Enhanced biocidal efficacy of alcohol based disinfectants with salt additives - PubMed
Surfaces contaminated with pathogens pose a significant risk of disease transmission and infection. Alcohol-based disinfectants are widely utilized to decontaminate high-touch areas across various settings. However, their limited antimicrobial activity and the emergence of alcohol-tolerant strains n …
Health Care–Associated Infections and Outcomes at the Intersections
The US Department of Health and Human Services’ Healthy People 2030 initiative calls for reductions in health care–associated infections (HAI) and a strong focus on addressing social determinants of health and eliminating health disparities. Advancing equity in health care to prevent HAI requires a...
Enhanced biocidal efficacy of alcohol based disinfectants with salt additives - PubMed
Surfaces contaminated with pathogens pose a significant risk of disease transmission and infection. Alcohol-based disinfectants are widely utilized to decontaminate high-touch areas across various settings. However, their limited antimicrobial activity and the emergence of alcohol-tolerant strains n …
Copper oxide-based surfaces can reduce C. diff icile spores
Copper oxide-containing surfaces significantly reduced Clostridioides difficile spores after 4 hours, according to study findings published in Infection Control & Hospital Epidemiology.
STOP-CDI Protocol Significantly Reduces Healthcare-Associated C. diff
The Screening and Targeted Prophylaxis for Clostridioides difficile infection (STOP-CDI) protocol, developed at the University of Pennsylvania, resulted in a substantial reduction in healthcare-associated CDI among patients screened.
Impact of adjunct bezlotoxumab for preventing Clostridioides difficile infection recurrence in patients post - hematopoietic stem cell transplantation - PubMed
In conclusion, the use of bezlotoxumab did not lead to statistically significant decreases in CDI recurrence in patients post-HSCT. Future studies should be conducted with a larger number of HSCT patients receiving bezlotoxumab to provide supporting evidence of its role in reducing CDI recurrence.
Does routine use of sporicidal disinfectants for all post-discharge hospital rooms reduce environmental contamination with Clostridioides difficile spores? - PubMed
In a culture survey of 30 U.S. hospitals, rates of Clostridioides difficile spore contamination after cleaning and disinfection of non-C. difficile infection (CDI) rooms were lower in facilities using sporicidal disinfectants in all post-discharge rooms versus only in CDI rooms (3.6% versus 5.1%, re …
Synergistic and off-target effects of bacteriocins in a simplified human intestinal microbiome: implications for Clostridioides difficile infection control - PubMed
Clostridioides difficile is a major cause of nosocomial diarrhea. As current antibiotic treatment failures and recurrence of infections are highly frequent, alternative strategies are needed for the treatment of this disease. This study explores the use of bacteriocins, specifically lacticin …
Effectiveness of oral vancomycin as prophylaxis against Clostridioides difficile infection in hematopoietic stem cell transplant patients - PubMed
In-hospital incidence of CDI in HSCT patients was significantly decreased with OVP. Randomized controlled trials are needed in this high-risk population to assess the efficacy and risks of OVP for CDI.
NACCHO's Efforts to Combat Healthcare-Associated Infections and Antimicrobial Resistance
CEO Lori Tremmel Freeman discusses NACCHO's capacity-building programs and strategies to strengthen local health departments in addressing evolving public health threats.
Synergistic and off-target effects of bacteriocins in a simplified human intestinal microbiome: implications for Clostridioides difficile infection control - PubMed
Clostridioides difficile is a major cause of nosocomial diarrhea. As current antibiotic treatment failures and recurrence of infections are highly frequent, alternative strategies are needed for the treatment of this disease. This study explores the use of bacteriocins, specifically lacticin …
Analysis of risk factors of Clostridioides difficile infection in patients with inflammatory bowel disease - PubMed
The risk factors for CDI in patients with IBD include younger age, female gender, low body mass index and hypoalbuminaemia, use of thiopurines, antibiotics, and glucocorticosteroids, prolonged hospitalisation, and gastritis and/or duodenitis.
Probiotics may help relieve and improve IBS symptoms, like bloating, abdominal pain, and bowel movement irregularity, by balancing the gut’s natural bacteria. Learn more.
Outbreak containment prevention bundles crucial in nosocomial infection prevention
Although Candida auris and Clostridioides difficile continue to be dangerous for patients, research published throughout this year has highlighted strides made in outbreak prevention and understanding nosocomial infections.
Bifidobacteria antagonize the life cycle of Clostridioides difficile - PubMed
Clostridioides difficile is a spore-forming pathogen capable of causing severe disease in humans. Critical stages in the biological cycle of this microorganism include sporogenesis/germination and toxin production by vegetative cells. Antagonizing these pivotal events could aid in prevention and tre …
(PDF) Effects of probiotics in elderly hospitalized tube-fed patients with antibiotics use
PDF | Background Several studies revealed the beneficial effects of probiotics against the incidence of antibiotic-associated diarrhea of hospitalized... | Find, read and cite all the research you need on ResearchGate
Effects of probiotics in elderly hospitalized tube-fed patients with antibiotics use - BMC Gastroenterology
Background Several studies revealed the beneficial effects of probiotics against the incidence of antibiotic-associated diarrhea of hospitalized patients but it is rarely to assess the nutrition status. This study investigated the effects of probiotics in elderly hospitalized tube-fed patients with antibiotics use and is the first study that concerns the nutritional status among these patients. Methods Elderly hospitalized tube-fed patients who were using antibiotics were recruited. Probiotics were given within 48 h after their first antibiotic therapy, and then twice daily 2 h after consuming antibiotics and a meal; the probiotics were continued to use for an additional 7 days after completion of antibiotics therapy. Anthropometric data, laboratory data, medication records, nutritional status, nutrition intake and data on stool form were collected. Results Twenty-nine patients served as probiotic group. 11 patients completed the study in both groups. In probiotic group, the stool form was found to exhibit no significant differences between the beginning and end of antibiotics therapy (5.5 ± 0.8 vs 5.1 ± 1.1, p = 0.21), but the stool frequency significantly decreased (2.0 ± 1.0 vs 1.6 ± 0.7, p = 0.05). In control group, the stool form between the beginning and end of antibiotics therapy exhibited significant improvement (5.6 ± 1.4 vs 4.5 ± 1.4, p = 0.01), but not in the frequency (2.7 ± 2.1 vs 2.4 ± 1.5, p = 0.1). The initial NRS 2002 score of the probiotic and control groups were similar. (3.6 ± 1.7 vs 3.7 ± 1.8, p = 1.00), and their nutrition status both significantly improved during the last visit before discharged (2.6 ± 0.9 vs 2.9 ± 1.3). Conclusion Probiotic supplementation in elderly hospitalized tube-fed patients significantly reduced stool frequency during antibiotic treatment. Improvements in stool form were observed only during the follow-up period. Nutritional status remained stable, with patients' nutritional needs adequately met throughout the study.
Probiotics May Not Fully Restore Gut Microbiome After Antibiotics: Benefits Exist, But Proof Is Limited - Gilmore Health News
Researchers find probiotics can mitigate some effects of antibiotics but lack conclusive evidence for fully restoring the gut microbiome. Benefits exist, but proof is limited.
Efficacy of copper-impregnated antimicrobial surfaces against Clostridioides difficile spores - PubMed
Copper coupons can substantially reduce C. difficile spores after 4 hours, but results vary depending on the initial spore concentration and presence or absence of organic material. Higher initial spore loads or excess organic material may prevent spores from contact with copper surfaces, thu …
A Simple Prediction Model for Clostridioides difficile Infection: A Hospital-Based Administrative Database Study - PubMed
This simple prediction score enables early medical intervention and modification of treatment plans to reduce the risk of developing primary hospital-onset CDI.
Oroville Hospital receives poor grade from health care watchdog organization
OROVILLE — In a nonprofit’s report released this week grading hospitals across the nation on overall performance in keeping patients safe from preventable harm and medical errors, Oroville Hospital received a D. The Leapfrog Group, an independent national nonprofit health care watchdog organization established in 2000, annually grades health care facilities on a scale from A to F, with A ...