FMT

Based on the findings from this large US multi-center cohort, the efficacy of FMT for the treatment of rCDI did not differ in children with IBD. Failed FMT among children with IBD was possibly related to the presence of clinically active IBD.

Clostridioides difficile infection (CDI) is the most common cause of antibiotic-associated diarrhea and has high rates of recurrent disease. As a disease associated with intestinal dysbiosis, gastrointestinal microbiome manipulation and fecal microbiota transplantation (FMT) have evolved as effectiv …

An investigation into a naturopath who claims he can treat autism using pills and enemas made from feces has expanded significantly, according to new documents filed in B.C. Supreme Court.

Dr. Cathy Williams knew something wasn’t right. The veterinarian had felt off for weeks after her 2014 trip to Madagascar. At first she just felt bloated

This article is part of Football League World’s ‘The Verdict’ series, which provides personal opinions from the FLW writers regarding the latest breaking news…

VF: virulence factors, HE: hepatic encephalopathy, FMT: Fecal microbiota transplant, PPI: proton pump inhibitors, LPS: lipopolysaccharides, VFDB: Virulence factor database, OTU: operational taxonomic units, SBP: spontaneous bacterial peritonitis, UTI: urinary tract infections, MRSA: methicillin resi …

Fecal microbiota transplantation (FMT) is a new and adequate route to modify the microbial ecosystem in gastrointestinal tract of the hosts. Intestina…

Looking to meet like-minded researchers with an interest in FMT? Got questions about your own FMT project or think you might be able to help others getting started in this area? Join us at our first virtual catch-up for FMT researchers! Date: Wednesday, December 8 Time: 3pm Format: Dr Hannah Wardill, senior author of the GRAFT guidelines will be telling us all about these awesome FMT guidelines, which we’ll use to spark some discussion on any points of interest. It will be a very informal affair - just bring yourself and your questions!

More research needed to determine impact on clinical outcomes versus standard of care

RT @MsSiciliaP: Day 2 of #apccmi2021. This was pretty interesting! Clinical symptoms of patient with relapsing #cdiff infection and #SARS_C…

Our study confirms excellent efficacy rates of FMT in the treatment of recurrent CDI. In addition, this study shows that it is possible to avoid short term SAE when FMT is administered via a nasoenteric tube by following a very stringent peri-procedural patient follow-up protocol. Our study also dem …

Background and Aims: Many studies have shown a high effectiveness of fecal microbiota transplantation (FMT) in treatment of recurrent or refractory Clostridioides difficile infection (CDI). Nevertheless, data on long term outcomes and complications after FMT are still lacking. We aimed to evaluate the efficacy, the peri- procedural safety profile and the long-term efficacy and safety of FMT for recurrent CDI during a median follow up period of 24 months. Methods: Our study included 60 consecutive patients that were treated from 2015 to 2019 for recurrent CDI. In all patients FMT was performed through the nasoenteric tube placed during gastroscopy. Fresh donor feces were used for FMT from unrelated donors. Pre-FMT preparation included CDI treatment with oral vancomycin 500 mg q.i.d. for at least five days and proton pump inhibitor (PPI) administration before FMT. Follow up data included information about recurrent CDI episodes, early and late complications, health status at 3, 12 and 24 months after FMT. Results: FMT was performed for 60 patients (median age 72.5 years) with recurrent CDI. Clinical improvement after the first FMT procedure was observed in 48 patients (80%). Ten of 12 initially non-responding patients had a clinical resolution after a second FMT leading to an increased overall cure rate of 96.7 %. The remaining two patients needed a third FMT with a final overall cure rate of 100%. Nine of 60 patients were under immunosuppressive therapy. Six immunosuppressed patients were in the group of initial responders and the remaining three in the initially non-responder group. We observed a very low rate of adverse events in the short and long-term after FMT. During the first eight weeks after the FMT procedure, the death of three patients occurred, but they were not related to the FMT procedure. Patients were followed up for a median of 20 months, with the range from 12 to 55 months. During the follow-up period no long-term serious adverse events (SAE) were documented. Conclusions: Our study confirms excellent efficacy rates of FMT in the treatment of recurrent CDI. In addition, this study shows that it is possible to avoid short term SAE when FMT is administered via a nasoenteric tube by following a very stringent peri-procedural patient follow-up protocol. Our study also demonstrates good safety with a low rate of long-term adverse events after FMT.

Fecal microbiota transplantation recipients did gain weight following the procedure.

Autism spectrum disorder (ASD) is a severe brain development disorder that is characterized by deficits in social communication and restricted, repetitive and stereotyped behaviors. Accumulating evidence has suggested that gut microbiota disorders play important roles in gastrointestinal symptoms and neurodevelopmental dysfunction in ASD patients. Manipulation of the gut microbiota by fecal microbiota transplantation (FMT) was recently shown to be a promising therapy for the treatment of various diseases. Here, we performed a clinical trial to evaluate the effect of FMT on gastrointestinal (GI) and ASD symptoms and gut microbiota alterations in children with ASD. We found that there was a large difference in baseline characteristics of behavior, GI symptoms, and gut microbiota between children with ASD and typically developing (TD) control children. FMT could improve GI symptoms and ASD symptoms without inducing any severe complications. Similarly, FMT significantly changed the serum levels of neurotransmitters. We further observed that FMT could promote the colonization of donor microbes and shift the bacterial community of children with ASD toward that of TD controls. The abundance of Eubacterium coprostanoligenes pre-FMT was positively correlated with high GSRS scores, whereas a decrease in Eubacterium coprostanoligenes abundance induced by FMT was associated with the FMT response. Our data suggest that FMT might be a promising therapeutic strategy to improve the GI and...

Fantastic transplant infectious diseases session @FISConf #FIS21, with excellent talk from @rohmaghani and @DrFrancesDavies on work on #FMT in those with intestinal #MDRO #AMR @BRCinfection @IHepatology @ImperialMDR pic.twitter.com/dpzt39mJdO— Ben Mullish (@bhmullish) November 8, 2021

The facts and fiction about faecal transplants.

Our understanding of the microbiome and its implications for human health and disease continues to develop. Fecal microbiota transplantation (FMT) is now an established treatment for recurrent Clostr...

Free Gastro/Hep learning/teaching tool Check Case 10

Hi there! At our last event there seemed to be interest in a meet-up for researchers with a shared interest in FMT. We're keen to find out more about what you want from this kind of event, so we can make it happen!

The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain p…

In a study published in Nature Microbiology, researchers @IcahnMountSinai address unanswered questions about how fecal microbiota transplantation (#FMT) can effectively restore a patient’s microbiome: https://t.co/Z0WaxL4qYK pic.twitter.com/gDqfnexCcI— Icahn School of Medicine at Mount Sinai (@IcahnMountSinai) October 14, 2021

@CDCgov my success post #fecaltransplant is 99%. In fact since the creation of @Progenabiome I am able to assess implantation success and follow patient’s microbiome so my death rate from #cdiff is ZERO. Tune in tomorrow for my talk @cdiffFoundation . #berigtheous #bebrave https://t.co/NvUYWzhcXB— sabine hazan md (@SabinehazanMD) November 4, 2021

Our understanding of the microbiome and its implications for human health and disease continues to develop. Fecal microbiota transplantation (FMT) is now an established treatment for recurrent Clostridioides difficile infection. There is also increasing evidence for the efficacy of FMT in inducing r …

The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain p…

Recipient background disease was a significant risk factor influencing FMT outcomes. Special attention should be taken when considering FMT for pediatric rCDI patients with underlying co-morbidities.