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Prescribed probiotic usage to prevent Clostridioides difficile infection among older patients receiving antibiotics: A retrospective cohort study - PubMed
Prescribed probiotic usage to prevent Clostridioides difficile infection among older patients receiving antibiotics: A retrospective cohort study - PubMed
The evidence from this study does not support recommendations for the routine use of prescribed probiotics to prevent primary CDI in older patients receiving antibiotics in situations where the CDI is infrequent.
·pubmed.ncbi.nlm.nih.gov·
Prescribed probiotic usage to prevent Clostridioides difficile infection among older patients receiving antibiotics: A retrospective cohort study - PubMed
GutMicrobiota Health on Twitter
GutMicrobiota Health on Twitter
“Can probiotics have anti-inflammatory effects worth considering in chronic intestinal diseases? https://t.co/yZ5fW9rbqA”
·twitter.com·
GutMicrobiota Health on Twitter
Integrated genome based evaluation of safety and probiotic characteristics of Lactiplantibacillus plantarum YW11 isolated from Tibetan kefir - PubMed
Integrated genome based evaluation of safety and probiotic characteristics of Lactiplantibacillus plantarum YW11 isolated from Tibetan kefir - PubMed
The comparative genomic analysis of Lactiplantibacillus plantarum YW11t (L. plantarum YW11) isolated from Tibetan kefir involves comparison of the complete genome sequences of the isolated strain with other closely related L. plantarum strains. This type of analysis can be used t …
·pubmed.ncbi.nlm.nih.gov·
Integrated genome based evaluation of safety and probiotic characteristics of Lactiplantibacillus plantarum YW11 isolated from Tibetan kefir - PubMed
Correction to: Transcriptome analysis of the Clostridioides difficile response to a specific lactobacilli probiotic formulation: explanations for its mechanisms of action - PubMed
Correction to: Transcriptome analysis of the Clostridioides difficile response to a specific lactobacilli probiotic formulation: explanations for its mechanisms of action - PubMed
Correction to: Transcriptome analysis of the Clostridioides difficile response to a specific lactobacilli probiotic formulation: explanations for its mechanisms of action
·pubmed.ncbi.nlm.nih.gov·
Correction to: Transcriptome analysis of the Clostridioides difficile response to a specific lactobacilli probiotic formulation: explanations for its mechanisms of action - PubMed
Probiotics for primary prevention of Clostridioides difficile infection: revisiting the evidence - PubMed
Probiotics for primary prevention of Clostridioides difficile infection: revisiting the evidence - PubMed
Prophylactic probiotics have been shown to be effective in preventing Clostridioides difficile infection (CDI), according to multiple meta-analyses. However, different medical societies have varying recommendations on their use for preventing CDI. In this commentary, we discuss current eviden …
·pubmed.ncbi.nlm.nih.gov·
Probiotics for primary prevention of Clostridioides difficile infection: revisiting the evidence - PubMed
World Gastroenterology Organisation (WGO)
World Gastroenterology Organisation (WGO)
The World Gastroenterology Organisation (WGO) is a federation of over 100 Member Societies and four Regional Associations of gastroenterology representing over 50,000 individual members worldwide.
·worldgastroenterology.org·
World Gastroenterology Organisation (WGO)
Status quo of the public’s knowledge of probiotics based on video-sharing platforms - BMC Public Health
Status quo of the public’s knowledge of probiotics based on video-sharing platforms - BMC Public Health
Background Probiotics have been deemed multipotent and unprecedentedly applied in the health field recently. However, there are challenges in promoting credible and reliable resources while avoiding misinformation regarding probiotics for the public. Methods This study analysed 400 eligible probiotic-related videos selected from YouTube, and the three most popular video-sharing platforms (Bilibili, Weibo and TikTok) in China. Video retrieval was performed on September 5th, 2022. GQS and tailored DISCERN tool assess each video’s quality, usage, and reliability. A comparative analysis of videos from different sources was carried out. Results The identity distribution of probiotic video-producers was predominantly experts (n = 202, 50.50%), followed by amateurs (n = 161, 40.25%) and health-related institutions (n = 37, 9.25%). The videos’ content category mainly discussed the function of probiotics (n = 120, 30%), the way to choose suitable products (n = 81, 20.25%), and the methods for taking probiotics (n = 71, 17.75%).The overall quality of videos was moderate (3/5 point) assessed by GQS, while the usage (1/6 point) and reliability (2/5 point) detailing probiotics assessed by tailored DISCERN tool were poor. The attitude of probiotic video-producers was primarily positive (n = 323, 80.75%), followed by neutral (n = 52, 13.00%) and negative (n = 25, 6.25%) (P
·news.google.com·
Status quo of the public’s knowledge of probiotics based on video-sharing platforms - BMC Public Health
Emerging issues in probiotic safety: 2023 perspectives
Emerging issues in probiotic safety: 2023 perspectives
Probiotics are used for both generally healthy consumers and in clinical settings. However, theoretical and proven adverse events from probiotic consumption exist. New probiotic strains and product...
·tandfonline.com·
Emerging issues in probiotic safety: 2023 perspectives
Transcriptome analysis of the Clostridioides difficile response to a specific lactobacilli probiotic formulation: explanations for its mechanisms of action
Transcriptome analysis of the Clostridioides difficile response to a specific lactobacilli probiotic formulation: explanations for its mechanisms of action
AbstractAims. Clostridioides difficile infections (CDI) are a major cause of morbidity and mortality in hospitalized patients. A probiotic formulation (Bio-K+)
·academic.oup.com·
Transcriptome analysis of the Clostridioides difficile response to a specific lactobacilli probiotic formulation: explanations for its mechanisms of action
Transcriptome analysis of the Clostridioides difficile response to a specific lactobacilli probiotic formulation: explanations for its mechanisms of action - PubMed
Transcriptome analysis of the Clostridioides difficile response to a specific lactobacilli probiotic formulation: explanations for its mechanisms of action - PubMed
The lactobacilli tested could have a role in the motility, the quorum sensing (QS), the survival of the spores and the germination potential of the spores, which are essential elements for the virulence of C. difficile.
·pubmed.ncbi.nlm.nih.gov·
Transcriptome analysis of the Clostridioides difficile response to a specific lactobacilli probiotic formulation: explanations for its mechanisms of action - PubMed
GutMicrobiota Health on Twitter
GutMicrobiota Health on Twitter
Where are we on the role of probiotics in IBS and IBD?.@soda_xl, Quigley & @ProfWhelan offer a quick overview in the field: small effects sizes seen in IBS and efficacy for ulcerative colitis remissionhttps://t.co/jIwXvEwNvd— GutMicrobiota Health (@GMFHx) March 13, 2023
·twitter.com·
GutMicrobiota Health on Twitter
Research Study Confirms Efficacy of Doctor's Biome Signature Probiotics Blend - Yahoo Finance
Research Study Confirms Efficacy of Doctor's Biome Signature Probiotics Blend - Yahoo Finance
A new in vitro research study conducted by the Eurofins Labs confirmed efficacy of Doctor's Biome proprietary blend of probiotics (10 lactobacilli and 5 bifidobacteria) in inhibition of Clostridium difficile (C. diff); a life-threatening diarrhea-causing bacteria.
·news.google.com·
Research Study Confirms Efficacy of Doctor's Biome Signature Probiotics Blend - Yahoo Finance
GutMicrobiota Health on Twitter
GutMicrobiota Health on Twitter
Separating the contribution to host health benefits made by postbiotics already present in probiotic products is not straightforward. Are bacterial extracellular vesicles the future postbiotics? https://t.co/hh61MuaxaQ— GutMicrobiota Health (@GMFHx) October 25, 2022
·twitter.com·
GutMicrobiota Health on Twitter
Cells | Free Full-Text | Multi-Strain Probiotic Mixture Affects Brain Morphology and Resting State Brain Function in Healthy Subjects: An RCT | HTML
Cells | Free Full-Text | Multi-Strain Probiotic Mixture Affects Brain Morphology and Resting State Brain Function in Healthy Subjects: An RCT | HTML
Probiotics can alter brain function via the gut–brain axis. We investigated the effect of a probiotic mixture containing Bifidobacterium longum, Lactobacillus helveticus and Lactiplantibacillus plantarum. In a randomized, placebo-controlled, double-blinded crossover design, 22 healthy subjects (6 m/16 f; 24.2 ± 3.4 years) underwent four-week intervention periods with probiotics and placebo, separated by a four-week washout period. Voxel-based morphometry indicated that the probiotic intervention affected the gray matter volume of a cluster covering the left supramarginal gyrus and superior parietal lobule (p 0.0001), two regions that were also among those with an altered resting state functional connectivity. Probiotic intervention resulted in significant (FDR 0.05) functional connectivity changes between regions within the default mode, salience, frontoparietal as well as the language network and several regions located outside these networks. Psychological symptoms trended towards improvement after probiotic intervention, i.e., the total score of the Hospital Anxiety and Depression Scale (p = 0.056) and its depression sub-score (p = 0.093), as well as sleep patterns (p = 0.058). The probiotic intervention evoked distinct changes in brain morphology and resting state brain function alongside slight improvements of psycho(bio)logical markers of the gut–brain axis. The combination of those parameters may provide new insights into the modes of action by which gut microbiota can affect gut–brain communication and hence brain function.
·mdpi.com·
Cells | Free Full-Text | Multi-Strain Probiotic Mixture Affects Brain Morphology and Resting State Brain Function in Healthy Subjects: An RCT | HTML
Impact of multispecies probiotic in preventing antibiotic-associated diarrhea unclear | 2 Minute Medicine
Impact of multispecies probiotic in preventing antibiotic-associated diarrhea unclear | 2 Minute Medicine
1. In a randomized control trial, administration of multispecies probiotics did not affect the incidence of antibiotic-associated diarrhea as defined by strict criteria. 2. Multispecies probiotic use was associated with a decreased risk of developing diarrhea regardless of etiology and of requiring intravenous rehydration due to diarrhea. Evidence Rating Level: 1 (Excellent) Study Rundown: Antibiotic-associated diarrhea
·2minutemedicine.com·
Impact of multispecies probiotic in preventing antibiotic-associated diarrhea unclear | 2 Minute Medicine
Thoughts about next-generation probiotics & postbiotics
Thoughts about next-generation probiotics & postbiotics
Postbiotics and next-generation probiotics are emerging strategies to promote health and manage disease through targeting the human microbiome in a specific way. This article updates what is known in the field.
·gutmicrobiotaforhealth.com·
Thoughts about next-generation probiotics & postbiotics
Saccharomyces boulardii Prophylaxis for Targeted Antibiotics and Infectious Indications to Reduce Healthcare Facility-Onset Clostridioides difficile Infection
Saccharomyces boulardii Prophylaxis for Targeted Antibiotics and Infectious Indications to Reduce Healthcare Facility-Onset Clostridioides difficile Infection
S. boulardii administration is associated with a significant HO-CDI risk reduction for inpatients receiving antibiotics associated with CDI. Institutions interested in targeted use of S. boulardii to limit potential adverse effects may consider prophylaxis for inpatients with pneumonia or receiving …
·pubmed.ncbi.nlm.nih.gov·
Saccharomyces boulardii Prophylaxis for Targeted Antibiotics and Infectious Indications to Reduce Healthcare Facility-Onset Clostridioides difficile Infection
Factors Determining Effective Probiotic Activity: Evaluation of Survival and Antibacterial Activity of Selected Probiotic Products Using an "In Vitro" Study
Factors Determining Effective Probiotic Activity: Evaluation of Survival and Antibacterial Activity of Selected Probiotic Products Using an "In Vitro" Study
There are many different probiotic products on the market. Are they all equally effective? What criteria should a probiotic formulation meet to provide the most benefit to the patient? The current research aims to evaluate the parameters that influence the effectiveness of market probiotic products. …
·pubmed.ncbi.nlm.nih.gov·
Factors Determining Effective Probiotic Activity: Evaluation of Survival and Antibacterial Activity of Selected Probiotic Products Using an "In Vitro" Study
Antagonistic activity of selenium-enriched Bifidobacterium breve against Clostridioides difficile
Antagonistic activity of selenium-enriched Bifidobacterium breve against Clostridioides difficile
Probiotics have the potential to be used in the prevention of Clostridioides difficile infection (CDI). In this study, selenium (Se)-enriched Bifidobacterium breve YH68-Se was obtained under optimal culture conditions with single-factor and response surface optimization. The overall environmental re …
·pubmed.ncbi.nlm.nih.gov·
Antagonistic activity of selenium-enriched Bifidobacterium breve against Clostridioides difficile
Online information in Spanish on probiotics, yoghurt, kefir, kombucha, fibre and prebiotics: an analysis of the quality of information and the certainty of the evidence supporting health claims | BMJ Open
Online information in Spanish on probiotics, yoghurt, kefir, kombucha, fibre and prebiotics: an analysis of the quality of information and the certainty of the evidence supporting health claims | BMJ Open
Objective To examine the certainty of the evidence supporting health claims about probiotics, yoghurt, kefir, kombucha, fibre and prebiotics, and to assess the quality of online information in Spanish. Design Content analysis. Methods We compiled a data set of 114 web pages by searching six popular search phrases in Spanish relating to probiotics, yoghurt, kefir, kombucha, fibre and prebiotics on Google.es and coded them for typology and health claims. We examined the certainty of the evidence for health claims from systematic reviews. Information quality was assessed according to 10 criteria, where a web page: mentions scientific publications and reports their conclusions; quantifies relative and absolute effects; acknowledges some limitations; discusses certainty of evidence; reports the potential harms, alternatives and costs; and does not argue based on personal experiences. Results Gastrointestinal health (86.0%), general health (57.9%), cardiovascular health (53.5%) and immune system health (50.9%) were the most widely mentioned topics. Half of claims (52.6%, 70/133) were supported by evidence from systematic reviews. Probiotics had the highest number of claims supported by evidence and kombucha the lowest. The highest certainty was found for antibiotic-associated diarrhoea, necrotising enterocolitis and otitis (moderate) in probiotics and yoghurt, infectious diarrhoea and hepatic encephalopathy (moderate) in prebiotics, and cardiovascular health (high to moderate) and colorectal cancer (moderate) in fibre. On a scale of 0–10, the median information quality score for all web pages was 3. Only 18.4% reported study conclusions, 7.9% quantified the effects, 28.9% acknowledged some limitations in the research and 42.1% reported potential harms. Conclusions Most online health claims for dietary interventions intended for improving health through the gut microbiome are supported by low or very low certainty of evidence. Online information does not align with the evidence and is incomplete or unbalanced. All data relevant to the study are included in a public, open access repository. The data set is available on the following: [https://figshare.com/articles/journal\_contribution/Supplemental\_material_1/20203415][1], [https://figshare.com/articles/journal\_contribution/Table\_S2/19425824][2], [https://figshare.com/articles/journal\_contribution/Supplemental\_material_3/20204021][3], [https://figshare.com/articles/journal\_contribution/Supplemental\_material_4/20204270][4]. [1]: https://figshare.com/articles/journal_contribution/Supplemental_material_1/20203415 [2]: https://figshare.com/articles/journal_contribution/Table_S2/19425824 [3]: https://figshare.com/articles/journal_contribution/Supplemental_material_3/20204021 [4]: https://figshare.com/articles/journal_contribution/Supplemental_material_4/20204270
·bmjopen.bmj.com·
Online information in Spanish on probiotics, yoghurt, kefir, kombucha, fibre and prebiotics: an analysis of the quality of information and the certainty of the evidence supporting health claims | BMJ Open