Slowing Early-Stage ALS With Microbiota Transplantations - Neuroscience News
Fecal microbiota transplantation from healthy individuals can help slow the progression of early ALS by altering a patient's microbiome and intervening in the inflammation process.
Ferring to Present Analyses of Data for REBYOTA™ (fecal microbiota, live – jslm), the First FDA-Approved Microbiome-Based Treatment for the Prevention of Recurrent C. difficile Infection, at DDW 2023
Ferring Pharmaceuticals today announced it will present analyses of data for REBYOTA™ (fecal microbiota, live – jslm) at Digestive Disease Week® (DDW 2023). The congress will take place May 6-9, 2023, in
Stool Biobank Project by the International Society of Microbiota: Call for Collaboration
The International Society of Microbiota is calling for a new project on Stool & Microbiota Bank Services. The International Society of Microbiota (ISM) is currently looking for stool storage facility or biobank service for screened and processed stool sample in academics, research institutes, hospitals or industries.
Microbiota-gut-brain axis and related therapeutics in Alzheimer's disease: prospects for multitherapy and inflammation control - PubMed
Alzheimer's disease (AD) is the most common type of dementia in the elderly and causes neurodegeneration, leading to memory loss, behavioral disorder, and psychiatric impairment. One potential mechanism contributing to the pathogenesis of AD may be the imbalance in gut microbiota, local and systemic …
Dry alginate beads for fecal microbiota transplantation: from model strains to fecal samples - PubMed
Clostridioides difficile infection (CDI) is a critical nosocomial infection with more than 124,000 cases per year in Europe and a mortality rate of 15-17%. The standard of care (SoC) is antibiotic treatment. Unfortunately, the relapse rate is high (∼35%) and SoC is significantly less effective again …
Restoring Balance with Advanced Fecal Microbiota Transplantation in C difficile Infections
Dr Paul Feuerstadt joins Dr David Hudesmand and Dr Jordan Axelrad in a discussion about treatment approaches for C difficile infections, and the latest advances in treating recurrent infections with fecal microbiota transplantation.
Fecal Microbiota Transplant (FMT) is a procedure in which healthy colon contents of a carefully screened donor is inserted into the colon of a compromised patient. FMT is a procedure to replace beneficial bacteria that has been killed or suppressed, most commonly by use of antibiotics. Currently it is utilized as an experimental treatment for Clostridium difficile infection (CDI). This procedure is predicted to reduce the cost both financially and physically for the CDI patient and facility. (Sourced from: https://clinicaltrials.gov/ct2/show/NCT04090346)
Crohn's disease is a life-long idiopathic inflammatory disease which affects the entire gastrointestinal tract and occasionally extra-intestinal organs. CD is thought to result from complex interactions between environmental factors, the gut microbes, and the genetic background and the immune system …
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: antibiotics, probiotics or faecal microbiota transplantation? - PubMed
Ageing and physiological functions of the human body are inversely proportional to each other. The gut microbiota and host immune system co-evolve from infants to the elderly. Ageing is accompanied by a decline in gut microbial diversity, immunity and metabolism, which increases susceptibility to in …
Efficacy of faecal microbiota transplantation in patients with progressive supranuclear palsy-Richardson's syndrome: a phase 2, single centre, randomised clinical trial - PubMed
The National Natural Science Foundation of China (No. 82122022, 82171248, 81873791, and 82230084), Natural Science Foundation of Henan Province for Excellent Young Scholars (no. 202300410357), and Henan Province Young and Middle-Aged Health Science and Technology Innovation Talent Project (YXKC20200 …
Fecal Microbiota Transplantation as a Cancer Therapeutic - PubMed
For decades, cancer research and treatment focused on the cellular level, viewing cancer as a genetic disease of cell transformation. In the era of chemotherapy and radiotherapy, studies from the second half of the 19th century suggesting an association between the microbiota and cancer were almost …
Great to see Laura Martinez-Gili @ImperialMDR @IHepatology speaking today at #ECCMID23, discussing our work on #FMT #IMT and #metabolomics in #CDI and beyond @EurFmt @BugsImperial @NPCUK1 @ImperialBRC pic.twitter.com/DhWZhDFJXU— Ben Mullish (@bhmullish) April 16, 2023
The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)
Myalgic encephalomyelitis (ME) or Chronic Fatigue Syndrome (CFS) is a neglected, debilitating multi-systemic disease without diagnostic marker or therapy. Despite evidence for neurological, immunological, infectious, muscular and endocrine pathophysiological ...
Over 40% of healthy mums preparing for fecal transplant to C-section babies found to carry potentially harmful pathogens
A randomised trial assessing whether the oral transfer of gut microbiota from mother to baby can safely restore normal microbiota after caesarean section (C-section) has found that over 42% of healthy mothers tested positive for potentially harmful pathogens and were unable to proceed with the transplant. The new research by Dr Otto Helve from Helsinki University Hospital and the Finnish Institute of Health and Welfare and colleagues, being presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Copenhagen, Denmark (15-18 April) underscores the importance of screening faecal, perineal and vaginal samples to ensure safety of the transplant process.
Design and manufacture of a lyophilised faecal microbiota capsule formulation to GMP standards
Faecal microbiota transplant (FMT) is an established and effective treatment for recurrent Clostridioides difficile infection (CDI) and has many other…
Fecal Microbiota Transplantation Across the Lifespan:... : Official journal of the American College of Gastroenterology | ACG
en and adults. Although complications of FMT have been reported, it is generally believed to be a safe procedure. Novel indications for FMT are being studied, with the hope that ultimately it may be useful for a variety of disorders. As this field continues to grow, however, it is necessary to consider efficacy, safety, and innovation across the lifespan. There are unique concerns regarding FMT as it pertains to children, adults, and the elderly. In this review, we seek to update clinicians, researchers, and regulators on how these factors must be balanced across the lifespan as we move forward with this innovative therapy....
Is faeces the new brown gold? An interesting talk about the possibilities of faecal microbiota transplantation. #nvmm #fmt #microbiota #microbiology pic.twitter.com/Zol5EaNxg4— Yara Bachour (@yara_bachour) April 4, 2023
Could fecal microbiota transplants cure chronic illnesses?
The Invisible Extinction explores the burgeoning new science of fecal microbiota transplants and how it can help those suffering from chronic illnesses
Gut microbiota and its metabolites in depression: from pathogenesis to treatment
Major depressive disorder is one of the most disabling mental disorders worldwide. Increasing preclinical and clinical studies have highlighted that c…
Future indications and clinical management for fecal microbiota transplantation (FMT) in immuno-oncology - PubMed
The gut microbiota has rapidly emerged as one of the "hallmarks of cancers" and a key contributor to cancer immunotherapy. Metagenomics profiling has established the link between microbiota compositions and immune checkpoint inhibitors response and toxicity, while murine experiments demonstrating th …
