FMT

Immune checkpoint inhibitors (ICIs) have improved the prognosis in multiple cancer types. However, ICIs can induce immune-related adverse events such as immune-mediated enterocolitis (IMC). The gut microbiota may be implicated in IMC development. Therefore, we investigated fecal microbiota transplan …

“We've shipped 1,630+ investigational #FMT preparations this year for recurrent C. difficile infections that fail standard of care. Learn more about accessing #FMT: https://t.co/GmfNLeOGSB #cdiff #FecalMicrobiotaTransplantation #microbiome #guthealth”

Fecal microbiota transplantation (FMT) is recommended for the prevention of recurrent Clostridioides difficile infection (CDI).1 Randomized trials have reported promising efficacy and safety among patients treated with FMT following standard of care (SOC) CDI antibiotics compared with SOC CDI antibiotics alone. However, these trials are small, with methodological limitations.2 Potential adverse events, especially in immunocompromised patients, highlight the importance of ensuring continued data collection on clinical outcomes.

Great news that all #MultipleSclerosis patients should know about. Hopefully #FMT is available in #Auspol & #doctors start making it available to patients quickly. #MS #health https://t.co/vDAz4NVz9w— Muzzpol (@Muzzpol) May 21, 2023

Depression is the most prevalent mental disorder in the world associated with huge socio-economic consequences. While depressive-related symptoms are well known, the molecular mechanisms underlying disease pathophysiology and progression remain largely unknown. The gut microbiota (GM) is emerging as …

Taken together, we demonstrated that dysbiosis of gut microbiota suppressed NMNAT2 expression, thus exacerbating neurobehavioral deficits and oxidative stress response in 6-OHDA-lesioned rats, which could be rescued by FMT or NMNAT2 restoration.

In summary, our study provides comprehensive evidence for the role of FMT in the treatment of T2D. FMT has the potential to become a promising strategy for the treatment of metabolic disorders, T2D, and diabetes-related complications.

Increasing evidence has shown that gut dysbacteriosis may play a crucial role in neuroinflammation in Parkinson's disease (PD). However, the specific mechanisms that link gut microbiota to PD remain unexplored. Given the critical roles of blood-brain barrier (BBB) dysfunction and mitochondrial dysfu …

Fecal microbiome transplants (FMT) offer a clinical cure for antibiotic-resistant therapies. However, the industry is focused on developing cultured microbiome strains, said a regulatory expert fro...

Yadav et al. apply a multiomics approach to study the effects of FMT from obese patients, pre- and post-RYGB surgery, into germ-free mice and show that the post-surgery stool improves host metabolism, with concomitant changes in microbiota composition and metabolomic differences compared with pre-surgery FMT mice.

Director Saffron Cassaday on why she made the documentary, Designer Shit, and how chronic illnesses and FMT aren't always taken as seriously as they should be.#designershit #FMT #chronicillness #documentary pic.twitter.com/jio3ubXyCk— Designer Shit (@Designer_Shit_) May 17, 2023

#Fecal microbiota #transplantation (#FMT) has achieved satisfactory results in preventing the recurrence of Clostridioides difficile infection, but these positive outcomes have only been partially replicated in other diseases.The application of cutting-…https://t.co/wPqMEXLBd0— Erwin Loh (@erwinloh) May 16, 2023

CHICAGO — In a Healio video exclusive, Glenn S. Tillotson, MSc, PhD, discusses the safety and sustained efficacy of Rebyota at 6 months for recurrent Clostridioides difficile infection in patients with immunocompromising conditions. “One thing we need to remember about this population is that they are often on antibiotics for other infections and conditions that suppress their immune

New findings from clinical trials reveal that Rebyota, a rectally administered treatment, demonstrates improved outcomes in patients with recurrent Clostridioides difficile infection (rCDI).

Fecal microbiota transplantation is an innovative approach to treat diseases where there is a relation between pathology and changes in gut microbiota composition.

NEJM Journal Watch reviews over 250 scientific and medical journals to present important clinical research findings and insightful commentary

TUESDAY, May 16, 2023 (HealthDay News) -- For immunocompetent adults with recurrent Clostridioides difficile infection (rCDI), fecal microbiota transplantation (FMT) yields a significant increase in resolution compared with alternative treatments,

Immune checkpoint blockade (ICB) has emerged as a promising immunotherapeutic approach for the treatment of various tumors. However, the efficacy of this therapy is limited in a subset of patients, and it is important to develop strategies to enhance immune responses. Studies have demonstrated a cri …

Inflammatory bowel diseases represent a complex array of diseases of incompletely known etiology that led to gastrointestinal tract chronic inflammation. In inflammatory bowel disease, a promising method of treatment is represented by fecal microbiota transplantation (FMT), FMT has shown its increas …

Alzheimer's disease (AD) is a degenerative disease of the central nervous system. The pathogenesis of AD has been explained using cholinergic, β-amyloid toxicity, tau protein hyperphosphorylation, and oxidative stress theories. However, an effective treatment method has not been developed. In recent …

Aging shows itself not just at the cellular level, with shortened telomeres and cell cycle arrest, but also at the organ and organismal level, with diminished brainpower, dry eyes, intestinal inflammation, muscular atrophy, wrinkles, etc. When the gut microbiota, often called the "virtual organ of t …

Antibiotics are double-edged swords. Although antibiotics are used to inhibit pathogenic bacteria, they also run the risk of destroying some of the healthy bacteria in our bodies. We examined the effect of penicillin on the organism through a microarray dataset, after which 12 genes related to immun …

In Germany, FMT is used less frequently than in the European comparison. One application hurdle is the regulatory classification of FMT as a non-approved drug, which leads to significantly higher costs in manufacturing and administration and makes reimbursement difficult. The European Commission rec …

Take a look at 6 of the top biotech companies working on the development of gut microbiome therapies to treat a range of diseases.

Fecal microbiota transplants are the most effective and affordable treatment for recurrent infections with Clostridioides difficile, an opportunistic bacterium and the most common cause of hospital-acquired intestinal infections. However, attempts to treat chronic noncommunicable diseases such as ulcerative colitis and metabolic syndrome via fecal microbiota transplantation (FMT) have yielded mixed results.

Porcari and colleagues review the key factors that influence FMT success, including those related to donors and recipients, working protocols, and mechanisms of microbiome engraftment. Moreover, the authors advocate for a closer interaction between microbiome scientists and clinicians to advance the field of therapeutic microbiome modulation.

Research of the gut microbiota allows a better understanding of its composition and function and reveals the links between changes in the composition of bacteria and various intestinal but also systemic diseases. The gut microbiota performs several of important functions in the host body and influen …