FMT

FMT

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Respiratory viral panel lowers antibiotic use duration in ventilated patients
Respiratory viral panel lowers antibiotic use duration in ventilated patients
Among ventilated ICU patients with suspected infection, the length of antibiotic use went down after respiratory viral panel testing was adopted, according to results published in Annals of the American Thoracic Society.“These results suggest that [respiratory viral panel] testing is a valuable tool to guide antibiotic use in patients with suspected infection,” Jacqueline Dinh, MD,
·healio.com·
Respiratory viral panel lowers antibiotic use duration in ventilated patients
The Magic Poop Potion
The Magic Poop Potion
An Indiana grandma killed off a devastating superbug with a homemade fecal transplant and then embarked on a crusade to win over the FDA.
·narratively.com·
The Magic Poop Potion
Microbiome modification for personalized treatment of dysbiotic diseases - PubMed
Microbiome modification for personalized treatment of dysbiotic diseases - PubMed
Fecal microbial transplantation (FMT) for inflammatory diseases or refractory immune checkpoint inhibitor therapy is less effective than for preventing recurrent Clostridioides difficile infection. This commentary outlines strategies to use biomarkers of successful FMT to guide newer approaches to r …
·pubmed.ncbi.nlm.nih.gov·
Microbiome modification for personalized treatment of dysbiotic diseases - PubMed
Finch wins US jury trial against Ferring over fecal-transplant patents
Finch wins US jury trial against Ferring over fecal-transplant patents
A federal jury in Delaware said on Friday that Swiss biopharmaceutical company Ferring Pharmaceuticals infringed patents for fecal transplant technology belonging to Finch Therapeutics and the University of Minnesota and should pay $25 million in damages and future royalties.
·reuters.com·
Finch wins US jury trial against Ferring over fecal-transplant patents
Family Stool Donation Predicts Failure of Fecal Microbiota Transplant for Clostridioides difficile Infection - PubMed
Family Stool Donation Predicts Failure of Fecal Microbiota Transplant for Clostridioides difficile Infection - PubMed
Colonoscopy-based FMT was highly effective for CDI, even in a population where immunosuppression and proton pump inhibitor use were common. Family stool donation was associated with FMT failure, compared with the use of a stool bank. The study suggests that the use of a stool bank may not only impro …
·pubmed.ncbi.nlm.nih.gov·
Family Stool Donation Predicts Failure of Fecal Microbiota Transplant for Clostridioides difficile Infection - PubMed
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·l.facebook.com·
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Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed
Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed
Previous studies have demonstrated that gut microbiota dysbiosis promotes the development of mastitis. The interaction of the vagus nerve and gut microbiota endows host homeostasis and regulates disease development, but whether the vagus nerve participates in the pathogenesis of mastitis is unclear. …
·pubmed.ncbi.nlm.nih.gov·
Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice - PubMed
Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment - PubMed
Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment - PubMed
Our findings support a model of IBD pathogenesis in which host inflammation promotes aggressive resident bacteria, which further drives a feed-forward process of dysbiosis exacerbated by gut inflammation. This model implies that effective management of IBD requires treating both the dysregulated hos …
·pubmed.ncbi.nlm.nih.gov·
Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment - PubMed
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
Acute graft-versus-host disease (aGVHD) is primarily driven by allogeneic donor T cells associated with an altered composition of the host gut microbiome and its metabolites. The severity of aGVHD after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not solely determined by the ho …
·pubmed.ncbi.nlm.nih.gov·
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism - PubMed
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
Microbiome dysbiosis has emerged as a critical factor influencing the outcomes of hematopoietic stem cell transplantation (HSCT). This comprehensive review delves into the intricate relationship between microbiome composition and HSCT outcomes, highlighting the mechanisms through which dysbiosis imp …
·pubmed.ncbi.nlm.nih.gov·
The Impact of Microbiome Dysbiosis on Hematopoietic Stem Cell Transplantation Outcomes: A Review Article - PubMed
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
Radiotherapy is a common treatment for abdominal and pelvic tumors, while the radiation-induced intestinal injury (RIII) is one of the major side-effects of radiotherapy, which reduces the life quality and impedes the treatment completion of cancer patients. Previous studies have demonstrated that e …
·pubmed.ncbi.nlm.nih.gov·
Polystyrene microplastics aggravate radiation-induced intestinal injury in mice - PubMed
When can we cure Crohn's? - PubMed
When can we cure Crohn's? - PubMed
Crohn's disease is a life-long idiopathic inflammatory disease which affects the entire gastrointestinal tract and occasionally extra-intestinal organs. CD is thought to result from complex interactions between environmental factors, the gut microbes, and the genetic background and the immune system …
·pubmed.ncbi.nlm.nih.gov·
When can we cure Crohn's? - PubMed
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Fecal Microbiota Transplant (FMT) has shown some success in treating inflammatory bowel diseases (IBD). There is emerging evidence that host engraftment of donor taxa is a tenet of successful FMT. We undertook a double-blind, randomized, placebo-controlled pilot study to characterize the response to …
·pubmed.ncbi.nlm.nih.gov·
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease - PubMed
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Ageing and physiological functions of the human body are inversely proportional to each other. The gut microbiota and host immune system co-evolve from infants to the elderly. Ageing is accompanied by a decline in gut microbial diversity, immunity and metabolism, which increases susceptibility to in …
·pubmed.ncbi.nlm.nih.gov·
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed
Asthma, a chronic inflammatory disorder of the airways, is a prevalent childhood chronic disease with a substantial global health burden. The complex etiology and pathogenesis of asthma involve genetic and environmental factors, posing challenges in diagnosis, severity prediction, and therapeutic st …
·pubmed.ncbi.nlm.nih.gov·
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review - PubMed
Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material - PubMed
Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material - PubMed
Recent studies indicate an important role of bacteriophages for successful fecal microbiota transplantation (FMT). However, wider clinical applications of FMT are hampered by to donor variability and concerns of infection risks by bacteria and human viruses. To overcome these challenges, mouse cecal …
·pubmed.ncbi.nlm.nih.gov·
Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material - PubMed
The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC - PubMed
The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC - PubMed
The role of the gut microbiota in the occurrence and progression of primary biliary cholangitis (PBC) is not fully understood. First, the fecal microbiota of patients with PBC (n = 4) (PBC-FMT) or healthy individuals (n = 3) (HC-FMT) was transplanted into pseudo germ-free mice or 2OA-B …
·pubmed.ncbi.nlm.nih.gov·
The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC - PubMed
Comparing treatment effects on dogs with acute hemorrhagic diarrhea syndrome: fecal microbiota transplantation, symptomatic therapy, or antibiotic treatment - PubMed
Comparing treatment effects on dogs with acute hemorrhagic diarrhea syndrome: fecal microbiota transplantation, symptomatic therapy, or antibiotic treatment - PubMed
Overall, in dogs with AHDS, neither FMT nor AT resulted in faster clinical improvement. In addition, C perfringens strains are self-limiting and do not require antibiotic therapy.
·pubmed.ncbi.nlm.nih.gov·
Comparing treatment effects on dogs with acute hemorrhagic diarrhea syndrome: fecal microbiota transplantation, symptomatic therapy, or antibiotic treatment - PubMed
The gut microbiome and dietary metabolites in the treatment of renal cell carcinoma - PubMed
The gut microbiome and dietary metabolites in the treatment of renal cell carcinoma - PubMed
The gut microbiome is interlinked with renal cell carcinoma (RCC) and its response to systemic treatment. Mounting data suggests that certain elements of the gut microbiome may correlate with improved outcomes. New generation sequencing techniques and advanced bioinformatic data curation are acceler …
·pubmed.ncbi.nlm.nih.gov·
The gut microbiome and dietary metabolites in the treatment of renal cell carcinoma - PubMed
β-resorcylic acid released by Limosilactobacillusreuteri protects against cisplatin-induced ovarian toxicity and infertility - PubMed
β-resorcylic acid released by Limosilactobacillusreuteri protects against cisplatin-induced ovarian toxicity and infertility - PubMed
Chemotherapy-induced premature ovarian insufficiency (CIPOI) triggers gonadotoxicity in women undergoing cancer treatment, leading to loss of ovarian reserves and subfertility, with no effective therapies available. In our study, fecal microbiota transplantation in a cisplatin-induced POI mouse mode …
·pubmed.ncbi.nlm.nih.gov·
β-resorcylic acid released by Limosilactobacillusreuteri protects against cisplatin-induced ovarian toxicity and infertility - PubMed
The influence of Akkermansia muciniphila on intestinal barrier function - PubMed
The influence of Akkermansia muciniphila on intestinal barrier function - PubMed
Intestinal barriers play a crucial role in human physiology, both in homeostatic and pathological conditions. Disruption of the intestinal barrier is a significant factor in the pathogenesis of gastrointestinal inflammatory diseases, such as inflammatory bowel disease. The profound influence of the …
·pubmed.ncbi.nlm.nih.gov·
The influence of Akkermansia muciniphila on intestinal barrier function - PubMed
Fructus Jujubae cooperated with water-expelling members in Shizao decoction alleviated intestinal injury and malignant ascites by modulating gut microbiota and metabolic homeostasis - PubMed
Fructus Jujubae cooperated with water-expelling members in Shizao decoction alleviated intestinal injury and malignant ascites by modulating gut microbiota and metabolic homeostasis - PubMed
FJ cooperated with WEM reduced intestinal injury and alleviated malignant ascites by modulating gut microbiota, short-chain fatty and tryptophan metabolism. These findings provide a scientific basis for the clinical application of FJ from SZD and the safe usage of SZD.
·pubmed.ncbi.nlm.nih.gov·
Fructus Jujubae cooperated with water-expelling members in Shizao decoction alleviated intestinal injury and malignant ascites by modulating gut microbiota and metabolic homeostasis - PubMed
Efficacy of donor-recipient-matched faecal microbiota transplantation in patients with IBS-D: A single-centre, randomized, double-blind placebo-controlled study - PubMed
Efficacy of donor-recipient-matched faecal microbiota transplantation in patients with IBS-D: A single-centre, randomized, double-blind placebo-controlled study - PubMed
Donor-recipient-matched FMT significantly improved the clinical symptoms, quality of life, and anxiety scores of the patients with IBS-D than random-donor FMT.
·pubmed.ncbi.nlm.nih.gov·
Efficacy of donor-recipient-matched faecal microbiota transplantation in patients with IBS-D: A single-centre, randomized, double-blind placebo-controlled study - PubMed
Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response - PubMed
Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response - PubMed
The intratumoral microbiome (TM) refers to the microorganisms in the tumor tissues, including bacteria, fungi, viruses, and so on, and is distinct from the gut microbiome and circulating microbiota. TM is strongly associated with tumorigenesis, progression, metastasis, and response to therapy. This …
·pubmed.ncbi.nlm.nih.gov·
Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response - PubMed
Washed microbiota transplantation combined with biological agents promotes histological remission in refractory severe ulcerative colitis with recurrent intestinal infection: A case report - PubMed
Washed microbiota transplantation combined with biological agents promotes histological remission in refractory severe ulcerative colitis with recurrent intestinal infection: A case report - PubMed
Ulcerative colitis (UC) is a chronic non-specific colitis disease. In recent years, fecal microbiota transplantation (FMT), including improved washed microbiota transplantation (WMT), and biological agents have helped improve the prognosis of patients with UC. However, a significant number of patien …
·pubmed.ncbi.nlm.nih.gov·
Washed microbiota transplantation combined with biological agents promotes histological remission in refractory severe ulcerative colitis with recurrent intestinal infection: A case report - PubMed
Respiratory diseases and gut microbiota: relevance, pathogenesis, and treatment - PubMed
Respiratory diseases and gut microbiota: relevance, pathogenesis, and treatment - PubMed
Preclinical evidence has firmly established a bidirectional interaction among the lung, gut, and gut microbiome. There are many complex communication pathways between the lung and intestine, which affect each other's balance. Some metabolites produced by intestinal microorganisms, intestinal immune …
·pubmed.ncbi.nlm.nih.gov·
Respiratory diseases and gut microbiota: relevance, pathogenesis, and treatment - PubMed