Clostridium difficile is a bacterium that affects the gastrointestinal tract and is the leading cause of antibiotic-associated diarrhea. A wide range of probiotics has been studied and used to p...

1. In a small randomized controlled trial, administration of a multispecies probiotic during antibiotic therapy and for 7 days afterwards significantly reduced risk of diarrhea from all causes compared to placebo. 2. Probiotic administration did not affect risk of antibiotic-associated diarrhea (AAD), defined as diarrhea either caused by C. difficile or without another identified pathogenic

InsightAce Analytic Pvt. Ltd. has announced the publication of a market research report titled "Global Live Biotherapeutic Product (LBP) Market (By Type of Product(Probiotic drugs, Other drugs), By Type of Molecule(Small molecules, Biologics), By Target disease indication(Graft Versus Host Disease, Necrotizing Enterocolitis, Primary Hyperoxaluria, Recurrent C. difficile Infection, Others), By Therapeutic area (Digestive and Gastrointestinal Disorders, Infectious Diseases, Rare Disorders, Others)

Clostridioides difficile infection (CDI) results in significant morbidity and mortality in hospitalised patients. The pathogenesis of CDI is intrinsically related to the ability of C. difficile to shuffle between active vegetative cells and dormant endospores through the processes of germination and …

Clostridioides difficile is responsible for post-antibiotic diarrhea and most of the pseudomembranous colitis cases. Multiple recurrences, one of the major challenges faced in C. difficile infection (CDI) management, can be considered as chronic infections, and the role of biofilm form …

Clostridioides difficile is responsible for post-antibiotic diarrhea and most of the pseudomembranous colitis cases. Multiple recurrences, one of the major challenges faced in C. difficile infection (CDI) management, can be considered as chronic infections, and the role of biofilm form …

The fertile gut of a dog or cat brims with benevolent bacteria. Various forces can ravage this delicate population, but these microorganisms can be reestablished

The rising prevalence of antibiotic resistant microbial pathogens presents an ominous health and economic challenge to modern society. The discovery and large-scale development of antibiotic drugs in previous decades was transformational, providing cheap, effective treatment for what would previousl …

Patients taking high-risk antibiotics and a probiotic capsule had a lower risk of healthcare-associated C diff infections.

(2022). Probiotics: insights and new opportunities for Clostridioides difficile intervention. Critical Reviews in Microbiology. Ahead of Print.

(2022). Probiotics: insights and new opportunities for Clostridioides difficile intervention. Critical Reviews in Microbiology. Ahead of Print.

Clostridioides difficile infection (CDI) is a life-threatening disease caused by the Gram-positive, opportunistic intestinal pathogen C. difficile. Despite the availability of antimicrobial drugs to treat CDI, such as vancomycin, metronidazole, and fidaxomicin, recurrence of infection …

AbstractIntroduction. Assessing nutritional requirements in large total body surface area (TBSA) burns is a challenge due to frequent metabolic variation. Studi

Aim: The objective of this study was to determine the effect of standard and candidate prebiotics on the adhesion and biofilm formation of Bacteroides sp. in monoculture and co-culture with Clostridioides difficile. Materials & methods: The effect of seven prebiotics on the adhesion and biofilm formation of Bacteroides sp. to three human cell lines was determined. The effect of Bacteroides sp. and fructooligosaccharides (FOS) on the adhesion and biofilm formation of C. difficile was tested by the co-incubation assay. Results: Inulin, mannose and raffinose presented the best anti-adhesion properties against Bacteroides sp. Combination of Bacteroides sp. with FOS decreased the adhesion of C. difficile. Conclusion: The study shows the potential role of prebiotics and synbiotics in decreasing the burden of C. difficile infections.

Aim: The objective of this study was to determine the effect of standard and candidate prebiotics on the adhesion and biofilm formation of Bacteroides sp. in monoculture and co-culture with Clostridioides difficile. Materials & methods: The effect of seven prebiotics …

Clostridioides difficile infection (CDI) is frequently associated with intestinal injury and mucosal barrier dysfunction, leading to an inflammatory response involving neutrophil localization and upregulation of pro-inflammatory cytokines. The severity of clinical manifestations is associated …

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E. lactis JDM1 is expected to be developed as a probiotic, and its probiotic properties are worthy of further exploration.

Probiotics administration can facilitate the restoration of host gut microbiota/metabolome after antibiotic treatment. Yet, the mechanism behind such beneficial effects remains unclear. This study constructed a rat model of antibiotic-induced gut dysbiosis to monitor the effects and mechanism of pro …

Clostridium difficile associated diarrhea (CDAD) in India is still an under-recognized etiology of diarrhea. This is largely due to lack of clinical suspicion, difficulty in culturing the

Probiotics are widely used as an adjuvant agent for the prevention of primary Clostridioides difficile infection (pCDI) and are less commonly used in the treatment of pCDI. Here, the different doses of Bifidobacterium breve YH68 were used to treat the pCDI mouse model and the actual therapeutic effe …

Clostridioides difficile infection (CDI) is a significant cause of hospital-acquired and antibiotic-mediated intestinal diseases and is a growing global public health concern. Overuse of antibiotics and their effect on normal intestinal flora has increased the incidence and severity of infections. T …

A computerized clinical decision support tool to prompt use of probiotics for primary prevention of Clostridioides difficile (CDI) infection was not associated

Google “probiotic” plus any body part or health condition and you’ll find probiotics for sale. Our writer breaks down the pros and cons.

The research team comprised of Shin Kurihara, Associate Professor of Department of Science and Technology on Food Safety, Faculty of Biology-Oriented Science and Technology, Kindai University (Kinokawa, Wakayama); Hiroyuki Nakai, Associate Professor of Food Science Program, Faculty of Agriculture, Department of Applied Biological Chemistry, Niigata University (Niigata, Japan); Rika Hirano, a graduate program research student …

A study found individuals receiving probiotics had a decrease in C. difficile diagnosed in stool samples than those who did not receive probiotics.

A study found individuals receiving probiotics had a decrease in C. difficile diagnosed in stool samples than those who did not receive probiotics.

Risk of bloodstream infection as a result of S. boulardii probiotic use appears restricted to S. boulardii recipients. Risk for probiotic-related bloodstream infection does not appear greater than the risk of any hospital-acquired bloodstream infection both inside and outside of the intensive care u …