The evidence from this study does not support recommendations for the routine use of prescribed probiotics to prevent primary CDI in older patients receiving antibiotics in situations where the CDI is infrequent.

“Can probiotics have anti-inflammatory effects worth considering in chronic intestinal diseases? https://t.co/yZ5fW9rbqA”

The comparative genomic analysis of Lactiplantibacillus plantarum YW11t (L. plantarum YW11) isolated from Tibetan kefir involves comparison of the complete genome sequences of the isolated strain with other closely related L. plantarum strains. This type of analysis can be used t …

Correction to: Transcriptome analysis of the Clostridioides difficile response to a specific lactobacilli probiotic formulation: explanations for its mechanisms of action

PROBIOTICS ARE LIVE MICROORGANISMS intended to have positive health effects when consumed (or applied to the body). Probiotics are in…

Prophylactic probiotics have been shown to be effective in preventing Clostridioides difficile infection (CDI), according to multiple meta-analyses. However, different medical societies have varying recommendations on their use for preventing CDI. In this commentary, we discuss current eviden …

The World Gastroenterology Organisation (WGO) is a federation of over 100 Member Societies and four Regional Associations of gastroenterology representing over 50,000 individual members worldwide.

Probiotics have shown great promise in promoting human health. Despite the promising evidence, there is little information on the clinical efficacy of…

Background Probiotics have been deemed multipotent and unprecedentedly applied in the health field recently. However, there are challenges in promoting credible and reliable resources while avoiding misinformation regarding probiotics for the public. Methods This study analysed 400 eligible probiotic-related videos selected from YouTube, and the three most popular video-sharing platforms (Bilibili, Weibo and TikTok) in China. Video retrieval was performed on September 5th, 2022. GQS and tailored DISCERN tool assess each video’s quality, usage, and reliability. A comparative analysis of videos from different sources was carried out. Results The identity distribution of probiotic video-producers was predominantly experts (n = 202, 50.50%), followed by amateurs (n = 161, 40.25%) and health-related institutions (n = 37, 9.25%). The videos’ content category mainly discussed the function of probiotics (n = 120, 30%), the way to choose suitable products (n = 81, 20.25%), and the methods for taking probiotics (n = 71, 17.75%).The overall quality of videos was moderate (3/5 point) assessed by GQS, while the usage (1/6 point) and reliability (2/5 point) detailing probiotics assessed by tailored DISCERN tool were poor. The attitude of probiotic video-producers was primarily positive (n = 323, 80.75%), followed by neutral (n = 52, 13.00%) and negative (n = 25, 6.25%) (P

Probiotics are used for both generally healthy consumers and in clinical settings. However, theoretical and proven adverse events from probiotic consumption exist. New probiotic strains and product...

AbstractAims. Clostridioides difficile infections (CDI) are a major cause of morbidity and mortality in hospitalized patients. A probiotic formulation (Bio-K+)

With antibiotic resistance on the rise, new solutions are needed to fight superbugs.

The lactobacilli tested could have a role in the motility, the quorum sensing (QS), the survival of the spores and the germination potential of the spores, which are essential elements for the virulence of C. difficile.

Where are we on the role of probiotics in IBS and IBD?.@soda_xl, Quigley & @ProfWhelan offer a quick overview in the field: small effects sizes seen in IBS and efficacy for ulcerative colitis remissionhttps://t.co/jIwXvEwNvd— GutMicrobiota Health (@GMFHx) March 13, 2023

Nature Microbiology - Systems genetics reveals interactions between host and microbial phenotypes in the murine gut, including a role for Akkermansia muciniphila in the production of...

A large database study found an association between probiotics and increased risk of fatal bacteremia in the ICU.

A new in vitro research study conducted by the Eurofins Labs confirmed efficacy of Doctor's Biome proprietary blend of probiotics (10 lactobacilli and 5 bifidobacteria) in inhibition of Clostridium difficile (C. diff); a life-threatening diarrhea-causing bacteria.

Separating the contribution to host health benefits made by postbiotics already present in probiotic products is not straightforward. Are bacterial extracellular vesicles the future postbiotics? https://t.co/hh61MuaxaQ— GutMicrobiota Health (@GMFHx) October 25, 2022

A history of safe use is a backbone of safety assessments for many current probiotic species, however, there is no global harmonization regarding requ…

Probiotics can alter brain function via the gut–brain axis. We investigated the effect of a probiotic mixture containing Bifidobacterium longum, Lactobacillus helveticus and Lactiplantibacillus plantarum. In a randomized, placebo-controlled, double-blinded crossover design, 22 healthy subjects (6 m/16 f; 24.2 ± 3.4 years) underwent four-week intervention periods with probiotics and placebo, separated by a four-week washout period. Voxel-based morphometry indicated that the probiotic intervention affected the gray matter volume of a cluster covering the left supramarginal gyrus and superior parietal lobule (p 0.0001), two regions that were also among those with an altered resting state functional connectivity. Probiotic intervention resulted in significant (FDR 0.05) functional connectivity changes between regions within the default mode, salience, frontoparietal as well as the language network and several regions located outside these networks. Psychological symptoms trended towards improvement after probiotic intervention, i.e., the total score of the Hospital Anxiety and Depression Scale (p = 0.056) and its depression sub-score (p = 0.093), as well as sleep patterns (p = 0.058). The probiotic intervention evoked distinct changes in brain morphology and resting state brain function alongside slight improvements of psycho(bio)logical markers of the gut–brain axis. The combination of those parameters may provide new insights into the modes of action by which gut microbiota can affect gut–brain communication and hence brain function.

Find out what is known about the anti-inflammatory effects of probiotics and their potential applications at the bedside.

1. In a randomized control trial, administration of multispecies probiotics did not affect the incidence of antibiotic-associated diarrhea as defined by strict criteria. 2. Multispecies probiotic use was associated with a decreased risk of developing diarrhea regardless of etiology and of requiring intravenous rehydration due to diarrhea. Evidence Rating Level: 1 (Excellent) Study Rundown: Antibiotic-associated diarrhea

Postbiotics and next-generation probiotics are emerging strategies to promote health and manage disease through targeting the human microbiome in a specific way. This article updates what is known in the field.

S. boulardii administration is associated with a significant HO-CDI risk reduction for inpatients receiving antibiotics associated with CDI. Institutions interested in targeted use of S. boulardii to limit potential adverse effects may consider prophylaxis for inpatients with pneumonia or receiving …

There are many different probiotic products on the market. Are they all equally effective? What criteria should a probiotic formulation meet to provide the most benefit to the patient? The current research aims to evaluate the parameters that influence the effectiveness of market probiotic products. …

Gene-edited probiotics combat C. difficile in gut

Probiotics have the potential to be used in the prevention of Clostridioides difficile infection (CDI). In this study, selenium (Se)-enriched Bifidobacterium breve YH68-Se was obtained under optimal culture conditions with single-factor and response surface optimization. The overall environmental re …

Objective To examine the certainty of the evidence supporting health claims about probiotics, yoghurt, kefir, kombucha, fibre and prebiotics, and to assess the quality of online information in Spanish. Design Content analysis. Methods We compiled a data set of 114 web pages by searching six popular search phrases in Spanish relating to probiotics, yoghurt, kefir, kombucha, fibre and prebiotics on Google.es and coded them for typology and health claims. We examined the certainty of the evidence for health claims from systematic reviews. Information quality was assessed according to 10 criteria, where a web page: mentions scientific publications and reports their conclusions; quantifies relative and absolute effects; acknowledges some limitations; discusses certainty of evidence; reports the potential harms, alternatives and costs; and does not argue based on personal experiences. Results Gastrointestinal health (86.0%), general health (57.9%), cardiovascular health (53.5%) and immune system health (50.9%) were the most widely mentioned topics. Half of claims (52.6%, 70/133) were supported by evidence from systematic reviews. Probiotics had the highest number of claims supported by evidence and kombucha the lowest. The highest certainty was found for antibiotic-associated diarrhoea, necrotising enterocolitis and otitis (moderate) in probiotics and yoghurt, infectious diarrhoea and hepatic encephalopathy (moderate) in prebiotics, and cardiovascular health (high to moderate) and colorectal cancer (moderate) in fibre. On a scale of 0–10, the median information quality score for all web pages was 3. Only 18.4% reported study conclusions, 7.9% quantified the effects, 28.9% acknowledged some limitations in the research and 42.1% reported potential harms. Conclusions Most online health claims for dietary interventions intended for improving health through the gut microbiome are supported by low or very low certainty of evidence. Online information does not align with the evidence and is incomplete or unbalanced. All data relevant to the study are included in a public, open access repository. The data set is available on the following: [https://figshare.com/articles/journal\_contribution/Supplemental\_material_1/20203415][1], [https://figshare.com/articles/journal\_contribution/Table\_S2/19425824][2], [https://figshare.com/articles/journal\_contribution/Supplemental\_material_3/20204021][3], [https://figshare.com/articles/journal\_contribution/Supplemental\_material_4/20204270][4]. [1]: https://figshare.com/articles/journal_contribution/Supplemental_material_1/20203415 [2]: https://figshare.com/articles/journal_contribution/Table_S2/19425824 [3]: https://figshare.com/articles/journal_contribution/Supplemental_material_3/20204021 [4]: https://figshare.com/articles/journal_contribution/Supplemental_material_4/20204270