Breaking the cycle: New treatments for recurrent C diff offer an alternative to repeated antibiotics | CIDRAP

FMT
Gut Instinct: Rebyota
Bacteria killer signals a milestone—and momentum—for microbiome therapeutics.
Cancer: The Next Microbiome Frontier
Three therapeutic regulatory approvals in less than a year signal that the promise of the human microbiome may finally be paying off. All of the approved therapies focus on treating recurrent Clostridium difficile infection, but what is next for the field? With promising oncology-related trial results from a number of researchers and companies such as […]
Fecal Microbiota Transplantation Market Growth (Size and Share) 2023-2031 Regional Outlook Analysis
"Final Report will add the analysis of the impact of COVID-19 on this industry."This full and thorough report, titled "Fecal Microbiota Transplantation Market" Insights of 2023, offers a thorough analysis of the market's
Gut Microbial Metabolome and Dysbiosis in Neurodegenerative Diseases: Psychobiotics and Fecal Microbiota Transplantation as a Therapeutic Approach-A Comprehensive Narrative Review - PubMed
The comprehensive narrative review conducted in this study delves into the mechanisms of communication and action at the molecular level in the human organism. The review addresses the complex mechanism involved in the microbiota-gut-brain axis as well as the implications of alterations in the micro …
Current and Emerging Applications of Fecal Microbiota Transplantation - PubMed
Fecal microbiota transplantation (FMT) is a life-changing treatment for people with recurrent Clostridioides difficile infection (rCDI). Frequently acquired in the hospital, CDI can cause serious gastrointestinal symptoms, including persistent watery diarrhea, abdominal pain, and severe dehydration. …
Pick fecal microbiota transplantation to enhance therapy for major depressive disorder - PubMed
In recent years, fecal microbiota transplantation (FMT) has emerged as a promising therapy for major depressive disorder (MDD). The goal of the operation is to restore a healthy gut microbiota by introducing feces from a healthy donor into the recipient's digestive system. The brain-gut axis is thou …
[Influence of different fecal microbiota transplantation cycles on the recovery of intestinal microbiota in the antibiotic cocktail-pretreated mice] - PubMed
Fecal bacteria transplantation helps to restore the intestinal microbiota structure of mice cleaned by antibiotics, and different transplantation frequencies and transplantation times have different recovery effects on the intestinal microbiota of mice pretreated with antibiotics, and the fecal bact …
Current and Emerging Applications of Fecal Microbiota Transplantation - PubMed
Fecal microbiota transplantation (FMT) is a life-changing treatment for people with recurrent Clostridioides difficile infection (rCDI). Frequently acquired in the hospital, CDI can cause serious gastrointestinal symptoms, including persistent watery diarrhea, abdominal pain, and severe dehydration. …
Targeting The Gut–Brain Axis With Live Biotherapeutic Products
Treating seizures with bacteria — Bloom Science's CEO, Dr. Christopher Reyes, explains how his company aims to leverage the gut–brain axis using live biotherapeutic products (LBP).
Washed microbiota transplantation for Clostridioides difficile infection: a national multi-center real-world study - PubMed
This study emphasizes the attractive value of WMT for CDI. Early WMT might be a recommendation for CDI, especially for those in serious condition or with complex comorbidities for decreasing deterioration, medical costs, and pain. This article is protected by copyright. All rights reserved.
Protocol for the safety and efficacy of fecal microbiota transplantation liquid in children with autism spectrum disorder: a randomized controlled study - PubMed
https://www.chictr.org.cn/, identifier ChiCTR2200058459.
Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations - PubMed
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction for which effective interventions are lacking. To investigate the effects of resistant starch (RS) as a microbiota-directed dietary supplement for NAFLD treatment, we coupled a 4-month randomized placebo-co …
Transformation of colitis and colorectal cancer: a tale of gut microbiota - PubMed
Intestinal inflammation modifies host physiology to promote the occurrence of colorectal cancer (CRC), as seen in colitis-associated CRC. Gut microbiota is crucial in cancer progression, primarily by inducing intestinal chronic inflammatory microenvironment, leading to DNA damage, chromosomal mutati …
Fecal Microbiota Transplantation-Mediated Ghrelin Restoration Improves Neurological Functions After Traumatic Brain Injury: Evidence from 16S rRNA Sequencing and In Vivo Studies - PubMed
This study aimed to investigate how gut microbiota dysbiosis impacts the repair of the blood-brain barrier and neurological deficits following traumatic brain injury (TBI). Through 16S rRNA sequencing analysis, we compared the gut microbiota of TBI rats and normal controls, discovering significant d …
Patient Perception of Route of Rectal Administration of Live Biotherapeutic Product for Recurrent Clostridioides difficile Infection - PubMed
LBP-recipients and LBP-naïve subjects alike felt that rectal delivery of microbiome therapy is not only acceptable but highly interesting as a treatment avenue.
Randomised clinical trial: Faecal microbiota transplantation for irritable bowel syndrome with diarrhoea - PubMed
FMT performed twice at an interval of four weeks did not significantly reduce IBS-SSS score. However, more patients had improvement in abdominal bloating, which was associated with a reduction in hydrogen sulphide-producing bacteria. (ClinicalTrials.gov NCT03125564).
Retraction statement: Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats - PubMed
Toral, M, Robles-Vera, I, de la Visitación, N, et al. Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats. Acta Physiol. 2019; 227:e13285. https://doi.org/10.1111/apha.13285. The above article, published online on April 20, 2 …
Fecal microbiota transplantation in a child with severe ASD comorbidities of gastrointestinal dysfunctions-a case report - PubMed
Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by social communication impairments and restricted, repetitive behaviors. In addition to behavioral interventions and psychotherapies, and pharmacological interventions, in-depth studies of intestinal microbiota in ASD has obvio …
Fecal microbiota transplantation alleviates experimental colitis through the Toll-like receptor 4 signaling pathway - PubMed
FMT may ameliorate DSS-induced colitis by regulating the TLR4 signaling pathway. TLR4 modulates the composition of gut microbiota and the expression of related genes to ameliorate colitis and maintain the stability of the intestinal environment. Akkermansia bear great therapeutic potential fo …
In vitro ruminal fermentation and cow-to-mouse fecal transplantations verify the inter-relationship of microbiome and metabolome biomarkers: potential to promote health in dairy cows - PubMed
We provided evidence that the bacterial biomarkers alter downstream metabolites. This could indirectly indicate that the two bacterial biomarkers have the potential to be used as next-generation probiotics for dairy cattle, although it needs more evidence to support our hypothesis. Two species, iR/i …
Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis - PubMed
To explore the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment approach for ulcerative colitis (UC), a comprehensive systematic review and meta-analysis of randomized controlled trials was conducted. To collect and evaluate randomized controlled trials of high quality on …
Microbiome Therapeutics Market 2023 Key Factors - Seres Therapeutics, Assembly Biosciences, Synthetic Biologics, Interxon
Global Microbiome Therapeutics Market is a professional market research study conducted by MarketsandResearch biz covering market growth prospects and potential The study provides an overview of the industry covering the market synopsis specifications product description and objectives The first portion ...
Europe Human Microbiome Market is growing with a CAGR of 19.9% by 2029
Microbiome is the genetic material of all the microbes bacteria fungi protozoa and viruses that live on and inside the human body The number of genes in all the microbes in one person s microbiome is 200 times the number ...
This Side Hustle Pays You to Poop: You Could Make $180,000 a Year for Your Bowel Movements
A woman found a side hustle to get paid to poop and now we’re all ready to send out our stool samples. How can we make money pooping?
Pooled allogeneic faecal microbiota MaaT013 for steroid-resistant gastrointestinal acute graft-versus-host disease: a single-arm, multicentre phase 2 trial - PubMed
MaaT Pharma.
What to Know About Fecal Transplant for Ulcerative Colitis
Research into using a fecal transplant for ulcerative colitis is in its early stages. Learn more about how it works, and possible benefits and risks.
Clostridioides difficile Infection in Pediatric Inflammatory Bowel Disease - PubMed
Children with IBD have an elevated incidence of CDI, but their CDI risk does not associate with established risk factors in adults with IBD. Existing testing methodologies are inadequate at differentiating CDI from C. difficile colonization in children with IBD. Fecal microbiota transplantation offe …
Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study - PubMed
Whether the alternated microbiota in the gut contribute to the risk of allograft rejection (AR) and pulmonary infection (PI) in the setting of lung transplant recipients (LTRs) remains unexplored. A prospective multicenter cohort of LTRs was identified in the four lung transplant centers. Paired fec …
Microbiota-Based-Therapy-for-the-Prevention-of-Recurrent-Clostridioides-difficile-Infection-A-Primer-on-REBYOTA-reg-fecal-microbiota-live-jslm
This-Special-Report-outlines-the-challenges-of-treating-Clostridioides-difficile-infection-CDI-and-preventing-recurrent-CDI-and-introduces-REBYOTA