FMT

The incidence rate of Autism Spectrum Disorder (ASD) diagnosis continues to rise; the US Centers for Disease Control and Prevention reports that the diagnosis of ASD in children today is 1 in 54 compared to 1 in 150 children in 2000

FMT exerted antidepressant effects on CUMS-induced depression in rats, and the mechanism involved various neurotransmitters, inflammatory factors, neurotrophic factors, and glucagon-like peptides.

This randomized clinical trial compares the ability of anaerobically prepared pooled donor vs autologous fecal microbiota transplantation to induce remission in patients with ulcerative colitis (UC).

Faecal microbiota transplant (FMT) is an established and effective treatment for recurrent Clostridioides difficile infection (CDI) and has many other potential clinical applications. However, preparation and quality of FMT is poorly standardised and clinical studies are hampered by a lack of well-d …

Type 1 diabetes mellitus (T1DM) is an autoimmune-mediated disease characterized by a reduced or absolute lack of insulin secretion and often associated with a range of vascular and neurological complications for which there is a lack of effective treatment other than lifestyle interventions and pharmacological treatments such as insulin injections. Studies have shown that the gut microbiota is involved in mediating the onset and development of many fecal and extrafecal diseases, including autoimmune T1DM. In recent years, many cases of gut microbiota transplantation for diseases of the bowel and beyond have been reported worldwide, and this approach has been shown to be safe and effective. Here, we conducted an experimental treatment study in two adolescent patients diagnosed with autoimmune T1DM for one year. Patients received one to three rounds of normal fecal microbiota transplants (FMT) and were followed for up to 30 weeks. Clinical outcomes were measured, including biochemical indices, medication regimen, and dosage adjustment. Fecal microbiota metagenomic sequencing after transplantation provides a reference for more reasonable and effective microbiota transplantation protocols to treat autoimmune T1DM. Our results suggest that FMT is an effective treatment for autoimmune T1DM.Clinical Trial Registrationhttp://www.chictr.org.cn, identifier ChiCTR2100045789.

Nature Reviews Neurology - In this Review, the authors provide detailed insight into how the gut microbiota influences the immune system, with implications for neuroinflammation, and discuss the...

Studies support a positive relationship between behavioural and GI symptoms in patients with ASD. This raises the possibility that an altered gut microbiome might lead to an altered balance of downstream products which may exacerbate ASD symptoms.#FMT #ASD #Autism #guthealth pic.twitter.com/fx5y6USDw0— Novel Biome (@NovelBiome) August 10, 2022

Nature Communications - Steatohepatitis is a chronic hepatic inflammation associated with increased risk of hepatocellular carcinoma progression. Here the authors show that intestinal dysbiosis in...

#Melanoma #FMT Clinical trials are helping us understand and utilize the #microbiome to treat cancer, especially ones that don't usually respond to #immunotherapy pic.twitter.com/rIBQzM2uIZ— Translational Drug Development (TD2) (@TD2_Oncology) August 1, 2022

Dear Doctors: It seems like news about the gut microbiome keeps getting weirder. I just read about a doctor who said the new trend will be each of us storing

Using strain-level microbiota profiling in patients treated with fecal microbiota transplantation (FMT), Podlesny et al. identify a mechanistic framework for post-FMT microbiome assembly that aligns with ecological theory. Donor strain engraftment is dependent on microbiome and clinical parameters, including antibiotic treatment and bowel lavage, independently of the treated disease.

Clostridioides difficile infection (CDI) is a potentially life-threatening cause of diarrhea that can result in multiple complications. Fulminant CDI that is nonresponsive to antibiotics may require surgical ileostomy or fecal microbiota transplant (FMT). We present a case of a patient with f …

Fecal communities transplanted into individuals can eliminate recurrent Clostridioides difficile infection (CDI) with high efficacy. However, this treatment is only used once CDI becomes resistant to antibiotics or has recurred multiple times. We sought to investigate whether a fecal community trans …

This report describes a remarkable case of C. difficile enteritis diagnosed at the time of total abdominal colectomy for C. difficile colitis.

Autism spectrum disorder (ASD) is a neurological and developmental condition that affects how humans communicate, learn new things and behave. Symptoms of ASD can include difficulties in interacting with ...

The human body is home to a variety of micro-organisms. Most of these microbial communities reside in the gut and are referred to as gut microbiota. Over the last decades, compelling evidence showed that a number of human pathologies are associated with microbiota dysbiosis, thereby suggesting that …

Background and Aims: Due to increasing knowledge of the "gut-liver axis", there has been growing interest regarding the use of fecal microbiota transplant in the management of chronic liver disease. There are limited data available and current guidelines are mostly based on expert opinions. W …

The long-term efficacy and possible adverse events of fecal microbiota transplantation (FMT) for irritable bowel syndrome (IBS) are unknown. This stud…

Nature Microbiology - Careful and responsible microbiome management is a critical strategy to counter biodiversity loss, but practical and regulatory hurdles must be addressed to maximize its utility.

Fecal microbiota transplantation (FMT) is a promising treatment for microbiota dysbiosis associated diseases, such as Clostridioides difficile infection (CDI) and inflammatory bowel disease (IBD). ...

Rupert Leong (University of Sydney) discusses a new double-blind, randomised, placebo-controlled trial of oral faecal microbiota transplantation for patients with active ulcerative colitis.Read the full article:Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS)

The present case report describes the effects of orally administered fecal microbiota transplantation (FMT) (frozen capsules) in a dog suffering from relapsing chronic diarrhea, needing a continuous low prednisolone dose to maintain the condition under ...

“RT @EnnalizaS: Dietary manipulation seems to work better in cd than uc but fmt seems to work better in uc than cd. Why? #ibd #fmt #diet #mi…”