C Diff Treatment

Bezlotoxumab was well tolerated and the incidence of recurrent CDI in a high-risk population for recurrence was only 21.4%.

If CDI laboratory testing is indicated in children with diarrhoea, the likelihood of C. difficile colonisation and co-infection with other intestinal pathogens should be considered. The currently available data support a change in the treatment strategy of CDI in children.

The immunological response against Clostridioides difficile (C. difficile) is crucial for an improved understanding of disease mechanisms and the development of novel therapeutic strategies. From April 2014 to February 2015, adult patients with C. difficile infection (CDI) were recruit …

The Clostridium Difficile Infections market report provides an edge while developing business strategies, by understanding trends shaping and driving the global Clostridium Difficile Infections market. A detailed review of the historical and forecasted Clostridium Difficile Infections market is included in the report, covering drug outreach in the 7MM.   Clostridium Difficile Infections Overview Clostridium difficile […]

Infectious and inflammatory disorders of the gastrointestinal system are life-threatening and occur frequently in hospitalized adults. Inflammatory and inflammation-related diseases of the gastrointestinal tract seen in the acutely and critically ill have numerous causes. In acute pancreatitis and t …

The product is designed to eliminate some of the drawbacks of fecal microbiota transplantation.

Clostridioides difficile infection (CDI) is a complex disease that by virtue of both its initial virulence and proclivity toward recurrent episodes causes a high morbidity, mortality, and financial burden. This burden is felt by patients and their families as well as the U.S. healthcare syste …

Novel C. difficile infection (CDI) vaccine shows promise lowering the severity of CDI and in preventing medically attended CDI.

The classification of disease severity according to the MN criteria would be particularly useful in predicting the patients' prognoses.

A new report based on samples from Texas and Kenya found significant proportions of samples from patients with CDI had nonsusceptible isolates.

OVP appears to be an efficacious option for prevention of CDI in high-risk subjects undergoing SAT. Nevertheless, additional data from RCTs are needed to establish OVP as good clinical practice and define optimal dosage and duration.

The Practice Guidelines Committee of the American Society for Transplantation and Cellular Therapy (ASTCT) partnered with its Transplant Infectious Disease Special Interest Group (TID-SIG) to update its 2009 compendium-style infectious disease guidelines for hematopoietic cell transplantation (HCT). …

The detection of a marked increase in unrecognized strains of C difficile suggests a 'pressing need' to understand mechanisms.

Risk factors for developing C. difficile-associated disease & the impact of the COVID-19 pandemic on the occurrence of C. difficile infection

There is no benefit of using vancomycin compared to metronidazole concerning recurrence rate requiring hospitalization, in-hospital and up to 4- and 8-week mortality rate in non-severe first episode of CDI.

Observational cohort.

Due to diverse roles of ClpP and the reliance of pathogens upon this system for infection, it has emerged as a target for antimicrobial development. Biology regulated by ClpP is organism dependent and has not been defined in Clostridioides difficile.

Fulminant Clostridioides difficile infection (FCDI) encompasses 3 to 5% of all CDI cases with associated mortality rates between 30 and 40%. Major treatment modalities include surgery and medical management with antibiotic and nonantibiotic therapies. However, identification of patients with …

I am a C. diff survivor. In June 2021 I went to the ER for a kidney stone. I passed it at the ER fairly quickly ( it was a small one). They tested my urine and did blood work, and said I didn’t have an infection but put me …

With a diagnosis of a C. difficile infection, dehydration can occur quickly.

Clostridium (Clostridioides) difficile infection (CDI) remains an urgent threat to patients in health systems worldwide. Recurrent CDI occurs in up to 30% of cases due to sustained dysbiosis of the gut microbiota which normally protects against CDI. Associated costs of initial and recurrent episodes …

Our results suggest that non-adherence with CDI treatment guidelines depends on the duration of symptoms and rapid EIA test results. Patients with an increased risk of recurrence were neglected.

Bezlotoxumab was associated with a meaningful reduction in recurrent CDI in this cohort largely comprising immunocompromised and transplant patients. Larger studies are warranted to evaluate bezlotoxumab in this population.

In February 2020 I was prescribed both clindamycin and cefalexin for a breast abscess. Three weeks after I finished my course of antibiotics, in March 2020, I started to have severe, painful abdominal cramping and diarrhea.  Each day became worse and worse until I was up through the night and …