Long Covid Symptoms

Scientific Reports - Novel brain SPECT imaging unravels abnormal cerebral perfusion in patients with postural orthostatic tachycardia syndrome and cognitive dysfunction

This evidence brief synthesizes the international literature on prolonged symptoms that can be attributed to infection with COVID-19.

Patients struggle with weakness, fatigue, breathing difficulties and concentration problems, significantly impacting their daily life

This study had HRA approval (20/HRA/4928).

Health-Related Quality of Life in Long COVID: Mapping the Condition-Specific C19-YRSm Measure Onto the EQ-5D-5L

In a population-based case-control study, Raphael Peter and colleagues investigate the clinical characteristics and diagnostic findings in patients with post-COVID-19 syndrome.

Erectile dysfunction (ED), deleterious impact of COVID-19 on erectile function, COVID-19, post-COVID-19 ED predictive models, post-COVID-19 Erectile dysfunction.

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In this large study of 32 million Medicare beneficiaries, we found approximately 194 000 post-COVID condition diagnoses. Post-COVID condition diagnosis rate was higher among nursing home residents, highlighting the substantial burden of COVID-19 in this vulnerable population. Community-dwelling bene …

Doctors agree that the numbers of young people with heart attack on the rise, but disagree about the cause. In the meantime, young people share their ...

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating but poorly-understood disease. ME/CFS symptoms can range from mild to severe, and include immune system effects alongside incapacitating fatigue and post-exertional disease exacerbation. In this study, we examined immunological profiles of people living with ME/CFS by flow cytometry, focusing on cytotoxic cells, to determine whether people with mild/moderate (n= 43) or severe ME/CFS (n=53) expressed different immunological markers. We found that people with mild/moderate ME/CFS had increased expression of cytotoxic effector molecules alongside enhanced proportions of early-immunosenescence cells, determined by the CD28-CD57- phenotype, indicative of persistent viral infection. In contrast, people with severe ME/CFS had higher proportions of activated circulating lymphocytes, determined by CD69+ and CD38+ expression, and expressed more pro-inflammatory cytokines, including IFNγ, TNF and IL-17, following stimulation in vitro , indicative of prolonged non-specific inflammation. These changes were consistent across different cell types including CD8+ T cells, mucosal associated invariant T cells and Natural Killer cells, indicating generalised altered cytotoxic responses across the innate and adaptive immune system. These immunological differences likely reflect different disease pathogenesis mechanisms occurring in the two clinical groups, opening up opportunities for the development of prognostic markers and stratified treatments. ![Graphical Abstract][1]/img Graphical Abstract ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement The analysis was mainly funded by the NIH: R01AI103629, with additional support from NIH: 5R01AI170839-03 and from The ME Association. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: This study was conducted according to the principles of the Declaration of Helsinki. Study approval was obtained from the LSHTM Medicine Research Ethics Committee 16 January 2012 (Ref.6123) and the National Research Ethics Service (NRES) London: Bloomsbury Research Ethics Committee 22 December 2011 (REC ref.11/10/1760, IRAS ID: 77765). Written informed consent was obtained from all study participants prior to inclusion in the study. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes [1]: pending:yes

After the COVID-19 pandemic, the incidence rate of postural orthostatic tachycardia syndrome increased significantly, according to new data published in the European Heart Journal – Quality of Care and Clinical Outcomes.“Postural orthostatic tachycardia syndrome (POTS) is a chronic condition characterized by an abnormal increase in heart rate upon standing, often accompanied by

The COVID-19 Symptoms Daily Diary (CSDD) is a patient-reported outcome measure designed to assess the severity of core COVID-19 symptoms in clinical trials. The preliminary version of the CSDD was developed based on regulatory guidance and the ...

COVID-19 has led to reports of fatigue and sleep problems. Brain function changes underlying sleep problems (SP) post-COVID-19 are unclear. This study investigated SP-related brain functional connectivity (FC) alterations. Fifty-five COVID-19 ...

After the COVID-19 pandemic, the main viral pathogens of ARTIs were unevenly distributed, and less bacterial and atypical pathogens were detected in primary care. The microbiological evidences can optimize the precision diagnosis and treatment of ARTIs in primary care with limited resources.

The pattern of myocardial injury and dysfunction development during follow-up is unclear in patients with myocarditis. This study aims to explore the developmental pattern of myocardial injury and cardiac dysfunction during the follow-up of ...

Journal of Internal Medicine Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may occur after infection. How often people develop ME/CFS after SARS-CoV-2 infection is unknown.…

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Everything has changed.

By Dr. Sanchari Sinha Dutta, Ph.D. RECOVER-Adult study reveals refined thresholds and symptom categorization, advancing research into long COVID’s complexities. Study: 2024 Update of the RECOVER-Adult Long COVID Research Index . Image Credit: Branislav Nenin / Shutterstock.co...

ted sociodemographic and clinical factors. 2764 adults who tested positive for COVID-19 were recruited at 12 weeks after diagnosis. Participants responded to an electronic survey [Newcastle Post-COVID Syndrome Questionnaire (symptoms); COVID-19 Yorkshire Rehabilitation Screen (activities; perceived global health, mobility, personal care, daily activities)]. 37.8% were classified as having Long-Covid based on the positive response to “Are you still troubled by symptoms?”. The majority of them reported a decline in global health, mobility, and participation in daily activities. Common changes in function included fatigue, breathlessness upon climbing stairs and when dressing, decline in participation in usual activities, anxiety, pain/discomfort, and reduced concentration. Having COVID-19 1 year prior was associated with change in perceived global health (OR = 1.5). Being infected 12 months prior (OR = 1.5), hospitalized for COVID-19 (OR = 2.2-2.4), 1 chronic comorbid conditions (OR = 1.6), and obesity (OR = 1.6) were associated with functional decline. Many of those infected with COVID-19 experience long-lasting symptoms impacting daily functioning. Multidisciplinary medical and rehabilitation services are needed to help improve recovery and maximize functioning. Many people experience symptoms months or years following COVID-19 infection. The impact of these symptoms on daily functioning and factors associated with functional decline are not well understood. This study aimed to describe functional changes among persons with Long-Covid and explore associated sociodemographic and clinical factors. 2764 adults who tested positive for COVID-19 were recruited at 12 weeks after diagnosis. Participants responded to an electronic survey [Newcastle Post-COVID Syndrome Questionnaire (symptoms); COVID-19 Yorkshire Rehabilitation Screen (activities; perceived global health, mobility, personal care, daily activities)]. 37.8% were classified as having Long-Covid based on the positive response to “Are you still troubled by symptoms?”. The majority of them reported a decline in global health, mobility, and participation in daily activities. Common changes in function included fatigue, breathlessness upon climbing stairs and when dressing, decline in participation in usual activities, anxiety, pain/discomfort, and reduced concentration. Having COVID-19 1 year prior was associated with change in perceived global health (OR = 1.5). Being infected 12 months prior (OR = 1.5), hospitalized for COVID-19 (OR = 2.2-2.4), 1 chronic comorbid conditions (OR = 1.6), and obesity (OR = 1.6) were associated with functional decline. Many of those infected with COVID-19 experience long-lasting symptoms impacting daily functioning. Multidisciplinary medical and rehabilitation services are needed to help improve recovery and maximize functioning. Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved....

A study found that patients with COVID-19 may have a higher risk of developing new gastrointestinal (GI) disorders compared with matched controls, highlighting the need for further research on long-term GI effects post COVID-19 infection.

A groundbreaking study funded by the US government has revealed a potential link between long Covid and a significant increase in cases of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).The study, conducted by the National Institutes of Health (NIH) as part of its RECOVER initiative to understand long Covid, found that 4.5 per cent of individuals recovering from Covid-19 met the diagnostic criteria for ME/CFS, compared to just 0.6 per cent of those who had never been infected.Led by Dr Suzanne D. Vernon from the Bateman Horne Centre, the research analysed data from 13,224 participants, including 11,785 individuals who had recovered from Covid-19 and 1,439 who had not contracted the virus. The findings, published in the Journal of General Internal Medicine, highlight a stark rise in ME/CFS cases following Covid-19 infections.Myalgic encephalomyelitis/chronic fatigue syndrome is a complex and debilitating condition often triggered by an infection. Symptoms include:Persistent fatigue lasting six months or more.Post-exertional malaise, where symptoms worsen after physical or mental activity.Unrefreshing sleep.Cognitive difficulties or dizziness upon standing (orthostatic intolerance).Many individuals with long Covid report similar symptoms, which has drawn attention to the possible connection between the two conditions.The study reported that new cases of ME/CFS have surged, rising 15 times higher than pre-pandemic levels. Among Covid-19 survivors, the most frequently reported symptoms were post-exertional malaise, orthostatic intolerance, and cognitive impairment.Dr Vernon and her team emphasised that these findings strengthen the evidence that viral infections, such as Covid-19, can lead to chronic fatigue syndrome.Study Limitations and Future DirectionsThe research acknowledged certain limitations, including the reliance on self-reported symptoms, the exclusion of hospitalised Covid-19 patients, and the fluctuating nature of ME/CFS symptoms.Despite these challenges, the study underscores the importance of understanding how Covid-19 may trigger chronic conditions like ME/CFS. The researchers noted that this knowledge could pave the way for better treatments, not only for ME/CFS but also for other long-term health issues linked to infections.As the global community continues to grapple with the long-term impacts of Covid-19, studies like this are crucial in addressing the broader health challenges posed by the pandemic. 

ObjectiveThis study evaluated the association between acute COVID-19 cases and the number of car crashes with varying COVID-19 vaccination rates, Long COVID rates, and COVID-19 mitigation strategies.BackgroundThe ongoing SARS-CoV-2 pandemic has led to ...

To assess the morbidity profile and identify factors associated with frailty syndrome in post-COVID-19 elderly patients treated at the only Reference Center for Elderly Health Care in northern Minas Gerais. This is a case series study, utilizing the ...

Catatonia Associated With Post-Acute COVID-19 in a Young Child

The Post COVID-19 condition (PCC) is a complex disease affecting health and everyday functioning. This is well reflected by a patient's inability to work (ITW). In this study, we aimed to investigate factors associated with ITW (1) and to design a machine learning-based model for predicting ITW (2) …

There is a high prevalence of Long COVID among patients hospitalized for acute COVID-19. Those who had a longer duration of symptoms before admission and a longer stay in the hospital appear to have a higher risk.

People with post-infectious diseases sometimes struggle to communicate the debilitating impact of their conditions. But a new technique can help them explain visually