H5N1 Flu

Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023-2024 - PubMed
Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023-2024 - PubMed
We show that human myxovirus resistance protein 1 (MxA) suppresses replication of highly pathogenic avian influenza A(H5N1) viruses isolated from mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral polymerase complex components …
·pubmed.ncbi.nlm.nih.gov·
Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023-2024 - PubMed
Marked neurotropism and potential adaptation of H5N1 clade 2.3.4.4.b virus in naturally infected domestic cats - PubMed
Marked neurotropism and potential adaptation of H5N1 clade 2.3.4.4.b virus in naturally infected domestic cats - PubMed
In April 2024, ten cats died in a rural South Dakota (SD) residence, showing respiratory and neurological symptoms. Necropsy and laboratory testing of two cats confirmed H5N1 clade 2.3.4.4b infection. The viral genome sequences are closely related to recent SD cattle H5N1 sequences. Cat H5N1 genomes …
·pubmed.ncbi.nlm.nih.gov·
Marked neurotropism and potential adaptation of H5N1 clade 2.3.4.4.b virus in naturally infected domestic cats - PubMed
Study reveals dangerous mutations in H5N1 bird flu
Study reveals dangerous mutations in H5N1 bird flu
One of the earliest strains of bird flu isolated from a human in Texas shows a unique constellation of mutations that enable it to more easily replicate in human cells and cause more severe disease in mice compared to a strain found in dairy cattle, researchers from Texas Biomedical Research Institute (Texas Biomed) report in Emerging Microbes & Infections.
·news-medical.net·
Study reveals dangerous mutations in H5N1 bird flu
Bird Flu and the Battle Against Emerging Diseases
Bird Flu and the Battle Against Emerging Diseases
The first human death from bird flu in the United States occurred on January 6 in a Louisiana hospital, less than three weeks before the second Donald Trump administration’s inauguration. Bird flu, also known as Avian influenza or H5N1, is a disease that has been on the watch list of scientists and ...
·thefulcrum.us·
Bird Flu and the Battle Against Emerging Diseases
White House Pandemic Office May Shrink Under Trump
White House Pandemic Office May Shrink Under Trump
Trump told TIME in April he would close the White House's pandemic preparedness office. It's losing most of its staff during the transition, according to Biden officials.
·time.com·
White House Pandemic Office May Shrink Under Trump
US awards Moderna $590 million for bird flu vaccine development
US awards Moderna $590 million for bird flu vaccine development
The U.S. government has awarded Moderna $590 million to advance the development of its bird flu vaccine, as the country doubles down on efforts to tackle increasing infections in humans.
·reuters.com·
US awards Moderna $590 million for bird flu vaccine development
Asymptomatic infection and antibody prevalence to co-occurring avian influenza viruses vary substantially between sympatric seabird species following H5N1 outbreaks - PubMed
Asymptomatic infection and antibody prevalence to co-occurring avian influenza viruses vary substantially between sympatric seabird species following H5N1 outbreaks - PubMed
Emerging infectious diseases are of major concern to animal and human health. Recent emergence of high pathogenicity avian influenza virus (HPAIV) (H5N1 clade 2.3.4.4b) led to substantial global mortality across a range of host species. Co-occurring species showed marked differences in mortality, ge …
·pubmed.ncbi.nlm.nih.gov·
Asymptomatic infection and antibody prevalence to co-occurring avian influenza viruses vary substantially between sympatric seabird species following H5N1 outbreaks - PubMed
Could bird flu pandemic 'dwarf' COVID-19?
Could bird flu pandemic 'dwarf' COVID-19?
For the first time, a person in the United States has died after being infected with the bird flu. The World Health Organization says the risk of infection for the general population remains low, but as VOA’s Dora Mekouar reports, some medical experts are still sounding the alarm.
·voanews.com·
Could bird flu pandemic 'dwarf' COVID-19?
What Is Bird Flu?
What Is Bird Flu?
This JAMA Patient Page explains the origins and transmissibility of bird flu, along with prevention, diagnosis, symptoms, potential complications, and management in humans.
·jamanetwork.com·
What Is Bird Flu?
TC Biopharm looks to begin proof-of-concept preclinical studies for TCB-008 to treat H5N1
TC Biopharm looks to begin proof-of-concept preclinical studies for TCB-008 to treat H5N1
TC Biopharm (Holdings) plc intends to begin proof-of-concept preclinical studies for its lead therapeutic TCB-008, to treat H5N1, or bird flu. TCB-008 is an allogeneic, unmodified cell therapy comprised of activated and expanded γδ T cells.
·bioworld.com·
TC Biopharm looks to begin proof-of-concept preclinical studies for TCB-008 to treat H5N1
Why monitoring outbreaks in animals key to track human cases of H5N1
Why monitoring outbreaks in animals key to track human cases of H5N1
Dr Rajeev Jayadevan, Co-Chairman of the Indian Medical Association's COVID task force, said that H5N1 remains a significant threat to poultry and wild bird populations. Recently, Maharashtra also reported India's first case of bird flu among other animals.
·indianexpress.com·
Why monitoring outbreaks in animals key to track human cases of H5N1
Bird flu is mutating, but antivirals still work
Bird flu is mutating, but antivirals still work
Researchers have identified nine mutations in a bird flu strain from a person in Texas. Bad news: this strain is more capable of causing disease and replicates better in the brain. Good news: approved antivirals are still effective.
·sciencedaily.com·
Bird flu is mutating, but antivirals still work
Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024 - PubMed
Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024 - PubMed
We isolated three genotypes of highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b from wild birds infected with H5N1 (n = 12) and H5N8 (n = 1) in Hong Kong SAR 2021-2024. Viruses from two spoonbills from late 2022 were genetically related to a virus from a human in China. Four tested vir …
·pubmed.ncbi.nlm.nih.gov·
Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024 - PubMed
The Haemagglutinin Gene of Bovine-Origin H5N1 Influenza Viruses Currently Retains Receptor-binding and pH-fusion Characteristics of Avian Host Phenotype - PubMed
The Haemagglutinin Gene of Bovine-Origin H5N1 Influenza Viruses Currently Retains Receptor-binding and pH-fusion Characteristics of Avian Host Phenotype - PubMed
Clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus (HPAIV) has caused a panzootic affecting all continents except Australia, expanding its host range to several mammalian species. In March 2024, H5N1 HPAIV was first detected in dairy cattle and goats in the United States. Over 891 dairy fa …
·pubmed.ncbi.nlm.nih.gov·
The Haemagglutinin Gene of Bovine-Origin H5N1 Influenza Viruses Currently Retains Receptor-binding and pH-fusion Characteristics of Avian Host Phenotype - PubMed