Screening for SARS-CoV-2 Antigen Before a Live Indoor Music Concert: An Observational Study | Annals of Internal Medicine
Covid19-Sources
Age-specific rate of severe and critical SARS-CoV-2 infections estimated with multi-country seroprevalence studies
Knowing the age-specific rates at which individuals infected with SARS-CoV-2 develop severe and critical disease is essential for designing public policy, for epidemic modeling, and for individual risk evaluation. In this study, we present the first estimates of these rates using multi-country serology studies, together with public data on hospital admissions and mortality. Our results show that the risk of severe and critical disease increases exponentially with age, but much less steeply than the risk of fatal illness. Importantly, the estimated rate of severe disease outcome in adolescents is an order of magnitude larger than the reported rate of vaccine side-effects; thus, showing how these estimates are relevant for health policy. Finally, we validate our results by showing that they are in close agreement with the estimates obtained from an indirect method that uses reported infection fatality rates estimates and hospital mortality data.
### Competing Interest Statement
The authors have declared no competing interest.
### Funding Statement
This work did not receive any specific funding.
### Author Declarations
I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Yes
The details of the IRB/oversight body that provided approval or exemption for the research described are given below:
This is an analysis of publicly available data, already used in previous studies.
All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.
Yes
I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).
Yes
I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.
Yes
All data and code used in this project are available
[https://github.com/dherrera1911/estimate\_covid\_severity.git][1]
[1]: https://github.com/dherrera1911/estimate_covid_severity.git
Evaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents | NEJM
Original Article from The New England Journal of Medicine — Evaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents
EVIDENCE FOR BIOLOGICAL AGE ACCELERATION AND TELOMERE SHORTENING IN COVID19 SURVIVORS
Introduction & Background the SARS-CoV-2 infection determines the COVID19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokines release, and immunosuppression. This condition has led to the death of about 2.15% of the total infected world population so far. Among survivors, the presence of the so-called persistent post-COVID19 syndrome (PPCS) is a common finding. In patients who survived the SARS-CoV-2 infection, overt PPCS presents one or more symptoms such as fatigue, dyspnea, memory loss, sleep disorders, and difficulty concentrating. The pathophysiology of PPCS is currently poorly understood, and whether epigenetic mechanisms are involved in this process is unexplored.
Methods & Results In this study, a cohort of 117 COVID19 survivors (post-COVID19) and 144 non-infected volunteers (COVID19-free) were analyzed using pyrosequencing of defined CpG islands previously identified as suitable for biological age determination. Besides, telomere length (TL) and ACE2 and DPP-4 receptor expression were determined. The results show a consistent biological age increase in the post-COVID19 population (58,44 ± 14,66 ChronoAge Vs. 67,18 ± 10,86 BioAge, P
Children’s hospitals are swamped with Covid patients — and it may only get worse
Nearly 1,600 kids with Covid-19 were hospitalized last week, according to the CDC — a new seven-day record and a 27 percent increase from the week before.
SARS-CoV-2-reactive T cells in healthy donors...
Nature - A study of patients with COVID-19 and healthy donors found CD4+ T cells that react to the spike protein of SARS-CoV-2 and human endemic coronaviruses; however, the effect of pre-existing...
Does Vitamin D Deficiency Raise COVID-19 Risk?
This Medical News Quick Uptake examines the debate about a link between vitamin D and COVID-19 risk.
Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant | NEJM
Original Article from The New England Journal of Medicine — Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant
Full article: One year on: an updated systematic review of SARS-CoV-2, COVID-19 and audio-vestibular symptoms
(2021). One year on: an updated systematic review of SARS-CoV-2, COVID-19 and audio-vestibular symptoms. International Journal of Audiology. Ahead of Print. There are multiple reports of hearing loss (e.g. sudden sensorineural), tinnitus and rotatory vertigo in adults having a wide range of COVID-19 symptom severity. The pooled estimate of prevalence based primarily on retrospective recall of symptoms, was 7.6% (CI: 2.5–15.1), 14.8% (CI: 6.3–26.1) and 7.2% (CI: 0.01–26.4), for hearing loss, tinnitus and rotatory vertigo, respectively. However, these could be an over-estimate because it was not always clear that studies report a change in symptom.
Frontiers | Do Ocular Fluids Represent a Transmission Route of SARS-CoV-2 Infection? | Medicine
The spread of the new SARS-CoV-2 is marked by a short timeline. In this scenario, explaining or excluding the possible transmission routes is mandatory to contain and manage the spread of the disease in the community. In the recent pandemic, it is still unclear how coronavirus can end up in ocular fluids. Nevertheless, eye redness and irritation in COVID-19 patients have been reported, suggesting that a possible ocular manifestation of SARS-CoV-2 infection may be conjunctivitis. On the basis of epidemiological data provided by previous SARS-Cove infection, numerous theories have been proposed: (1) conjunctiva as the site of direct inoculation by infected droplets; (2) the nasolacrimal duct as a migration route of the virus to the upper respiratory tract, or (3) haematogenic infection of the tear gland. The demand for further investigations to verify ocular involvement in COVID-19 infection came out from the results of recent meta-analysis studies, so the eye cannot be completely excluded as a transmission route of the infection. Thus, healthcare personnel and all the people that enter in contact with infected or suspected patients must always use the prescribed protective equipment.
Low-field Magnetic Resonance Imaging of Pediatric COVID-19 - Full Text View - ClinicalTrials.gov
SARS-CoV-2 (Severe acute respiratory syndrome coronavirus type 2) is a new coronavirus and identified causative agent of COVID-19 disease. They predominantly cause mild colds, but can sometimes cause severe pneumonia. While the molecular basis for the changes in lung tissue or multi-organ involvement has been described, the age-specific long-term consequences, especially in children and adolescents, are still largely unexplained and not understood. Early publications from the primarily affected Chinese provinces described rather mild, partly asymptomatic courses in children. This is consistent with the observation that the risk of severe COVID-19 disease increases steeply from the age of 70 years, and is also determined by the severity of obesity and other risk factors. Developmental expression of tissue factors may be one reason for the relative protection of younger patients from severe courses of the disease.
However, it is now becoming increasingly clear that some individuals with milder initial symptoms of COVID-19 may suffer from variable and persistent symptoms for many months after initial infection - this includes children. A modern low-field MRI is located in Erlangen, Germany. This technique has already been used to demonstrate persistent damage to lung tissue in adult patients after COVID-19. The device with a field strength of 0.55 Tesla (T) currently has the world's largest bore (and is thus particularly suitable for patients with claustrophobia, among other things), a very quiet operating noise, and lower energy absorption in the tissue due to the weaker magnetic field than MRI scanners with 1.5T or 3T. This allows MRI imaging in a very wide pediatric population without the need for sedation.
The purpose of this study is to assess the frequency of lung parenchymal changes using low-field magnetic resonance imaging (LF-MRI) in pediatric and adolescent patients with past SARS-CoV-2 infection detected by PCR.
Uni-Klinikum Erlangen: Medikament gegen Autoantikörper hilft bei Long COVID
Dank einem Medikament, das ursprünglich zur Bekämpfung von Herzerkrankungen entwickelt wurde, ist es einem Ärzteteam der Augenklinik (Direktor: Prof. Dr. Friedrich E. Kruse) des Universitätsklinikums Erlangen nun im Rahmen eines individuellen Heilversuchs erstmals gelungen, dass ein 59-jähriger Mann mit Long-COVID-Syndrom beschwerdefrei wurde. Ob der Wirkstoff BC 007 auch anderen Betroffenen hilft, soll bald in einer klinischen Studie überprüft werden. „Momentan können wir leider nicht mehr Menschen mit dem Medikament behandeln, da es noch nicht alle Zulassungsstudien durchlaufen hat“, sagt Prof. Dr. Christian Mardin, leitender Oberarzt der Augenklinik.
Transmission of SARS-CoV-2 Delta Variant Among Vaccinated Healthcare Workers, Vietnam by Nguyen Van Vinh Chau, Nghiem My Ngoc, Lam Anh Nguyet, Vo Minh Quang, Nguyen Thi Han Ny, Dao Bach Khoa, Nguyen Thanh Phong, Le Mau Toan, Nguyen Thi Thu Hong, Nguyen Thi Kim Tuyen, Voong Vinh Phat, Le Nguyen Truc Nhu, Nguyen Huynh Thanh Truc, Bui Thi Ton That, Huynh Phuong Thao, Tran Nguyen Phuong Thao, Vo Trong Vuong, Tran Thi Thanh Tam, Ngo Tan Tai, Ho The Bao, Huynh Thi Kim Nhung, Nguyen Thi Ngoc Minh, Nguyen Thi My Tien, Nguy Cam Huy, Marc Choisy, Dinh Nguyen Huy Man, Dinh Thi Bich Ty, Nguyen To Anh, Le Thi Tam Uyen, Tran Nguyen Hoang Tu, Lam Minh Yen, Nguyen Thanh Dung, Le Manh Hung, Nguyen Thanh Truong, Tran Tan Thanh, Guy Thwaites, Le Van Tan, OUCRU COVID-19 Research Group :: SSRN
Background: Data on breakthrough SARS-CoV-2 Delta variant infections are limited.Methods: We studied breakthrough infections among healthcare workers of
Coronavirus (COVID-19) latest insights - Office for National Statistics
A cluster randomised trial of the impact of a policy of daily testing for 1 contacts of COVID-19 cases on attendance and COVID-19 2 transmission in English secondary schools and colleges
(301) Warum Impfen schlauer ist / Ranga Yogeshwar - YouTube
Ivermectin: Keine Evidenz für Wirksamkeit gegen COVID-19
Das Parasitenmedikament Ivermectin wird von manchen Lobbygruppen auch als Therapieoption gegen COVID-19 propagiert. Ein neuer Cochrane Review findet keine überzeugenden Studiendaten, die dies stützen würden. Allerdings ist die Evidenzlage noch unsicher, aktuell laufende Studien werden hier hoffentlich bald für Klarheit sorgen.
A long-term perspective on immunity to COVID
Clinical evidence for long-lasting immunity to SARS-CoV-2 infection
Adverse Events Following Immunization (AEFIs) for COVID-19 in Ontario: December 13, 2020 to July 31, 2021
COVID-19 Vaccines | Public Health Ontario
Resources for public health partners and health care providers to support implementation of COVID-19 vaccine programs.
COVID-19 Vaccine Safety in Adolescents Aged 12–17 Years — United States, December 14, 2020–July 16, 2021
Prof Francois Balloux: ‘The pandemic has created a market for gloom and doom’ | Coronavirus | The Guardian
The UCL scientist and ‘militant corona centrist’ on the risk of new variants, psychosomatic long Covid and when he expects the crisis to end
SARS-CoV-2 spike and its adaptable furin cleavage site
Much attention has been drawn to the origin of SARS-CoV-2, the causative agent of
COVID-19. One notable feature of SARS-CoV-2 is a four-amino acid insert starting with
proline (SPRRAR|S) at the junction of the receptor-binding (S1) and fusion (S2) domains
of the spike protein. Following the release of the SARS-CoV-2 genome, several groups
identified this insert as a potential cleavage site for the protease furin—the insert
has also been referred to as a polybasic site and proposed to be part of the proximal
origin of the ongoing pandemic.
How can IPAC save itself?
How can a field faced with broken public and professional trust mend itself? A small foray into the fatal dangers of closed-mindedness and myopic thinking, and what can be done about it now.
Multi‐inflammatory syndrome and Kawasaki disease in children during the COVID‐19 pandemic: A nationwide register‐based study and time series analysis - Koskela - - Acta Paediatrica - Wiley Online Library
Aim
We investigated whether the ongoing COVID-19 pandemic was associated with the occurrence of Kawasaki disease or with multi-inflammatory syndrome in children (MIS-C).
Methods
This national Finn...
Viral Load of SARS-CoV-2 in Respiratory Aerosols Emitted by COVID-19 Patients while Breathing, Talking, and Singing | Clinical Infectious Diseases | Oxford Academic
AbstractBackground. Multiple SARS-CoV-2 superspreading events suggest that aerosols play an important role in driving the COVID-19 pandemic. To better understan
Long Covid Kids | What is Long Covid Kids? | Long Lasting Covid Symptoms
Long Covid Kids is a Parent & Patient Led Advocacy & Support Group. Raising Awareness of Long Lasting Covid Symptoms. Long Covid Research, Symptom Gallery, Member Stories, Resources and Peer to Peer Support Group.
BNT162b2 vaccine breakthrough: clinical characteristics of 152 fully vaccinated hospitalized COVID-19 patients in Israel
The mRNA coronavirus disease 2019 (COVID-19) vaccines have shown high effectiveness
in the prevention of symptomatic COVID-19, hospitalization, severe disease and death.
Nevertheless, a minority of vaccinated individuals might become infected and experience
significant morbidity. Characteristics of vaccine breakthrough infections have not
been studied. We sought to portray the population of Israeli patients, who were hospitalized
with COVID-19 despite full vaccination.
Teens hospitalized for COVID-19 at nearly 3 times typical flu hospitalization rate
DIVI Intensivregister