C Diff Transmission

Clostridioides difficile (C. difficile or C. diff) is a bacterium that is normally present in the body in small numbers. However, disruption of the body’s

This study shows that companion animals may constitute a source of infection of toxigenic and antimicrobial resistant human associated C. difficile isolates. Additionally, it contributes with important data on the genetic proximity between C. difficile isolates from both sources, addin …

Clostridioides difficile is an anaerobic, Gram-positive bacterium widely present in the hospital environment due to its ability to generate spores. The transfer of spores to patients through the hands of medical personnel is one of the most frequent paths of C. difficile transmission. …

Little is known about zoonotic pathogens and their antimicrobial resistance in South American camelids (SAC) in Germany including Clostridioides (C.) difficile. The aim of this study was to investigate prevalence, molecular characteristics and antimicrobial resistance of C. d …

Clostridioides difficile (C. difficile) is the most common pathogen causing antibiotic-associated intestinal diseases in humans and some animal species, but it can also be present in various environments outside hospitals. Thus, the objective of this study was to investigate the presen …

Clostridioides difficile is an anaerobic, Gram-positive bacterium widely present in the hospital environment due to its ability to generate spores. The transfer of spores to patients through the hands of medical personnel is one of the most frequent paths of C. difficile transmission. …

C. difficile colonization is associated with the development of CDI among ICU patients.

The Difficile Infections Clostridium Difficile Associated Disease Treatment market is predicted to grow at a compound annual growth rate CAGR of 6 from 2023 to 2033 to reach a staggering valuation of US 1 448 75 Million In 2023 the ...

High BMI and recent exposure to certain antibiotic drug classes are significant risk factors for asymptomatic Clostridioides difficile colonization in

No significant change in HO-CDI incidence was observed in patients with sepsis hospitalized in general wards before and after Japan's first state of emergency declaration. Our study revealed that HO-CDI in general wards in Japan had been consistently decreasing since before the COVID-19 pandemic.

Most often, the first place a patient enters a hospital is through the emergency department and sometimes by emergency medical services. Where else to better stop Clostridioides difficile from coming into the hospital than at the entrance?

Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhoea, and is responsible for a spectrum of diseases characterised by high levels of recurrence, morbidity ...

Patients with CF (pwCF) have high antibiotic use and an altered intestinal microbiome, known risk factors for infection with Clostridioides difficile. However, in adults with CF, C. difficile infection (CDI) is uncommon and asymptomatic colonization with C. difficile occurs frequently, for reasons t …

Hospital-acquired superbugs ‘absolutely‘ contribute to a number of patient deaths annually

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Trust us, what happens when you flush a commercial toilet is worse than you thought.

Engineers used laser lights to illuminate particles invisible to the naked eye that spread after a public restroom toilet is flushed.

Clostridioides difficile is an obligate anaerobic pathogen among the most common causes of healthcare-associated infections. It poses a global threat due to the clinical outcomes of infection and resistance to antibiotics recommended by international guidelines for its eradication. In particu …

The presented scoring system can be easily applied by clinicians at the bedside to decide which patients with AAD are likely to have CDI.

Prospective evaluation of data-driven models to predict daily risk of Clostridioides difficile infection at 2 large academic health centers - ERRATUM

Using lasers and cameras, scientists visualized the plume of tiny, aerosolized particles ejected from commercial toilets during flushing

Clostridioides difficile, due to its long survival time in a hospital environment, is considered to be one of the most frequent factors in healthcare-associated infections. Patient care requires not only rapid and accurate diagnosis, but also knowledge of individual risk factors for infection …

In a new experiment using bright green lasers and camera equipment, scientists from Colorado Boulder University were able to visualize airborne particles, invisible to the naked eye, that are shot into the air when a lidless toilet is flushed.

Scientists use AMD technology to combat Healthcare-associated Infections and Antibiotic-resistant Microbes

Background Since 2008, Danish national surveillance of Clostridioides difficile has focused on binary toxin-positive strains in order to monitor epidemic types such as PCR ribotype (RT) 027 and 078. Additional surveillance is needed to provide a more unbiased representation of all strains from the clinical reservoir. Aim Setting up a new sentinel surveillance scheme for an improved understanding of type distribution relative to time, geography and epidemiology, here presenting data from 2016 to 2019. Methods For 2─4 weeks in spring and autumn each year between 2016 and 2019, all 10 Danish Departments of Clinical Microbiology collected faecal samples containing toxigenic C. difficile. Isolates were typed at the national reference laboratory at Statens Serum Institut. The typing method in 2016–17 used tandem-repeat-sequence typing, while the typing method in 2018–19 was whole genome sequencing. Results During the study period, the sentinel surveillance scheme included ca 14–15% of all Danish cases of C. difficile infections. Binary toxin-negative strains accounted for 75% and 16 of the 20 most prevalent types. The most common sequence types (ST) were ST2/13 (RT014/020) (19.5%), ST1 (RT027) (10.8%), ST11 (RT078) (6.7%), ST8 (RT002) (6.6%) and ST6 (RT005/117) (5.1%). The data also highlighted geographical differences, mostly related to ST1 and temporal decline of ST1 (p = 0.0008) and the increase of ST103 (p = 0.002), ST17 (p = 0.004) and ST37 (p = 0.003), the latter three binary toxin-negative. Conclusion Sentinel surveillance allowed nationwide monitoring of geographical differences and temporal changes in C. difficile infections in Denmark, including emerging types, regardless of binary toxin status.

A new visualization of pathogen exposure risk in public bathrooms also provides a methodology to help reduce it.

Scientific Reports - Commercial toilets emit energetic and rapidly spreading aerosol plumes

A new visualization of pathogen exposure risk in public bathrooms also provides a methodology to help reduce it.