H5N1 Flu

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Revealing novel CD8+ T-cell epitopes from the H5N1 avian influenza virus in HBW/B1 haplotype ducks - PubMed
Revealing novel CD8+ T-cell epitopes from the H5N1 avian influenza virus in HBW/B1 haplotype ducks - PubMed
The duck CD8+ T-cell response effectively defends against H5N1 highly pathogenic avian influenza virus (HPAIV) infection, but the recognized peptide is rarely identified. Here, we found that the ratio of CD8+ T cells and the expression of IFN-γ and cytotoxicity-associated genes …
·pubmed.ncbi.nlm.nih.gov·
Revealing novel CD8+ T-cell epitopes from the H5N1 avian influenza virus in HBW/B1 haplotype ducks - PubMed
Confirmation of highly pathogenic avian influenza H5N1 in skuas, Antarctica 2024 - PubMed
Confirmation of highly pathogenic avian influenza H5N1 in skuas, Antarctica 2024 - PubMed
From December 2023 to March 2024, a surveillance program aiming to detect Highly Pathogenic Avian Influenza (HPAI) H5N1 was conducted on Antarctica territories, specifically at Fildes Peninsula (King George Island, Maritime Antarctic), and James Ross Island. At Fildes Peninsula, samples from marine …
·pubmed.ncbi.nlm.nih.gov·
Confirmation of highly pathogenic avian influenza H5N1 in skuas, Antarctica 2024 - PubMed
Avian influenza: past, present and future - PubMed
Avian influenza: past, present and future - PubMed
Avian influenza is not a new disease, but the emergence of high pathogenicity avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/96 lineage (Gs/GD) has necessitated fundamental changes to prevention and control strategies for this disease. No longer just an avian disease, avian influenza is c …
·pubmed.ncbi.nlm.nih.gov·
Avian influenza: past, present and future - PubMed
Strategic challenges in the global control of high pathogenicity avian influenza - PubMed
Strategic challenges in the global control of high pathogenicity avian influenza - PubMed
H5Nx A/Goose/Guangdong/1/96 Eurasian lineage high pathogenicity avian influenza (HPAI) viruses have been the main HPAI strains detected globally since 2005. These have spread around the world, causing a panzootic that has spanned six continents, with continual threat to not only wild and captive bir …
·pubmed.ncbi.nlm.nih.gov·
Strategic challenges in the global control of high pathogenicity avian influenza - PubMed
Targets of influenza human T-cell response are mostly conserved in H5N1 - PubMed
Targets of influenza human T-cell response are mostly conserved in H5N1 - PubMed
Frequent recent spillovers of subtype H5N1 clade 2.3.4.4b highly pathogenic avian influenza (HPAI) virus into poultry and mammals, especially dairy cattle, including several human cases, increased concerns over a possible future pandemic. Here, we performed an analysis of epitope data curated in the …
·pubmed.ncbi.nlm.nih.gov·
Targets of influenza human T-cell response are mostly conserved in H5N1 - PubMed
Why bird flu mountain lion deaths are a worrying sign
Why bird flu mountain lion deaths are a worrying sign
Experts warn the virus' spread to apex predators signals broader ecological risks and highlights the challenges of managing wildlife diseases.
·newsweek.com·
Why bird flu mountain lion deaths are a worrying sign
Bird flu reaches zoos, further threatening endangered species
Bird flu reaches zoos, further threatening endangered species
As bird flu rips through poultry and dairy farms, it’s not just the rare human cases that are alarming experts. There are now reports across the U.S. of bird flu threatening, and in some cases, killing endangered animals at zoos. NBC News' David Noriega has the details.
·nbcnews.com·
Bird flu reaches zoos, further threatening endangered species
Bird flu kills 20 big cats at sanctuary south of Seattle
Bird flu kills 20 big cats at sanctuary south of Seattle
Twenty big cats, including a Bengal tiger, several cougars, and a lynx, died after contracting bird flu at an animal sanctuary in Shelton, Washington earlier this month.
·kptv.com·
Bird flu kills 20 big cats at sanctuary south of Seattle
Multiple bird flu cases detected across England
Multiple bird flu cases detected across England
LONDON: Bird farms across England's eastern coast had to enforce preventative bird flu measures starting Monday after a spate of cases were detected in the latest outbreak of the virus.
·thestar.com.my·
Multiple bird flu cases detected across England
Preliminary report on genomic epidemiology of the 2024 H5N1 influenza A virus outbreak in U.S. cattle (Part 1 of 2)
Preliminary report on genomic epidemiology of the 2024 H5N1 influenza A virus outbreak in U.S. cattle (Part 1 of 2)
Due to length constraints on virological.org posts, we are splitting this report into two parts that should be read as a single report. This is Part 1, containing Background, Data, Methods, and Findings sections 1 through 5. See Part 2 for Findings sections 6 through 9, Concluding remarks, Acknowledgements, and References. Michael Worobey, University of Arizona, Tucson, AZ 85705, USA Karthik Gangavarapu, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, ...
·virological.org·
Preliminary report on genomic epidemiology of the 2024 H5N1 influenza A virus outbreak in U.S. cattle (Part 1 of 2)
Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of H5N1 into agriculture in North America
Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of H5N1 into agriculture in North America
Since late 2021, a panzootic of highly pathogenic H5N1 avian influenza virus has driven significant morbidity and mortality in wild birds, domestic poultry, and mammals. In North America, infections in novel avian and mammalian species suggest the potential for changing ecology and establishment of new animal reservoirs. Outbreaks among domestic birds have persisted despite aggressive culling, necessitating a re-examination of how these outbreaks were sparked and maintained. To recover how these viruses were introduced and disseminated in North America, we analyzed 1,818 Hemagglutinin (HA) gene sequences sampled from North American wild birds, domestic birds and mammals from November 2021-September 2023 using Bayesian phylodynamic approaches. Using HA, we infer that the North American panzootic was driven by ∼8 independent introductions into North America via the Atlantic and Pacific Flyways, followed by rapid dissemination westward via wild, migratory birds. Transmission was primarily driven by Anseriformes, shorebirds, and Galliformes, while species such as songbirds, raptors, and owls mostly acted as dead-end hosts. Unlike the epizootic of 2015, outbreaks in domestic birds were driven by ∼46-113 independent introductions from wild birds, with some onward transmission. Backyard birds were infected ∼10 days earlier on average than birds in commercial poultry production settings, suggesting that they could act as “early warning signals” for transmission upticks in a given area. Our findings support wild birds as an emerging reservoir for HPAI transmission in North America and suggest continuous surveillance of wild Anseriformes and shorebirds as crucial for outbreak inference. Future prevention of agricultural outbreaks may require investment in strategies that reduce transmission at the wild bird/agriculture interface, and investigation of backyard birds as putative early warning signs. ### Competing Interest Statement The authors have declared no competing interest.
·biorxiv.org·
Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of H5N1 into agriculture in North America
Refined semi-lethal aerosol H5N1 influenza model in cynomolgus macaques for evaluation of medical countermeasures
Refined semi-lethal aerosol H5N1 influenza model in cynomolgus macaques for evaluation of medical countermeasures
Highly pathogenic avian influenza A H5N1 viruses cause high mortality in humans and have pandemic potential. Effective vaccines and treatments against this threat are urgently needed. Here, we have refined our previously established model of lethal ...
·pmc.ncbi.nlm.nih.gov·
Refined semi-lethal aerosol H5N1 influenza model in cynomolgus macaques for evaluation of medical countermeasures
Orogastric Exposure of Cynomolgus Macaques to Bovine HPAI H5N1 Virus Results in Subclinical Infection
Orogastric Exposure of Cynomolgus Macaques to Bovine HPAI H5N1 Virus Results in Subclinical Infection
Since early 2022 highly pathogenic avian influenza (HPAI) H5N1 virus infections have been reported in wild aquatic birds and poultry throughout the United States (US) with spillover into several mammalian species1-6. In March 2024, HPAIV H5N1 clade 2.3.4.4b was first detected in dairy cows in Tex...
·researchsquare.com·
Orogastric Exposure of Cynomolgus Macaques to Bovine HPAI H5N1 Virus Results in Subclinical Infection
H5 Bird Flu: Current Situation
H5 Bird Flu: Current Situation
H5 bird flu is causing outbreaks in wild birds and poultry, other animals and sporadic human cases.
·cdc.gov·
H5 Bird Flu: Current Situation
K-State won’t take poultry or wild birds with bird flu
K-State won’t take poultry or wild birds with bird flu
MANHATTAN (KSNT) – The Kansas State University (K-State) Veterinary Health Center reported Tuesday it is not taking any more poultry or wild birds due to a rise in bird flu cases. K-State iss…
·ksnt.com·
K-State won’t take poultry or wild birds with bird flu
Raw Farm Recalls Raw Milk in California Due to H5N1 Bird Flu Risk
Raw Farm Recalls Raw Milk in California Due to H5N1 Bird Flu Risk
The rising incidence of bird flu in the Central Valley is raising serious concerns for public health and food safety. The detection of the virus in dairy cattle has sparked alarm, as it increases the risk of transmission to other animals and potentially to humans. In response, biosecurity measures have been strengthened to protect the population and ensure food quality.
·msn.com·
Raw Farm Recalls Raw Milk in California Due to H5N1 Bird Flu Risk
Severe Conjunctivitis an H5N1 symptom. Ark Valley Voice
Severe Conjunctivitis an H5N1 symptom. Ark Valley Voice
Just when we thought we'd gotten back to some version of "normal" after the terrible years of the COVID-19 pandemic, now there are growing cases of bird
·arkvalleyvoice.com·
Severe Conjunctivitis an H5N1 symptom. Ark Valley Voice