FMT

FMT increases the relative abundance of F. prausnitzii in patients with recurrent CDI, and this microbial shift remains several months later. The baseline abundance of F. prausnitzii in donors or recipients was not associated with future treatment response, although a true predictive capacity cannot …

This case suggests a role for early, repeat FMT during an initial presentation of a severe Clostridioides difficile colitis episode refractory to pharmacologic antimicrobial therapy. It also adds to emerging literature regarding the timing of antibiotic cessation surrounding FMT.

Carbapenem-resistant Klebsiella pneumoniae infection in a renal transplant patient was successfully treated with fecal microbiota transplantation. Learn more.

In clinical practice, fecal microbiota transplantation (FMT) has been established as an unparalleled therapy to date for multiple recurrent Clostridioides difficile infections (CDI). The implementation of the FMT in practice requires a significant investment to meet legal, security and financial req …

Clostridioides difficile infection (CDI) is an urgent health threat being the most common healthcare-associated infection, and its management is a clinical conundrum. Over 450 000 infections are seen in the United States with similar incidence seen in the rest of the developed world. The majority of …

Clostridioides difficile infection (CDI) is a consequence of flagrant use of antibiotics, an aging population with increasing comorbidities, and increased hospitalizations. The treatment of choice for CDI is antibiotics (vancomycin or fidaxomicin), with a possibility of recurrent CDI despite …

Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections. FMT is generally considered safe and well-tolerated - even in high-risk patients. Most short-term risks are mild and known to be associated with delivery methods. Long …

These results provide novel and provocative evidence that modulation of the gut microbiome via FMT induces alterations in circulating and intestinal tissue miRNAs. These findings contribute to a greater understanding of the molecular mechanisms underlying FMT and identify new potential targets for t …

Clostridioides difficile is a major cause of health-care related infections and antibiotic-associated diarrhea. High recurrence rates following antibiotic treatment, along with the emergence of hypervirulent and multidrug resistant ribotypes makes essential the development of safe, effective, novel …

In the 4th century AD, a Chinese doctor called Ge Hong performed treated his diarrhoea patients with faeces from healthy...Read More...

Experts have uncovered a new molecular reason why faecal transplants are highly effective in treating infections such as C. difficile (a nasty bacteria that can infect the bowel), which could lead to more targeted treatments for this and other similar diseases.

MicroRNAs showed that fecal microbiota transplants are effective for treating infections like Clostridioides difficile infection, according to a study published in Gastroenterology. Tanya M. Monaghan, MD, clinical associate professor, honorary consultant in gastroenterology, and Anne McLaren Fellow in the School of Medicine at the University of Nottingham, and colleagues assessed sera from

Fecal microbiota transplants are effective in at least 80% of C. diff cases, although until now, researchers did not know why.

Fecal microbiota transplants are effective in at least 80% of C. diff cases, although until now, researchers did not know why.

Genetic analysis helps ensure successful fecal microbiota transplants

Further knowledge sharing should help inform refinements of stool banking guidelines and best practices.

The availability of highly sensitive molecular tests for the detection of Clostridioides difficile in feces leads to overtreatment of patients who are probably only colonized. In this prospective study, the usefulness of fecal calprotectin (fCP) is evaluated in a cohort of patients with detec …