Findings from this study demonstrate the importance of underlying chronic conditions in the development of recurrent C. difficile disease and the shortcomings of current treatment options for recurrent cases. Additionally, our findings indicate that initial treatment selection may impact the likelih …

Among clusters determined by cgMLST analysis, roughly 40% included unexplained HA-CDI acquisitions, which may be explained by unidentified epidemiological links, asymptomatic colonization, and/or shared common community reservoirs. The use of DLST, followed by whole genome sequencing analysis, is a …

Researchers use whole genome sequencing to make surprising discovery about hospital-acquired C. diff infections.

The strains identified in Chongqing, Southwest China, exhibited high genetic diversity. Enhance full awareness of high-risk patients with HA-CDI infection, particularly those with gastrointestinal and hepatocellular diseases, and emphasize caution in the use of tetracycline and capecitabine. These f …

A new study conducted by researchers at The University of Texas MD Anderson Cancer Center suggests that enhanced infection prevention and control (IPC) measures implemented to address the COVID-19 pandemic ...

Urban Norway rats (Rattus norvegicus) can carry various human pathogens, and may be involved in pathogen propagation and transmission to humans. From January 31-August 14, 2021, a community outbreak of Shigella flexneri serotype 2a occurred among unhoused or poorly housed people in the Downtown East …

Clostridioides (Clostridium) difficile is a leading cause of infectious diarrhea in humans and production animals and can be found in a variety of environmental sources. The prevalence and diversity of multi-locus sequence type clade 5 strains of C. difficile in Australian production a …

Infections cause notable treatment-related morbidity during pediatric acute lymphoblastic leukemia/lymphoma (ALL/LLy) therapy. Infections are the most critical cause of morbidity and mortality in children undergoing treatment for acute lymphoblastic leukemia (ALL). Children with ALL, who are frequently underweight, are at increased risk of community-acquired pathogens, nosocomial multidrug-resistant pathogens, and opportunistic microorganisms. A weakened immune system from ALL itself and chemotherapy's side effects further worsen the prognosis. PubMed and Google Scholar articles were curated in a Google document with shared access. Discussion and development of the paper were achieved over Zoom meetings. This narrative review aims to analyze and summarize various pathogens responsible for infections in children receiving treatment for ALL and their treatment regimen and prophylaxis. The incidence of viral infection is higher in ALL patients, followed by bacterial and fungal infections. Prevention via prophylaxis and timely initiation of treatment is essential for positive outcomes.

An infection with Clostridioides difficile (or C. diff in the trade) that occurs 72 hours after admission to the hospital is considered hospital-acquired. Medicare penalizes hospitals financially if

High rates of acquisition of toxigenic Clostridioides difficile colonization without subsequent infection during acute lymphoblastic leukemia treatment in children

Social vulnerability index, race, and poverty were associated with increased rates of CDI, calling attention to population-level health disparities.

Variations in HO-CDI incidence seemed to trend with COVID-19 incidence but were not fully explained by our case mix. Other factors contributing to the variability in HO-CDI incidence beyond listed patient characteristics need to be explored.

Implementing strict IPC measures during the COVID-19 pandemic in a cancer hospital led to a significant decrease in many HAIs and a reduction in nosocomial RVIs.

In this study of patients with CDI receiving CA, a numerically higher proportion were cured with fidaxomicin vs. vancomycin, but this result did not reach statistical significance. Overall recurrence was lower than anticipated in both arms compared to previous studies that did not extend duration of …

Major Japanese clonal strains, ST8 and ST17, have been in the hospital environment for a long time and cause healthcare-associated iC. difficile/i infections. The C. idifficile/i toxin genes were transcribed in the isolates from both patients with and without iC. difficile/i infection bu …

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This list outlines the standardized infection ratio for Clostridium difficile in each U.S. state based on data collected by CDC.

Nature Medicine - Whole-genome sequencing of Clostridioides difficile from a densely sampled intensive care unit (ICU) population showed that many of these patients harbor toxigenic C. difficile....

We evaluated the association between census tract measures of socioeconomic status and Clostridioides difficile infection (CDI) rates in the Denver metro area from 2016 to 2019. Social vulnerability index, poverty, and race were associated with CDI. Findings may relate to differences in chron …

Clostridioides difficile infection is one of the most significant causes of nosocomial diarrhea associated with antibiotic use worldwide. In recent years, the incidence of Clostridioides difficile infection in Latin American countries has increased due to the emergence and spread of epidemic Clostri …

C difficile Cross-Transmission in US ICUs May Be Rare, Study Suggests

A recent study compared different antibiotics and the risk for community-associated CDI. Read IDSA’s Journal Club review by Christopher J. Graber, MD, MPH, FIDSA.

Findings revealed more than 5,000 excess deaths from CDI and 35.6% excess risk compared to the expected number of disease deaths calculated using data from the National Vital Statistics System.

A person’s biology may play more of a role in how Clostridioides difficile, or C. diff, spreads more so than healthcare facility preventive measures, a new study finds. This means that transmission of the bacteria may not be entirely dependent on how well healthcare workers carry out infection control protocol. The study was published Monday in Nature Medicine.

Les patients porteurs asymptomatiques de Clostridioides difficile (anciennement Clostridium difficile) sont-ils des réservoirs cachés d'infections nosocomiales ? S'ils le sont très rarement pour les autres, les porteurs asymptomatiques à l'admission sont 24 fois plus à risque de développer une infection clinique.

We have previously reported on the susceptibility and epidemiology of Clostridioides difficile isolates from six geographically dispersed medical centers in the United States. This current survey was conducted with isolates collected in 2020-2021 from six geographically dispersed medical cent …

Clostridioides difficile (C. difficile) infection is still a threat to many healthcare settings worldwide. Clostridioides difficile epidemiology has changed over the last 20 years, largely due to the emergence of hypervirulent and antimicrobial-resistant C. difficile strains. Th …