FMT

The idea is that FMT will help re-educate the recipient's gut microbiome, induce the gut's re-colonization, and restore microbial diversity. Learn more at https://t.co/muFzfpffur#IBD #IBS #asd #autism #FMT #guthealthmatters #guthealth #cdiff #research #gut #guthealing pic.twitter.com/Ru3fIB7R7P— Novel Biome (@NovelBiome) October 3, 2022

ObjectiveTo evaluate the safety and efficacy of fecal microbiota transplantation for autoimmune diseases and autoinflammatory diseases.MethodsRelevant literature was retrieved from the PubMed database, Embase database, Cochrane Library database, etc. The search period is from the establishment of the database to January 2022. The outcomes include clinical symptoms, improvement in biochemistry, improvement in intestinal microbiota, improvement in the immune system, and adverse events. Literature screening and data extraction were independently carried out by two researchers according to the inclusion and exclusion criteria, and RevMan 5.3 software was used for statistics and analysis.ResultsOverall, a total of 14 randomized controlled trials (RCTs) involving six types of autoimmune diseases were included. The results showed the following. 1) Type 1 diabetes mellitus (T1DM): compared with the autologous fecal microbiota transplantation (FMT) group (control group), the fasting plasma C peptide in the allogenic FMT group at 12 months was lower. 2) Systemic sclerosis: at week 4, compared with one of two placebo controls, three patients in the experimental group reported a major improvement in fecal incontinence. 3) Ulcerative colitis, pediatric ulcerative colitis, and Crohn’s disease: FMT may increase clinical remission, clinical response, and endoscopic remission for patients with ulcerative colitis and increase clinical remission for patients with Crohn’s disease. 4) Psoriati...

Bone Marrow Transplantation - Safety and efficacy of fecal microbiota transplantation in the treatment of graft-versus-host disease

FMT may decrease the mortality of patients with severe and fulminant CDI, and larger studies are needed to validate these findings.

#FMT as a potential double edged sword: improving liver outcomes and AUD/craving outcomes… interesting data coming on this #LiverTwitter @JasmohanBajaj pic.twitter.com/iXcvZqO5nw— Juan Pablo (JP) Arab, MD (@juanpabloarab) October 1, 2022

Danish trial halted early after FMT treatment proved 'so much better' than antibiotics alone

The effect of the gut microbiota on patients' outcomes after allogeneic haematopoietic cell transplantation (HCT) is now well established. In particular, gut microbiota dysbiosis has been associated with acute graft-versus-host disease (GVHD). Furthermore, increasing data also suggest an effect of t …

MINNEAPOLIS/ST. PAUL (09/29/2022) — Recently published in Clinical Gastroenterology and Hepatology, researchers from the University of Minnesota Medical School found that Fecal Microbiota Transplant (FMT) using capsules containing freeze-dried microbes taken orally has similar safety and effectiveness to colonoscopic administration of liquid FMT for treating recurrent Clostridioides difficile infection (CDI). Every year in the United States, approximately 500,000 people develop CDI — which is typically a complication of antibiotics. Antibiotics are also used to treat CDI, which further damage the intestinal microbiota. The U of M research team developed standardized FMT preparations — which are composed of intestinal microbes that can restore a healthy intestinal microbiota. This strategy repairs the damage caused by antibiotics and restores resistance against CDI. “Capsule FMT can avoid complications of colonoscopy and facilitate access to this potentially life-saving therapy,” said Byron Vaughn, MD, MS, associate professor in the Medical School and gastroenterologist at M Health Fairview. In this multicentered, national prospective study, 301 FMTs were performed in 269 patients. Two-thirds of the procedures were capsule FMT. CDI cure rates were 86% at one month and 81% at two months. There was no difference in the one-month or two-month cure rate between capsule and colonoscopic FMT. While highly effective overall, the research team says patient selection is a key factor to optimizing FMT success. Older age, hemodialysis and post-FMT antibiotics were associated with lower cure rates. Further research is suggested to identify patients that do not have a successful FMT and understand why they don’t respond to the therapy. This work was supported by Achieving Cures Together, a nonprofit organization dedicated to advancing microbiome-based research. ### About the University of Minnesota Medical SchoolThe University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and educating the next generation of physicians. Our graduates and faculty produce high-impact biomedical research and advance the practice of medicine. We acknowledge that the U of M Medical School, both the Twin Cities campus and Duluth campus, is located on traditional, ancestral and contemporary lands of the Dakota and the Ojibwe, and scores of other Indigenous people, and we affirm our commitment to tribal communities and their sovereignty as we seek to improve and strengthen our relations with tribal nations. For more information about the U of M Medical School, please visit med.umn.edu.

The gut microbiota (GM) has been recognized as an important factor in the development of metabolic diseases such as obesity; it has been reported that the composition of the GM differs in obese ...

In this short article @NatRevGastroHep, we discussed one important study which shows sterile fecal filtrate - a refined form of #FMT -is effective in treating GI disease. The gut phages might be one of the explanations…https://t.co/WGYes8w86S— Tao Zuo (@Tao_Zuo_) September 29, 2022

There is still much to learn about the human microbiome and its role in fighting disease, but ongoing studies at Lawson Health Research Institute, including a focus on fecal microbial transplants (FMT), are making strides in harnessing this comple

/PRNewswire/ -- The "Microbiome Therapeutics Market Size, Share & Trends Analysis Report by Type (FMT, Microbiome Drugs), by Application (C. difficile, Crohn's...

Clostridioides difficile (C. difficile) is a gram-positive, anaerobic, spore-forming bacterium that produces toxins A and B, disrupting the intestinal brush border and resulting in severe diarrhea. The most common causes of infection include prolonged antibiotic use, proton pump inhibitors (P …

Dr Lodise summarizes foundational trials that led to the use of fecal microbiota transplant for the treatment of rCDI.

Drs Chopra and Feuerstadt summarize challenges with current treatments and discuss live biotherapeutic products that are being studied for recurrent C difficile infection (rCDI).

An FDA advisory committee recently voted there was adequate data to support the safety and efficacy of fecal microbiota transplant therapy Rebyota for the treatment of adult patients with recurrent Clostridioides difficile infection. Following a full day of discussion and presentations on the epidemiology of C. difficile infection (CDI) in the U.S. and available data on Rebyota (RBX2660,

Fecal transplantation in the intestine is an effective cure—and far superior to today's standard treatment—for a life-threatening infection

A fecal microbiota transplant (FMT) trial was halted early due to clear evidence the treatment was superior to placebo.

Randomized clinical trial shows fecal transplantation can effectively cure patients with C. difficile intestinal infections. ...

🎟️ Tickets for our home Continental Cup fixtures are on sale now.🏠 Join us at The Oakwood for our meetings with Bristol City and Crystal Palace.🔴⚪ #cafc— Charlton Athletic Women (@CAFCWomen) September 27, 2022

Fecal microbiota transplantation (FMT) is a novel microbiota-based therapeutic method that transfers stool from donor into a recipient and its applica…

Our case report provides preliminary evidence regarding the use of FMT in a patient with Clostridioides difficile and ADHD. We speculate that gut microbiome modulation, in particular the gain or loss of specific microbial species and pathways involving the metabolism of SCFAs, tryptophan and …

Fecal microbiota transplantation (FMT) is a successful method for treating recurrent Clostridioides difficile (C. difficile) infection (rCDI) with around 90% efficacy. Due to the relative simplicity of this approach, it is being widely used and currently, thousands of patients have bee …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may present risk to patients treated with donor-derived microbiome therapies when appropriate manufacturing controls and inactivation processes are lacking. We report that the manufacturing steps for SER-109, a purified investigational mic …

Nature Medicine - Understanding the factors underlying colonization of donor microbes in recipients of fecal microbiota transplantation is a necessary first step to aid development of directed...

“The whole is something besides the parts”, wrote the Greek philosopher Aristotle more than 2000 years ago. Author and gastroenterologist Emeran Mayer (Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA), gives us a renewed appreciation of this phrase in the context of our understanding of the body and the brain. In The Gut-Immune Connection, Mayer takes us back to a holistic way of thinking that accounts for the full complexity of the interconnection between our gut, our mind, and the trillions of microbes that live in our gastrointestinal tract.

Et studie af behandling med fæcestransplantation (FMT) på patienter med særlig tarmsygdom måtte indstilles, da metoden viste sig så effektiv, at det ville være uetisk at fortsætte. 1/7 #fmt #sundpol #dkvid #dksund #dkforsk pic.twitter.com/EEptjF96gt— HealthAU (@HealthAarhusUni) September 26, 2022

Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, many patients fail to respond to this therapy or experience side effects. Recently, gut microbiota have emerged as a key determinant of ICB efficacy and toxicity, making manipulation of the microbiome a novel therapeutic strategy with which to improve ICB outcomes.

Fecal microbiota transplantation (FMT) is a successful method for treating recurrent Clostridioides difficile (C. difficile) infection (rCDI) with around 90% efficacy. Due to the relative simplicity of this approach, it is being widely used and currently, thousands of patients have bee …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may present risk to patients treated with donor-derived microbiome therapies when appropriate manufacturing controls and inactivation processes are lacking. We report that the manufacturing steps for SER-109, a purified investigational mic …