C Diff Treatment

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Clostridioides difficile infection (CDI) is the leading cause of health care–associated infections in the United States. The increasing incidence and recurrence rates of CDI together with its associated morbidity and mortality are great concerns. Newer treatment methods, such as narrow-spectrum antibiotics, monoclonal antibodies, and microbial replacement therapies, are being developed and implemented. We searched PubMed to identify published literature from 2010 to 2018 using the following keywords: Clostridium difficile, treatment, and therapy.

The Peggy Lillis Foundation for C. diff Education & Advocacy held our 7th Annual National C. diff Advocacy Summit both in person and virtually on May 2.  This year’s Summit had a variety of passionate speakers and panelists committed to C. diff education, antimicrobial stewardship, and patient advocacy. The Summit …

There has been a rise in antibiotic resistance in secondary conditions such as Clostridium difficile (C. difficile) due to overuse of antibiotics. Oral antibiotics are used to treat C. difficile, which further disrupts the intestinal flora resulting in unwanted side effects. Naturopathic treatments often have fewer side effects and lower secondary infection risk than pharmaceutical interventions making them ideal for pediatric use. This case report describes the effective treatment of a pediatric clinical case of C. difficile using naturopathic and complementary alternative medicines (CAMs) including black seed oil (Nigella sativa), bentonite clay, and probiotics. A healthy two-year-old patient presented to a pediatrician with symptoms of, and subsequently confirmed, C. difficile after having been recently hospitalized and treated for a gluteal abscess and cellulitis using clindamycin, vancomycin, and piperacillin/tazobactam. Through a shared decision-making process, the patient’s mother and providers developed a treatment plan for the C. difficile infection (CDI), which included black seed oil, bentonite clay, and Lactobacillus probiotics. No C. difficile was detected via stool immunoassay after 4 days of combined CAM therapy. Our results underscore the need for additional research regarding the effectiveness of naturopathic CAMs including black seed oil, bentonite clay, and probiotics as alternatives to antibiotic treatment of CDI in children.

The greatest risk factors for recurrent Clostridioides difficile infection (CDI) were age of at least 65 years, severe primary CDI, and use of non-CDI antibiotics. Patients with these risk factors should be prioritized for bezlotoxumab therapy.

Objective The severity of Clostridioides difficile infection (CDI) is an important prognostic factor. The "MN criteria," proposed in Japan in 2017, attempted to remedy the shortfalls in the reported guidelines proposed globally to determine CDI severity. We therefore assessed the accuracy of the MN …

Reducing the burden of CDI on patients and the health care system should be a priority. Patients with appropriate indications who are at heightened risk of CDI may be suitable candidates for omadacycline therapy. In these patients, omadacycline may be preferable to antibiotics with a high CDI risk.

Clostridioides difficile is a common cause of nosocomial infection. Antibiotic-induced dysbiosis in the intestinal microbiota is a core cause of C. difficile infection (CDI). Akkermansia muciniphila plays an active role in maintaining gastrointestinal balance and might offer the …

Fidaxomicin had a 13.5% higher rate of 4-week sustained response compared to vancomycin and 13.2% higher rate for 8-week sustained response.

There are several companies preparing new treatments for recurrent C difficile infections.

There are several potential treatments on the horizon for C difficile infections.

Citing outbreaks of Clostridioides difficile infection in both America and Europe, the researchers emphasized the need for more effective treatments.

Clostridioides difficile infection (CDI) is the primary cause of health-care-associated infectious diarrhea. Treatment requires mostly specific antibiotics such as metronidazole (MTZ), vancomycin or fidaxomicin. However, approximately 20% of treated patients experience recurrences. Treatment …

Outcomes were worse for patients hospitalized once for Clostridioides difficile infection compared with alternative reasons for hospitalization, but the risk of adverse outcomes did not seem to increase with recurrent admissions for C difficile, explained Preethi Venkat, MD, second-year internal medicine resident at University of California, San Diego, at Digestive Disease Week 2022.

Japanese Clinical Practice Guidelines for Management of Clostridioides (Clostridium) difficile infection

With limitations on fidaxomicin at their facility, a hospital looked at vancomycin usage to determine if they needed to align with the new IDSA/SHEA CDI treatment guideline.

Clostridioides difficile infection (CDI) is routinely diagnosed by PCR, with or without toxin enzyme immunoassay testing. The role of therapy for positive PCR and negative toxin remains unclear. The objective of this study was to determine whether clinical outcomes of PCR+/cycle threshold …

Antibiotics are modifiable risk factors for Clostridioides difficile infection (CDI), driving pathogenesis via gut microbiome disruption. The management of patients with CDI prescribed concomitant non-CDI antibiotics is problematic and influences CDI outcome and recurrence risk. Though an assessment of the ongoing requirement for concomitant antibiotics is essential, discontinuation is often not possible. Antibiotics for other reasons might also need to be commenced during CDI therapy. Attempts to minimise the number and duration of antibiotics with a change to a low-risk class are recommended.

Treating the disease could reduce the risk of patient distress.

Researchers compared the agents for treating both initial and recurrent Clostridioides difficile infections in a Medicare population.

Charlton Athletic can confirm the departure of ten first-team players, following the expiration of their current contracts. The list is as follows: Sophie Hillyerd, Rebecca Jane, Vyan Sampson, Hollie Olding, Jess King, Elisha Sulola, Megan Wynne and Elise Hughes. King has been part of the Addicks’ squad since 2020, while Sulola and Sampson signed for the […]

The detection of a marked increase in unrecognized strains of C difficile suggests a 'pressing need' to understand mechanisms.

BMI did not have an association with increased risk for death in any BMI category, according to study investigators.

“@GareyKgarey at #MADID2022: the elderly and those with history of prior #cdiff 💩 should be prime targets to prevent recurrence 🎯”

“@GareyKgarey at #MADID2022: Why is metronidazole so crappy for #Cdiff? Antibiotic resistance! (and a bit of PK/PD)”

“@GareyKgarey at #MADID2022: VAN and FDX resistance in #cdiff, way less than metronidazole but don't get too comfy 😬”

A team of investigators studied Clostridioides difficile infection (CDI) isolates to gauge resistance in the 2 antibiotics.

“Thanks @DDWMeeting for the opportunity to share our findings on the long-term impact of recurrent #Cdiff hospitalizations in patients with #IBD. Special thanks to my mentor Dr. Sid Singh for his guidance and support!”

Colleen R. Kelly, MD, FACG, speaks at MAD-ID 2022 on alternatives to antibiotics for C diff infection, including the use of probiotics and fecal microbiota transplantation.