FMT

Fecal microbiota transplant (FMT) is a promising option for patients struggling with CDI recurrences. But how can we ensure the treatment is successful?

Our study provides new data to support the multiple benefits of FMT in the case of COVID-19 and CD co-infection by improving patients' quality of life and inflammatory syndrome.

Thought provoking talk by @IlievLab on #fungi in #IBD… I was intrigued by the idea that #FMT with higher #candida had better engraphment #yeast #gut #immunology #CCCongress23 pic.twitter.com/bW6GnhONcM— Mindy Engevik (@micromindy) January 20, 2023

Did you know that a recent study showed that FMT (fecal microbiota transplant) has the potential to significantly alter the serum levels of neurotransmitters, including serotonin, GABA, and dopamine? Fascinating! #FMT #Neurotransmitter #Serotonin #GABA #Dopamine #ASD #Autism pic.twitter.com/jrWcBGr03o— Novel Biome (@NovelBiome) January 19, 2023

Tomorrow our host @drjamesmcilroy starts a new series of solo podcast episodes, titled BiomeBites, focussed on exploring topics that frequently come up on Inside Matters. Tune in to episode 001 to learn more about intestinal microbiota transfer, also known as IMT or #FMT pic.twitter.com/2SsKvAfi5F— Inside Matters Podcast (@_insidematters) January 18, 2023

en and adults. Although complications of FMT have been reported, it is generally felt to be a safe procedure. Novel indications for FMT are being studied, with the hope that ultimately it may be useful for a variety of disorders. As this field continues to grow, however, it is necessary to consider efficacy, safety, and innovation across the lifespan. There are unique concerns regarding FMT as it pertains to children, adults, and the elderly. In this review, we seek to update clinicians, researchers, and regulators on how these factors must be balanced across the lifespan as we move forward with this innovative therapy. Fecal microbiota transplantation (FMT) is a rapidly growing therapy aimed at reconstituting the dysbiotic microbiota of a patient with the beneficial stool microbiota of a healthy individual. The efficacy rates of FMT are very robust for recurrent Clostridioides difficile infection in both children and adults. Although complications of FMT have been reported, it is generally felt to be a safe procedure. Novel indications for FMT are being studied, with the hope that ultimately it may be useful for a variety of disorders. As this field continues to grow, however, it is necessary to consider efficacy, safety, and innovation across the lifespan. There are unique concerns regarding FMT as it pertains to children, adults, and the elderly. In this review, we seek to update clinicians, researchers, and regulators on how these factors must be balanced across the lifespan as we move forward with this innovative therapy. © 2022 by The American College of Gastroenterology...

Fecal microbiota transplantation (FMT) is known to be an effective treatment for recurrent Clostridioides difficile infection. New research reveals why.

Antibiotic-mediated microbiota destruction and the consequent loss of colonization resistance can result in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients. Clearance of VRE ...

Objectives Perturbations of the intestinal microbiota have been associated with mental health disorders, including major depressive disorder (MDD). Therefore, f...

Changes in critical immune markers were found in recurrent CDI patients with successful fecal microbiota transplantation (#FMT).https://t.co/2GqCF3hWFm— Contagion (@Contagion_Live) January 16, 2023

In patients with first or second C difficile infection, first-line faecal microbiota transplantation is highly effective and superior to the standard of care vancomycin alone in achieving sustained resolution from C difficile.

Following Therapeutic Goods Administration approval of its first-generation donor-derived microbiome-based therapy, Biomictra, for recurrent Clostridioides difficile infection, Australia’s Biomebank is scaling up to meet increasing global demand for fecal microbiota products and is developing a more scalable second-generation synthetic product.

OpenBiome Webinar On December 14, 2022, the OpenBiome team held a live webinar to discuss a new FDA guidance governing the use of FMT and approval of REBYOTA™. A video of the webinar, key takeaways, and FAQ are shared below. Key Takeaways The U.S. FDA recently announced final guidance for the use of FMT in…

The global fecal transplant therapy market is estimated to grow significantly in the coming years owing to increasing awareness about this procedure

Clostridium difficile is a gram-positive, spore-forming, bacterium that is mainly caused by recent hospitalizations, advanced age, or antibiotic treatments.

What’s the cost of an FMT? 💰881 € per unit.Cost decreases with scale. Thank you, @EdKuijper2 @jvanprehn @R_Rajasingham @FfitzP @IDMathModeler and others, for your insights into EarlyFMT and #CDI. Important points. #FMT @LancetGastroHep More here:https://t.co/SJRx0KT8Jo pic.twitter.com/pho1SYSWcJ— Simon MD Baunwall (@SMDBaunwall) January 11, 2023

Characterized by the presence of amyloid plaques, neurofibrillary tangles and neuroinflammation, Alzheimer's disease (AD) is a progressive neurodegenerative disorder with no known treatment or cure. Global disease projections warrant an urgent and rapid therapeutic for the treatment of this devastat …

Clostridioides difficile infection in intestinal transplantation: The quest for better outcomes continues

Faecal microbiota transplantation for first and second episodes of Clostridioides difficile infection - Authors' reply

Faecal microbiota transplantation for first and second episodes of Clostridioides difficile infection

Faecal microbiota transplantation for first and second episodes of Clostridioides difficile infection

Restoration of multiple secondary BA levels, including BA epimers implicated in immunoregulation, are associated with restoration of fecal baiE gene counts, suggesting that the 7-α-dehydroxylation step is rate-limiting.

CDI hospitalization in post-intestine transplant patients occurs commonly and is associated with a longer length of stay and higher costs during hospitalization. The CDI was the most common cause of readmission after the index admission of CDI in these patients.

Simon Baunwall and colleagues1 report a randomised, placebo-controlled trial of encapsulated faecal microbiota transplantation in patients with a first or second occurrence of Clostridioides difficile infection, following treatment with vancomycin. Existing guidelines allow consideration of faecal microbiota transplantation as an adjunct to antimicrobials in patients at first recurrence of C difficile infection if they are deemed to have a high risk of recurrence.2 However, Baunwall and colleagues' study raises questions as to whether all patients with C difficile infection could benefit from faecal microbiota transplantation.

Corrigendum to: Efficacy and Outcomes of Faecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection in Children with Inflammatory Bowel Disease

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease. Not only genetics, but the intestinal environment affected by gut microbiota is also the key to...

Major players in the microbiome market are MicroBiome Therapeutics LLC., Seres Therapeutics, Enterome Bioscience, Second Genome.......@ @ https://t.co/s3iAWrRQCu#Fecal #Microbiota #FMT #Drugs #Inflammatory #BowelDisease pic.twitter.com/KZ5jO67yH2— ramacharitbrc (@ramacharitbrc) January 6, 2023

Earlier is the leitmotif of a study reported in The Lancet Gastroenterology & Hepatology by Simon Baunwall and colleagues.1 High clinical efficacy and superiority of faecal microbiota transplantation was observed compared with the standard of care, vancomycin, administered for the first or second Clostridioides difficile infection episode, instead of after the recommended multiple recurrences.2 Due to a significantly lower rate of resolution in the placebo group, the trial was terminated before the designated number of patients was enrolled.

Dr. Martin Blaser and Dr. Gloria Dominguez-Bello talk to PEOPLE about their quest to save the human microbiome — before it's too late

Fecal microbiota transplantation 6 months before bariatric surgery did not reduce body weight in a small cohort of patients with obesity in Finland, according to study results published in JAMA Network Open. “The intestinal microbiota has aroused interest as a potential target for the treatment of obesity,” Perttu Lahtinen, MD, of the department of gastroenterology at