FMT

Fecal transplantation has been very successful in treating humans with issues such as C-difficile infection, which is also a leading cause of diarrhea in horses. Ontario Veterinary College researcher, Dr. Luis Arroyo and his team are about to begin a study which could make treating gastro-intestinal (GI) issues in horses using fecal microbiota transplantation (FMT) […]

England-based Microbiotica has raised $ | England-based Microbiotica has raised $67 million in a series B round to push two microbiome-based lead assets through phase 1b trials, slated to start this year.

According to the CDC, C. difficile is a bacterium that causes severe diarrhea and colitis. It’s estimated to cause almost half a million infections in the U.S. each year. About one in six patients who get C. difficile will get it again in the subsequent 2-8 weeks. One in eleven people over age 65 diagnosed with a healthcare-associated C. difficile infection die within one month.

The product is designed to eliminate some of the drawbacks of fecal microbiota transplantation.

Rupert Leong (University of Sydney) discusses a new double-blind, randomised, placebo-controlled trial of oral faecal microbiota transplantation for patients with active ulcerative colitis.Read the full article:Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS)

I was diagnosed with C. diff and ended up in the hospital for three weeks.  I was put on vancomycin and dificid. I had a recurrence and ended up getting an FMT.  I also ended up in rehab because I developed reactive arthritis. I relapsed again after one year after …

(2022). The potential utility of fecal (or intestinal) microbiota transplantation in controlling infectious diseases. Gut Microbes: Vol. 14, No. 1, 2038856.

I was hospitalized twice for C. diff, once in June 2021 and then again in October 2021. I had no idea what C. diff was but I was in critical condition when I came to the emergency room. My electrolytes were so out of whack. My hemoglobin was at 5 …

#IBDHorizons22💩How does the #microbiome differ in #IBD patients?💩How can the microbiome be manipulated?💩What influences the microbiome?💩Antibiotic use helpful?💩FMT a treatment for #cdiff, but what about IBD?@IBD_FloMD pic.twitter.com/0QXGmy5MQ6— IBD Horizons (@IBDHorizons) March 5, 2022

The idea of treating psychiatric disorders with another person's poo is gaining traction in research and clinical circles. But how does it work and what do we need to know before it can be widely used to mend minds?

In a small study, a one-day fecal microbiota transplant allowed some peanut-allergic adults to safely eat one to two peanuts several months later.

Antibiotic-resistant bacteria are multiplying. To stop them, we must preserve the drugs we have—and find new antibiotics now. Mary Millard lives with an antibiotic-resistant infection, caused by bacteria known as Pseudomonas aeruginosa, that she acquired during heart surgery in 2014.

Fecal transplant therapy (FMT) in peanut allergy shows good results in small trial. We go inside what’s next for the therapy.

Recurrent infection by Clostridioides difficile has recently been treated by fecal microbiota transplantation (FMT). As viable SARS-CoV-2 was recovered from stool of asymptomatic individuals, the FMT procedure could be a potential risk of SARS-CoV-2 transmission, thus underlying the need to r …

Fecal microbiota transplantation (FMT) is used commonly for treatment of Clostridioides difficile infections (CDIs), although prospective safety data …

hether FMT recipient age and underlying co-morbidity influenced clinical outcomes and microbiome restoration when treated from shared fecal donor sources. Methods: Eighteen rCDI patients participating in a single-center, open-label prospective cohort study received fecal preparation from a self-designated (single case) or two universal donors. Twelve age-matched healthy children and four pediatric ulcerative colitis (UC) cases from an independent serial FMT trial, but with a shared fecal donor were examined as controls for microbiome restoration using 16S rRNA gene sequencing of longitudinal fecal specimens. Results: FMT was significantly more effective in rCDI recipients without underlying chronic co-morbidities where fecal microbiome composition in post-transplant responders was restored to levels of healthy children. Microbiome reconstitution was not associated with symptomatic resolution in some rCDI patients who had co-morbidities. Significant elevation in Bacteroidaceae, Bifidobacteriaceae, Lachnospiraceae, Ruminococcaceae, and Erysipelotrichaceae was consistently observed in pediatric rCDI responders, while Enterobacteriaceae decreased, correlating with augmented complex carbohydrate degradation capacity. Conclusion: Recipient background disease was a significant risk factor influencing FMT outcomes. Special attention should be taken when considering FMT for pediatric rCDI patients with underlying co-morbidities....

Cancer Immunology, Immunotherapy - Human gut microbial species found to associate with clinical responses to immune checkpoint inhibitors (ICIs) are often tested in mice using fecal microbiota...

Peanut allergies are hard to treat and can cause fatal or near-fatal anaphylactic reactions. People usually don't outgrow peanut allergy, requiring lifelong scrutiny of food labels to avoid even small traces of peanut.

(2022). The potential utility of fecal (or intestinal) microbiota transplantation in controlling infectious diseases. Gut Microbes: Vol. 14, No. 1, 2038856.

PHOENIX — A fecal microbiota transplant from healthy donors enabled patients with severe peanut allergy to safely eat small amounts of peanut, according to a presentation at American Academy of Allergy, Asthma & Immunology Annual Meeting.“These results were very encouraging,” Rima Rachid, MD, director of the Allergen Immunotherapy Program and co-director of the Food Allergy

FREE WEBINAR: The Power of the #Microbiome: Can it be unlocked to break the cycle of recurrent #CDiff infection (CDI)? Teena Chopra, MD will answer all aspects of this question. No CEs available. Register at https://t.co/HCPKpNFBAl#CMSA #Ferring #CaseManagement pic.twitter.com/I63s5xcvDs— CMSA (@CMSANational) February 23, 2022

The Addicks have fallen to 16th in League One after suffering four successive defeats.

Charlton Athletic have allowed Johl Powell to depart the club on a loan deal to get more regular action, with Kent Online confirming that he has now joined Maidstone on a short-term deal. The midfielder has been unable to break into the Addicks first-team on a regular basis so far and has instead been limited […]

ClinicalTrials.gov NCT03843385 . DRKS (Deutsches Register für Klinische Studien) DRKS00020471.

There have been reports of #FMT #stooltransplant in #transplant patients for #clostridioidesdifficile. But screening may be complicated -- and the regulatory landscape more so.Added to "C. difficile" folder at https://t.co/BOMS6dj5fu https://t.co/dpS9umDdJu— transplantid.net (@TransplantIDNet) February 21, 2022

An investigational oral microbiome treatment was 70% more effective than placebo in preventing emClostridioides difficile/em infection recurrence.

The AGA FMT National Registry also announces collaborations with American Gut and OpenBiome.