C Diff Prevention

A quasi-experimental study performed in a pediatric hematology-oncology unit demonstrated that whole-room ultraviolet-C disinfection was associated with a significant reduction in hospital-onset Clostridioides difficile infection (p

A small study found oral vancomycin prophylaxis prevented C diff infection in thoracic transplant patients.

Infection control efforts to combat hospital-onset Clostridioides difficile infection may be better spent on health care workers’ hand hygiene compliance and environmental cleaning than on visitor contact precautions, a new study suggests.

LGG administration neither prevented acquisition of ARO nor accelerated loss of ARO colonization.

The equine hindgut ecosystem is specialized in dietary fibers' fermentation to provide horses' energy and contribute to its health. Nevertheless, antibiotics are known to disrupt the hindgut microbiota, affecting the fibrolytic activity of bacteria and the intestinal immune balance, leading to disea …

Methods capable of maintaining gut microbiota homeostasis to prevent bacterial translocation and infection under external threats are critical for multiple facets of human health but have been rarely reported. Here, we describe the elicitation of mucosal immunity to modulate the gut microbiota by oral delivery of living probiotics into Peyer’s patches. Probiotics are individually camouflaged within a yeast membrane, on which the embedded β-glucan can facilitate the phagocytosis of microfold cells that locate in the intestinal epithelium. The delivery of probiotics into lymphoid follicles after oral ingestion promotes robust mucosal immune responses and notably upgrades the production of secretory immunoglobulin A. The provoked immunity positively regulates the gut microflora, which, in turn, retains gut homeostasis and provides defense against environmental attacks. In two murine models of gut barrier impairment, oral administration with camouflaged probiotics effectively prevents the breakdown of intestinal barrier and evidences limited bacterial translocation and systemic inflammation.

Use of probiotics for primary prevention of CDI among adult inpatients receiving antibiotics is not supported.

Prehospital monitor/defibrillators may represent a significant reservoir of C. diff and other pathogenic bacteria. Improved disinfection protocols for reusable monitoring equipment and transition to disposable monitoring equipment used in the prehospital setting may reduce the risk of patient and EM …

This model has potential clinical utility for identifying modifiable conditions in real time, such as low staffing coupled with high care demand.

Commercial colorimetric indicators provide rapid and easy-to-interpret information on the UV-C dose delivered to sites in patient rooms. The indicators may be useful for training environmental services personnel and optimizing the effectiveness of UV-C room decontamination devices.

Outbreaks of MRSA, c.difficile, the norovirus and other hospital-acquired infections used to dominate the healthcare news. But references to such on..

Hospital-associated infections incur substantial costs, leaving the door open for tech-driven hand hygiene compliance monitoring to potentially replace the gold standard of direct observation.

COVID-19 patients receiving at least 2 antibiotics were at a higher CDI risk.

A universal gloving initiative was associated with a statistically significant increase in both gloving and hand hygiene compliance. CDI rates decreased during this intervention.

Health care-associated infections remain a significant economic burden for health care systems in the United States.

Clostridiodes difficile infection (CDI) is the most important cause of healthcare-associated diarrhea. The decreasing trend of CDI from 15 % to 4 % observed at the Italian Hospital of Desio over a 10-year period is due to prevention strategies. Our data highlight the importance of surveillance studi …

Medical care for patients hospitalized with COVID-19 is an evolving process. Most COVID-19 inpatients (58-95%) received empiric antibiotics to prevent the increased mortality due to ventilator-associated pneumonia and other secondary infections observed in COVID-19 patients. The expected consequence …

Rockville, Md.- Researchers from Wake Forest School of Medicine in North Carolina have demonstrated that a common diabetes drug inhibits the spread of Clostridioides difficile, or C. diff--a...

Manufacturers of UV-C light technology can point to data that prove it works and is an effective antimicrobial innovation.