C Diff Molecular

C Diff Molecular

Draft genome sequences of two distinct Clostridioides difficile isolates coinfecting a patient - PubMed
Draft genome sequences of two distinct Clostridioides difficile isolates coinfecting a patient - PubMed
Clostridioides difficile is a spore-forming anaerobic Gram-positive bacillus. In this study, two distinct strains of C. difficile causing coinfection were isolated from the same fecal sample. Whole-genome sequencing was performed on these two strains to elucidate their genomic characte …
·pubmed.ncbi.nlm.nih.gov·
Draft genome sequences of two distinct Clostridioides difficile isolates coinfecting a patient - PubMed
VRE Colonization Linked to Higher Mortality in Sepsis Patients
VRE Colonization Linked to Higher Mortality in Sepsis Patients
Study found that VRE colonization is linked to higher mortality, increased need for mechanical ventilation, and renal replacement therapy, while MRSA and C diff colonization showed less impact.
·google.com·
VRE Colonization Linked to Higher Mortality in Sepsis Patients
Microbiological pathogens in fecal samples of foals during the first year of life - PubMed
Microbiological pathogens in fecal samples of foals during the first year of life - PubMed
In general, the examined pathogens showed an age dependent occurrence, but infections in foals outside of the common age group could not be ruled out with certainty due to small sample numbers in some of the age groups. Although Rotavirus A was the most prevalent pathogen in this study, netF- …
·pubmed.ncbi.nlm.nih.gov·
Microbiological pathogens in fecal samples of foals during the first year of life - PubMed
Is there an association between colonisation of vancomycin resistant Enterococci, methicillin resistant Staphylococcus Aureus, or Clostridiodes Difficile and mortality in sepsis? - PubMed
Is there an association between colonisation of vancomycin resistant Enterococci, methicillin resistant Staphylococcus Aureus, or Clostridiodes Difficile and mortality in sepsis? - PubMed
We found that VRE colonisation, but not MRSA or C. diff colonisation, was associated with increased hospital mortality in septic patients.
·pubmed.ncbi.nlm.nih.gov·
Is there an association between colonisation of vancomycin resistant Enterococci, methicillin resistant Staphylococcus Aureus, or Clostridiodes Difficile and mortality in sepsis? - PubMed
The N-terminus of the Clostridioides difficile transferase A component directs toxin activity and potency - PubMed
The N-terminus of the Clostridioides difficile transferase A component directs toxin activity and potency - PubMed
Clostridioides difficile infection is the leading cause of antibiotic-associated, hospital-acquired diarrhea in the USA; the pathology of which is mediated by toxins. The presence of a toxin known as the C. difficile Transferase (CDT) in some clinical isolates is linked to severe sympt …
·pubmed.ncbi.nlm.nih.gov·
The N-terminus of the Clostridioides difficile transferase A component directs toxin activity and potency - PubMed
Protection against Clostridioides difficile disease by a naturally avirulent strain - PubMed
Protection against Clostridioides difficile disease by a naturally avirulent strain - PubMed
Clostridioides difficile is a leading cause of healthcare infections. Gut dysbiosis promotes C. difficile infection (CDI) and CDIs promote gut dysbiosis, leading to frequent CDI recurrence. Although therapies preventing recurrent CDI have been developed, including live biotherapeutic products, exist …
·pubmed.ncbi.nlm.nih.gov·
Protection against Clostridioides difficile disease by a naturally avirulent strain - PubMed
The impact of the COVID-19 pandemic on hospital-acquired infections and multi-drug resistant organisms, in comparison to seasonal influenza - PubMed
The impact of the COVID-19 pandemic on hospital-acquired infections and multi-drug resistant organisms, in comparison to seasonal influenza - PubMed
In the COVID-19 era, HAIs and MDROs rates significantly declined, while CRE rates increased, possibly due to a national trend in Israel since 2016. Steady HHC rates suggest additional factors like enhanced environmental cleaning, personal protective equipment usage, and increased infection preventio …
·pubmed.ncbi.nlm.nih.gov·
The impact of the COVID-19 pandemic on hospital-acquired infections and multi-drug resistant organisms, in comparison to seasonal influenza - PubMed
Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy - PubMed
Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy - PubMed
Our findings indicate that lower rates of allergy in children growing up on farms or with pets may be related to early establishment of typical anaerobic commensals in their gut microbiota. However, further studies are needed to validate our observations in this small birth cohort study.
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy - PubMed
Clostridium difficile Bacteremia in an Elderly Patient with Multiple Comorbidities: A Case Report - PubMed
Clostridium difficile Bacteremia in an Elderly Patient with Multiple Comorbidities: A Case Report - PubMed
Clostridium difficile (C. difficile) stands as a primary cause of health-care-associated colitis in adults; however, extraintestinal manifestations of C. difficile, particularly bacteremia, are exceptionally rare. In this report, we document a case of an elderly male with multip …
·pubmed.ncbi.nlm.nih.gov·
Clostridium difficile Bacteremia in an Elderly Patient with Multiple Comorbidities: A Case Report - PubMed
The Lingering Shadow: Unpacking Long COVID | Health
The Lingering Shadow: Unpacking Long COVID | Health
Around 5-10% of COVID-19 sufferers experience long-term symptoms, known as long COVID. Research suggests persistent virus in the body may be a primary cause. Scientists call for trials of antivirals and innovative treatments to address long COVID, urging increased awareness and preventive measures.
·devdiscourse.com·
The Lingering Shadow: Unpacking Long COVID | Health
Zebrafish (Danio rerio) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases - PubMed
Zebrafish (Danio rerio) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases - PubMed
The zebrafish (Danio rerio) has emerged as a valuable model for studying host-pathogen interactions due to its unique combination of characteristics. These include extensive sequence and functional conservation with the human genome, optical transparency in larvae that allows for high-resolut …
·pubmed.ncbi.nlm.nih.gov·
Zebrafish (Danio rerio) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases - PubMed
Dual RNA-seq study of the dynamics of coding and non-coding RNA expression during Clostridioides difficile infection in a mouse model - PubMed
Dual RNA-seq study of the dynamics of coding and non-coding RNA expression during Clostridioides difficile infection in a mouse model - PubMed
Clostridioides difficile is the leading cause of healthcare-associated diarrhea in industrialized countries. Many questions remain to be answered about the mechanisms governing its interaction with the host during infection. Non-coding RNAs (ncRNAs) contribute to shape virulence in many patho …
·pubmed.ncbi.nlm.nih.gov·
Dual RNA-seq study of the dynamics of coding and non-coding RNA expression during Clostridioides difficile infection in a mouse model - PubMed
Impact of Gut Microbiome Interventions on Glucose and Lipid Metabolism in Metabolic Diseases: A Systematic Review and Meta-Analysis - PubMed
Impact of Gut Microbiome Interventions on Glucose and Lipid Metabolism in Metabolic Diseases: A Systematic Review and Meta-Analysis - PubMed
In this study, it is demonstrated that gut microbiota-targeted interventions can improve key metabolic outcomes, offering a potential therapeutic strategy for managing metabolic diseases. However, the effectiveness of these interventions varies depending on the type, duration, and population charact …
·pubmed.ncbi.nlm.nih.gov·
Impact of Gut Microbiome Interventions on Glucose and Lipid Metabolism in Metabolic Diseases: A Systematic Review and Meta-Analysis - PubMed
Intestinal Insights: The Gut Microbiome's Role in Atherosclerotic Disease: A Narrative Review - PubMed
Intestinal Insights: The Gut Microbiome's Role in Atherosclerotic Disease: A Narrative Review - PubMed
Recent advances have highlighted the gut microbiota as a significant contributor to the development and progression of atherosclerosis, which is an inflammatory cardiovascular disease (CVD) characterized by plaque buildup within arterial walls. The gut microbiota, consisting of a diverse collection …
·pubmed.ncbi.nlm.nih.gov·
Intestinal Insights: The Gut Microbiome's Role in Atherosclerotic Disease: A Narrative Review - PubMed
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile - PubMed
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile - PubMed
The role of microbes and their metabolites in modulating tuft cell (TC) dynamics in the large intestine and the relevance of this pathway to infections is unknown. Here, we uncover that microbiome-driven colonic TC hyperplasia protects against Clostridioides difficile infection. Using selective anti …
·pubmed.ncbi.nlm.nih.gov·
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile - PubMed
Research News
Research News
University of Houston, College of Pharmacy - Backed by a one-year, $40,000 grant from the Society of Infectious Diseases Pharmacists (SIDP), UHCOP Research Assistant Professor Taryn A. Eubank, Pharm.D., BCIDP, is investigating whether Enterococcus colonization during CDI impacts disease severity in hospitalized patients.
·uh.edu·
Research News
Complete genome sequences of toxigenic Clostridioides difficile isolated from Australian feral horses - PubMed
Complete genome sequences of toxigenic Clostridioides difficile isolated from Australian feral horses - PubMed
Recent increases in community-associated iClostridioides difficile/i infections have highlighted the importance of monitoring toxigenic iC. difficile/i from animal and environmental sources. We provide the complete circularized genomes of two toxigenic iC. difficile/i strains isolated fr …
·pubmed.ncbi.nlm.nih.gov·
Complete genome sequences of toxigenic Clostridioides difficile isolated from Australian feral horses - PubMed
Structural insight into recognition of Clostridioides difficile toxin A by novel neutralizing nanobodies targeting QTIN-like motifs within its receptor-binding domain - PubMed
Structural insight into recognition of Clostridioides difficile toxin A by novel neutralizing nanobodies targeting QTIN-like motifs within its receptor-binding domain - PubMed
Clostridioides difficile causes a large proportion of nosocomial colon infections producing toxins TcdA and TcdB as key virulence factors. TcdA and TcdB have analogous domain structures with a receptor-binding domain containing C-terminal combined repetitive oligopeptides (CROPs), an attractive targ …
·pubmed.ncbi.nlm.nih.gov·
Structural insight into recognition of Clostridioides difficile toxin A by novel neutralizing nanobodies targeting QTIN-like motifs within its receptor-binding domain - PubMed
Impacts of perR on oxygen sensitivity, gene expression, and murine infection in Clostridioides difficile 630Δ erm - PubMed
Impacts of perR on oxygen sensitivity, gene expression, and murine infection in Clostridioides difficile 630Δ erm - PubMed
spaniClostridioides difficile/i is a diarrheal pathogen and a major public health concern. To improve humans' understanding of iC. difficile/i , a variety of iC. difficile/i isolates are used in research, including iC. difficile/i 630Δ ierm/i . 630Δ ierm/i is a derivative of the/span …
·pubmed.ncbi.nlm.nih.gov·
Impacts of perR on oxygen sensitivity, gene expression, and murine infection in Clostridioides difficile 630Δ erm - PubMed
Meta-analysis of predictors of healthcare-associated Clostridioides difficile infection - PubMed
Meta-analysis of predictors of healthcare-associated Clostridioides difficile infection - PubMed
Our systematic review and meta-analysis of 40 studies (n = 3,905,559) identified gastric acid suppressants, recent hospitalization, antibiotic exposure, and certain comorbidities as independent predictors of healthcare-associated Clostridioides difficile infection (HA-CDI) among adult …
·pubmed.ncbi.nlm.nih.gov·
Meta-analysis of predictors of healthcare-associated Clostridioides difficile infection - PubMed
Gut microbiota-derived 3-indoleacetic acid confers a protection against sepsis-associated encephalopathy through microglial aryl hydrocarbon receptors - PubMed
Gut microbiota-derived 3-indoleacetic acid confers a protection against sepsis-associated encephalopathy through microglial aryl hydrocarbon receptors - PubMed
Gut microbiota-derived IAA confers a protection against SAE by activating AhR in microglia, improving neuronal and cognitive impairments. Thus, IAA holds the promise as a potential therapeutic agent for managing SAE.
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota-derived 3-indoleacetic acid confers a protection against sepsis-associated encephalopathy through microglial aryl hydrocarbon receptors - PubMed
Synergistic Interplay of Diet, Gut Microbiota, and Insulin Resistance: Unraveling the Molecular Nexus - PubMed
Synergistic Interplay of Diet, Gut Microbiota, and Insulin Resistance: Unraveling the Molecular Nexus - PubMed
This comprehensive review explores the intricate relationship between gut microbiota, diet, and insulin resistance, emphasizing the novel roles of diet-induced microbial changes in influencing metabolic health. It highlights how diet significantly influences gut microbiota composition, with differen …
·pubmed.ncbi.nlm.nih.gov·
Synergistic Interplay of Diet, Gut Microbiota, and Insulin Resistance: Unraveling the Molecular Nexus - PubMed