C Diff Transmission

Please sign our Petition to Designate C. difficile as a Nationally Notifiable Disease.

A study looked at hospital admissions of Medicare patients and saw a large percentage of recurrent Clostridioides difficile infections (rCDI) as the primary diagnosis.

The burden of Clostridioides difficile infection (CDI) has greatly increased. We evaluated the risks for CDI transmission to community members after hospitalized patients are discharged. We conducted a systematic literature review in MEDLINE/PubMed, EMBASE, CINAHL plus EBSCO, Web of Science, Cochran …

Maja Rupnik from @NLZOH_si shows the importance of #research on #Cdifficile in the food chain and in animals and the understanding of how #Cdiff is transmitted in the community @IMI_JU @efpia @cdiffFoundation pic.twitter.com/BAm56WIB55— COMBACTE (@COMBACTE) June 17, 2021

We report a rare case of CA fulminant pseudomembranous colitis caused by ribotype 027 C. difficile after H. pylori eradication therapy.

Although CDI in pediatric oncology and HSCT patients was associated with chemotherapy delay and hospitalization in approximately a quarter of patients, it was not associated with morbidity or mortality because patients had no attributable intensive care unit admission nor death. H2-antagonists are i …

Clostridioides difficile infection is a leading cause of healthcare-associated infections with significant morbidity and mortality. For the past decade, the bulk of infection prevention and epidemiologic surveillance efforts have been directed toward mitigating hospital-acquired C. diffici …

Despite considerable heterogeneity, evidence suggests substantial incidence of recurrent and primary CDI, even after considerable efforts in the last decade.

Nowadays, pet animals are known to be asymptomatic carriers of Clostridioidesdifficile. This study was conducted to investigate the burden of toxigenic C. difficile among diarrheic dogs and cats using direct PCR on fecal samples to reveal better insights about the epidemiology o …

Disease transmission among wild boars, domestic animals and humans is a public health concern, especially in areas with high wild boar densities. In this study, fecal samples of wild boars (n = 200) from different locations of the Metropolitan Area of Barcelona were analyzed by PCR to explore …

Rom J Intern Med. 2021 May 29. doi: 10.2478/rjim-2021-0020. Online ahead of print.ABSTRACTIntroduction Information on healthcare-associated C.difficile

As the type and amount of data continues to grow, mathematical, statistical, and computational modeling will play an increasing role in healthcare epidemiology. Gaps remain in producing models that are generalizable to a variety of time periods, geographic locations, and populations. However, with e …

Testing for and incidence of infection (CDI) was examined at a single center before and during the first surge of the COVID-19 pandemic. Incidence of CDI remained stable but testing statistically significantly decreased during the first surge despite an increase in antibiotic use. There were no new …

The Importance of an Indoor Air Quality Strategy #cdiff #infectioncontrol https://t.co/hhzaIrg5cw pic.twitter.com/nPUqhp5N8E— Peggy Lillis Fund (@PeggyFund) May 24, 2021

In Spain, the prevalence rate of both HA-CDI and CA-CDI have been increasing. Burden of CDI as well as clinical and epidemiological characteristics of CDI patients will help to support public health decision-making.

Diarrheal disease, a major cause of morbidity and mortality in dairy calves, is strongly associated with the health and composition of the gut microbiome. Clostridioides difficile is an opportunistic pathogen that proliferates and can produce enterotoxins when the host experiences gut dysbiosis. However, even asymptomatic colonization with C. difficile can be associated with differing degrees of microbiome disruption in a range of species, including people, swine, and dogs. Little is known about the interaction between C. difficile and the gut microbiome in dairy calves. In this study, we sought to define microbial features associated with C. difficile colonization in pre-weaned dairy calves less than 2 weeks of age. We characterized the fecal microbiota of 80 calves from 23 different farms using 16S rRNA sequencing and compared the microbiota of C. difficile -positive (n=24) and C. difficile -negative calves (n=56). Farm appeared to be the greatest source of variability in the gut microbiota. When controlling for calf age, diet, and farm location, there was no significant difference in Shannon alpha diversity ( P = 0.50) or in weighted UniFrac beta diversity (P=0.19) between C. difficile -positive and –negative calves. However, there was a significant difference in beta diversity as assessed using Bray-Curtiss diversity ( P =0.0077), and C. difficile -positive calves had significantly increased levels of Ruminococcus (gnavus group) ( Adj. P =0.052) , Lachnoclostridium ( Adj. P =0.060) , Butyricicoccus ( Adj. P =0.060), and Clostridium sensu stricto 2 compared to C. difficile -negative calves. Additionally, C. difficile -positive calves had fewer microbial co-occurrences than C. difficile –negative calves, indicating reduced bacterial synergies. Thus, while C. difficile colonization alone is not associated with dysbiosis and is therefore unlikely to result in an increased likelihood of diarrhea in dairy calves, it may be associated with a more disrupted microbiota. ### Competing Interest Statement The authors have declared no competing interest.

Despite considerable heterogeneity, evidence suggests substantial incidence of recurrent and primary CDI, even after considerable efforts in the last decade.

CDI prevalence among those hospitalized with a COVID-19 infection was not found to be increased despite more use of antibiotics.

Clostridioides difficile is one of the most frequent causes of nosocomial infections in humans leading to (antibiotic-associated) diarrhea and severe pseudomembranous colitis. With an increasing frequency, C. difficile infections (CDI) are also observed independently of hospitalization and the age o …

Understanding the burden of C. difficile across the United States, panelists explore common risk factors associated with the condition and discuss the different ways it can manifest in patients.

Sources of transmission and challenges that impact the management of community-onset C. difficile.  

Empiric broad-spectrum antimicrobial therapy, including coverage of MRSA and Pseudomonas aeruginosa, is generally recommended for healthcare-associated infections.

A memory haunts Christina Fuhrman: the image of her toddler Pearl lying pale and listless in a hospital bed, tethered to an IV to keep her hydrated as she struggled against a superbug infection.

The estimated national burden of Clostridioides difficile infections and related hospitalizations declined between 2011 and 2017 because of a decrease in health care-associated infections, according to findings published in the New England Journal of Medicine. “It is important for the CDC to track the national progress in C. difficile infection (CDI) prevention efforts. Therefore, it is

Epidemiological analyses of mandatory surveillance data on healthcare associated infections (HCAI); MRSA, MSSA and Gram-negative bacteraemia (Escherichia coli (E. coli), Pseudomonas aeruginosa ( P. aeruginoa), Klebsiella species (Klebsiella spp.)), and Clostridioides difficile (C. difficile) infection.