FMT

Fecal microbiota transplantation (FMT) is an emerging and effective therapy for the treatment of inflammatory bowel disease (IBD). Previous studies have reported that compared with FMT, whole intestinal microbiota transplantation (WIMT) can more precisely replicate the community structure and reduce …

Clostridioides difficile is a gram-positive, spore-forming, obligate anaerobe that infects the colon. C. difficile is estimated to cause nearly half a million cases in the United States annually, with about 29,000 associated deaths. Unfortunately, the current antibiotic treatment is no …

In this post, we ask whether dietary interventions, prebiotics, probiotics and medication that target the microbiome are useful for weight management.

The 11th Gut Microbiota for Health World Summit focused on emerging gut microbiome-targeted treatments in digestive, immune and cardiometabolic health. This post highlights the major take-aways from the conference and explores how they might impact clinical practice in the foreseeable future.

it is noted that FMT favors the response of melanoma to immunotherapy, translated into significant clinical benefit. However, further studies are necessary for the complete elucidation of the bacteria and the mechanisms involved, as well as for the translation of new evidence to oncological care pra …

Last week at IMMUNOLOGY2023, the 106th annual meeting hosted by The American Association of Immunologists, our computational modeling partner, The NIMML…

ICYMI! 📢📢📢This CE webinar on C. difficile and Microbiome Restoration with @kristadgens and @anniejayTX is still available! Check it out!https://t.co/GsmED4Mqt3#Cdiff #CDI #IDTWitter #TwitteRx pic.twitter.com/fHIAq55rsO— SIDP (@SIDPharm) May 23, 2023

Antimicrobial resistance (AMR) is one of the greatest challenges facing humanity, causing a substantial burden to the global healthcare system. AMR in Gram-negative organisms is particularly concerning due to a dramatic rise in infections caused by extended-spectrum beta-lactamase and carbapenemase- …

Alzheimer's disease (AD) is the most common neurodegenerative disease, yet it currently lacks effective treatment due to its complex etiology. The pathological changes in AD have been linked to the neurotoxic immune responses following aggregation of Aβ and phosphorylated tau. The gut microbiota (GM …

RBX2660 showed similar efficacy and safety in treating patients with and without immunocompromised conditions.

/PRNewswire/ -- Prior to Ferring Pharmaceuticals' Rebyota, physicians interested in using fecal microbiota transplants (FMT) to treat patients with recurrent...

📢 Hiring now!We're expanding our 5-year IBD microbial manipulation research program in Adelaide🥦💩🦠✅Post-doc scientist ✅ Trial coordinator#microbiome #Diet #IBD #FMTEnquires to A/Prof Rob Bryant @RobVBryant or Dr Alice Day @Alice_APD https://t.co/Q5UEbBXSF3 pic.twitter.com/U1bjmZpix7— Dr Alice Day (@Alice_APD) May 23, 2023

Fecal microbiota transplants are the most effective and affordable treatment for recurrent infections with Clostridioides difficile, an opportunistic bacterium and the most common cause of hospital-acquired intestinal infections. However, attempts to treat chronic noncommunicable diseases such as ulcerative colitis and metabolic syndrome via fecal microbiota transplantation (FMT) have yielded mixed results.

While clinical trials may be most closely associated with cancer research, two experts with Sanford Health say the impacts are far more widespread in the medical field.

The researcher discusses the findings in a new study on the efficacy and safety of fecal microbiota (REBYOTA™), the first microbiota-based live biotherapeutic

In this limited series, efficacy of FMT in pediatric SOT is comparable to efficacy in the general pediatric recurrent CDI population. There may be an increased risk of procedure-related SAE in SOT patients and larger cohort studies are needed.

Live fecal microbiota oral capsules (Vowst) for prevention of CDI recurrence

On the brink of innovative science and biotechnology, Seres Therapeutics, Inc. (NASDAQ:MCRB) is a company that is making waves. With

“We want to develop a fecal microbial transplantation (FMT)-based treatment in the form of an oral capsule with a defined set of purely cultivated microbes to address the downfalls of FMT,” said the winner of the proof-of-concept study at a microbiome conference.Korea Biomedical Review (KBR) spoke w

In this limited series, efficacy of FMT in pediatric SOT is comparable to efficacy in the general pediatric recurrent CDI population. There may be an increased risk of procedure-related SAE in SOT patients and larger cohort studies are needed.

There were no differences in the number of relapses between the study groups at the 12-mo follow-up. Thus, our results do not support the use of a single-dose FMT for the maintenance of remission in UC.

A crypt autochthonous microbial population called crypt-associated microbiota (CAM) is localized intimately with gut regenerative and immune machinery. The present report utilizes laser capture microdissection coupled with 16S amplicon sequencing to characterize the CAM in patients with ulcerative c …

Immune checkpoint inhibitors (ICIs) have improved the prognosis in multiple cancer types. However, ICIs can induce immune-related adverse events such as immune-mediated enterocolitis (IMC). The gut microbiota may be implicated in IMC development. Therefore, we investigated fecal microbiota transplan …

“We've shipped 1,630+ investigational #FMT preparations this year for recurrent C. difficile infections that fail standard of care. Learn more about accessing #FMT: https://t.co/GmfNLeOGSB #cdiff #FecalMicrobiotaTransplantation #microbiome #guthealth”

Fecal microbiota transplantation (FMT) is recommended for the prevention of recurrent Clostridioides difficile infection (CDI).1 Randomized trials have reported promising efficacy and safety among patients treated with FMT following standard of care (SOC) CDI antibiotics compared with SOC CDI antibiotics alone. However, these trials are small, with methodological limitations.2 Potential adverse events, especially in immunocompromised patients, highlight the importance of ensuring continued data collection on clinical outcomes.

Great news that all #MultipleSclerosis patients should know about. Hopefully #FMT is available in #Auspol & #doctors start making it available to patients quickly. #MS #health https://t.co/vDAz4NVz9w— Muzzpol (@Muzzpol) May 21, 2023

Depression is the most prevalent mental disorder in the world associated with huge socio-economic consequences. While depressive-related symptoms are well known, the molecular mechanisms underlying disease pathophysiology and progression remain largely unknown. The gut microbiota (GM) is emerging as …

Taken together, we demonstrated that dysbiosis of gut microbiota suppressed NMNAT2 expression, thus exacerbating neurobehavioral deficits and oxidative stress response in 6-OHDA-lesioned rats, which could be rescued by FMT or NMNAT2 restoration.

In summary, our study provides comprehensive evidence for the role of FMT in the treatment of T2D. FMT has the potential to become a promising strategy for the treatment of metabolic disorders, T2D, and diabetes-related complications.