FMT

Experts discuss differences in designs of clinical trials of 4 emerging microbiota-based live biotherapeutics - RBX2660, SER-109, CP101, VE303, for treatment of rCDI.

Gut microbial composition codevelops with the host from birth and is influenced by several factors, including drug use, radiation, psychological stress, dietary changes and physical stress. Importantly, gut microbial dysbiosis has been clearly associated with several diseases, including cancer, rheumatoid arthritis and Clostridium difficile-associated diarrhoea, and is known to affect human health and performance. Herein, we discuss that a shift in the gut microbiota with age and reversal of age-related modulation of the gut microbiota could be a major contributor to the incidence of numerous age-related diseases or overall human performance. In addition, it is suggested that the gut microbiome of long-lived animals such as reptiles should be investigated for their unique properties and contribution to the potent defense system of these species could be extrapolated for the benefit of human health. A range of techniques can be used to modulate the gut microbiota to have higher abundance of “beneficial” microbes that have been linked with health and longevity.

Impressive case of remission of metastatic melanoma after fecal microbiota treatment #FMT #melanoma #cancerMicrobiota modulates the response to immunotherapy. 👌👏😍 #UEGWeek pic.twitter.com/ncWAo7PHRF— Sara Nikolić (@SN_gastro) October 11, 2022

Understanding the factors underlying colonization of donor microbes in recipients of fecal #microbiota transplantation is a necessary first step to develop directed approaches to couple colonization to clinical outcomes. #FMT https://t.co/TNFCx5O9CU— Nature Medicine (@NatureMedicine) September 19, 2022

The results of this trial suggest that microbiota restoration might be necessary to obtain sustained resolution following C difficile infection.

Join us for a free webinar where international speakers will discuss their work within the field of Fecal Microbiota Transplant (FMT)!

Opening of the common interest group meeting for #FMT and stool banking at #UEGWeek @ehmsg @eurFMT pic.twitter.com/d5rPxFcUGU— Simon MD Baunwall (@SMDBaunwall) October 9, 2022

Leading specialist @ChristianHvas from @HepGas @AUHdk setting the scene for timing of #FMT @my_ueg 2022 https://t.co/wohKIBUGQs— Mette Julsgaard (@JulsgaardMette) October 9, 2022

Our case report provides preliminary evidence regarding the use of FMT in a patient with C. difficile and ADHD. We speculate that gut microbiome modulation, in particular the gain or loss of specific microbial species and pathways involving the metabolism of SCFAs, tryptophan and GABA, may me …

"The Combined Escherichia coli Nissle 1917 and #Tryptophan Treatment Modulates Immune and Metabolome Responses to Human Rotavirus Infection in a Human Infant Fecal Microbiota-Transplanted Malnourished Gnotobiotic Pig Model" #FMT #GutMicrobiome https://t.co/f2cmzaHmn5— Katie Guzzetta 🌻 (@ktguzz) October 7, 2022

Researchers evaluated the efficacy and safety of fecal microbiota transplantation after vancomycin vs vancomycin alone for first or second C difficile infection.

It was great to talk to @drjamesmcilroy on the @_insidematters about the past, present and potential future for research and treatments related to the #GutMicrobiome #FMT - a long listen but hopefully of interest @IHepatology @ImperialMDR @BugsImperial https://t.co/eboYPHJbaT— Ben Mullish (@bhmullish) October 6, 2022

Mucosal Immunology - Microbiome-based interventions to modulate gut ecology and the immune system

You see it as poop, but scientists think it's a potent drug...Swipe to find out why and how poop can be therapeutic and let me know what you think about this therapy - would you love to try it?#immunology #gutmicrobiota #gut #scicomm #fmt #fecalmicrobiotatransplant pic.twitter.com/XFrFSeLBZi— Wealth Okete (@wealthokete) October 6, 2022

Fecal microbiota transplantation (FMT) is a novel microbiota-based therapeutic method that transfers stool from donor into a recipient and its applica…

This study applied a protocol for fecal microbiota transplantation to irritable bowel syndrome with high response rates and sustained effects. Ten possible were identified, who were correlated to fecal microbiota transplantation effects.

Research is under way on whether faecal micro-organisms can treat colorectal cancer and even long Covid. Read more at straitstimes.com.

Drs Tom Lodise and Bincy Abraham provide an overview of fecal microbiota transplantation and long-term safety of FMT use.

A nice commentary piece in @Gut_BMJ about our recent #LOTUS paper evaluating differences in efficacy from #FMT donors. Love the concept of a ‘microbiome clinician’ to translate FMT into clinical practice. @NOKaakoush @rupertleong #UC #IBD #microbiomehttps://t.co/Xz33FUxMCX— Laurence Luu (@LaurenceLuu) October 4, 2022

The idea is that FMT will help re-educate the recipient's gut microbiome, induce the gut's re-colonization, and restore microbial diversity. Learn more at https://t.co/muFzfpffur#IBD #IBS #asd #autism #FMT #guthealthmatters #guthealth #cdiff #research #gut #guthealing pic.twitter.com/Ru3fIB7R7P— Novel Biome (@NovelBiome) October 3, 2022

ObjectiveTo evaluate the safety and efficacy of fecal microbiota transplantation for autoimmune diseases and autoinflammatory diseases.MethodsRelevant literature was retrieved from the PubMed database, Embase database, Cochrane Library database, etc. The search period is from the establishment of the database to January 2022. The outcomes include clinical symptoms, improvement in biochemistry, improvement in intestinal microbiota, improvement in the immune system, and adverse events. Literature screening and data extraction were independently carried out by two researchers according to the inclusion and exclusion criteria, and RevMan 5.3 software was used for statistics and analysis.ResultsOverall, a total of 14 randomized controlled trials (RCTs) involving six types of autoimmune diseases were included. The results showed the following. 1) Type 1 diabetes mellitus (T1DM): compared with the autologous fecal microbiota transplantation (FMT) group (control group), the fasting plasma C peptide in the allogenic FMT group at 12 months was lower. 2) Systemic sclerosis: at week 4, compared with one of two placebo controls, three patients in the experimental group reported a major improvement in fecal incontinence. 3) Ulcerative colitis, pediatric ulcerative colitis, and Crohn’s disease: FMT may increase clinical remission, clinical response, and endoscopic remission for patients with ulcerative colitis and increase clinical remission for patients with Crohn’s disease. 4) Psoriati...

Bone Marrow Transplantation - Safety and efficacy of fecal microbiota transplantation in the treatment of graft-versus-host disease

FMT may decrease the mortality of patients with severe and fulminant CDI, and larger studies are needed to validate these findings.

#FMT as a potential double edged sword: improving liver outcomes and AUD/craving outcomes… interesting data coming on this #LiverTwitter @JasmohanBajaj pic.twitter.com/iXcvZqO5nw— Juan Pablo (JP) Arab, MD (@juanpabloarab) October 1, 2022

Danish trial halted early after FMT treatment proved 'so much better' than antibiotics alone

The effect of the gut microbiota on patients' outcomes after allogeneic haematopoietic cell transplantation (HCT) is now well established. In particular, gut microbiota dysbiosis has been associated with acute graft-versus-host disease (GVHD). Furthermore, increasing data also suggest an effect of t …

MINNEAPOLIS/ST. PAUL (09/29/2022) — Recently published in Clinical Gastroenterology and Hepatology, researchers from the University of Minnesota Medical School found that Fecal Microbiota Transplant (FMT) using capsules containing freeze-dried microbes taken orally has similar safety and effectiveness to colonoscopic administration of liquid FMT for treating recurrent Clostridioides difficile infection (CDI). Every year in the United States, approximately 500,000 people develop CDI — which is typically a complication of antibiotics. Antibiotics are also used to treat CDI, which further damage the intestinal microbiota. The U of M research team developed standardized FMT preparations — which are composed of intestinal microbes that can restore a healthy intestinal microbiota. This strategy repairs the damage caused by antibiotics and restores resistance against CDI. “Capsule FMT can avoid complications of colonoscopy and facilitate access to this potentially life-saving therapy,” said Byron Vaughn, MD, MS, associate professor in the Medical School and gastroenterologist at M Health Fairview. In this multicentered, national prospective study, 301 FMTs were performed in 269 patients. Two-thirds of the procedures were capsule FMT. CDI cure rates were 86% at one month and 81% at two months. There was no difference in the one-month or two-month cure rate between capsule and colonoscopic FMT. While highly effective overall, the research team says patient selection is a key factor to optimizing FMT success. Older age, hemodialysis and post-FMT antibiotics were associated with lower cure rates. Further research is suggested to identify patients that do not have a successful FMT and understand why they don’t respond to the therapy. This work was supported by Achieving Cures Together, a nonprofit organization dedicated to advancing microbiome-based research. ### About the University of Minnesota Medical SchoolThe University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and educating the next generation of physicians. Our graduates and faculty produce high-impact biomedical research and advance the practice of medicine. We acknowledge that the U of M Medical School, both the Twin Cities campus and Duluth campus, is located on traditional, ancestral and contemporary lands of the Dakota and the Ojibwe, and scores of other Indigenous people, and we affirm our commitment to tribal communities and their sovereignty as we seek to improve and strengthen our relations with tribal nations. For more information about the U of M Medical School, please visit med.umn.edu.

The gut microbiota (GM) has been recognized as an important factor in the development of metabolic diseases such as obesity; it has been reported that the composition of the GM differs in obese ...