FDA Approves Adalimumab for Pediatric Ulcerative Colitis
The approval is based on results from the ENVISION I Phase 3 study, which showed biologic use linked to clinical remission and maintenance in patients.
Oral vancomycin for clostridioides difficile prophylaxis in allogenic hematopoietic cell transplant
Oral vancomycin was associated with reduced CDI incidence in patients that underwent an alloHCT without negatively affecting post-transplant outcomes. The contribution of confounders cannot be excluded. This article is protected by copyright. All rights reserved.
Myxopyronin B inhibits growth of a Fidaxomicin-resistant Clostridioides difficile isolate and interferes with toxin synthesis
The anaerobic, gastrointestinal pathogen Clostridioides difficile can cause severe forms of enterocolitis which is mainly mediated by the toxins it produces. The RNA polymerase inhibitor Fidaxomicin is the current gold standard for the therapy of C. difficile infections due to several beneficial fea …
The role of the microbiota in the management of intensive care patients
The composition of the gut microbiota is highly dynamic and changes according to various conditions. The gut microbiota mainly includes difficult-to-cultivate anaerobic bacteria, hence knowledge about its composition has significantly arisen from culture-independent methods based on next-generation …
Successful fidaxomicin hospital discharges of adult patients with Clostridioides difficile infections post 2021 guidelines - are economic barriers finally coming down?
We reviewed C.difficile positive patients discharged on fidaxomicin after local adoption of 2021C.difficile infection (CDI) guidelines. From June 14 - Oct 3, 2021, 80% (12/15) had copayments $0-$35, and 27% (4/15) required prior authorization. The 30-day CDI recurrence was 7%.
What’s the “Diff” with C. Diff? A Management Update - CriticalCareNow
Reading Time: 4 minutes The Pre-brief Clostridioides difficile is a gram-positive anaerobic bacillus that produces spores as well as exotoxins, toxin A and toxin B.…
The results are likely specific to areas without hypervirulent strains of Clostridioides difficile, such as #Australia. #cdiffhttps://t.co/UYlw3BfV3j— Contagion (@Contagion_Live) December 6, 2021
Also known as C. diff for short, Clostridium difficile is an extremely difficult intestinal disease to manage…but not an impossible one. Joining Dr. Neil Nandi to share her insights on how to best mange C. diff in IBD patients is Dr. Jessica Allegretti, the Associate Director of the Crohn's and Colitis Center and the Director of the Fecal Microbiota Transplant Program at the Brigham and Women's Hospital in Boston, Massachusetts.
The #Cdiff Checklist https://t.co/7y8MpqR3qK help when talking with the doctor about symptoms. If talking about diarrhea feels awkward or embarrassing, this simple tool can help start the dialogue. Stay connected with us here, or visit our website for #Cd
Incidence and Outcomes Associated With Clostridioides difficile Infection in Solid Organ Transplant Recipients
In this study, increasing CDI trends in annual cohorts of SOT recipients were observed. Posttransplant CDI was associated with mortality, and late-onset CDI was associated with a greater risk of death than early-onset CDI. These findings suggest that preventive strategies should not be limited to th …
Efficacy, Safety of Current Treatments for C. Diff Infection, Recurrent C. Diff Infection - Pharmacy Times
Teena Chopra, MD, MPH, professor of infectious diseases at Wayne State University, discusses the current treatment strategies for C. diff infection and recurrent C. diff infection, as well as the efficacy and safety of these treatments.
Medicare plans limit access to treatments for C. difficile infection - Healio
Medicare beneficiaries have limited access to recommended treatments for Clostridioides difficile infection, researchers reported in Clinical Infectious Diseases. In June, the Infectious Diseases Society of America and Society for Healthcare Epidemiology of America published updated guidelines for managing C. difficile infection (CDI), which included a recommendation to use fidaxomicin over oral
VIDEO: Physicians should not 'undertreat' IBD patients with C. difficile infection - Healio
In this Healio Gastroenterology video exclusive, Jessica R. Allegretti, MD, MPH, director of the fecal microbiota center at Brigham and Women’s Hospital, discussed treatment options for recurrence for Clostridioides difficile infection. Allegretti moderated the symposium at Advances in Inflammatory Bowel Diseases 2021.