FMT

Fecal microbiota transplantation (FMT) is highly effective in preventing recurrent Clostridioides difficile infection (rCDI). However, the mechanisms underpinning its clinical efficacy are incompletely understood. Herein, we provide an overview of rCDI pathogenesis followed by a discussion of potent …

Several studies suggest that butyrate may be important in alleviating gut infections, such as reducing inflammation caused by the healthcare-associated Clostridioides difficile . While studies in both animal models and human studies correlate high levels of butyrate with reduced C. diffici …

FDA approves second microbiome-based C. difficile therapy

Fecal microbiota transplantation (FMT) has achieved satisfactory results in preventing the recurrence of Clostridioides difficile infection, but these positive outcomes have only been partially replicated in other diseases. Several factors influence FMT success, including those related to donors and …

Microbiota therapies offer exciting potential to reduce the burden of recurrent Clostridioides difficile infection, experts say.

A scientific review concluded that fecal microbiota transplantation is more effective than antibiotics against recurrent ‘Clostridioides difficile’ infections; researchers are also investigating its possibilities in mental health and to improve the effect of immunotherapy in cancer

CHICAGO — Treatment with Rebyota did not affect concurrent medication use in patients with inflammatory bowel disease and recurrent Clostridioides difficile infection, Jessica R. Allegretti, MD, MPH, explains in this Healio video. Allegretti presented data at Digestive Disease Week on safety outcomes and concomitant medication changes after treatment with Rebyota (fecal microbiota,

Fecal microbiota transplants are the most effective and affordable treatment for recurrent infections with Clostridioides difficile, an opportunistic bacterium and the most common cause of hospital-acquired intestinal infections. However, attempts to treat chronic noncommunicable diseases such as ulcerative colitis and metabolic syndrome via fecal microbiota transplantation (FMT) have yielded mixed results. Two review articles publishing May 10 in the journal Cell Host and Microbe discuss what we do and don’t know about why FMTs work (when they do).

What is the "optimal formula" for donor selection and feces processing for fecal microbiota transplantation in ulcerative colitis?

Fecal microbiota transplantation (FMT) is highly effective in preventing recurrent Clostridioides difficile infection (rCDI). However, the mechanisms underpinning its clinical efficacy are incompletely understood. Herein, we provide an overview of rCDI pathogenesis followed by a discussion of potent …

Fecal microbiota transplantation (FMT) has achieved satisfactory results in preventing the recurrence of Clostridioides difficile infection, but these positive outcomes have only been partially replicated in other diseases. Several factors influence FMT success, including those related to donors and …

The microbiome plays a vital role in maintaining homeostasis of the intestinal microenvironment and immune response in allogeneic hematopoietic cell transplantation (HCT) recipients. Disruption of the intestinal microbiome has been associated with the development of acute graft-versus-host disease ( …

As a long-term condition that affects the airways and lungs, chronic obstructive pulmonary disease (COPD) is characterized by inflammation, emphysema, breathlessness, chronic cough, and sputum production. Currently, the bronchodilators and anti-inflammatory drugs prescribed for COPD are mostly off-t …

Clostridioides difficile, which causes life-threatening diarrheal disease, is considered an urgent threat to healthcare setting worldwide. The current standards of care solely rely on conventional antibiotic treatment, however, there is a risk of promoting recurrent C. difficile infection (rCDI) bec …

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Clostridioides difficile, which causes life-threatening diarrheal disease, is considered an urgent threat to healthcare setting worldwide. The current standards of care solely rely on conventional antibiotic treatment, however, there is a risk of promoting recurrent C. difficile infection (rCDI) bec …

Ferring’s Rebyota therapeutic was studied in this population and demonstrated a 79% efficacy.

Seres Therapeutics, Inc. (Nasdaq: MCRB), a leading microbiome therapeutics company, today reported initial clinical data about SER-155. SER-155 is an

CHICAGO — In a Healio video exclusive, Ken Blount, PhD, discusses successful restoration of gut microbiota and clonal engraftment as soon as 1 week after treatment with Rebyota in those with recurrent Clostridioides difficile infection. Blount and colleagues sought to quantify and define clonal engraftment and durable microbiome compositional changes with FDA-approved Rebyota (fecal

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Ferring’s Rebyota, which was FDA approved late last year, demonstrated a high efficacy and favorable safety profile in the prevention of recurrent Clostridioides difficile.

Ferring Presents Four Analyses of Data for REBYOTA at DDW 2023.

CHICAGO — More than 20% of patients with inflammatory bowel disease experienced recurrent Clostridioides difficile infection 1 year after fecal microbiota transplantation, according to data presented at Digestive Disease Week. “While there are data on the short-term efficacy of FMT for eradicating C. diff infections in patients with IBD, there is less known about longer-term

We report a patient with a 5-year diagnosis of akinetic-rigid Parkinson's disease under treatment with Levodopa-Carbidopa Intestinal Gel therapy through a PEG-J tube due to motor complications, in which, in the context of a clinical study, we successfully and safely administered fecal microbiota tra …

Dr Daphne Moutsoglou #DDW2023 Oral lyophilised #FMT (in capsule) in mild to moderate #UCSee results Underpowered study - difficult to draw conclusions IMO pic.twitter.com/aEkZO3lIvi— Seb (@ibdseb) May 7, 2023

BENNINGTON — A jury has awarded a Salem, N.Y., man $250,000 after finding medical negligence on the part of a physician who treated him in 2014 during a stay at

According to a recent Cochrane Review, stool transplantation has proven to be a more effective method of treating Clostridioides difficile infection as compared to standard antibiotic treatment. According to a recent Cochrane Review headed by a professor at Upstate Medical University, stool tran

⁦@Siew_C_Ng⁩ presenting #FMT trial in bloating with #IBS ⁦@DDWMeeting⁩ #DDW23 ⁦@ANMSociety⁩ ⁦@RomeFoundation⁩ pic.twitter.com/jI0r8iVXBM— Madhusudan (Madhu) Grover M.D., AGAF (@mgrover_gi) May 6, 2023

Lunch n learn on #Cdiff and microbiota therapies @DDWMeeting with #twitterless Dr. Byron Vaughn and super star GI fellow Dr. Lawrence Leung from Kaiser San Francisco@AmerGastroAssn pic.twitter.com/ducw1vMNib— Sahil Khanna, MBBS, MS, FACG, AGAF (he/him) (@Khanna_S) May 6, 2023

The FDA approval could be the first ripple in a flood of therapies targeting the gut microbiome.