FMT

The gut microbiota (GM) has been recognized as an important factor in the development of metabolic diseases such as obesity; it has been reported that the composition of the GM differs in obese ...

In this short article @NatRevGastroHep, we discussed one important study which shows sterile fecal filtrate - a refined form of #FMT -is effective in treating GI disease. The gut phages might be one of the explanations…https://t.co/WGYes8w86S— Tao Zuo (@Tao_Zuo_) September 29, 2022

There is still much to learn about the human microbiome and its role in fighting disease, but ongoing studies at Lawson Health Research Institute, including a focus on fecal microbial transplants (FMT), are making strides in harnessing this comple

/PRNewswire/ -- The "Microbiome Therapeutics Market Size, Share & Trends Analysis Report by Type (FMT, Microbiome Drugs), by Application (C. difficile, Crohn's...

Clostridioides difficile (C. difficile) is a gram-positive, anaerobic, spore-forming bacterium that produces toxins A and B, disrupting the intestinal brush border and resulting in severe diarrhea. The most common causes of infection include prolonged antibiotic use, proton pump inhibitors (P …

Dr Lodise summarizes foundational trials that led to the use of fecal microbiota transplant for the treatment of rCDI.

Drs Chopra and Feuerstadt summarize challenges with current treatments and discuss live biotherapeutic products that are being studied for recurrent C difficile infection (rCDI).

An FDA advisory committee recently voted there was adequate data to support the safety and efficacy of fecal microbiota transplant therapy Rebyota for the treatment of adult patients with recurrent Clostridioides difficile infection. Following a full day of discussion and presentations on the epidemiology of C. difficile infection (CDI) in the U.S. and available data on Rebyota (RBX2660,

Fecal transplantation in the intestine is an effective cure—and far superior to today's standard treatment—for a life-threatening infection

A fecal microbiota transplant (FMT) trial was halted early due to clear evidence the treatment was superior to placebo.

Randomized clinical trial shows fecal transplantation can effectively cure patients with C. difficile intestinal infections. ...

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Fecal microbiota transplantation (FMT) is a novel microbiota-based therapeutic method that transfers stool from donor into a recipient and its applica…

Our case report provides preliminary evidence regarding the use of FMT in a patient with Clostridioides difficile and ADHD. We speculate that gut microbiome modulation, in particular the gain or loss of specific microbial species and pathways involving the metabolism of SCFAs, tryptophan and …

Fecal microbiota transplantation (FMT) is a successful method for treating recurrent Clostridioides difficile (C. difficile) infection (rCDI) with around 90% efficacy. Due to the relative simplicity of this approach, it is being widely used and currently, thousands of patients have bee …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may present risk to patients treated with donor-derived microbiome therapies when appropriate manufacturing controls and inactivation processes are lacking. We report that the manufacturing steps for SER-109, a purified investigational mic …

Nature Medicine - Understanding the factors underlying colonization of donor microbes in recipients of fecal microbiota transplantation is a necessary first step to aid development of directed...

“The whole is something besides the parts”, wrote the Greek philosopher Aristotle more than 2000 years ago. Author and gastroenterologist Emeran Mayer (Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA), gives us a renewed appreciation of this phrase in the context of our understanding of the body and the brain. In The Gut-Immune Connection, Mayer takes us back to a holistic way of thinking that accounts for the full complexity of the interconnection between our gut, our mind, and the trillions of microbes that live in our gastrointestinal tract.

Et studie af behandling med fæcestransplantation (FMT) på patienter med særlig tarmsygdom måtte indstilles, da metoden viste sig så effektiv, at det ville være uetisk at fortsætte. 1/7 #fmt #sundpol #dkvid #dksund #dkforsk pic.twitter.com/EEptjF96gt— HealthAU (@HealthAarhusUni) September 26, 2022

Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, many patients fail to respond to this therapy or experience side effects. Recently, gut microbiota have emerged as a key determinant of ICB efficacy and toxicity, making manipulation of the microbiome a novel therapeutic strategy with which to improve ICB outcomes.

Fecal microbiota transplantation (FMT) is a successful method for treating recurrent Clostridioides difficile (C. difficile) infection (rCDI) with around 90% efficacy. Due to the relative simplicity of this approach, it is being widely used and currently, thousands of patients have bee …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may present risk to patients treated with donor-derived microbiome therapies when appropriate manufacturing controls and inactivation processes are lacking. We report that the manufacturing steps for SER-109, a purified investigational mic …

The human gut is a complex microbial ecosystem comprising approximately 100 trillion microbes collectively known as the "gut microbiota". At a rough estimate, the human gut microbiome contains almost 3.3 million genes, which are about 150 times more than the total human genes present in the human ge …

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👍 from @FDA: An advisory board recommended the agency approve a fecal microbiota transfer (FMT) product for recurrent #Cdiff infections. Committee members swayed by strong "need" rather than strong data: https://t.co/TXSej2hp22 #IDTwitter #GITwitter @ingridhein @medpagetoday— MedPage Infectious Disease (@MedPageID) September 24, 2022

Real-world data showed no difference in cure rates at 1 and 2 months

Fecal microbiota transplantation (FMT) is one of the recommended treatments for recurrent Clostridioides difficile infection, but endoscopy and available oral formulations still have several limitations in their preparation, storage, and administration. The need for a viable oral formulation that facilitates the implementation of this highly effective therapy in different settings has led us to test the microcrystalline cellulose particles as an adsorbent of concentrated filtered fresh feces in comparison to lyophilized feces. This free-flowing material can provide protection to bacteria and results in a dried product able to maintain the viability of the microbiota for a long time. Adsorbate formulation showed a stabilizing effect in gut microbiota, maintaining bacteria viability and preserving its diversity, and is a competitive option for lyophilized capsules.

Minnesota: In a prospective trial published in the Journal of Clinical Gastroenterology and Hepatology, fecal microbiota transplantation (FMT) administered through oral capsule or colonic...

In patients with first or second C difficile infection, first-line faecal microbiota transplantation is highly effective and superior to the standard of care vancomycin alone in achieving sustained resolution from C difficile.

Committee members swayed by strong 'need' rather than strong data