H5N1 Flu

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Bird flu: US reports first human death in person infected with H5N1
Bird flu: US reports first human death in person infected with H5N1
The US has reported its first human death from avian influenza H5N1 in a person who had been admitted to hospital in Louisiana after being exposed to a non-commercial backyard flock and wild birds.1 The patient was over 65 and reported to have underlying medical conditions. “The department expresses its deepest condolences to the patient’s family and friends. …
·bmj.com·
Bird flu: US reports first human death in person infected with H5N1
Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals.
Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals.
In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds and other mammals including humans. Here, we present molecular and virological evidence that the cattle B3.13 genotype H5N1 viruses rapidly accumulated adaptations in polymerase genes that enabled better replication in bovine cells, as well as cells of other mammalian species including humans and pigs. We find evidence of several mammalian adaptations gained early in the evolution of these viruses in cattle including PB2 M631L, which is found in all cattle sequences, and PA K497R, which is found in the majority. Structurally, PB2 M631L maps to the polymerase-ANP32 interface, an essential host factor for viral genome replication. We show this mutation adapts the virus to co-opt bovine ANP32 proteins and thereby enhances virus replication in bovine and primary human airway cells. Importantly, we show that ongoing evolution during 2024 in the PB2 gene, including a convergently arising D740N substitution, further increases polymerase activity in a range of mammalian cells. Thus, the continued circulation of H5N1 in dairy cattle allows virus adaption improving replicative ability in cattle and increasing zoonotic spillover risk. ### Competing Interest Statement The authors have declared no competing interest.
·biorxiv.org·
Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals.
Over half of U.S. milk now being tested for H5N1 - Brownfield Ag News
Over half of U.S. milk now being tested for H5N1 - Brownfield Ag News
A veterinary disease expert says more than half of the raw milk produced in the U.S. is now being tested for the H5N1 avian influenza virus. Dr. Keith Poulsen with the Wisconsin Veterinary Diagnostic Laboratory tells Brownfield progress is being made towards USDA’s goal of testing all raw milk for the virus. “Over 50% of […]
·brownfieldagnews.com·
Over half of U.S. milk now being tested for H5N1 - Brownfield Ag News
US Records Its First Death From Bird Flu in Tragic End to Louisiana Case
US Records Its First Death From Bird Flu in Tragic End to Louisiana Case
The first human death linked to bird flu has been reported in the United States, health authorities in Louisiana announced Monday, while noting the patient had underlying medical conditions.
·sciencealert.com·
US Records Its First Death From Bird Flu in Tragic End to Louisiana Case
Bird flu risk remains low after first US death, WHO says
Bird flu risk remains low after first US death, WHO says
The risk to the general population from H5N1 bird flu remains low, a World Health Organization spokesperson said on Tuesday, following the first death of a patient from the virus in the United States.
·reuters.com·
Bird flu risk remains low after first US death, WHO says
The First US Bird Flu Death Is a Stark Warning
The First US Bird Flu Death Is a Stark Warning
A Louisiana patient is the first person in the United States to die as a result of H5N1 infection. One expert likens what happens next to Russian roulette.
·wired.com·
The First US Bird Flu Death Is a Stark Warning
Bird flu outbreak: Is it still safe to eat eggs?
Bird flu outbreak: Is it still safe to eat eggs?
With 66 human cases and one death from bird flu in the current outbreak, there are several ways Americans could become sick.
·newsweek.com·
Bird flu outbreak: Is it still safe to eat eggs?
Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of H5N1 into agriculture in North America - PubMed
Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of H5N1 into agriculture in North America - PubMed
Since late 2021, a panzootic of highly pathogenic H5N1 avian influenza virus has driven significant morbidity and mortality in wild birds, domestic poultry, and mammals. In North America, infections in novel avian and mammalian species suggest the potential for changing ecology and establishment of …
·pubmed.ncbi.nlm.nih.gov·
Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of H5N1 into agriculture in North America - PubMed
California Veterinarians Say Virus-Hit Dairies See More Abortions in First-Calf Heifers and Dry Cows
California Veterinarians Say Virus-Hit Dairies See More Abortions in First-Calf Heifers and Dry Cows
Any existing herd health problems are amplified by HPAI H5N1, practitioners report. Across the U.S., they are asking regulatory agencies for more consistent testing and reporting protocols. They are also encouraging producers to invest dollars in better nutrition and cow comfort resources.
·bovinevetonline.com·
California Veterinarians Say Virus-Hit Dairies See More Abortions in First-Calf Heifers and Dry Cows
Louisiana reports first bird flu-related human death in US
Louisiana reports first bird flu-related human death in US
A patient in Louisiana who had been hospitalized with the first human case of highly pathogenic avian influenza, or bird flu, has died, health officials said Monday.
·foxnews.com·
Louisiana reports first bird flu-related human death in US
U.S. records its first human bird flu death
U.S. records its first human bird flu death
A patient in Louisiana has died of bird flu. Health authorities considered the case to be the first severe H5N1 infection in a U.S. resident.
·nbcnews.com·
U.S. records its first human bird flu death
Louisiana reports first bird flu-related death in US
Louisiana reports first bird flu-related death in US
A U.S. patient who had been hospitalized with H5N1 bird flu has died, the Louisiana Department of Health said on Monday, marking the country's first reported human death from the virus.
·reuters.com·
Louisiana reports first bird flu-related death in US