Long Covid Molecular

/PRNewswire/ -- In patients with long COVID, lower pulmonary gas exchange may be associated with impaired cognitive function, according to a study being...

Between up to 20 per cent of Australians who get COVID-19 will develop symptoms of long COVID, including brain fog and fatigue, but its exact causes remain a medical mystery.

For patients with Long Covid, lower pulmonary gas exchange may be associated with lower gray and white matter volume, according to new MRI research to be presented at the Radiological Society of North America (RSNA) conference.

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WASHINGTON — The correlation between autoantibodies and new-onset autoimmune disease in individuals with long COVID symptoms remains “controversial,” according to a speaker at ACR Convergence 2024. “Disclaimer: This is a controversial topic,” Leonard H. Calabrese, DO, professor of medicine at the Cleveland Clinic Lerner College of Medicine, at Case Western Reserve

A parliamentary inquiry found between two and twenty per cent of Australians who get the virus will develop symptoms of long COVID including brain fog and fatigue, but its exact causes remain a mystery.

Few would have thought that the COVID pandemic would have a silver lining, but scientists in Chicago may just have found one.

A forward-thinking GP practice in Midlothian is actively

GENETIC LINK - An Imperial-led study has highlighted how rare variants of a gene regulating the gut lining may increase the risk of MIS-C by up to four times.

Introduction Post-COVID syndrome (PCS) is characterized by a polymorphism of symptoms with hypothetical pathophysiological mechanisms. Here, we aimed to analyze the profile of inflammatory cytokines in patients with PCS and to study the relationship between this profile, the clinical symptoms as well as the endothelial function in PCS. Methods Our analytical study involved all eligible patients (n = 66) with PCS included from April 2021 to December 2021. The serum concentration of cytokines IFN-γ, IL-1α, IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-27, IP-10, MCP-1 and TNF-α was quantified by flow cytometry. Endothelial function was explored by assessing microvascular flow and reactivity using thermal probes. A comparative study was carried out according to the presence of each PCS symptom. Results The average age of our patients was 55.9 ± 16.2 years. The sex ratio was 0.69. Forty-one patients (62%) presented with a severe form of acute infection. The most frequently reported symptoms were dyspnea (67%), fatigue (50%), and memory problems (32%). Fifty-seven patients (86%) had endothelial dysfunction. The majority of patients had increased levels of IP-10 (100%), IL-8 (95%), IFN-γ (95%), MCP-1 (80%), and TNF-α (70%). The serum concentration of IL-10 was below the threshold of quantification in 89% of subjects. The severe form of acute infection was associated with elevated IL-10, MCP-1, and IL-27. Increased IL-6 and IL-27 levels were associated with fatigue while IL-8 concentrations were higher in patients who reported dyspnea. Elevation of IL-8 level was more common in patients with profound impairment of endothelial function. Conclusion Our results further support the presence of endothelial dysfunction in PCS and show an elevation of pro-inflammatory cytokines with a downmodulation of the IL-10- anti-inflammatory response. In addition, immuno-clinical phenotypes emerge, such as an inflammatory profile mediated by IL-6 and IL-27 in fatigue and IL-8 in dyspnea. The identification of immuno-clinical phenotypes would allow a better understanding of the pathophysiology of PCS symptoms.

Scientific Reports - Different dynamics of soluble inflammatory mediators after clearance of respiratory SARS-CoV-2 versus blood-borne hepatitis C virus infections

Introduction Long coronavirus disease (COVID) poses a significant burden following the coronavirus disease 2019 (COVID-19) pandemic. Debate persists regarding the impact of nonsteroidal anti-inflammatory drug (NSAID) administration during acute-phase COVID-19 on the development of long COVID. Hence, this study aimed to assess the potential association between NSAID use and long COVID using data from patients with COVID-19 in Korea’s National Health Insurance Service. Methods This nested case-control study defined the study cohort as patients diagnosed with COVID-19 for the first time between 2020 and 2021. The primary exposure investigated was NSAID prescriptions within 14 days of the initial COVID-19 diagnosis. We used propensity score matching to create three control patients matched to each patient in the NSAID exposure group. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated after the adjustment for demographics, Charlson Comorbidity Index, and existing comorbidities. Results Among the 225,458 patients diagnosed with COVID-19, we analyzed data from 254 with long COVID. The adjusted OR (aOR) for NSAID exposure during acute-phase COVID-19 was higher in long COVID cases versus controls (aOR, 1.79; 95% CI, 1.00–3.19), suggesting a potential relationship. However, a sensitivity analysis revealed that the increased odds of NSAID exposure in the acute phase became statistically non-significant (aOR, 1.64; 95% CI, 0.90–2.99) when COVID-19 self-quarantine duration was included as a covariate. Additionally, acetaminophen exposure was not significantly associated (aOR, 1.12; 95% CI, 0.75–1.68), while antiviral drugs demonstrated a stronger association (aOR, 3.75; 95% CI, 1.66–8.48). Conclusion Although this study suggests a possible link between NSAID use in the acute COVID-19 infection stage and a higher risk of long COVID as well as both NSAID and acetaminophen use during the chronic COVID-19 period and a lower risk of long COVID, the association was not statistically significant. Further research is needed to determine the causal relationship between the various treatment options for acute COVID-19 and the development of long COVID.

The new findings suggests that even if vaccine-induced immune memory is not detected in the blood, it may still persist in tissues.

🥑 Make smarter food choices. Become a member at http://zoe.com The COVID-19 pandemic is in the rear-view mirror, so what did we learn about mask wearing, vaccines and prevention? And how can you stay healthy to face a future pandemic? Professor Tim Spector, one of the world’s top 100 most cited scientists, looks back on the pandemic and what we learnt about symptoms, transmission and vaccines in the early stages. We’ll reflect on ZOE’s role - collecting data from millions of people on their symptoms, identifying COVID hotspots and shaping public understanding of the virus. Then we discuss the possibility of the next pandemic, and how we can individually protect ourselves against it. By the end of this episode, listeners feel more equipped to stay safe in the face of another global pandemic. 🌱 Try our new plant based wholefood supplement - Daily30+ https://zoe.com/daily30?utm_medium=zoe_podcast&utm_source=podcast_platform&utm_campaign=d30 Follow ZOE on Instagram | https://www.instagram.com/zoe/ Timecodes 00:00 What did we learn from COVID? 01:44 Quickfire questions 04:22 ZOE's response to the pandemic 10:10 5 crucial days 14:06 How new symptoms were discovered 23:40 Did the virus come from a lab? 28:00 Were face masks worth it? 29:02 The data on lockdowns 36:01 The economic costs 37:50 Effectiveness of vaccines 40:04 Side effects of vaccines 46:10 Is there a cure for Long COVID? 48:39 The role of food choices 51:24 How to fight off infections 52:30 The risks of junk food 📚Books by our ZOE Scientists The Food For Life Cookbook | https://amzn.to/4amfIMX Every Body Should Know This by Dr Federica Amati | https://amzn.to/4blJsLg Food For Life by Prof. Tim Spector | https://amzn.to/4amZinu Free resources from ZOE: Live Healthier: Top 10 Tips From ZOE Science & Nutrition | https://zoe.com/freeguide Gut Guide - For a Healthier Microbiome in Weeks | https://zoe.com/gutguide Mentioned in today's episode The WHO estimates of excess mortality associated with the COVID-19 pandemic (2022), published in Nature https://www.nature.com/articles/s41586-022-05522-2 Long COVID: major findings, mechanisms and recommendations (2023), published in Nature Reviews Microbiology https://www.nature.com/articles/s41579-022-00846-2 Benefit-risk assessment of Covid-19 vaccine, MRNA (MRNA-1273) for males age 18–64 years (2023), published in Vaccine: X https://www.sciencedirect.com/science/article/pii/S2590136223000669 Physical interventions to interrupt or reduce the spread of respiratory viruses (2023), published in Cochrane Database of Systematic Reviews https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006207.pub6/full Have feedback or a topic you'd like us to cover? Let us know here: https://gf6hx47iu5g.typeform.com/topicsuggestion Episode transcripts are available here: https://zoe.com/learn/category/podcasts

Chronic fatigue syndrome (CFS) is a complex and long-term illness characterized by extreme fatigue that doesn't improve with rest, and can worsen with physical activity.

WASHINGTON — Among patients with systemic autoimmune rheumatic diseases, circulating interleukin-18 levels were lower in those with long COVID vs. those without, according to data presented at ACR Convergence 2024. “We were interested to see if inflammatory cytokines were associated with long COVID among patients with rheumatic disease,” Jeffrey Sparks, MD, of Brigham and

Scientific Reports - Altered leukocyte pattern and inflammatory markers in unvaccinated long covid patients: a cross-sectional study

A study using a Korean database found that COVID-19 infection raised long-term risks for various autoimmune and autoinflammatory skin disorders, and vaccination may reduce these risks.

BBC Before Long Covid there was post-viral fatigue – a mysterious set of illnesses caused by other infections. Now scientists are starting to unravel their secrets. Since an acute infection with Co…

Background Long COVID, a highly heterogeneous syndrome affecting millions of people worldwide, is emerging as an urgent public health threat, but data on the predictors of specific clinical manifestations over long follow-up periods are limited. The aim of this study is to investigate the role of viral variants and other predictors in long COVID incidence and clinical manifestations. Methods All COVID-19 patients aged  18 years and hospitalized from March 1 2020 to April 2022 in two Italian University Hospitals were enrolled. Incidence and clinical presentation of long COVID were assessed through structured questionnaires delivered by phone calls. The association between possible risk factors collected during hospitalization and long COVID was reported using an adjusted logistic regression and reported as odds ratios (ORs) with their 95% confidence intervals (CIs). Results Among 1,012 recruited patients, over a median follow-up of 19 months (IQR: 15–24 months), the cumulative incidence of long COVID was 91.7%, with the most common clinical manifestations involving the respiratory system (80.5%) and the neurological system (77.3%). Among 1,012 recruited patients, over a median follow-up of 19 months (IQR: 15–24 months), the cumulative incidence of long COVID was 91.7%, with the most common clinical manifestations involving the respiratory system (80.5%) and the neurological system (77.3%). Overall, 54% reported long COVID symptomatology between 18 and 24 months. Multivariate analysis suggested that being vaccinated against SARS-CoV-2 was associated with reduced odds of reporting any long COVID symptomatology (OR: 0.34; 95% CI: 0.21–0.58), while infection with the Delta variant was a strong predictor (OR: 9.61, p

Two dons of the University of Lagos (UNILAG); Professor Njideka Okubadejo, Neurologist at the Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos (CMUL) and Dr. Iorhen Akase, Infectious Diseases Physician, at the Infectious Diseases Unit, Department of Medicine, CMUL; have made a groundbreaking research on the neurological manifestations of long COVID in Nigeria, and published same in the prestigious Journal of NeuroVirology. This study, carried out in collaboration with researchers from Northwestern […]

COVID-19 vaccines reduced mortality, hospitalizations and ICUs admissions. Conversely, the impact of vaccination on Long COVID-19 syndrome is still un…

Researchers found that the COVID-19 virus triggers immune changes that may one day be harnessed to help fight cancer.

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Streaming now at https://abc7.ws/484PqhJ A new Northwestern Medicine study in Chicago shows that severe COVID-19 may shrink cancer cells in patients, doctors told ABC7. Full story: https://abc7chicago.com/post/chicago-northwestern-medicine-study-shows-severe-covid-19-may-shrink-cancer-cells/15548871/

Long-lived plasma cell compartment in the bone marrow may hold the answer, says researcher

Researchers are trying to get to the root of the problem, in hopes of helping these patients who are suffering the longest.

Nature Aging - Zhang et al. performed a multi-regional multi-omics study, identifying brain-wide mitochondrial and synaptic defects in neurons and glial inflammation as key mechanisms underlying...

IL-18 levels were consistently lower across participants with different SARDs, remission status, and COVID-19 disease characteristics.