DDW 2022 Updates: IBS, Eosinophilic Esophagitis, and C difficile - Clinical Advisor
Read updates on effective treatments for IBS, the effects of food allergies on proton pump inhibitor efficacy, and oral microbiome therapy for C difficile and more from DDW 2022.
Seres Therapeutics Presents Microbiome Therapeutic Research at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting - Yahoo Finance
CAMBRIDGE, Mass., June 01, 2022--Seres Therapeutics, Inc. (Nasdaq: MCRB), a leading microbiome therapeutics company, announced the presentation of preclinical data supporting further investigation of a rationally designed microbial consortium candidate (DE486) to prevent or treat gastrointestinal (GI) mucositis – a common and often painful complication of radiation and chemotherapy involving the breakdown of the rapidly-dividing epithelial cells lining the GI tract. These results are available o
An Unusual Presentation of Clostridioides Difficile Colitis in a Patient on Opioids - Cureus
Clostridioides difficile colitis is an inflammation of the colon due to toxins produced by a gram-positive bacterium called Clostridioides difficile (also known as Clostridium difficile). Clostr...
Excellent thread @AvrahamCooperMD! We recently performed a large scale meta-analysis (42k+ metagenomic samples) looking the gut #microbiome associated with #Cdiff, especially in healthy infants! You can check out the preprint: https://t.co/DGoRN6QJJv https://t.co/o6JK7BzzWh— Pamela Ferretti (@pam_ferretti) May 30, 2022
Iron Effects on Clostridioides difficile Toxin Production and Antimicrobial Susceptibilities
Despite the benefits of red blood cell (RBC) transfusion therapy, it can render patients vulnerable to iron overload. The excess iron deposits in various body tissues cause severe complications and organ damage such as cardiotoxicity and mold infections. Clostridioides difficile infection (CD …
An Update on Clostridioides difficile Binary Toxin - PubMed
Infection with Clostridioides difficile (CDI), a common healthcare-associated infection, includes symptoms ranging from mild diarrhea to severe cases of pseudomembranous colitis. Toxin A (TcdA) and toxin B (TcdB) cause cytotoxicity and cellular detachment from intestinal epithelium and are re …
Higher in vivo fecal concentrations of Clostridioides difficile toxins A and B in patients with NAP-1/027 strain infection
Ultrasensitive, quantitative Clostridioides difficile stool toxin measurement demonstrated significantly higher concentrations of toxins A and B in patients infected with the NAP-1/027 strain compared to patients infected with other strains. These data provide in vivo confirmation of the in vitro as …
Effects of broad-spectrum antibiotics on the colonisation of probiotic yeast Saccharomyces boulardii in the murine gastrointestinal tract | Scientific Reports - Nature.com
Scientific Reports - Effects of broad-spectrum antibiotics on the colonisation of probiotic yeast Saccharomyces boulardii in the murine gastrointestinal tract
Identification of functional Spo0A residues critical for sporulation in Clostridioides difficile - PubMed
Clostridioides difficile is an anaerobic, Gram-positive pathogen that is responsible for C. difficile infection (CDI). To survive in the environment and spread to new hosts, C. difficile must form metabolically dormant spores. The formation of spores requires activation of the transcription factor S …
Infectious complications in acute graft-versus-host disease after Liver transplantation
Our study reiterates that despite prophylaxis, infectious complications in GVHD following LT are common and lead to exceptionally high mortality. Individualized antimicrobial treatment, prophylaxis and monitoring strategies remain a critical component of GVHD management. Further study to optimize th …
Highly Efficient Genome Editing in Clostridium difficile Using the CRISPR-Cpf1 System
Clostridium difficile is often the primary cause of nosocomial diarrhea, leading to thousands of deaths annually worldwide. The availability of an efficient genome editing tool for C. difficile is essential to understanding its pathogenic mechanism and physiological behavior. Here, we describe a str …
Genetic diversity of C. difficile, a particularly problematic pathogen - Science Daily
Researchers have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen, particularly in health care settings.
Notes from the Field: Escherichia coli O157:H7 Outbreak in Children with Clostridioides difficile Colonization Associated with an Improperly Treated Swimming Pool - Pennsylvania, June 2021
Notes from the Field: Escherichia coli O157:H7 Outbreak in Children with Clostridioides difficile Colonization Associated with an Improperly Treated Swimming Pool - Pennsylvania, June 2021
The WalRK Two-Component System Is Essential for Proper Cell Envelope Biogenesis in Clostridioides difficile
The WalR-WalK two-component regulatory system (TCS) is found in all Firmicutes, in which it regulates the expression of multiple genes required for remodeling the cell envelope during growth and division. Unlike most TCSs, WalRK is essential for viability, so it has attracted interest as a po …
Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen Clostridioides difficile - PubMed
The glycyl radical enzyme (GRE) family utilizes a glycyl radical cofactor, installed by AdoMet radical activating enzymes, to catalyze difficult chemical reactions in a variety of microbial metabolic pathways. Although GREs are widely encoded and expressed by bacteria found in the gut microbiome, th …
These results suggest that K. pneumoniae can cross-feed and shift the metabolism of C. difficile, as well as enhance the pro-inflammatory capacity of C. difficile. We speculate that interspecies interactions could be among the earliest events that occur as C. difficile colonizes the host. As a resul …
Clostridioides difficile surface layer protein triggered inflammasome activation is mediated by membrane lipid raft - PubMed
Clostridioides difficile is the leading cause of nosocomial infectious diarrhea, with clinical symptoms ranging from mild diarrhea to pseudomembranous colitis and toxic megacolon. Despite the use of vancomycin and fidaxomicin as standard drugs for the treatment of C. difficileinfection (CDI), clinic …
In C Diff, New Attention Being Paid to the Role of the Virome
Most of the discussion around fecal microbiota transplantation has focused on bacterial communities, but new advances have shed more light on the role of the virome.
CDI Risk Increases With 5-ASA in Pediatric IBD Patients
The use of 5-aminosalicylic acid significantly increases the risk for emClostridioides difficile/em infection in children with inflammatory bowel disease.
U.Va. computer models help in understanding C. difficile, antibiotic resistance
The Papin Lab makes it possible to apply the understanding of the nature of the bacteria to new treatment options for C. difficile bacterial infection.
The role of short-chain fatty acids in Clostridioides difficile infection: A review
Clostridioides difficile is a Gram-positive, obligate anaerobic, spore-producing intestinal opportunistic pathogen. CDI outbreaks in Europe and the Americas in recent years are a major health concern. Intestinal short-chain fatty acids (SCFAs) are an important energy source for colonic epithelial ce …
TcdB of Clostridioides difficile Mediates RAS-Dependent Necrosis in Epithelial Cells - PubMed
A Clostridioides difficile infection (CDI) is the most common nosocomial infection worldwide. The main virulence factors of pathogenic C. difficile are TcdA and TcdB, which inhibit small Rho-GTPases. The inhibition of small Rho-GTPases leads to the so-called cytopathic effect, a reorga …
