FMT

FMT

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@dralicehan @MIDCUSA @SeresTX @Rebiotix @finch_tx @AntibioticDoc @DrToddLee @IdVilchez @DrNickIDPharmD Due to the covid pandemic, the cost of FMTs shot up to closer to 2k here. Decreased availability is another issue (open-biome pulling back in this space
@dralicehan @MIDCUSA @SeresTX @Rebiotix @finch_tx @AntibioticDoc @DrToddLee @IdVilchez @DrNickIDPharmD Due to the covid pandemic, the cost of FMTs shot up to closer to 2k here. Decreased availability is another issue (open-biome pulling back in this space
Due to the covid pandemic, the cost of FMTs shot up to closer to 2k here. Decreased availability is another issue (open-biome pulling back in this space). I would entertain use of #fmt over fidaxomicin for recurrence. #fecalmatters— anand v (@DocViswanathan) June 15, 2022
·twitter.com·
@dralicehan @MIDCUSA @SeresTX @Rebiotix @finch_tx @AntibioticDoc @DrToddLee @IdVilchez @DrNickIDPharmD Due to the covid pandemic, the cost of FMTs shot up to closer to 2k here. Decreased availability is another issue (open-biome pulling back in this space
High Dose Intramuscular Vitamin D3 Supplementation Impacts the Gut Microbiota of Patients With Clostridioides Difficile Infection
High Dose Intramuscular Vitamin D3 Supplementation Impacts the Gut Microbiota of Patients With Clostridioides Difficile Infection
Background and AimCurrent therapeutic strategies for Clostridioides difficile infections (CDI), including oral vancomycin, metronidazole and fecal microbial transplantation, have limited efficacy and treatment failure may occur in as many as one- third of cases. Recent studies have reported that lower concentrations of 25-hydroxyvitamin D are associated with CDI severity and recurrence. However, there have been no studies on microbiota composition after the administration of vitamin D in patients with CDI. Therefore, our study aimed to compare the microbiota composition between the two groups, including eight CDI-positive patients with vitamin D supplementation and ten CDI-positive patients without vitamin D supplementation by using 16S rRNA microbial profiling.MethodsTwenty subjects were enrolled in this prospective randomized controlled study. One subject dropped out due to lack of contact with the guardian after discharge and one subject dropped out due to withdrawal of consent. Thus, 18 patients with CDI and vitamin D insufficiency (vitamin D level 17 ng/mL) were divided into two groups: CDI with vitamin D supplementation (n = 8) and CDI without vitamin D supplementation (control: n = 10). Subjects with vitamin D insufficiency were randomized to receive 200,000 IU intramuscular cholecalciferol whereas patients in the control group received only oral vancomycin. Stool samples were obtained twice before vancomycin was administered and eight weeks after treatment; the V...
·t.co·
High Dose Intramuscular Vitamin D3 Supplementation Impacts the Gut Microbiota of Patients With Clostridioides Difficile Infection
Species- and strain-level assessment using rrn long-amplicons suggests donor’s influence on gut microbial transference via fecal transplants in metabolic syndrome subjects
Species- and strain-level assessment using rrn long-amplicons suggests donor’s influence on gut microbial transference via fecal transplants in metabolic syndrome subjects
Fecal microbiota transplantation (FMT) is currently used for treating Clostridium difficile infection and explored for other clinical applications in experimental trials. However, the effectiveness...
·tandfonline.com·
Species- and strain-level assessment using rrn long-amplicons suggests donor’s influence on gut microbial transference via fecal transplants in metabolic syndrome subjects
Dr Siobhain O'Mahony on Twitter
Dr Siobhain O'Mahony on Twitter
@ElenaLucarini90 presenting her wonderful work on #FMT and #viscerapain pic.twitter.com/fhFeGbTYzQ— Dr Siobhain O'Mahony (@somahony1) June 12, 2022
·twitter.com·
Dr Siobhain O'Mahony on Twitter
Kay - Peggy Lillis Foundation
Kay - Peggy Lillis Foundation
I am a public health dentist and practiced clinical dentistry for nearly 30 years. On January 11, 2022, I underwent periodontal surgery (tooth extraction and socket graft). The periodontist prescribed clindamycin for 6 days. There was no infection present, it was a “prophylactic” protocol to prevent possible infection. I returned …
·peggyfoundation.org·
Kay - Peggy Lillis Foundation
RT @john_damianosMD: What factors⬆️#FMT response in ulcerative colitis? 💩donor: ⬆️diversity, ⬆️ Bacteroides&Clostridia 💩recipient: ⬆️specie…
RT @john_damianosMD: What factors⬆️#FMT response in ulcerative colitis? 💩donor: ⬆️diversity, ⬆️ Bacteroides&Clostridia 💩recipient: ⬆️specie…
What factors⬆️#FMT response in ulcerative colitis?💩donor: ⬆️diversity, ⬆️ Bacteroides&Clostridia💩recipient: ⬆️species richness, ⬆️Candida, ⬆️donor microbial similarity💩clinical: ⬇️age, ⬇️severe disease, ⬇️disease durationhttps://t.co/YRmGH6Qb6M#GITwitter #IBD #microbiome— John Damianos, M.D. (@john_damianosMD) June 4, 2022
·twitter.com·
RT @john_damianosMD: What factors⬆️#FMT response in ulcerative colitis? 💩donor: ⬆️diversity, ⬆️ Bacteroides&Clostridia 💩recipient: ⬆️specie…
Alba Talavera on Twitter
Alba Talavera on Twitter
Don’t miss our poster about fecal microbiota transplantation in HIV at @SEIMC_ #seimc2022 #HIV #FMT #microbiota pic.twitter.com/hgUpGvEXaW— Alba Talavera (@AlbaTalaveraR) June 4, 2022
·twitter.com·
Alba Talavera on Twitter
Helsinki One Health on Twitter
Helsinki One Health on Twitter
Last young investigator talk is by Mohsen Hanifeh, studying canine fecal microbiota transplants #FMT and antibiotic responsive enteropathy in dogs. #eldtk @LifeSciHelsinki pic.twitter.com/Whw3RN0rea— Helsinki One Health (@HelsinkiOne) June 7, 2022
·twitter.com·
Helsinki One Health on Twitter
🙌Fascinating talk this AM 🌄on precision microbiota 💩 modulation to ⬇️reperfusion-ischemic injury post #OLT by #Kupiec-Weglinski. Initial😬w/ the 1st slide 👇but 👍exposition to dissect an initial serendipitous observation. Is #Rifaximin
🙌Fascinating talk this AM 🌄on precision microbiota 💩 modulation to ⬇️reperfusion-ischemic injury post #OLT by #Kupiec-Weglinski. Initial😬w/ the 1st slide 👇but 👍exposition to dissect an initial serendipitous observation. Is #Rifaximin
🙌Fascinating talk this AM 🌄on precision microbiota 💩 modulation to ⬇️reperfusion-ischemic injury post #OLT by #Kupiec-Weglinski. Initial😬w/ the 1st slide 👇but 👍exposition to dissect an initial serendipitous observation. Is #Rifaximin the "new" pre-OLT #FMT? #ATCBoston2022 pic.twitter.com/nXEnaGbcaI— Paul K. Sue MD CM (@paulksue1) June 7, 2022
·twitter.com·
🙌Fascinating talk this AM 🌄on precision microbiota 💩 modulation to ⬇️reperfusion-ischemic injury post #OLT by #Kupiec-Weglinski. Initial😬w/ the 1st slide 👇but 👍exposition to dissect an initial serendipitous observation. Is #Rifaximin
Colin Hill on Twitter
Colin Hill on Twitter
If the microbiome isn’t complex enough already, let’s consider the human gut plasmidome 😀. Lovely work from ⁦@SteveStockyPhD et al in the lab. ⁦@Pharmabiotic⁩ ⁦@UccMicrobiology⁩ https://t.co/xbY4VKCTW2 https://t.co/OEN7ZYtYWe— Colin Hill (@colinhillucc) June 2, 2022
·twitter.com·
Colin Hill on Twitter
Phase Genomics on Twitter
Phase Genomics on Twitter
Here’s your guide to genome-resolved #metagenomics. Come to booth 1029 tomorrow at #ASMicrobe to learn about the technology behind recent discoveries in #phage host association, #AMR tracking, and #FMT research. Discover the possibilities here: https://t.co/Cq1WqQL69Q pic.twitter.com/6Uh1DeltXL— Phase Genomics (@PhaseGenomics) June 9, 2022
·twitter.com·
Phase Genomics on Twitter
Novel Biome on Twitter
Novel Biome on Twitter
As part of our goal to continuously improve, we have added two additional assessments. 1. Childhood Autism Rating Scale (CARS), both pre-and post-FMT treatment. 2. Quality of Life in Autism Questionnaire (QoLA) throughout our treatment protocol. #FMT #guthealth #autism pic.twitter.com/NaKiNMBGNR— Novel Biome (@NovelBiome) June 10, 2022
·twitter.com·
Novel Biome on Twitter
RXKEVING on Twitter
RXKEVING on Twitter
“RT @PeggyFund: How does an FMT work? In a healthy gut, C. diff is out-competed by many different bacterial species. Receiving antibiotic tr…”
·twitter.com·
RXKEVING on Twitter
The Future of Feces - The Regulatory Review
The Future of Feces - The Regulatory Review
As fecal microbiota transplantation gains traction in the medical world, regulators may need to step in.
·theregreview.org·
The Future of Feces - The Regulatory Review
A Systematic Review of the Efficacy and Safety of Fecal Microbiota Transplantation in the Treatment of Hepatic Encephalopathy and Clostridioides difficile Infection in Patients With Cirrhosis - Cureus
A Systematic Review of the Efficacy and Safety of Fecal Microbiota Transplantation in the Treatment of Hepatic Encephalopathy and Clostridioides difficile Infection in Patients With Cirrhosis - Cureus
The microbiome of the human gut and liver coexists by influencing the health and disease state of each system. Fecal microbiota transplantation (FMT) has recently emerged as a potential treatmen...
·cureus.com·
A Systematic Review of the Efficacy and Safety of Fecal Microbiota Transplantation in the Treatment of Hepatic Encephalopathy and Clostridioides difficile Infection in Patients With Cirrhosis - Cureus
Fecal Microbiota Transplantation found to be an optimal cost-effective treatment for recurrent C. difficile infection - News-Medical.Net
Fecal Microbiota Transplantation found to be an optimal cost-effective treatment for recurrent C. difficile infection - News-Medical.Net
Research recently published in Clinical Infectious Diseases from the University of Minnesota Medical School has found that Fecal Microbiota Transplantation, or FMT, is an optimal cost-effective treatment for first recurrent Clostridioides difficile infection, or CDI or C-Diff.
·news-medical.net·
Fecal Microbiota Transplantation found to be an optimal cost-effective treatment for recurrent C. difficile infection - News-Medical.Net
Research Brief: Study finds fecal microbiota transplantation to be cost effective treatment for any recurrent Clostridiodes Difficile infection - EurekAlert
Research Brief: Study finds fecal microbiota transplantation to be cost effective treatment for any recurrent Clostridiodes Difficile infection - EurekAlert
University of Minnesota Medical School has found that Fecal Microbiota Transplantation, or FMT, is an optimal cost-effective treatment for first recurrent Clostridioides difficile infection.
·eurekalert.org·
Research Brief: Study finds fecal microbiota transplantation to be cost effective treatment for any recurrent Clostridiodes Difficile infection - EurekAlert
Refining a Protocol for Faecal Microbiota Engraftment in Animal Models After Successful Antibiotic-Induced Gut Decontamination
Refining a Protocol for Faecal Microbiota Engraftment in Animal Models After Successful Antibiotic-Induced Gut Decontamination
BackgroundThere is mounting evidence for the therapeutic use of faecal microbiota transplant (FMT) in numerous chronic inflammatory diseases. Germ free mice are not always accessible for FMT research and hence alternative approaches using antibiotic depletion prior to FMT in animal studies are often used. Hence, there is a need for standardising gut microbiota depletion and FMT methodologies in animal studies. The aim of this study was to refine gut decontamination protocols prior to FMT engraftment and determine efficiency and stability of FMT engraftment over time.MethodsMale C57BL/6J mice received an antibiotic cocktail consisting of ampicillin, vancomycin, neomycin, and metronidazole in drinking water for 21 days ad libitum. After antibiotic treatment, animals received either FMT or saline by weekly oral gavage for 3 weeks (FMT group or Sham group, respectively), and followed up for a further 5 weeks. At multiple timepoints throughout the model, stool samples were collected and subjected to bacterial culture, qPCR of bacterial DNA, and fluorescent in-situ hybridisation (FISH) to determine bacterial presence and load. Additionally, 16S rRNA sequencing of stool was used to confirm gut decontamination and subsequent FMT engraftment.ResultsAntibiotic treatment for 7 days was most effective in gut decontamination, as evidenced by absence of bacteria observed in culture, and reduced bacterial concentration, as determined by FISH as well as qPCR. Continued antibiotic administ...
·t.co·
Refining a Protocol for Faecal Microbiota Engraftment in Animal Models After Successful Antibiotic-Induced Gut Decontamination
Novel Biome on Twitter
Novel Biome on Twitter
FMT has been widely and effectively used to treat recurrent Clostridium difficile infections (rCDI) in patients that are non-responsive to antibiotic therapy. Demonstrating high success rates, over 90%, and favourable safety profiles.#fmt #microbiome #cdiff #cdifficile pic.twitter.com/cHO8bHISOA— Novel Biome (@NovelBiome) June 1, 2022
·twitter.com·
Novel Biome on Twitter
Research Brief: Study finds fecal microbiota transplantation to be cost effective treatment for any recurrent Clostridiodes Difficile infection | Medical School - University of Minnesota
Research Brief: Study finds fecal microbiota transplantation to be cost effective treatment for any recurrent Clostridiodes Difficile infection | Medical School - University of Minnesota
MINNEAPOLIS/ST. PAUL (06/02/2022) — Research recently published in Clinical Infectious Diseases from the University of Minnesota Medical School has found that Fecal Microbiota Transplantation, or FMT, is an optimal cost-effective treatment for first recurrent Clostridioides difficile infection, or CDI or C-Diff. “The most effective therapies for CDI are also the cost effective therapies,” said Dr. Radha Rajasingham, MD, co-investigator and assistant professor of medicine at the Medical School and an infectious disease physician at M Health Fairview. “FMT should be moved earlier in the treatment algorithm for CDI. Our model suggests it is effective and cost effective when used in patients after a single episode of recurrent CDI.” The research used mathematical modeling to understand both the effectiveness and cost effectiveness of earlier use of FMT in the treatment of CDI. CDI is a devastating infection of the colon that almost always results from antibiotics disrupting healthy gut bacteria. While this disease is caused by antibiotics, it is often treated with antibiotics, including fidaxomicin for initial, non-severe CDI or vancomycin for severe CDI, followed by FMT for any recurrent CDI.s. Unfortunately in many cases, CDI recurs in the same person again. This cycle of infection is called recurrent CDI. Current guidelines recommend using FMT as a last resort for people with recurrent CDI. The goal of this research was to examine the benefits of using FMT earlier in the cycle of CDI. “Based on this analysis, we would recommend that rather than waiting for multiple recurrent CDI, providers should consider FMT use for any recurrent CDI,” said co-author Dr. Byron Vaughn, MD, MS, associate professor in the Medical School and gastroenterologist at M Health Fairview. The authors suggest future research examine the role of FMT to prevent all recurrent CDI or even as primary prevention of CDI in high risk individuals. This work was supported by the National Institutes of Allergy and Infectious Diseases [K23AI13885 to RR; K25AI118476 to EE]. -30- About the University of Minnesota Medical SchoolThe University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and educating the next generation of physicians. Our graduates and faculty produce high-impact biomedical research and advance the practice of medicine. We acknowledge that the U of M Medical School, both the Twin Cities campus and Duluth campus, is located on traditional, ancestral and contemporary lands of the Dakota and the Ojibwe, and scores of other Indigenous people, and we affirm our commitment to tribal communities and their sovereignty as we seek to improve and strengthen our relations with tribal nations. For more information about the U of M Medical School, please visit med.umn.edu. ContactKat DodgeMedia Relations Manager kdodge@umn.edu
·med.umn.edu·
Research Brief: Study finds fecal microbiota transplantation to be cost effective treatment for any recurrent Clostridiodes Difficile infection | Medical School - University of Minnesota
The PROMISE Trial: an innovative FMT Trial to beat liver cirrhosis
The PROMISE Trial: an innovative FMT Trial to beat liver cirrhosis
Do you know what a Faecal Microbiota Transplant (FMT) is? If you’re thinking it is the transfer of poo from a donor with healthy gut bacteria to someone else, you’d be right! But why? In this seminar organised by NIHR Guy’s and St Thomas’ Biomedical Research Centre, we explore the PROMISE clinical trial led by Debbie Shawcross, Professor of Hepatology and Chronic Liver Failure, who is investigating the use of Faecal Microbiota Transplant (FMT) as a frozen ‘poo’ capsule to help patients who have permanent liver damage (liver cirrhosis).
·t.co·
The PROMISE Trial: an innovative FMT Trial to beat liver cirrhosis
Novel Biome on Twitter
Novel Biome on Twitter
The promising outcomes of FMT to improve symptoms and alter the gut microbiota in patients with rCDI have led to the expansion of research evaluating the efficacy of FMT for a wide variety of both gastrointestinal (GI) and non-GI disorders. #FMT #guthealthmatters #cdiff #asd pic.twitter.com/aeK9NwhIx2— Novel Biome (@NovelBiome) May 26, 2022
·twitter.com·
Novel Biome on Twitter
Australasian Human Microbiome Research Network on Twitter
Australasian Human Microbiome Research Network on Twitter
Excited to kick off our second #FMT meet up for #AHMRN with invited speaker @nadiamorim helping us decide whether to use #GF or #antibiotic depleted mice for #FMT work! pic.twitter.com/3GLB23nDXL— Australasian Human Microbiome Research Network (@microbiome_net) May 25, 2022
·twitter.com·
Australasian Human Microbiome Research Network on Twitter