FMT

FMT

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Long-Term Safety Following Faecal Microbiota Transplantation as a Treatment for Recurrent Clostridioides difficile Infection Compared with Patients Treated with a Fixed Bacterial Mixture: Results from a Retrospective Cohort Study
Long-Term Safety Following Faecal Microbiota Transplantation as a Treatment for Recurrent Clostridioides difficile Infection Compared with Patients Treated with a Fixed Bacterial Mixture: Results from a Retrospective Cohort Study
Faecal microbiota transplantation (FMT) is the recommended treatment for recurrent C. difficile infection (rCDI) following a second recurrence. FMT is considered safe in the short term when procedures for the screening of donors and transferred material are followed. However, the long-term safety profile of FMT treatment is largely unknown. In a retrospective cohort study, we assessed the long-term safety of patients treated for rCDI with FMT or a fixed bacterial mixture, rectal bacteriotherapy (RBT). The overall survival, risk of hospital admission, onset of certain pre-specified diseases (cancer, diabetes mellitus, hypertension and inflammatory bowel disease) and risk of being diagnosed with a multidrug-resistant organism were assessed by undertaking a review of the treated patients’ medical records for up to five years following treatment. A total of 280 patients were treated for rCDI with FMT (n = 145) or RBT (n = 135) between 2016 and 2020. In the five years following treatment, there were no differences in survival (adjusted hazard ratio (aHR) 1.03; 95% CI 0.68–1.56), p = 0.89), risk of hospital admission ((aHR 0.92; 95% CI 0.72–1.18), p = 0.5) or onset of any of the analysed diseases. In conclusion, FMT was not associated with increased mortality, risk of hospital admission or onset of disease following treatment when compared with RBT.
·t.co·
Long-Term Safety Following Faecal Microbiota Transplantation as a Treatment for Recurrent Clostridioides difficile Infection Compared with Patients Treated with a Fixed Bacterial Mixture: Results from a Retrospective Cohort Study
Microbiome-based therapeutics
Microbiome-based therapeutics
Nature Reviews Microbiology - Microbiome-based therapeutics hold great promise for reducing disease susceptibility and enhancing disease resistance. In this Review, Sorbara and Pamer explore the...
·nature.com·
Microbiome-based therapeutics
Evolution of FMT - From early clinical to standardized treatments
Evolution of FMT - From early clinical to standardized treatments
Faecal microbiota transplantation (FMT) is widely reported to be an effective treatment against recurrent Clostridioides difficile infections. Recent clinical studies support the therapeutic use of FMT for several other pathologies including inflammatory bowel disease, several types of cancer, and o …
·pubmed.ncbi.nlm.nih.gov·
Evolution of FMT - From early clinical to standardized treatments
Maria Oliva-Hemker, MD on Twitter
Maria Oliva-Hemker, MD on Twitter
Good news for pediatric patients who need fecal microbiota transplantation (#FMT) for treatment of C difficile infection. @HopkinsKids we have been performing FMTs in children since 2013 & with @HopkinsMedicine we are part of @OpenBiome FMT referral network. #GITwitter https://t.co/fPBiO28PRn— Maria Oliva-Hemker, MD (@molivahemker) January 26, 2022
·twitter.com·
Maria Oliva-Hemker, MD on Twitter
RT @john_damianosMD: Risk factors for #FMT failure in C. difficile: 👵 advanced age 💩 severe CDI 🔥 IBD 💊 peri-FMT use of non-CDI antibiotics…
RT @john_damianosMD: Risk factors for #FMT failure in C. difficile: 👵 advanced age 💩 severe CDI 🔥 IBD 💊 peri-FMT use of non-CDI antibiotics…
Risk factors for #FMT failure in C. difficile:👵 advanced age💩 severe CDI🔥 IBD💊 peri-FMT use of non-CDI antibiotics🏥 prior CDI-related hospitalizations🛏 inpatient status🤎 poor quality bowel prep#medtwitter #GITwitter #GI #Cdiff #microbiome https://t.co/HdmhZrgHc7— John Damianos, M.D. (@john_damianosMD) January 26, 2022
·twitter.com·
RT @john_damianosMD: Risk factors for #FMT failure in C. difficile: 👵 advanced age 💩 severe CDI 🔥 IBD 💊 peri-FMT use of non-CDI antibiotics…
A timely article by @sunnyheiwong & @JosephSung8 exploring the unknowns of #FMT as a therapeutic agent and how we should proceed. https://t.co/4bM9IURYgV #GItweeter #microbiome #MedTwitter #DGBI #IBD #probiotic @JGH_latest
A timely article by @sunnyheiwong & @JosephSung8 exploring the unknowns of #FMT as a therapeutic agent and how we should proceed. https://t.co/4bM9IURYgV #GItweeter #microbiome #MedTwitter #DGBI #IBD #probiotic @JGH_latest
A timely article by @sunnyheiwong & @JosephSung8 exploring the unknowns of #FMT as a therapeutic agent and how we should proceed. https://t.co/4bM9IURYgV#GItweeter #microbiome #MedTwitter #DGBI #IBD #probiotic @JGH_latest pic.twitter.com/HNjwbaja1h— Kewin Siah (@KewinSiah) January 25, 2022
·twitter.com·
A timely article by @sunnyheiwong & @JosephSung8 exploring the unknowns of #FMT as a therapeutic agent and how we should proceed. https://t.co/4bM9IURYgV #GItweeter #microbiome #MedTwitter #DGBI #IBD #probiotic @JGH_latest
Daniel J Drucker on Twitter
Daniel J Drucker on Twitter
Will we ever be able to meet the demand for a new diet consisting of probiotics, prebiotics and whole grains (the PPW formulation), in combination with #FMT #T2D @SciReports https://t.co/J4zZ3TKla7
·twitter.com·
Daniel J Drucker on Twitter
Predictors of Fecal Microbiota Transplant Failure in Clostridioides difficile Infection: An Updated Meta-analysis
Predictors of Fecal Microbiota Transplant Failure in Clostridioides difficile Infection: An Updated Meta-analysis
Adequate bowel preparation at the time of FMT and optimizing antibiotic stewardship practices in the peri-FMT period can improve the success of FMT. Patients with nonmodifiable risk factors should be counseled about the risk of FMT failure. Our results may help develop a risk stratification model to …
·pubmed.ncbi.nlm.nih.gov·
Predictors of Fecal Microbiota Transplant Failure in Clostridioides difficile Infection: An Updated Meta-analysis
OpenBiome Announces New Collaboration with the University of Minnesota to Treat Patients with Recurrent C. difficile Infections
OpenBiome Announces New Collaboration with the University of Minnesota to Treat Patients with Recurrent C. difficile Infections
CAMBRIDGE, MA —OpenBiome is announcing a collaboration with the University of Minnesota’s  Microbiota Therapeutics Program  to ensure that patients with recurrent  C. difficile  infections have access to fecal microbiota transplantation (FMT) until an FDA
·t.co·
OpenBiome Announces New Collaboration with the University of Minnesota to Treat Patients with Recurrent C. difficile Infections
A Case of Ischemic Colitis Complicated by Clostridioides Difficile Infection Treated with Fecal Microbiota Transplantation
A Case of Ischemic Colitis Complicated by Clostridioides Difficile Infection Treated with Fecal Microbiota Transplantation
Ischemic colitis is an inflammatory condition of the colon that results from insufficient blood supply commonly caused by enterocolitis, vessel occlusion, or shock. In contrast, pseudomembranous colitis is a clinical manifestation of Clostridioides difficile infection (CDI). Ischemic colitis caused …
·pubmed.ncbi.nlm.nih.gov·
A Case of Ischemic Colitis Complicated by Clostridioides Difficile Infection Treated with Fecal Microbiota Transplantation
Microbiota diversity and bacterial load after successful treatment of Clostridioides difficile infection with honey lavage in 4 patients
Microbiota diversity and bacterial load after successful treatment of Clostridioides difficile infection with honey lavage in 4 patients
In this letter, an experimental therapy in four patients with therapy-resistant Clostridioides difficile infection is described. These four patients were treated with Manuka honey via colon lavage. First, the patients received a three-day fidaxomicin treatment. The colon lavage was performed …
·pubmed.ncbi.nlm.nih.gov·
Microbiota diversity and bacterial load after successful treatment of Clostridioides difficile infection with honey lavage in 4 patients
UCCpsychiatry on Twitter
UCCpsychiatry on Twitter
Establishment and resilience of transplanted gut microbiota in aged mice https://t.co/iErQXitCLe— UCCpsychiatry (@UCCpsychiatry) January 15, 2022
·twitter.com·
UCCpsychiatry on Twitter
The growth of faecal microbiota transplantation in the UK: time for a registry? - The Lancet Gastroenterology & Hepatology
The growth of faecal microbiota transplantation in the UK: time for a registry? - The Lancet Gastroenterology & Hepatology
The importance of the microbiome to health is increasingly being recognised. A search of the National Institutes of Health database showed that 180 faecal microbiota transplantation (FMT) studies are currently recruiting, or due to recruit, to investigate the use of FMT for diverse indications, including hypertension, metastatic melanoma, and autism. Additionally, the practice of microbial manipulation through probiotics and FMT to treat recurrent and refractory Clostridioides difficile infection is becoming increasingly commonplace.
·thelancet.com·
The growth of faecal microbiota transplantation in the UK: time for a registry? - The Lancet Gastroenterology & Hepatology
Alterations and Prediction of Functional Profiles of Gut Microbiota After Fecal Microbiota Transplantation for Iranian Recurrent Clostridioides difficile Infection with Underlying Inflammatory Bowel Disease: A Pilot Study
Alterations and Prediction of Functional Profiles of Gut Microbiota After Fecal Microbiota Transplantation for Iranian Recurrent Clostridioides difficile Infection with Underlying Inflammatory Bowel Disease: A Pilot Study
FMT leads to significant alterations of the community structure of gut bacteria in rCDI patients with IBD. The change in relative abundance of Proteobacteria and bacterial diversity indicated that FMT promotes recovery from intestinal permeability and inflammation in rCDI patients. Moreover, strong …
·pubmed.ncbi.nlm.nih.gov·
Alterations and Prediction of Functional Profiles of Gut Microbiota After Fecal Microbiota Transplantation for Iranian Recurrent Clostridioides difficile Infection with Underlying Inflammatory Bowel Disease: A Pilot Study
Cheltenham - time for some self respect | CAS Trust
Cheltenham - time for some self respect | CAS Trust
After the abject performance at The Mornflake Stadium on Wednesday night it isn't easy to summon up much enthusiasm for the trip to Cheltenham on Saturday. We've only played them twice before but we've lost both times and there was little evidence at Crewe that we are in the form…
·castrust.org·
Cheltenham - time for some self respect | CAS Trust