H5N1 Vaccine

H5N1 Vaccine

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Using computational biology to develop pan-H5 vaccine against avian influenza
Using computational biology to develop pan-H5 vaccine against avian influenza
Researchers from Diosynvax Ltd. presented data from a study that aimed to evaluate the efficacy of a pan-H5 vaccine designed using computational biology and being developed for protection against avian influenza.
·bioworld.com·
Using computational biology to develop pan-H5 vaccine against avian influenza
Netherlands starts bird flu vaccination program at hen farm
Netherlands starts bird flu vaccination program at hen farm
(Reuters) -The Netherlands, one of the world's largest egg exporters, has launched a pilot program on a laying-hen farm to vaccinate poultry against bird flu with the aim of achieving large-scale
·globalbankingandfinance.com·
Netherlands starts bird flu vaccination program at hen farm
Health Secretary RFK Jr. Calls for Intensive Testing of Bird Flu Drugs on Poultry
Health Secretary RFK Jr. Calls for Intensive Testing of Bird Flu Drugs on Poultry
Therapeutic drugs should be “intensively” tested on US poultry flocks infected with bird flu, Health and Human Services Secretary Robert F. Kennedy Jr. said, arguing that the medications could help identify treatments for human cases.
·bloomberg.com·
Health Secretary RFK Jr. Calls for Intensive Testing of Bird Flu Drugs on Poultry
Netherlands to test avian flu vaccine on poultry
Netherlands to test avian flu vaccine on poultry
Belgium is also struggling with the virus, with multiple infections detected across the country in recent weeks.
·brusselstimes.com·
Netherlands to test avian flu vaccine on poultry
Arcturus confident of retaining BARDA funding for bird flu trial, despite Moderna uncertainty
Arcturus confident of retaining BARDA funding for bird flu trial, despite Moderna uncertainty
Arcturus Therapeutics believes it’s “highly unlikely” it will lose the promised government funding for its bird flu mRNA vaccine trial, despite reports swirling that Moderna’s own financial support | Arcturus believes it’s “highly unlikely” it will lose the government funding for its mRNA bird flu vaccine trial, despite rumors swirling that Moderna’s funding will be revoked.
·fiercebiotech.com·
Arcturus confident of retaining BARDA funding for bird flu trial, despite Moderna uncertainty
The US may start vaccinating chickens and cows against bird flu
The US may start vaccinating chickens and cows against bird flu
The US Department of Agriculture announced it will allocate $100 million to develop vaccines and other therapies to help contain the spread of bird flu on poultry and dairy farms
·newscientist.com·
The US may start vaccinating chickens and cows against bird flu
Avian Influenza (H5N1) Vaccines: What's the Status? | ASM.org
Avian Influenza (H5N1) Vaccines: What's the Status? | ASM.org
As H5N1 influenza A (bird flu) spreads, the need for a vaccine grows. Do seasonal flu vaccines protect against H5N1? What current H5N1 vaccines exist—and what developments are underway?
·asm.org·
Avian Influenza (H5N1) Vaccines: What's the Status? | ASM.org
Mechanisms of miR-18a-5p Target NEDD9-Mediated Suppression of H5N1 Influenza Virus in Mammalian and Avian Hosts
Mechanisms of miR-18a-5p Target NEDD9-Mediated Suppression of H5N1 Influenza Virus in Mammalian and Avian Hosts
MicroRNAs (miRNAs) are key regulators of gene expression, exerting post-translational control through mRNA silencing or degradation. These molecules play pivotal roles in host–pathogen interactions, particularly in modulating antiviral immune responses. The global public health threat posed by the H5N1 Highly Pathogenic Avian Influenza (HPAI) virus necessitates urgent exploration of novel therapeutic strategies. Our investigation revealed significant dysregulation of miR-18a-5p following influenza virus infection, observed consistently across both in vitro and in vivo models. Experimental evidence demonstrated that miR-18a-5p overexpression effectively inhibits H5N1 virus propagation through multiple mechanisms: (1) in vitro studies using A549 cells transfected with miR-18a-5p mimics showed a substantial reduction in viral replication; (2) animal models (mice and chickens) with elevated miR-18a-5p expression exhibited markedly suppressed AIV replication, reduced pathogenicity, and improved survival rates. The therapeutic potential of miR-18a-5p was particularly evident in its ability to significantly decrease mortality rates in H5N1-infected animals. Furthermore, this miRNA demonstrated robust protective effects against virus-induced lung damage, suggesting its dual role in both preventing and treating H5N1 infections. These findings position miR-18a-5p as a promising candidate for the development of broad-spectrum antiviral interventions, offering a novel strategic approach to combat this serious public health challenge.
·mdpi.com·
Mechanisms of miR-18a-5p Target NEDD9-Mediated Suppression of H5N1 Influenza Virus in Mammalian and Avian Hosts
RFK Team's Moves on Vaccines, Bird Flu Stoke Health Worries (1)
RFK Team's Moves on Vaccines, Bird Flu Stoke Health Worries (1)
The latest actions by federal health authorities overseen by Robert F. Kennedy Jr. on vaccine development and evaluation are raising alarms among public health experts about the nation’s ability to handle a major health crisis like bird flu.
·news.bloomberglaw.com·
RFK Team's Moves on Vaccines, Bird Flu Stoke Health Worries (1)
BREAKING - USDA Approval Imminent for H5N1 Bird Flu Vaccine in Cattle
BREAKING - USDA Approval Imminent for H5N1 Bird Flu Vaccine in Cattle
Medgene's 'protein-based prescription-platform vaccine' nears USDA approval for cattle vaccination, with meat and dairy from field-tested vaccinated cattle likely already in the food supply.
·thefocalpoints.com·
BREAKING - USDA Approval Imminent for H5N1 Bird Flu Vaccine in Cattle
A new shield against bird flu - Reflections on a new vaccine - The Tufts Daily
A new shield against bird flu - Reflections on a new vaccine - The Tufts Daily
With the COVID-19 pandemic still fresh in the minds of many U.S. citizens, concerns over the government’s ability to contain emerging health threats persist. The ongoing struggle to control the H5N1 bird flu outbreak has raised alarms, particularly as the virus has begun spreading beyond poultry to cows and even humans. While the likelihood of a pandemic remains low, if one does occur, it could be as disruptive as 2020, if not worse.
·tuftsdaily.com·
A new shield against bird flu - Reflections on a new vaccine - The Tufts Daily
Zapnometinib counteracts different H5N strains through MEK1/2 inhibition
Zapnometinib counteracts different H5N strains through MEK1/2 inhibition
Avian influenza viruses, particularly the H5 and H7 subtypes, can cause widespread outbreaks in birds and pose a significant zoonotic risk due to their potential to mutate and develop the ability for human-to-human transmission. Researchers from the University of Muenster described the preclinical efficacy of zapnometinib, a selective MEK1/2 inhibitor, against H5N1 clade 2.3.4.4b.
·bioworld.com·
Zapnometinib counteracts different H5N strains through MEK1/2 inhibition