissue,5 and are also prescribed as gastroprotection for patients being treated with medications which increase the risk of ulceration, such as non-steroidal …

Learn what a long-term study on antibiotic resistance in patients with periodontitis showed, and its implications for dentistry.

Antimicrobials such as clindamycin, cephalosporins, penicillins, and fluoroquinolones have been linked with causing C diff infection in prior research.

Doxycycline is associated with a lower risk of CDI compared to azithromycin when used for atypical coverage in CAP. Thus, patients who are at such risk may benefit from doxycycline as a first-line agent for atypical coverage, rather than the use of a macrolide antibiotic, if Legionella is not of con …

Nature Medicine - A low rate of Clostridioides difficile transmission within an intensive care unit supports the effectiveness of prevention practices and highlights the greater risk to carriers of...

A new study on Clostridioides difficile infections finds that choosing an alternative antibiotic for high-risk patients with pneumonia can reduce infection risk.

A new study published today in the American Journal of Infection Control (AJIC) reveals that the use of doxycycline may help protect against Clostridioides difficile (C. diff) infection for some patients ...