C Diff Treatment

In clinical guidelines issued by the American College of Gastroenterology and published online May 19 in the American Journal of Gastroenterology, recommendations are presented for the management of Clostridioides ...

Clostridioides difficile is a leading health threat. This pathogen initiates intestinal infections during gut microbiota dysbiosis caused by oral administration of antibiotics. C. difficile is difficult to eradicate due to its ability to form spores, which are not susceptible to antibi …

Dr David Johnson highlights the practice-changing implications of expert recommendations on diagnosing and managing these common infections.

Metronidazole resistance in clinical Clostridioides difficile is often described as unstable, since resistant strains reportedly appear susceptible following freezer storage or brief passage. This has presented a conundrum for adopting susceptibility testing to accurately evaluate the connect …

A woman with ulcerative colitis shares her best travel tips.

Hematopoietic stem cell transplant is generally associated with increased C difficile infection risk.

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IntroductionThe contribution of healthcare-associated infections (HAI) to mortality can be estimated using statistical methods, but mortality review (MR) is better suited for routine use in clinical settings. The European Centre for Disease Prevention and Control recently introduced MR into its HAI …

Patients included in the study had a median of 3 prior CDI episodes and 4 risk factors for recurrent infections.

Articles, guidelines, presentations, webcasts and directives from our scientists and partners in the field of clinical microbiology and infectious diseases.

Study finds Clostridioides difficile infection to be associated with increased length of hospital stay and delay in scheduled chemotherapy in pediatric patients with cancer.

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Patients with cancer-related diarrhea appeared 40% more likely than those without the condition to discontinue index therapy, according to retrospective study results presented during the virtual ASCO Annual Meeting.Cancer-related diarrhea also prompted earlier switches to alternate regimens and additional health care utilization, results showed.

Incidence of Clostridioides difficile infection (CDI) has been increasing in recent decades due to different factors, namely (i) extended use of broad-spectrum antibiotics, (ii) transmission within asymptomatic and susceptible patients, and (iii) unbalanced gastrointestinal microbiome and col …

Diarrhea is a common problem in nursing homes. A survey among nursing facilities in Poland was used to characterize diarrhea outbreaks, the burden caused for residents and caregivers and the employed measures. Survey results confirmed that diarrhea is a common problem in nursing homes and in most ca …

An assessment of the frontline agents show similarities infection cure and recurrence rates at 30 days.

The bowel resting strategy might reduce switching from metronidazole to vancomycin among patients with Clostridioides difficile infection, but it might not reduce mortality or recurrence, a new study found.

Clostridium difficile infection (CDI) is inflammation of the colon caused by a bacteria called clostridium difficile and is the most common cause of infectious diarrhea in hospitalized patients.

In this study, we report the results of the epidemiological analysis of Clostridioides difficile ribotypes (RTs) and antimicrobial susceptibility testing. Most isolates were RT027, representing 73% (84/115) of isolates. No isolates with reduced susceptibility to fidaxomicin were found; howeve …

Hospitalization for inflammatory bowel disease is common and requires coordination of care. The goals of hospitalization are to markedly improve symptoms, transition management to an outpatient regimen, and prevent complications. Initially, providers should determine the phenotype and severity of di …

The present experiments determined the effects of the narrow-spectrum antibiotic vancomycin on inflammatory pain-stimulated and pain-depressed behaviors in rats. Persistent inflammatory pain was modeled using dilute formalin (0.5%). Two weeks of oral vancomycin administered in drinking water attenua …

Antibiotic-associated diarrhea and Clostridioides difficile infection (CDI) occur frequently among adults. The pathophysiology of CDI is related to disruption of normal gut flora and risk factors include hospitalization, use of antibiotic therapy, and older age. Clinical manifestations can range fro …

C difficile and sepsis infections can be especially difficult to treat.

Fidaxomicin, and to a lesser extent vancomycin, reduces C. difficile shedding and contamination of the hospital environment relative to metronidazole. Treatment choice may play a role in reducing healthcare-associated C. difficile transmission.