Fighting C Difficile Infection during the COVID-19 Pandemic
Dr. Nicola Petrosillo discusses treating C difficile infection and maintaining antimicrobial stewardship during the height of the COVID-19 pandemic in Italy.
Investigational Therapies, Modalities May Change Recurrent C Difficile Treatment Trajectory
During the C Diff Foundation's Annual conference, providers and stakeholders offered insights on the latest investigational therapies and modalities as they advance through clinical trials.
VIDEO: Preventing and treating C. diff icile infection
WASHINGTON; In this video, infectious disease pharmacist Kerry LaPlante, PharmD, FCCP, FIDSA, discusses a presentation she gave at the World Anti-Microbial Resistance Congress on Clostridioides difficile infection. LaPlante, who is department chair and a professor of pharmacy at the University of Rhode Island College of Pharmacy, talked about the importance of infection control and being a
Effective definition of low humoral response to Clostridioides difficile infection
Antibodies IgG CD anti-toxin B detection at a dilution of 1:400, using a B ELISA technique, effectively identified patients at increased risk of recurrence. This information could help assist in the management of patients.
Management and characteristics of patients suffering from Clostridiodes difficile infection in primary care
GPs provide relevant ambulatory care for mild primary episodes of CDI using oral metronidazole. Persistent diarrhoea despite an appropriate anti-Clostridiodes regimen should be interpreted as an early predictor of relapse.
Is There Still Value in Prescribing Metronidazole for C Difficile Treatment? - Contagionlive.com
Although no longer indicated as a first-line therapy, metronidazole still has therapeutic benefits and can serve patients in certain settings and circumstances.
An End In Sight for C Difficile? - Contagionlive.com
At the C Diff Foundation Conference, promising investigational modalities and therapies, as well as better treatment approaches are all being discussed in hopes of some real inroads being made in this field in the near future.
Microbiome Therapeutic Demonstrates Reduction of C. Difficile Recurrence - Pharmacy Times
SER-109, an investigational, oral, biologically-sourced microbiome therapeutic designed to reduce recurrence of C. difficile infection (CDI), demonstrated a 31.1% absolute reduction in the rate of CDI recurrence over 12 weeks compared to placebo
Following up on my talk yesterday at #ACG2021, correction to where @AmCollegeGastro recommends metronidazole for low risk patients with #Cdiff. I made an #error confusing @AmCollegeGastro and @IDSAInfo guidelines. @DrPaulGastro @DrStollman @ckellymd @DrJessicaA pic.twitter.com/Ls3R1PGW7U— Sahil Khanna, MBBS, MS, FACG (@Khanna_S) October 28, 2021
European Society of Clinical Microbiology and Infectious Diseases: 2021 update on the treatment guidance document for Clostridioides difficile infection in adults
Important changes compared with previous guideline include but are not limited to: (1) metronidazole is no longer recommended for treatment of CDI when fidaxomicin or vancomycin are available, (2) fidaxomicin is the preferred agent for treatment of initial CDI and the first recurrence of CDI when av …
Potential Cost Savings Associated with Targeted Substitution of Current Guideline-Concordant Inpatient Agents with Omadacycline for the Treatment of Adult Hospitalized Patients with Community-Acquired Bacterial Pneumonia at High Risk for Clostridioides difficile Infections: Results of Healthcare-Decision Analytic Model from the United States Hospital Perspective
The findings of this simulated model suggest that prioritizing the use of omadacycline over current CABP treatments in hospitalized CABP with a DRS ≥ 6 may potentially reduce attributable HCA-CDI costs. The findings are not unique to omadacycline and could be applied to any antibiotic that confers a …
Systematic Review and meta-analysis: efficacy of vancomycin taper and pulse regimens in clostridioides difficile infection
Limitations of our analysis are a small number of included studies and heterogeneity. Vancomycin taper-and-pulse seems superior to pulse alone or taper alone for recurrent CDI. A randomized controlled trial comparing vancomycin taper-and-pulse to fidaxomicin and microbiome restoration is needed.
What's the Difference Between ID and Gastro C. difficile Recommendations?
Clinicians have two updated sets of recommendations for managing patients with Clostridioides difficile infection (CDI), and there are some notable differences to consider.
Real-World Comparison of Bezlotoxumab to Standard of Care Therapy for Prevention of Recurrent Clostridioides difficile Infection in Patients at High Risk for Recurrence
BEZ is effective for the prevention of rCDI and reduction in all-cause hospital readmission for patients at high risk for recurrence, supporting current guideline recommendations.