FMT

The pathogenic mechanisms underlying distal symmetric polyneuropathy (DSPN), a common neuropathy in patients with diabetes mellitus (DM), are not fully understood. Here, we discover that the gut microbiota from patients with DSPN can induce a phenotype exhibiting more severe peripheral neuropathy in …

Intestinal failure-associated liver disease (IFALD) is a common hepatobiliary complication resulting from long-term parenteral nutrition (PN) in patients with intestinal failure. The spectrum of IFALD ranges from cholestasis, steatosis, portal fibrosis, and cirrhosis. Development of IFALD is a multi …

The evidence for FMT in the treatment of chronic pouchitis is sparse which limits any recommendations being made for its use in clinical practice. Current evidence from low-quality studies suggests a variable clinical response and remission rate but the treatment is well tolerated with a good safety …

Pressure-overloaded left ventricular remodeling in young population is progressive and readily degenerate into heart failure. The aims of this study were to identify a plasma metabolite that predicts and is mechanistically linked to the disease. Untargeted metabolomics determined elevated plasma kyn …

Fecal microbiota transplantation combined with anti-PD-1 is safe in melanoma in the first-line setting.

Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease, that includes Crohn's disease (CD) and ulcerative colitis (UC), having progressively increasing global incidence. Disturbed intestinal flora has been highlighted as an important feature of IBD and offers promi …

A new next-generation probiotic, Christensenella minuta was first discovered in 2012 from healthy human stool and described under the phylum Firmicutes. C. minuta is a subdominant commensal bacterium with highly heritable properties that exhibits mutual interactions with other h …

These findings indicate that omega-3 PUFAs ameliorate androgen-induced gut microbiota dysbiosis. The gut microbiota plays a key role in the regulation of omega-3-mediated IR protective effects in polycystic ovary syndrome mice. Moreover, omega-3 PUFA-regulated improvements in the ovarian dysfunction …

The bi-directional interaction between gut microbiota and the central nervous system has been coined the gut microbiota-brain axis. Fecal microbiota transplantation (FMT) is the administration of a solution of fecal matter from a donor into the intestinal tract of a recipient. Preclinical FMT experi …

Amber Specialty Pharmacy, an innovator and leader in the specialty pharmacy industry, has been selected as one of only two pharmacies nationally selec

In recent years, immune checkpoint blockade (ICB) therapy has become an important treatment strategy for gastrointestinal tumors, however, it only benefits about 1/3 of patients. Since the microbiome has been shown to play an important role in the human body for a long time, a growing number of stud …

yFMT could reshape the dysbiosis of gut microbiota and metabolites, maintain gut barrier integrity, and improve muscle mitochondrial dysfunction, eventually alleviating sarcopenia in aged rats. yFMT might be a new therapeutic strategy for age-related sarcopenia.

Summary Seres Therapeutics and Nestlé Health Science received FDA approval for VOWST, a drug to prevent recurrent C. difficile infection, triggering a $125M payment from Nestlé to Seres.Seres reported a Q1 2023 net loss of $71.2M, up from a $56.6M loss in Q1 2022, with increased expenses due to VOWST development and manufacturing costs.The company ...

Here is a brief report of 5 cases of the use of fecal microbiota, live-jslm (Rebyota) in the management of recurrent Clostridioides difficile infection.

Hamilton Health Sciences’ (HHS) McMaster Children’s Hospital (MCH) has opened Canada’s first pediatric stool bank. The healthy stool samples are used to create a treatment for the recurring gut infection Clostridium difficile, or C. diff, in children when antibiotics haven’t worked. This treatment has become a common procedure in adults but MCH is on the leading edge of using it for children.

The largest safety evaluation of any microbiota-based live biotherapeutic reveals data for the first approved microbiome therapy for C. diff.

Administrating the donor's transplant to the small intestine had a higher response and results in long-term colonization of beneficial bacteria than administrating it to the large intestine.

Neoadjuvant chemoimmunotherapy (NACI) has shown promise in the treatment of resectable esophageal squamous cell carcinoma (ESCC). The microbiomes of patients can impact therapy response, and previous studies have demonstrated that intestinal microbiota influences cancer immunotherapy by activating g …

The gut microbiota and bile acid metabolism are key determinants of the response of inflammatory bowel disease to biologic therapy. However, the molecular mechanisms underlying the interactions between the response to anti-α4β7-integrin therapy and the gut microbiota and bile acid metabolism remain …

Clostridioides difficile infections (CDI) are a leading cause of healthcare-associated infections with a high relapse rate. Current treatment guidelines recommend fidaxomicin as the primary therapy for initial CDI episodes and suggest alternative approaches for recurrent episodes, including fecal mi …

The formation of an inactive spore by the anaerobic gastrointestinal pathogen, Clostridioides difficile , is required for its survival outside of the mammalian host. The sporulation process is induced by the regulator, Spo0A; yet, how Spo0A is activated in C. difficile remains unknown. …

The human microbiome has a strong influence on metabolism and immunity. Learn about how the power of the microbiome may break the cycle of recurrent C. diff.

“#MEAwarenessHour “A study undertaken in a single centre in Australia has already reported significant clinical improvement in 70% of #MECFS patients administered an FMT." #pwME #MyalgicEncephalomyelitis”

Calliope Holingue researches how the microbiome and mind affect each other. She's part of a growing field, exploring how that connection could ultimately improve treatments for mental conditions.

A recent systematic review published in the Diabetes Research and Clinical Practice found the effect of fecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic...

Nature Neuroscience - Autism spectrum disorder (ASD) is characterized by heterogeneous phenotypes. Disruption of the gut–brain axis (GBA) has been implicated in ASD although with limited...

The ISME Journal - Pesticide exposure and the microbiota-gut-brain axis

Nature Reviews Microbiology - The human microbiome has a crucial role in global health, with implications for achieving the Sustainable Development Goals (SDGs). Understanding and harnessing the...

After the historic approvals of Seres’ and Ferring’s microbiome-based treatments for recurrent Clostridioides difficile infection, the two companies are waiting to see who dominates the $1bn market. Physicians say patients will steer the choice of treatments.

Seres Therapeutics and Nestle Health Science received FDA approval for VOWST, a drug to prevent recurrent C. difficile infection. Learn more about MCRB stock now.