Secondary prophylaxis for Clostridioides difficile infection for patients on non- Clostridioides difficile antibiotics: A retrospective cohort study - PubMed
Secondary prophylaxis with CDI antibiotics appears to be associated with a reduced risk of recurrence in patients with previous non-severe CDI episode. Further studies are needed to confirm this finding.
Assessing the stability and sporicidal efficacy of oxidising disinfectants - PubMed
The role of the healthcare environment in the transmission of clinical pathogens is well established. We investigated the chemical stability and sporicidal efficacy of oxidising disinfectant products in the presence of simulated clean and medical dirty conditions. Performance of chlorine-releasing a …
CDC Strategies Tested for Preventing Hospital-Onset C difficile
Incidence of hospital-onset Clostridioides difficile infection differed between hospitals that implemented the CDC prevention strategies and those that did not, but not necessarily because of the strategies.
Antimicrobial effects of cannabidiol on select agriculturally important Clostridia - PubMed
Amino acid-fermenting Clostridia have undesirable effects in agricultural systems, which can be mitigated by antibiotics, but resistance necessitates alternatives. Here, we demonstrate the efficacy of cannabidiol on growth and ammonia inhibition of five agriculturally relevant Clostridia: Clostridiu …
CDC's Hospital-Onset Clostridioides difficile Prevention Framework in a Regional Hospital Network - PubMed
In this quality improvement study of a regional hospital network, implementation of the Framework was not temporally associated with declining HO-CDI incidence. Further study of the effectiveness of multimodal prevention measures for controlling HO-CDI is warranted.
Live Biotherapeutic Products for the Prevention of Recurrent Clostridioides difficile Infection - PubMed
Live biotherapeutic products provide a safe and effective option for the prevention of rCDI and represent an improvement over conventional FMT. Additional studies are needed to further determine their place in therapy relative to bezlotoxumab and in the setting of immunosuppression and inflammatory …
Infection Control Measure Performance in Long-Term Care Hospitals and Their Relationship to Joint Commission Accreditation - PubMed
Although this study was not designed to establish causality, positive associations were observed between Joint Commission accreditation and CLABSI and CAUTI measures, and Joint Commission-accredited LTCHs attained more consistent high performance over the four-year study period for all three measure …
Impact of a syndrome-based stewardship intervention on antipseudomonal beta-lactam use, antimicrobial resistance, C. difficile rates, and cost in a safety-net community hospital - PubMed
Broad-spectrum antimicrobials are commonly used without indication and contribute to antimicrobial resistance (AMR). We implemented a syndrome-based stewardship intervention in a community hospital that targeted common infectious syndromes and antipseudomonal beta-lactam (APBL) use. Our intervention …
The Role of Probiotics in the Prevention of Clostridioides difficile Infection in Patients with Chronic Kidney Disease - PubMed
In patients suffering from chronic kidney disease (CKD), substantial unfavourable alterations in the intestinal microbiota composition, i.e., dysbiosis, have been noted. The main causes of such dysbiosis among others are insufficient dietary fibre content in the diet, fluid restrictions, medications …
Effect of Virtual Reality Simulation Versus Traditional Education on Rates of Clostridium difficile Infection: An Experimental Cluster Randomized Controlled Trial and Return on Investment Analysis - PubMed
Findings showed that VRS was an effective instructional method. [J Contin Educ Nurs. 202x;5x(x):xx-xx.].
Evaluation of infection prevention and control programmes according to ECDC/WHO in Spain 2012-2022: indicators of core component 1 - PubMed
Spain is currently at a basic level on the structure, organization and management of IPC programmes. Profound differences were found between hospitals depending on size and type.
Rosin as a Natural Alternative for the effective disinfection of ESKAPE Pathogens and Clostridioides difficile spores - PubMed
The findings from this study highlight the potential of Rosin and Rosetax-21 as both bactericidal and sporicidal disinfectants, with their efficacy varying based on the conditions and the pathogens tested. This presents an avenue for the development of novel healthcare disinfection strategies, espec …
Estimating excess mortality and economic burden of Clostridioides difficile infections and recurrences during 2015-2019: The RECUR England study - PubMed
CDI poses a substantial mortality and economic burden, further amplified by rCDIs.
Many Hands, Light Work: A Partnership Approach to Reducing Clostridioides difficile Burden on an Oncology Unit
An increase in hospital-onset Clostridioides difficile (HO-CDI) prompted an interprofessional team to implement enhanced environmental service cleanin…
Many Hands, Light Work: A Partnership Approach to Reducing Clostridioides difficile Burden on an Oncology Unit - PubMed
An increase in hospital-onset Clostridioides difficile (HO-CDI) prompted an interprofessional team to implement enhanced environmental service cleaning practices and adopt a routine cleaning program undertaken by clinical staff. These interventions resulted in a reduction of HO-CDI from 7.27 cases p …
UV Light Kills C. difficile, Saving Dollars and Lives
Considered safe and effective in killing certain types of bacteria, ultraviolet-C light, when used to disinfect hospital rooms, could prevent Clostridium difficile infections and potentially save millions of dollars.
To Your Good Health: How to prevent and protect yourself from C. diff
DEAR DR. ROACH: I have an immunoglobulion A (IgA) deficiency and have had to take many antibiotics over the years. But I have never contracted Clostridioides difficile (C. diff) until
Entry door for deadly C. difficile toxin suggests new mode of protection - Boston Children's Answers A new target for fighting Clostridium difficile
Researchers report a key target in fighting Clostridium difficile -- a receptor called Frizzled, through which C. diff’s most potent toxin gets into cells.
Approaching pathogenic Clostridia from a One Health perspective - PubMed
Spore-forming pathogens have a unique capacity to thrive in diverse environments, and with temporal persistence afforded through their ability to sporulate. These behaviors require a One Health approach to identify critical reservoirs and outbreak-associated transmission chains, given their capacity …
Robust and Transparent Silver Oxide Coating Fabricated at Room Temperature Kills Clostridioides difficile Spores, MRSA, and Pseudomonas aeruginosa - PubMed
Antimicrobial coatings can inhibit the transmission of infectious diseases when they provide a quick kill that is achieved long after the coating application. Here, we describe the fabrication and testing of a glass coating containing Ag2O microparticles that was prepared from sodium sili …