C Difficile

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Has C. difficile Met Its Match?
Has C. difficile Met Its Match?
Living organisms rely on iron for survival and replication. Can new research discoveries disrupt C. difficile’s ability to maintain iron homeostasis?
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Has C. difficile Met Its Match?
Comparative evaluation of the detection rate, workflow and associated costs of a multiplex PCR panel versus conventional methods in diagnosis of infectious gastroenteritis - PubMed
Comparative evaluation of the detection rate, workflow and associated costs of a multiplex PCR panel versus conventional methods in diagnosis of infectious gastroenteritis - PubMed
Introduction. Infectious gastroenteritis is a common reason for consulting a physician. Although most cases of gastrointestinal illness are self-limiting, the identification of the etiologic pathogen by stool specimen analysis is important in cases of more severe illness and for epidemiologic …
·pubmed.ncbi.nlm.nih.gov·
Comparative evaluation of the detection rate, workflow and associated costs of a multiplex PCR panel versus conventional methods in diagnosis of infectious gastroenteritis - PubMed
Identification of Clostridioides difficile mutants with increased daptomycin resistance - PubMed
Identification of Clostridioides difficile mutants with increased daptomycin resistance - PubMed
Daptomycin is a cyclic lipopeptide antibiotic used to treat infections caused by some Gram-positive bacteria. Daptomycin disrupts synthesis of the peptidoglycan (PG) cell wall by inserting into the cytoplasmic membrane and binding multiple forms of the undecaprenyl carrier lipid required for PG synt …
·pubmed.ncbi.nlm.nih.gov·
Identification of Clostridioides difficile mutants with increased daptomycin resistance - PubMed
Assessment of Knowledge and Practice of Healthcare Providers in Saudi Arabia Regarding Clostridioides difficile Infection Diagnosis and Management: A Cross-Sectional Questionnaire-Based Study - PubMed
Assessment of Knowledge and Practice of Healthcare Providers in Saudi Arabia Regarding Clostridioides difficile Infection Diagnosis and Management: A Cross-Sectional Questionnaire-Based Study - PubMed
The study revealed a significant knowledge gap among Saudi healthcare providers regarding CDI diagnosis, management, and severity classification, highlighting the need for improved education and adherence to guidelines to improve patient outcomes and reduce recurrence risks.
·pubmed.ncbi.nlm.nih.gov·
Assessment of Knowledge and Practice of Healthcare Providers in Saudi Arabia Regarding Clostridioides difficile Infection Diagnosis and Management: A Cross-Sectional Questionnaire-Based Study - PubMed
Microbiota-Based Live Biotherapeutic Products for Clostridioides Difficile Infection- The Devil is in the Details - PubMed
Microbiota-Based Live Biotherapeutic Products for Clostridioides Difficile Infection- The Devil is in the Details - PubMed
Clostridioides difficile infection (CDI) remains a significant contributor to healthcare costs and morbidity due to high rates of recurrence. Currently, available antibiotic treatment strategies further disrupt the fecal microbiome and do not address the alterations in commensal flora (dysbio …
·pubmed.ncbi.nlm.nih.gov·
Microbiota-Based Live Biotherapeutic Products for Clostridioides Difficile Infection- The Devil is in the Details - PubMed
Reduced Vancomycin Susceptibility in Clostridioides difficile is Associated with Lower Rates of Initial Cure and Sustained Clinical Response - PubMed
Reduced Vancomycin Susceptibility in Clostridioides difficile is Associated with Lower Rates of Initial Cure and Sustained Clinical Response - PubMed
Reduced vancomycin susceptibility in C. difficile was associated with decreased odds of 30-day SCR and lower 14-day initial cure rates in the studied patient cohort.
·pubmed.ncbi.nlm.nih.gov·
Reduced Vancomycin Susceptibility in Clostridioides difficile is Associated with Lower Rates of Initial Cure and Sustained Clinical Response - PubMed
Current Trends and Challenges of Microbiome Research in Bladder Cancer - PubMed
Current Trends and Challenges of Microbiome Research in Bladder Cancer - PubMed
Recent findings underscore the complexities involved in microbiome research, particularly in the context of bladder cancer. Challenges include low microbial biomass in urine samples, potential contamination issues during collection and processing, variability in sequencing methods and primer selecti …
·pubmed.ncbi.nlm.nih.gov·
Current Trends and Challenges of Microbiome Research in Bladder Cancer - PubMed
Identification of Clostridioides difficile mutants with increased daptomycin resistance - PubMed
Identification of Clostridioides difficile mutants with increased daptomycin resistance - PubMed
Daptomycin is a cyclic lipopeptide antibiotic used to treat infections caused by some Gram-positive bacteria. Daptomycin disrupts synthesis of the peptidoglycan (PG) cell wall by inserting into the cytoplasmic membrane and binding multiple forms of the undecaprenyl carrier lipid required for PG synt …
·pubmed.ncbi.nlm.nih.gov·
Identification of Clostridioides difficile mutants with increased daptomycin resistance - PubMed
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection - PubMed
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection - PubMed
Clostridioides difficile is the leading cause of antibiotic-associated infectious diarrhea. The development of C.difficile infection is tied to perturbations of the bacterial community in the gastrointestinal tract, called the gastrointestinal microbiota. Repairing the gastrointestinal microbiota by …
·pubmed.ncbi.nlm.nih.gov·
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection - PubMed
Gastrointestinal PCR panel results and antibiotic use in acute gastroenteritis cases: How appropriate are we in our usage? - PubMed
Gastrointestinal PCR panel results and antibiotic use in acute gastroenteritis cases: How appropriate are we in our usage? - PubMed
The utilization of GI PCR panels in AGE patients has revolutionized the field of diagnostics by providing rapid and accurate identification of pathogens. In units without the possibility of GI PCR testing, CRP, procalcitonin, CRP/albumin ratio and procalcitonin/albumin ratio may be useful in the dec …
·pubmed.ncbi.nlm.nih.gov·
Gastrointestinal PCR panel results and antibiotic use in acute gastroenteritis cases: How appropriate are we in our usage? - PubMed
Single-Centre Retrospective Audit of Clostridium difficile Infections Post Ileostomy Reversal - PubMed
Single-Centre Retrospective Audit of Clostridium difficile Infections Post Ileostomy Reversal - PubMed
Background Clostridium difficile (C. difficile) infection can have serious implications on patient outcomes, especially post ileostomy reversal. The symptoms can range from asymptomatic/mild to severe, with significant morbidity or mortality. Thus far, no study has been published to determine …
·pubmed.ncbi.nlm.nih.gov·
Single-Centre Retrospective Audit of Clostridium difficile Infections Post Ileostomy Reversal - PubMed
Characterizing the flavodoxin landscape in Clostridioides difficile - PubMed
Characterizing the flavodoxin landscape in Clostridioides difficile - PubMed
Clostridioides difficile infections have become a major challenge in medical facilities. The bacterium is capable of spore formation allowing the survival of antibiotic treatment. Therefore, research on the physiology of C. difficile is important for the development of alternative trea …
·pubmed.ncbi.nlm.nih.gov·
Characterizing the flavodoxin landscape in Clostridioides difficile - PubMed
Rapid discrimination between clinical Clostridioides difficile infection and colonization by quantitative detection of TcdB toxin using a real-time cell analysis system - PubMed
Rapid discrimination between clinical Clostridioides difficile infection and colonization by quantitative detection of TcdB toxin using a real-time cell analysis system - PubMed
This study explored the novel application of the RTCA assay in effectively discerning clinical CDI from CDC cases.
·pubmed.ncbi.nlm.nih.gov·
Rapid discrimination between clinical Clostridioides difficile infection and colonization by quantitative detection of TcdB toxin using a real-time cell analysis system - PubMed
A rationally designed antimicrobial peptide from structural and functional insights of Clostridioides difficile translation initiation factor 1 - PubMed
A rationally designed antimicrobial peptide from structural and functional insights of Clostridioides difficile translation initiation factor 1 - PubMed
A significant increase of hospital-acquired bacterial infections during the COVID-19 pandemic has become an urgent medical problem. Clostridioides difficile is an urgent antibiotic-resistant bacterial pathogen and a leading causative agent of nosocomial infections. The increasing recurrence o …
·pubmed.ncbi.nlm.nih.gov·
A rationally designed antimicrobial peptide from structural and functional insights of Clostridioides difficile translation initiation factor 1 - PubMed
Genomic surveillance of Clostridioides difficile transmission and virulence in a healthcare setting - PubMed
Genomic surveillance of Clostridioides difficile transmission and virulence in a healthcare setting - PubMed
Clostridioides difficile infection (CDI) is a major cause of healthcare-associated diarrhea, despite the widespread implementation of contact precautions for patients with CDI. Here, we investigate strain contamination in a hospital setting and the genomic determinants of disease outcomes. Ac …
·pubmed.ncbi.nlm.nih.gov·
Genomic surveillance of Clostridioides difficile transmission and virulence in a healthcare setting - PubMed
Culture-independent detection of low-abundant Clostridioides difficile in environmental DNA via PCR - PubMed
Culture-independent detection of low-abundant Clostridioides difficile in environmental DNA via PCR - PubMed
Clostridioides difficile represents a major burden to public health. As a well-known nosocomial pathogen whose occurrence is highly associated with antibiotic treatment, most examined C. difficile strains originated from clinical specimen and were isolated under selective conditions em …
·pubmed.ncbi.nlm.nih.gov·
Culture-independent detection of low-abundant Clostridioides difficile in environmental DNA via PCR - PubMed
The burden of Clostridioides difficile infections in South-East Asia and the Western Pacific: A narrative review - PubMed
The burden of Clostridioides difficile infections in South-East Asia and the Western Pacific: A narrative review - PubMed
The regional CDI burden in Asia is still incompletely documented, seemingly due to low awareness and limited laboratory testing. Despite this apparent under recognition, the current CDI burden highlights the need for broader surveillance and for application of preventative measures against CDI in As …
·pubmed.ncbi.nlm.nih.gov·
The burden of Clostridioides difficile infections in South-East Asia and the Western Pacific: A narrative review - PubMed
Clostridioides difficile -mucus interactions encompass shifts in gene expression, metabolism, and biofilm formation - PubMed
Clostridioides difficile -mucus interactions encompass shifts in gene expression, metabolism, and biofilm formation - PubMed
Clostridioides difficile results in upwards of 250,000 infections and 12,000 deaths annually in the United States. Community-acquired infections continue to rise and recurrent disease is common, emphasizing a vital need to understand C. difficile pathogenesis. C. difficile undou …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile -mucus interactions encompass shifts in gene expression, metabolism, and biofilm formation - PubMed
Molecular docking, dynamics and in vitro analysis of multi-target inhibitors for Clostridioides difficile - PubMed
Molecular docking, dynamics and in vitro analysis of multi-target inhibitors for Clostridioides difficile - PubMed
The opportunistic pathogen, Clostridioides difficile owes its extreme pathogenicity for its ability to develop antibiotic resistance and recurrent infections. The current antibiotics used for the treatment are showing declining sensitivity and rising antibiotic resistance. Therefore, it is of …
·pubmed.ncbi.nlm.nih.gov·
Molecular docking, dynamics and in vitro analysis of multi-target inhibitors for Clostridioides difficile - PubMed
Epidemiology and outcomes of infections during extracorporeal membrane oxygenation in adult patients with COVID-19 ARDS- A single center study - PubMed
Epidemiology and outcomes of infections during extracorporeal membrane oxygenation in adult patients with COVID-19 ARDS- A single center study - PubMed
The most common infections in our patients were bloodstream infections followed by pneumonia. High rates of gram negative infections, including those caused by carbapenem resistant bacteria, reflect the Indian critical care unit epidemiology in general. Despite these high infection rates with antimi …
·pubmed.ncbi.nlm.nih.gov·
Epidemiology and outcomes of infections during extracorporeal membrane oxygenation in adult patients with COVID-19 ARDS- A single center study - PubMed
Impact of infectious diseases consultation for hospitalized patients with Clostridioides difficile infection - PubMed
Impact of infectious diseases consultation for hospitalized patients with Clostridioides difficile infection - PubMed
Clostridioides difficile infection (CDI) is associated with substantial morbidity and mortality. This study described outcomes associated with mandatory infectious diseases (ID) consultation in hospitalized patients with CDI. ID consultation was associated with increased appropriate concomita …
·pubmed.ncbi.nlm.nih.gov·
Impact of infectious diseases consultation for hospitalized patients with Clostridioides difficile infection - PubMed
Rapid Isothermal Detection of Pathogenic Clostridioides difficile Using Recombinase Polymerase Amplification - PubMed
Rapid Isothermal Detection of Pathogenic Clostridioides difficile Using Recombinase Polymerase Amplification - PubMed
Nosocomial-associated diarrhea due to Clostridioides difficile infection (CDI) is diagnosed after sample precultivation by the detection of the toxins in enzyme immunoassays or via toxin gene nucleic acid amplification. Rapid and direct diagnosis is important for targeted treatment to prevent …
·pubmed.ncbi.nlm.nih.gov·
Rapid Isothermal Detection of Pathogenic Clostridioides difficile Using Recombinase Polymerase Amplification - PubMed
Faecal microbiota transplantation for multidrug-resistant organism decolonization in spinal cord injury patients: a case series - PubMed
Faecal microbiota transplantation for multidrug-resistant organism decolonization in spinal cord injury patients: a case series - PubMed
FMT is a safe and effective strategy to eradicate MDR bacteria, even in spinal cord injured patients. FMT can allow relaxation of isolation facilitates, the participation of patients in a complete rehabilitation program, their social integration, and transfer to follow-up rehabilitation centres.
·pubmed.ncbi.nlm.nih.gov·
Faecal microbiota transplantation for multidrug-resistant organism decolonization in spinal cord injury patients: a case series - PubMed