C Diff Treatment

C Diff Treatment

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Impact of Subinhibitory Concentrations of Metronidazole on Morphology, Motility, Biofilm Formation and Colonization of Clostridioides difficile
Impact of Subinhibitory Concentrations of Metronidazole on Morphology, Motility, Biofilm Formation and Colonization of Clostridioides difficile
Clostridioides difficile infection (CDI) is the primary cause of health-care-associated infectious diarrhea. Treatment requires mostly specific antibiotics such as metronidazole (MTZ), vancomycin or fidaxomicin. However, approximately 20% of treated patients experience recurrences. Treatment …
·pubmed.ncbi.nlm.nih.gov·
Impact of Subinhibitory Concentrations of Metronidazole on Morphology, Motility, Biofilm Formation and Colonization of Clostridioides difficile
Dr Preethi Venkat Discusses Impact of Recurrent C difficile Hospitalizations in Patients With IBD
Dr Preethi Venkat Discusses Impact of Recurrent C difficile Hospitalizations in Patients With IBD
Outcomes were worse for patients hospitalized once for Clostridioides difficile infection compared with alternative reasons for hospitalization, but the risk of adverse outcomes did not seem to increase with recurrent admissions for C difficile, explained Preethi Venkat, MD, second-year internal medicine resident at University of California, San Diego, at Digestive Disease Week 2022.
·t.co·
Dr Preethi Venkat Discusses Impact of Recurrent C difficile Hospitalizations in Patients With IBD
Clinical Outcomes of Treated and Untreated C. difficile PCR-Positive/Toxin-Negative Adult Hospitalized Patients: a Quasi-Experimental Noninferiority Study
Clinical Outcomes of Treated and Untreated C. difficile PCR-Positive/Toxin-Negative Adult Hospitalized Patients: a Quasi-Experimental Noninferiority Study
Clostridioides difficile infection (CDI) is routinely diagnosed by PCR, with or without toxin enzyme immunoassay testing. The role of therapy for positive PCR and negative toxin remains unclear. The objective of this study was to determine whether clinical outcomes of PCR+/cycle threshold …
·pubmed.ncbi.nlm.nih.gov·
Clinical Outcomes of Treated and Untreated C. difficile PCR-Positive/Toxin-Negative Adult Hospitalized Patients: a Quasi-Experimental Noninferiority Study
How can patients with Clostridioides difficile infection on concomitant antibiotic treatment be best managed? - The Lancet Infectious Diseases
How can patients with Clostridioides difficile infection on concomitant antibiotic treatment be best managed? - The Lancet Infectious Diseases
Antibiotics are modifiable risk factors for Clostridioides difficile infection (CDI), driving pathogenesis via gut microbiome disruption. The management of patients with CDI prescribed concomitant non-CDI antibiotics is problematic and influences CDI outcome and recurrence risk. Though an assessment of the ongoing requirement for concomitant antibiotics is essential, discontinuation is often not possible. Antibiotics for other reasons might also need to be commenced during CDI therapy. Attempts to minimise the number and duration of antibiotics with a change to a low-risk class are recommended.
·thelancet.com·
How can patients with Clostridioides difficile infection on concomitant antibiotic treatment be best managed? - The Lancet Infectious Diseases
Squad update following conclusion of 2021/22 season - Charlton Athletic
Squad update following conclusion of 2021/22 season - Charlton Athletic
Charlton Athletic can confirm the departure of ten first-team players, following the expiration of their current contracts. The list is as follows: Sophie Hillyerd, Rebecca Jane, Vyan Sampson, Hollie Olding, Jess King, Elisha Sulola, Megan Wynne and Elise Hughes. King has been part of the Addicks’ squad since 2020, while Sulola and Sampson signed for the […]
·cafcwomen.co.uk·
Squad update following conclusion of 2021/22 season - Charlton Athletic
David Ha on Twitter
David Ha on Twitter
“@GareyKgarey at #MADID2022: the elderly and those with history of prior #cdiff 💩 should be prime targets to prevent recurrence 🎯”
·twitter.com·
David Ha on Twitter
David Ha on Twitter
David Ha on Twitter
“@GareyKgarey at #MADID2022: Why is metronidazole so crappy for #Cdiff? Antibiotic resistance! (and a bit of PK/PD)”
·twitter.com·
David Ha on Twitter
David Ha on Twitter
David Ha on Twitter
“@GareyKgarey at #MADID2022: VAN and FDX resistance in #cdiff, way less than metronidazole but don't get too comfy 😬”
·twitter.com·
David Ha on Twitter
Preethi Venkat, MD, MPH on Twitter
Preethi Venkat, MD, MPH on Twitter
“Thanks @DDWMeeting for the opportunity to share our findings on the long-term impact of recurrent #Cdiff hospitalizations in patients with #IBD. Special thanks to my mentor Dr. Sid Singh for his guidance and support!”
·twitter.com·
Preethi Venkat, MD, MPH on Twitter
Role of the Microbiome in Preventing Recurrent C difficile Infection
Role of the Microbiome in Preventing Recurrent C difficile Infection
Colleen R. Kelly, MD, FACG, speaks at MAD-ID 2022 on alternatives to antibiotics for C diff infection, including the use of probiotics and fecal microbiota transplantation.
·contagionlive.com·
Role of the Microbiome in Preventing Recurrent C difficile Infection
Empowered Patient Podcast: Correcting Imbalance in the Gut Microbiome to Treat Clostridium Difficile Infections with Dr. Tom Lendvay Tend
Empowered Patient Podcast: Correcting Imbalance in the Gut Microbiome to Treat Clostridium Difficile Infections with Dr. Tom Lendvay Tend
Dr. Tom Lendvay is the Chief Medical Officer of Tend, which addresses the gut microbiome of the severe intestinal infection Clostridium difficile CDIF. Currently, recurrent Clostridium difficile is the only FDA-regulated disease for the use of microbiome transplants outside of a clinical trial. Clinical trials are also underway applying microbiome transplants to intestinal diseases such as inflammatory bowel diseases, irritable bowel syndrome, and even other diseases outside of the gut. Tom explains, "Tend is focused on two types of offerings. One is a device called the CAP device, a collection processing device that allows a clinician or a researcher to collect a sample and process it, mix it, filter it and encapsulate it into orally ingestible capsules that can be stored in a freezer." "The other side is the data side, which is understanding. So, doing microbiome analyses on the donors, on the recipient ill patients and seeing how their microbiome changes over time and learning who's the best donor for the best recipient. Those two offerings do not exist today, and right now, the process for a clinician, for a researcher to provide microbiome transplants to their patients is extremely onerous and laborious." @Tend_Health #FMT #CDIF #Microbiome #GutMicrobiome #MedicalDevice #Healthcare #Patient
·t.co·
Empowered Patient Podcast: Correcting Imbalance in the Gut Microbiome to Treat Clostridium Difficile Infections with Dr. Tom Lendvay Tend
American Gastroenterological Association (AGA) on Twitter
American Gastroenterological Association (AGA) on Twitter
“The registry will also expand to: 💊🦠Dive deeper into effectiveness of FMT and live biotherapeutic products (LBPs) to treat severe & fulminant #Cdiff 🤝Partner with Gail Hecht & @KnightLabNews to detect and characterize microbes that could be transmitted by FMT or LBPs”
·twitter.com·
American Gastroenterological Association (AGA) on Twitter
Real-World Comparison of Bezlotoxumab to Standard of Care Therapy for Prevention of Recurrent Clostridioides difficile Infection in Patients at High Risk for Recurrence | Clinical Infectious Diseases | Oxford Academic
Real-World Comparison of Bezlotoxumab to Standard of Care Therapy for Prevention of Recurrent Clostridioides difficile Infection in Patients at High Risk for Recurrence | Clinical Infectious Diseases | Oxford Academic
Bezlotoxumab was significantly associated with reduced odds of recurrent Clostridioides difficile infection and all-cause readmission at 90 days on both unadjus
·academic.oup.com·
Real-World Comparison of Bezlotoxumab to Standard of Care Therapy for Prevention of Recurrent Clostridioides difficile Infection in Patients at High Risk for Recurrence | Clinical Infectious Diseases | Oxford Academic
Alice Han on Twitter
Alice Han on Twitter
“I have used Bezlotoxumab with fairly good success in my refractory recurrent c diff patients- especially my immunocompromised transplant recipient patients and patients with underlying malignancies. #cdiff #MedTwitter”
·twitter.com·
Alice Han on Twitter
Philip HOWARD OBE - NHS NE&Yorks AMR on Twitter
Philip HOWARD OBE - NHS NE&Yorks AMR on Twitter
“#nhs standard contract for #cdiff is now cases not rates. See @HealthFdn QI made simple. Lots of tools. https://t.co/0yrkdk8xH5”
·twitter.com·
Philip HOWARD OBE - NHS NE&Yorks AMR on Twitter
kerrie Davies on Twitter
kerrie Davies on Twitter
“RT @AntibioticLeeds: #cdiff treatments history”
·twitter.com·
kerrie Davies on Twitter
Mortality, healthcare resource utilization, and cost among Medicare beneficiaries with Clostridioides difficile infection with and without sepsis
Mortality, healthcare resource utilization, and cost among Medicare beneficiaries with Clostridioides difficile infection with and without sepsis
Sepsis was common among Medicare beneficiaries with CDI. CDI patients with sepsis, especially after an rCDI, experienced higher mortality, HRU, and costs compared with those without sepsis.
·pubmed.ncbi.nlm.nih.gov·
Mortality, healthcare resource utilization, and cost among Medicare beneficiaries with Clostridioides difficile infection with and without sepsis