Bird flu-infected San Bernardino County dairy cows may have concerning new mutation
A new H5N1 bird flu mutation has appeared in a cluster of infected dairy cows. It's a genetic change that scientists say could not only make the virus more lethal, but increase its spread between mammals and possibly humans.
A replicating recombinant vesicular stomatitis virus model for dairy cattle H5N1 influenza virus glycoprotein evolution - PubMed
Highly pathogenic avian influenza H5 viruses have spread globally, established sustained transmission in mammals and caused human infections. Research on these viruses is restricted to high biocontainment laboratories. We report the characterization and utility of a surrogate, replicating virus that …
Six additional states enroll in USDA milk testing strategy for H5N1
WASHINGTON — The U.S. Department of Agriculture’s (USDA) Animal and Plant Health Inspection Service (APHIS) has announced an additional six states are enrolling in the National Milk Testing Strategy (NMTS). This brings the total number of states testing under NMTS guidelines to 36 since the first round of states joined in early December. With the […]
Examining the Survival of A(H5N1) Influenza Virus in Thermised Whole Cow Milk
The recent spillover events of highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b to dairy cattle, and high viral shedding in the milk from infected animals, has created concern that milk and dairy products could be a route for human infection. It has been demonstrated that pasteurization is effective in inactivating A(H5N1) in milk. However, multiple dairy products are made with unpasteurized but thermised milk. The aim of this study was to examine whether some conditions commonly used for thermisation are effective against inactivation of A(H5N1) in whole milk. For this purpose, we artificially inoculated whole raw cow milk with 6.5 log10 EID50 A(H5N1) and heated for 15 seconds at 60°C, 63°C and 66°C, the viral infectivity was tested using embryonated chicken eggs. We observed over 4 and 5 log10 reduction in viral infectivity at 60°C and 63°C, respectively. The viral infectivity was reduced to below the detection limit at 66°C. We also calculated the D-values, the time required to reduce the viral titer by one log10, for each treatment and as expected, we observed a decrease in D-values with increasing thermisation temperature. These data demonstrate that thermisation is effective in reducing the viral load and thus they allow for informed risk assessment of A(H5N1) contaminated dairy products made from thermized milk.
### Competing Interest Statement
The authors have declared no competing interest.
HPAI in cattle needs urgent action, transmission fears grow
The current intensive circulation of H5N1 in cattle increases the risk of H5N1 viruses better adapting to mammals, potentially spilling over to other livestock and humans.
Pandemic risk stemming from the bovine H5N1 outbreak: an account of the knowns and unknowns - PubMed
H5N1 subtype influenza A viruses represent a long-standing pandemic concern. Owing to their global occurrence in poultry, humans are routinely exposed to these viruses, and hundreds of human cases have been documented worldwide since 2003. The relevant viral lineages are not static, however, and hav …
Illinois continuing to monitor H5N1 in dairy cattle - Brownfield Ag News
The Illinois state veterinarian says the state is increasing its efforts to monitor dairy cattle for H5N1 avian flu. Dr. Mark Ernst tells Brownfield, “The Illinois Department of Public Health is beginning their initiation of milk testing at processors, and so that should give us an idea as to whether or not we have any […]
Timing (early December 2024) and molecular characterisation of the transmission to cattle of H5N1 influenza A virus genotype D1.1, clade 2.3.4.4b - Influenza virus / H5N1-global - Virological
Jonathan E. Pekar, Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK Thomas P. Peacock, The Pirbright Institute, Woking, UK, GU24 0NF; Department of Infectious Disease, Imperial College London, UK, W2 1PG Louise Moncla, University of Pennsylvania, PA 19104, USA Praneeth Gangavarapu, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA Divya Venkatesh, Department of Biology, University of Oxford, Oxford OX1 3SY, UK Daniel H. Go...
How a Group of Immigrant Farmworkers is Preparing for Avian Flu to Hit New York Dairy Farms
Amid heightened fears of immigration raids, Alianza Agricola has spent months educating hundreds of their coworkers on how to prepare for an avian flu outbreak.
Drinking raw milk on rise despite bird flu dangers
An important health alert involving raw milk: Right now consumer consumption is rising despite safety warnings from medical experts.https://www.kare11.com/ar...
Wisconsin Department of Agriculture Provides Update on HPAI/H5N1 in Dairy Cattle in Wisconsin
In December 2024, the Wisconsin Department of Agriculture, Trade and Consumer Protection (DATCP) identified three cases of highly pathogenic avian influenza (HPAI H5N1) in poultry flocks. Nationally, the U.S. Department of Agriculture (USDA) has confirmed 36 cases of H5N1 in livestock across four st
‘Safe and secure’: State reaches bird flu-free status among dairy cows
(The Center Square) – Pennsylvania has become the first major dairy producing state to achieve HPAI-free status from the USDA for its milk supply. The milestone comes after a multidisciplinary push to begin bulk testing for the virus. HPAI stands for highly pathogenic avian influenza, or as its more commonly called: bird flu. The status […]
Milk from Maricopa County dairy cows tested positive for bird flu
A sample of milk from a herd of dairy cows in Maricopa County has tested positive for H5N1 avian influenza, or bird flu, according to the Arizona Department of Agriculture.